Page last updated: 2024-10-25

cyproheptadine and Diarrhea

cyproheptadine has been researched along with Diarrhea in 10 studies

Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"The potential role of endogenous opiates in the mediation of the diarrheal actions of prostaglandin-F2 alpha (PGF2 alpha), 5-hydroxytryptophan (5-HTP) and methacholine was investigated."7.66Naloxone reversal of drug-induced diarrhea in mice. ( Bertermann, RE; Dajani, EZ; Roge, EA; Schweingruber, FL; Woods, EM, 1979)
" Treatment with cimetidine (H2 receptor antagonist) resulted in diarrhea, however, the addition of cyproheptadine (H1 receptor antagonist) was beneficial in amelioration of the cutaneous symptoms of mastocytosis."3.68Systemic mastocytosis treated with histamine H1 and H2 receptor antagonists. ( Falk, ES; Gasior-Chrzan, B, 1992)
"The potential role of endogenous opiates in the mediation of the diarrheal actions of prostaglandin-F2 alpha (PGF2 alpha), 5-hydroxytryptophan (5-HTP) and methacholine was investigated."3.66Naloxone reversal of drug-induced diarrhea in mice. ( Bertermann, RE; Dajani, EZ; Roge, EA; Schweingruber, FL; Woods, EM, 1979)
"Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power."1.25Carcinoid myopathy and treatment with cyproheptadine (Periactin). ( Berry, EM; Maunder, C; Wilson, M, 1974)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19907 (70.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (20.00)2.80

Authors

AuthorsStudies
Costas, C2
Louzao, MC2
Raposo-García, S1
Vale, C2
Vieytes, MR2
Botana, LM2
Abal, P1
Suzuki, T1
Watanabe, R1
Vilariño, N1
Carrera, C1
Boente-Juncal, A1
Dajani, EZ1
Woods, EM1
Roge, EA1
Bertermann, RE1
Schweingruber, FL1
Gasior-Chrzan, B1
Falk, ES1
Orr, KB1
Harper, MJ1
Skarnes, RC1
Berry, EM1
Maunder, C1
Wilson, M1
Gillett, DJ1
Smith, RC1
Göschke, H1
Loong, SC1
Lance, JW1
Rawle, KC1

Other Studies

10 other studies available for cyproheptadine and Diarrhea

ArticleYear
Intestinal secretory mechanisms in Okadaic acid induced diarrhoea.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 169

    Topics: Animals; Chlorides; Cyproheptadine; Diarrhea; Jejunum; Mice; Okadaic Acid; Phosphoprotein Phosphatas

2022
Serotonin involvement in okadaic acid-induced diarrhoea in vivo.
    Archives of toxicology, 2021, Volume: 95, Issue:8

    Topics: Animals; Cyproheptadine; Diarrhea; Enzyme Inhibitors; Female; Mice; Neuropeptide Y; Okadaic Acid; Pe

2021
Naloxone reversal of drug-induced diarrhea in mice.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 240, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Antidiarrheals; Cyproheptadine; Diarrhea; Dose-Response Relationship,

1979
Systemic mastocytosis treated with histamine H1 and H2 receptor antagonists.
    Dermatology (Basel, Switzerland), 1992, Volume: 184, Issue:2

    Topics: Biopsy; Cimetidine; Colon; Cyproheptadine; Diarrhea; Drug Therapy, Combination; Humans; Liver; Male;

1992
The carcinoid syndrome: An example due to an ileal polyp.
    The Australian and New Zealand journal of surgery, 1970, Volume: 39, Issue:3

    Topics: Autopsy; Carcinoid Tumor; Cyanosis; Cyproheptadine; Diarrhea; Female; Humans; Hydroxyindoleacetic Ac

1970
Inhibition of abortion and fetal death produced by endotoxin or prostaglandin F2alpha.
    Prostaglandins, 1972, Volume: 2, Issue:4

    Topics: Abortion, Induced; Abortion, Threatened; Animals; Cyproheptadine; Diarrhea; Endotoxins; Female; Feta

1972
Carcinoid myopathy and treatment with cyproheptadine (Periactin).
    Gut, 1974, Volume: 15, Issue:1

    Topics: Acid Phosphatase; Cyproheptadine; Diarrhea; Feces; Female; Fenclonine; Humans; Hydroxyindoleacetic A

1974
Treatment of the carcinoid syndrome by hemihepatectomy and radical excision of the primary lesion.
    American journal of surgery, 1974, Volume: 128, Issue:1

    Topics: Aged; Cyproheptadine; Diarrhea; Fenclonine; Heart Valve Diseases; Hepatectomy; Humans; Hydroxyindole

1974
[Drug therapy of the carcinoid syndrome].
    Deutsche medizinische Wochenschrift (1946), 1968, Jun-21, Volume: 93, Issue:25

    Topics: Asthma; Carcinoid Tumor; Chlorpromazine; Cyclophosphamide; Cyproheptadine; Diarrhea; Humans; Methyse

1968
The control of flushing and diarrhoea in carcinoid syndrome by an antiserotonin agent, BC105.
    The Medical journal of Australia, 1968, Nov-09, Volume: 2, Issue:19

    Topics: Blood Circulation; Chloramphenicol; Cyproheptadine; Diarrhea; Face; Humans; Hyperemia; Ileum; Liver

1968