cyproheptadine has been researched along with Disease Models, Animal in 42 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rupatadine had a beneficial effect on histologic changes in a chronic murine model of asthma." | 7.79 | The effect of rupatadine on lung histopathology in a murine model of chronic asthma. ( Bagriyanik, AH; Firinci, F; Karaman, M; Karaman, O; Kiray, M; Tuncel, T; Uysal, P; Uzuner, N; Yilmaz, O, 2013) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 7.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 5.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| "Rupatadine had a beneficial effect on histologic changes in a chronic murine model of asthma." | 3.79 | The effect of rupatadine on lung histopathology in a murine model of chronic asthma. ( Bagriyanik, AH; Firinci, F; Karaman, M; Karaman, O; Kiray, M; Tuncel, T; Uysal, P; Uzuner, N; Yilmaz, O, 2013) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 3.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 1.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| "When cyproheptadine was given at a dose of 13 or 20mg/kg 1min after soman exposure, the incidence of seizures was reduced from 100% to 13% and 30%, respectively." | 1.46 | Anticonvulsant efficacy of antihistamine cyproheptadine in rats exposed to the chemical warfare nerve agent soman. ( Kan, RK; Skovira, JW; Winkler, JL, 2017) |
| "In the present study convulsions were induced in mice by, maximum electroshock (MES), picrotoxin, and pentylenetetrazol (PTZ)." | 1.36 | Proconvulsant potential of cyproheptadine in experimental animal models. ( Goel, RK; Singh, D, 2010) |
| " However, the neural mechanism by which extracellular 5-HT is elevated to a toxic level for the syndrome remains to be determined." | 1.35 | Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. ( Huang, X; Krishnamoorthy, S; Ma, Z; Tao, R; Vukovich, NP; Zhang, G, 2009) |
| "Cyproheptadine has been shown to produce dose-dependent inhibition of haem polymerization activity both in vitro and in vivo." | 1.31 | Haem polymerase as a novel target of antimalarial action of cyproheptadine. ( Agrawal, R; Dutta, GP; Jain, SK; Shukla, OP; Tekwani, BL; Tripathi, R, 2002) |
| "Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent." | 1.31 | Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001) |
| "Cyproheptadine and verapamil were not effective in reversing chloroquine resistance and probable drug toxicity was observed with these drugs in combination with chloroquine." | 1.29 | Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. ( Kyle, DE; Milhous, WK; Rossan, RN, 1993) |
| "When cyproheptadine was injected 2 h after the completion of training, the correct response in the retention test period was not decreased." | 1.27 | Portacaval anastomosis attenuates the impairing effect of cyproheptadine on avoidance learning in rats--an involvement of the serotonergic system. ( Ishikawa, K; Kubo, T; Matsumoto, A; Shibanoki, S; Tsuda, K, 1988) |
| " Microspheres are injected into the carotid circulations and group embolus dose-response relationships are calculated." | 1.27 | A model for quantitative evaluation of embolic stroke therapy. ( DeGirolami, U; Hemenway, CC; Henry, ME; Kochhar, A; Lyden, PD; Mazzarella, V; Zivin, JA, 1987) |
| "This vasospasm was essentially unaffected by intravenous cyproheptadine." | 1.26 | Cerebrovascular responses to subarachnoid blood and serotonin in the monkey. ( Boisvert, DP; Grace, MG; Overton, TR; Reiffenstein, RJ; Weir, BK, 1979) |
| "An animal model of food allergy has been developed in which some aspects of the allergic response could be quantified and the effects of various drugs evaluated." | 1.26 | Intestinal anaphylaxis in the rat as a model of food allergy. ( Byars, NE; Ferraresi, RW, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (47.62) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 10 (23.81) | 29.6817 |
| 2010's | 10 (23.81) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Tarrasón, G | 1 |
| Carcasona, C | 1 |
| Eichhorn, P | 1 |
| Pérez, B | 1 |
| Gavaldà, A | 1 |
| Godessart, N | 1 |
| Malavige, GN | 1 |
| Wijewickrama, A | 1 |
| Fernando, S | 1 |
| Jeewandara, C | 1 |
| Ginneliya, A | 1 |
| Samarasekara, S | 1 |
| Madushanka, P | 1 |
| Punchihewa, C | 1 |
| Paranavitane, S | 1 |
| Idampitiya, D | 1 |
| Wanigatunga, C | 1 |
| Dissanayake, H | 1 |
| Prathapan, S | 1 |
| Gomes, L | 1 |
| Aman, SAB | 1 |
| John, AS | 1 |
| Ogg, GS | 1 |
| Gu, S | 1 |
| Fu, WY | 1 |
| Fu, AKY | 1 |
| Tong, EPS | 1 |
| Ip, FCF | 1 |
| Huang, X | 2 |
| Ip, NY | 1 |
| Winkler, JL | 1 |
| Skovira, JW | 1 |
| Kan, RK | 1 |
| Singh, D | 2 |
| Goel, RK | 2 |
| Zhang, G | 1 |
| Krishnamoorthy, S | 1 |
| Ma, Z | 1 |
| Vukovich, NP | 1 |
| Tao, R | 1 |
| Paoluzzi, L | 1 |
| Scotto, L | 1 |
| Marchi, E | 1 |
| Seshan, VE | 1 |
| O'Connor, OA | 1 |
| Yi, LT | 1 |
| Xu, HL | 1 |
| Feng, J | 1 |
| Zhan, X | 1 |
| Zhou, LP | 1 |
| Cui, CC | 1 |
| Kilic, FS | 1 |
| Dogan, AE | 1 |
| Baydemir, C | 1 |
| Erol, K | 1 |
| Telegdy, G | 1 |
| Schally, AV | 1 |
| Tuncel, T | 1 |
| Karaman, M | 1 |
| Firinci, F | 1 |
| Uysal, P | 1 |
| Kiray, M | 1 |
| Bagriyanik, AH | 1 |
| Yilmaz, O | 1 |
| Karaman, O | 1 |
| Uzuner, N | 1 |
| Agrawal, R | 1 |
| Tripathi, R | 1 |
| Tekwani, BL | 1 |
| Jain, SK | 1 |
| Dutta, GP | 1 |
| Shukla, OP | 1 |
| Auclair, D | 1 |
| Hopwood, JJ | 1 |
| Brooks, DA | 1 |
| Lemontt, JF | 1 |
| Crawley, AC | 1 |
| Tupal, S | 1 |
| Faingold, CL | 1 |
| Yamashita, H | 1 |
| Makino, T | 1 |
| Mizukami, H | 1 |
| Nose, M | 1 |
| Krieger, DT | 1 |
| Andreas, K | 1 |
| Fischer, HD | 1 |
| Schmidt, J | 1 |
| Cousins, SW | 1 |
| Guss, RB | 1 |
| Howes, EL | 1 |
| Rosenbaum, JT | 1 |
| Soter, NA | 1 |
| Kyle, DE | 1 |
| Milhous, WK | 1 |
| Rossan, RN | 1 |
| Singh, N | 1 |
| Puri, SK | 1 |
| Nisijima, K | 1 |
| Yoshino, T | 1 |
| Yui, K | 1 |
| Katoh, S | 1 |
| Skurikhin, EG | 1 |
| Dygai, AM | 1 |
| Suslov, NI | 1 |
| Provalova, NV | 1 |
| Zyuz'kov, GN | 1 |
| Gol'dberg, ED | 1 |
| Boisvert, DP | 1 |
| Weir, BK | 1 |
| Overton, TR | 1 |
| Reiffenstein, RJ | 1 |
| Grace, MG | 1 |
| Kupor, LR | 2 |
| Lowance, DC | 1 |
| McPhaul, JJ | 2 |
| Garovoy, MR | 1 |
| Mullins, JD | 1 |
| Byars, NE | 1 |
| Ferraresi, RW | 1 |
| Vinegar, R | 1 |
| Truax, JF | 1 |
| Selph, JL | 1 |
| Peroutka, SJ | 1 |
| Kitamura, K | 1 |
| Lim, M | 1 |
| Steinman, L | 1 |
| Kuhn, C | 1 |
| Bero, L | 1 |
| Ignar, D | 1 |
| Lurie, S | 1 |
| Field, E | 1 |
| Kubo, T | 1 |
| Shibanoki, S | 1 |
| Matsumoto, A | 1 |
| Tsuda, K | 1 |
| Ishikawa, K | 1 |
| Zivin, JA | 1 |
| DeGirolami, U | 1 |
| Kochhar, A | 1 |
| Lyden, PD | 1 |
| Mazzarella, V | 1 |
| Hemenway, CC | 1 |
| Henry, ME | 1 |
| Adams, LM | 1 |
| Geyer, MA | 1 |
| Bekemeier, H | 1 |
| Hirschelmann, R | 1 |
| Giessler, AJ | 1 |
| Buhner, D | 1 |
| Grant, JA | 1 |
| Voss, C | 1 |
| Hartmann, N | 1 |
| Hübner, G | 1 |
| Hall, CE | 1 |
| Ayachi, S | 1 |
| Hall, O | 1 |
| Bolton, WK | 1 |
| Spargo, BA | 1 |
| Lewis, EJ | 1 |
| Nemir, P | 1 |
| Hamilton, WM | 1 |
| Brody, JI | 1 |
3 reviews available for cyproheptadine and Disease Models, Animal
| Article | Year |
|---|---|
Physiopathology of Cushing's disease.
Topics: Adenoma; Biomechanical Phenomena; Bromocriptine; Circadian Rhythm; Cushing Syndrome; Cyproheptadine; | 1983 |
Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin.
Topics: Acute Disease; Angioedema; Body Temperature; Chronic Disease; Cold Temperature; Cyproheptadine; Derm | 1981 |
[Experimental induction of obesity in animals].
Topics: Adrenocorticotropic Hormone; Animals; Aurothioglucose; Cats; Cyproheptadine; Diet; Dietary Fats; Dis | 1972 |
39 other studies available for cyproheptadine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricy | 2017 |
A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection.
Topics: Acute Disease; Adult; Animals; Anti-Allergic Agents; Blood Platelets; Cyproheptadine; Dengue; Dengue | 2018 |
Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs.
Topics: Alzheimer Disease; Androstenes; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyproheptadine; Di | 2018 |
Anticonvulsant efficacy of antihistamine cyproheptadine in rats exposed to the chemical warfare nerve agent soman.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Death; Cerebral Cortex; Convulsants; Cyprohepta | 2017 |
Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
Topics: Animals; Anticonvulsants; Cyproheptadine; Diazepam; Disease Models, Animal; Dose-Response Relationsh | 2009 |
Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Body Temperature; Clorgyline; Cyproheptadine; D | 2009 |
The anti-histaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylase inhibitor.
Topics: Actins; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomi | 2009 |
Proconvulsant potential of cyproheptadine in experimental animal models.
Topics: Animals; Anticonvulsants; Cyproheptadine; Disease Models, Animal; Drug Interactions; Histamine H1 An | 2010 |
Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Cyproheptadine; Depression; Di | 2011 |
The acute effects of mirtazapine on pain related behavior in healthy animals.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyprohe | 2011 |
Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Bicuculline; Cyproh | 2012 |
The effect of rupatadine on lung histopathology in a murine model of chronic asthma.
Topics: Animals; Asthma; Cyproheptadine; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; His | 2013 |
Haem polymerase as a novel target of antimalarial action of cyproheptadine.
Topics: Animals; Antimalarials; Chloroquine; Cyproheptadine; Disease Models, Animal; Drug Resistance; Enzyme | 2002 |
Replacement therapy in Mucopolysaccharidosis type VI: advantages of early onset of therapy.
Topics: Age Factors; Animals; Animals, Newborn; Autopsy; Bone and Bones; Cats; Complement Hemolytic Activity | 2003 |
Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice.
Topics: Animals; Cyproheptadine; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Ep | 2006 |
Pharmacological characterization of a chronic pruritus model induced by multiple application of 2,4,6-trinitrochlorobenzene in NC mice.
Topics: Animals; Antipruritics; Cell Degranulation; Chronic Disease; Cromolyn Sodium; Cyproheptadine; Dermat | 2007 |
[Effect of central effective substances on alcohol preference].
Topics: Alcohol Drinking; Alcoholism; Animals; Arecoline; Atropine; Central Nervous System Stimulants; Cypro | 1983 |
Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology.
Topics: Animals; Capillary Permeability; Cyproheptadine; Disease Models, Animal; Dose-Response Relationship, | 1984 |
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; D | 1993 |
Modulation of halofantrine resistance after coadministration of halofantrine with diverse pharmacological agents in a rodent malaria model.
Topics: Animals; Antimalarials; Cyproheptadine; Disease Models, Animal; Drug Resistance; Female; Male; Mice; | 2000 |
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature | 2001 |
Role of the central nervous system in hemopoiesis regulation during experimental neuroses.
Topics: Animals; Brain Chemistry; Central Nervous System; Conflict, Psychological; Cyproheptadine; Disease M | 2001 |
Cerebrovascular responses to subarachnoid blood and serotonin in the monkey.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Cyproheptadine; Disease Models, Animal; Female | 1979 |
Single and multiple drug therapy in autologous immune complex nephritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azathioprine; Basement Membrane; Compleme | 1976 |
Treatment of autologous immune complex glomerulonephritis with vasoactive amine antagonists.
Topics: Animals; Capillary Permeability; Chlorpheniramine; Cyproheptadine; Disease Models, Animal; Drug Ther | 1977 |
Intestinal anaphylaxis in the rat as a model of food allergy.
Topics: Anaphylaxis; Animals; Antigens; Capillary Permeability; Cromolyn Sodium; Cyproheptadine; Disease Mod | 1976 |
Quantitative studies of the pathway to acute carrageenan inflammation.
Topics: Acute Disease; Animals; Carrageenan; Chemotaxis; Cyproheptadine; Disease Models, Animal; Edema; Indo | 1976 |
Treatment of lethal pertussis vaccine reaction with histamine H1 antagonists.
Topics: Animals; Brain Diseases; Cyproheptadine; Disease Models, Animal; Histamine H1 Antagonists; Mice; Mic | 1987 |
Endocrine consequences of perinatal methadone exposure.
Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Disease Models, Animal; Hypothalamo-Hypophyseal Sy | 1987 |
Portacaval anastomosis attenuates the impairing effect of cyproheptadine on avoidance learning in rats--an involvement of the serotonergic system.
Topics: Animals; Avoidance Learning; Brain; Cyproheptadine; Disease Models, Animal; Dose-Response Relationsh | 1988 |
A model for quantitative evaluation of embolic stroke therapy.
Topics: Animals; Arterioles; Cerebral Cortex; Cyproheptadine; Disease Models, Animal; Intracranial Embolism | 1987 |
Effects of DOM and DMT in a proposed animal model of hallucinogenic activity.
Topics: Amphetamines; Animals; Cyproheptadine; Disease Models, Animal; DOM 2,5-Dimethoxy-4-Methylamphetamine | 1985 |
Carrageenin-induced thrombosis in rats and mice: a model for testing antithrombotic substances?
Topics: Animals; Carrageenan; Cyproheptadine; Dibenzylchlorethamine; Disease Models, Animal; Dose-Response R | 1985 |
Serum sickness.
Topics: Animals; Antigen-Antibody Complex; Capillary Permeability; Cyproheptadine; Disease Models, Animal; H | 1985 |
Effect of cortisol and cyproheptadine on anaphylactoid and arthritic responses of the rat to dextran.
Topics: Acute Disease; Anaphylaxis; Animals; Arthritis; Chronic Disease; Cyproheptadine; Dextrans; Disease M | 1973 |
Chronic autologous immune complex glomerulopathy: effect of cyproheptadine.
Topics: Animals; Antigen-Antibody Complex; Basement Membrane; Biopsy; Cyproheptadine; Disease Models, Animal | 1974 |
Intravenous cyproheptadine hydrochloride in the treatment of pulmonary embolism: an experimental study.
Topics: Animals; Blood Coagulation Factors; Blood Platelets; Blood Pressure; Cardiology; Cell Aggregation; C | 1972 |