cyproheptadine has been researched along with Chronic Disease in 41 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003." | 9.30 | Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind, randomized, multicenter, placebo-controlled clinical trial. ( Aoki, H; Hide, M; Suzuki, T; Tanaka, A, 2019) |
| "Rupatadine is effective and well tolerated in the relief of urticaria symptoms, improving quality of life over 6 weeks in children with CSU." | 9.22 | Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2-11 years. ( Barkai, L; Izquierdo, I; Maurer, M; Mezei, G; Mitha, E; Potter, P; Santamaría, E, 2016) |
| "Cetirizine is commonly used in the treatment of urticaria." | 9.19 | Clinical effectiveness and safety of cetirizine versus rupatadine in chronic spontaneous urticaria: a randomized, double-blind, 6-week trial. ( Dakhale, GN; Hiware, SK; Mahatme, MS; Mishra, DB; Mukhi, JI; Salve, AM; Shinde, AT, 2014) |
| "This analysis includes the pooled data from two randomized, double-blind, placebo-controlled, multicentre studies in which chronic urticaria patients were treated with rupatadine at different doses." | 9.14 | The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo- controlled treatment with rupatadine 10 and 20 mg. ( Giménez-Arnau, A; Izquierdo, I; Maurer, M, 2009) |
| "Levocetirizine was found to be more efficacious than rupatadine in CIU patients, but both drugs caused mild sedation." | 6.80 | Levocetirizine and rupatadine in chronic idiopathic urticaria. ( Badyal, DK; Johnson, M; Kwatra, G; Thomas, EA, 2015) |
| "Rupatadine is a better choice in CIU in comparison to levocetirizine due to better efficacy and safety profile." | 6.76 | Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety. ( Ahmed, I; Goud, P; Jaida, J; Maiti, R; Palani, A; Raghavendra, BN, 2011) |
| "Rupatadine is a new potent nonsedative anti-H1." | 6.73 | Rupatadine in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled multicentre study. ( Arnaiz, E; Donado, E; Gimenez-Arnau, A; Ianosi, S; Izquierdo, I; Kaszuba, A; Malbran, A; Perez, I; Poop, G; Pujol, RM, 2007) |
| "Loratadine is a new selective peripheral histamine H1-receptor antagonist, that is orally effective, long-acting, and devoid of significant central and autonomic nervous system activity." | 6.67 | Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria. ( Belaich, S; Bruttmann, G; DeGreef, H; Lachapelle, JM; Paul, E; Pedrali, P; Tennstedt, D, 1990) |
| "Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003." | 5.30 | Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind, randomized, multicenter, placebo-controlled clinical trial. ( Aoki, H; Hide, M; Suzuki, T; Tanaka, A, 2019) |
| "Rupatadine is effective and well tolerated in the relief of urticaria symptoms, improving quality of life over 6 weeks in children with CSU." | 5.22 | Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2-11 years. ( Barkai, L; Izquierdo, I; Maurer, M; Mezei, G; Mitha, E; Potter, P; Santamaría, E, 2016) |
| "Cetirizine is commonly used in the treatment of urticaria." | 5.19 | Clinical effectiveness and safety of cetirizine versus rupatadine in chronic spontaneous urticaria: a randomized, double-blind, 6-week trial. ( Dakhale, GN; Hiware, SK; Mahatme, MS; Mishra, DB; Mukhi, JI; Salve, AM; Shinde, AT, 2014) |
| "This analysis includes the pooled data from two randomized, double-blind, placebo-controlled, multicentre studies in which chronic urticaria patients were treated with rupatadine at different doses." | 5.14 | The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo- controlled treatment with rupatadine 10 and 20 mg. ( Giménez-Arnau, A; Izquierdo, I; Maurer, M, 2009) |
| "A continuous multiclinical, randomized and prospective study has been carried out in our department to compare the efficacy of different cytoprotective (sucralfate, DE-NOL, Vitamin A) and antisecretory drugs (atropine, cimetidine, ranitidine, famotidine, pirenzepine) on ulcer healing in patients with chronic gastric ulcer (GU) and duodenal ulcer (DU)." | 5.07 | Dynamism of cytoprotective and antisecretory drugs in patients with unhealed gastric and duodenal ulcers. ( Garamszegi, M; Hunyady, B; Mózsik, G; Németh, A; Pakodi, F; Vincze, A, 1994) |
| "Combined H1 (cyproheptadine) and H2 antihistamines (cimetidine) were tried in eight patients with chronic urticaria who were previously unresponsive to conventional anti-urticarial regimens, including type I antihistamines, hydroxyzine, ephedrine and corticosteroids." | 3.66 | Treatment of chronic idiopathic urticaria with combined H1 and H2 blockers. ( Kohler, PF; Phanuphak, P; Schocket, A, 1978) |
| "Levocetirizine was found to be more efficacious than rupatadine in CIU patients, but both drugs caused mild sedation." | 2.80 | Levocetirizine and rupatadine in chronic idiopathic urticaria. ( Badyal, DK; Johnson, M; Kwatra, G; Thomas, EA, 2015) |
| "Rupatadine is a better choice in CIU in comparison to levocetirizine due to better efficacy and safety profile." | 2.76 | Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety. ( Ahmed, I; Goud, P; Jaida, J; Maiti, R; Palani, A; Raghavendra, BN, 2011) |
| "Rupatadine is a new potent nonsedative anti-H1." | 2.73 | Rupatadine in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled multicentre study. ( Arnaiz, E; Donado, E; Gimenez-Arnau, A; Ianosi, S; Izquierdo, I; Kaszuba, A; Malbran, A; Perez, I; Poop, G; Pujol, RM, 2007) |
| "Loratadine is a new selective peripheral histamine H1-receptor antagonist, that is orally effective, long-acting, and devoid of significant central and autonomic nervous system activity." | 2.67 | Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria. ( Belaich, S; Bruttmann, G; DeGreef, H; Lachapelle, JM; Paul, E; Pedrali, P; Tennstedt, D, 1990) |
| "The 18% incidence of recurrence highlights the fact that cough often is the manifestation of a chronic or recurring process that requires chronic or episodic therapy." | 1.29 | An algorithmic approach to chronic cough. ( Akers, S; Bartter, T; DuBois, J; Pratter, MR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (39.02) | 18.7374 |
| 1990's | 11 (26.83) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 7 (17.07) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hide, M | 1 |
| Suzuki, T | 1 |
| Tanaka, A | 1 |
| Aoki, H | 1 |
| Dakhale, GN | 1 |
| Shinde, AT | 1 |
| Mahatme, MS | 1 |
| Hiware, SK | 1 |
| Mishra, DB | 1 |
| Mukhi, JI | 1 |
| Salve, AM | 1 |
| Johnson, M | 1 |
| Kwatra, G | 1 |
| Badyal, DK | 1 |
| Thomas, EA | 1 |
| Abajian, M | 1 |
| Curto-Barredo, L | 1 |
| Krause, K | 1 |
| Santamaria, E | 2 |
| Izquierdo, I | 4 |
| Church, MK | 1 |
| Maurer, M | 5 |
| Giménez-Arnau, A | 4 |
| Potter, P | 1 |
| Mitha, E | 1 |
| Barkai, L | 1 |
| Mezei, G | 1 |
| Dueñas-Laita, A | 1 |
| Ruiz-Muñoz, P | 1 |
| Armentia, A | 1 |
| Pinacho, F | 1 |
| Martín-Armentia, B | 1 |
| Di Leo, E | 1 |
| Nettis, E | 1 |
| Cassano, N | 1 |
| Foti, C | 1 |
| Delle Donne, P | 1 |
| Vena, GA | 1 |
| Vacca, A | 1 |
| Metz, M | 1 |
| Maiti, R | 1 |
| Jaida, J | 1 |
| Raghavendra, BN | 1 |
| Goud, P | 1 |
| Ahmed, I | 1 |
| Palani, A | 1 |
| TAKEUCHI, K | 1 |
| TAKEUCHI, T | 1 |
| Yamashita, H | 1 |
| Makino, T | 1 |
| Mizukami, H | 1 |
| Nose, M | 1 |
| Pujol, RM | 1 |
| Ianosi, S | 1 |
| Kaszuba, A | 1 |
| Malbran, A | 1 |
| Poop, G | 1 |
| Donado, E | 1 |
| Perez, I | 1 |
| Arnaiz, E | 1 |
| Mullol, J | 1 |
| Bousquet, J | 1 |
| Bachert, C | 1 |
| Canonica, WG | 1 |
| Kowalski, ML | 1 |
| Martí-Guadaño, E | 1 |
| Picado, C | 1 |
| Scadding, G | 1 |
| Van Cauwenberge, P | 1 |
| Harvey, RP | 1 |
| Wegs, J | 1 |
| Schocket, AL | 1 |
| Neumann, Y | 1 |
| Patty, I | 1 |
| Benedek, S | 1 |
| Deák, G | 1 |
| Jávor, T | 1 |
| Kenéz, P | 1 |
| Morón, F | 1 |
| Nagy, L | 1 |
| Simon, L | 1 |
| Tárnok, F | 1 |
| Mózsik, G | 2 |
| Soter, NA | 1 |
| Lee, HS | 1 |
| Song, DH | 1 |
| Kim, JH | 1 |
| Lee, YM | 1 |
| Han, ES | 1 |
| Yoo, KJ | 1 |
| Hunyady, B | 1 |
| Garamszegi, M | 1 |
| Németh, A | 1 |
| Pakodi, F | 1 |
| Vincze, A | 1 |
| Bacher, NM | 1 |
| Sanzone, MM | 1 |
| Kaup, B | 1 |
| Rudichenko, VM | 1 |
| Komissarenko, IV | 1 |
| Slavnov, VN | 1 |
| Markov, VV | 1 |
| Oleĭnik, VA | 1 |
| Pratter, MR | 1 |
| Bartter, T | 1 |
| Akers, S | 1 |
| DuBois, J | 1 |
| Chaudhry, IB | 1 |
| Soni, SD | 1 |
| Hellewell, JS | 1 |
| Deakin, JF | 1 |
| Phanuphak, P | 1 |
| Schocket, A | 1 |
| Kohler, PF | 1 |
| Nagao, T | 1 |
| Ohshimo, T | 1 |
| Mitsunobu, K | 1 |
| Sato, M | 1 |
| Otsuki, S | 1 |
| Czarny, D | 1 |
| Visitsuntorn, N | 1 |
| Tuchinda, M | 1 |
| Arunyanark, N | 1 |
| Kerdsomnuk, S | 1 |
| Abu Shareeah, AM | 1 |
| Pedersen, MF | 1 |
| Silver, H | 2 |
| Blacker, M | 2 |
| Weller, MP | 2 |
| Lerer, B | 2 |
| Belaich, S | 1 |
| Bruttmann, G | 1 |
| DeGreef, H | 1 |
| Lachapelle, JM | 1 |
| Paul, E | 1 |
| Pedrali, P | 1 |
| Tennstedt, D | 1 |
| García Rojas, JF | 1 |
| Mangas Rojas, A | 1 |
| Barba Chacón, A | 1 |
| García Osle, M | 1 |
| Zamora Madaria, E | 1 |
| Monroe, EW | 1 |
| Fox, RW | 1 |
| Green, AW | 1 |
| Izuno, GT | 1 |
| Bernstein, DI | 1 |
| Pleskow, WW | 1 |
| Willis, I | 1 |
| Brigante, JR | 1 |
| Geller, LI | 1 |
| Amatniak, AG | 1 |
| Murashko, VV | 1 |
| Zhuravlev, AK | 1 |
| Shylle, ChI | 1 |
| Shabashova, NI | 1 |
| Skliarova, MA | 1 |
| Michaëlsson, G | 1 |
| Hall, CE | 1 |
| Ayachi, S | 1 |
| Hall, O | 1 |
| Pesse, F | 1 |
| Quappe, G | 1 |
| Sarkany, I | 1 |
| Macmillan, AL | 1 |
3 reviews available for cyproheptadine and Chronic Disease
| Article | Year |
|---|---|
Rupatadine for the treatment of allergic rhinitis and urticaria.
Topics: Anti-Allergic Agents; Chronic Disease; Cyproheptadine; Histamine H1 Antagonists; Humans; Platelet Ac | 2011 |
Rupatadine in allergic rhinitis and chronic urticaria.
Topics: Adolescent; Animals; Anti-Allergic Agents; Child; Chronic Disease; Clinical Trials as Topic; Cyprohe | 2008 |
Physical urticaria/angioedema as an experimental model of acute and chronic inflammation in human skin.
Topics: Acute Disease; Angioedema; Body Temperature; Chronic Disease; Cold Temperature; Cyproheptadine; Derm | 1981 |
20 trials available for cyproheptadine and Chronic Disease
| Article | Year |
|---|---|
Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind, randomized, multicenter, placebo-controlled clinical trial.
Topics: Adolescent; Adult; Anti-Allergic Agents; Asian People; Child; Chronic Disease; Cyproheptadine; Doubl | 2019 |
Clinical effectiveness and safety of cetirizine versus rupatadine in chronic spontaneous urticaria: a randomized, double-blind, 6-week trial.
Topics: Adult; Cetirizine; Chronic Disease; Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antago | 2014 |
Levocetirizine and rupatadine in chronic idiopathic urticaria.
Topics: Adolescent; Adult; Aged; Cetirizine; Child; Chronic Disease; Cyproheptadine; Female; Histamine H1 An | 2015 |
Rupatadine 20 mg and 40 mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria.
Topics: Adult; Aged; Chronic Disease; Cold Temperature; Cross-Over Studies; Cyproheptadine; Double-Blind Met | 2016 |
Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2-11 years.
Topics: Age Factors; Child; Child, Preschool; Chronic Disease; Cyproheptadine; Double-Blind Method; Female; | 2016 |
Successful treatment of chronic drug-resistant urticaria with alprazolam.
Topics: Alprazolam; Chronic Disease; Cyproheptadine; Humans; Platelet Membrane Glycoproteins; Receptors, G-P | 2009 |
The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo- controlled treatment with rupatadine 10 and 20 mg.
Topics: Adult; Chronic Disease; Cyproheptadine; Dose-Response Relationship, Drug; Female; Health Surveys; Hi | 2009 |
Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety.
Topics: Adolescent; Adult; Cetirizine; Child; Chronic Disease; Cyproheptadine; Female; Follow-Up Studies; Hi | 2011 |
Rupatadine in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled multicentre study.
Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Cyproheptadine; Double-Blind Method; Female; Humans | 2007 |
A controlled trial of therapy in chronic urticaria.
Topics: Adult; Chlorpheniramine; Chronic Disease; Cimetidine; Clinical Trials as Topic; Cyproheptadine; Drug | 1981 |
[Antihistaminic therapy of chronic urticaria. Results of a multicenter study with azatadine and terfenadine].
Topics: Adult; Benzhydryl Compounds; Chronic Disease; Clinical Trials as Topic; Cyproheptadine; Female; Hist | 1984 |
Cytoprotective effect of vitamin A and its clinical importance in the treatment of patients with chronic gastric ulcer.
Topics: Antacids; Chronic Disease; Cyproheptadine; Drug Therapy, Combination; Gastric Mucosa; Humans; Prospe | 1983 |
Cyproheptadine augmentation of haloperidol in chronic schizophrenic patients: a double-blind placebo-controlled study.
Topics: Adult; Chronic Disease; Cyproheptadine; Double-Blind Method; Drug Therapy, Combination; Female; Foll | 1995 |
Dynamism of cytoprotective and antisecretory drugs in patients with unhealed gastric and duodenal ulcers.
Topics: Antacids; Anti-Ulcer Agents; Atropine; Chronic Disease; Cyproheptadine; Duodenal Ulcer; Humans; Pros | 1994 |
Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia.
Topics: Adult; Attention; Chronic Disease; Cross-Over Studies; Cyproheptadine; Discrimination Learning; Doub | 2002 |
Comparative efficacy of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.
Topics: Adult; Chronic Disease; Cyproheptadine; Female; Histamine Antagonists; Humans; Loratadine; Male; Pru | 1992 |
Treatment of chronic schizophrenia with cyproheptadine: a double-blind placebo-controlled study.
Topics: Adult; Chronic Disease; Cyproheptadine; Dose-Response Relationship, Drug; Double-Blind Method; Drug | 1991 |
Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Chronic Disease; Clinical Trials as Topic; Cyprohepta | 1990 |
Treatment of chronic schizophrenia with cyproheptadine.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Cyproheptadine; Drug Therapy, Combination; Female; | 1989 |
Efficacy and safety of loratadine (10 mg once daily) in the management of idiopathic chronic urticaria.
Topics: Chronic Disease; Clinical Trials as Topic; Cyproheptadine; Double-Blind Method; Histamine H1 Antagon | 1988 |
18 other studies available for cyproheptadine and Chronic Disease
| Article | Year |
|---|---|
Treatment of acquired cold urticaria with rupatadine.
Topics: Adult; Chronic Disease; Cold Temperature; Cyproheptadine; Female; Humans; Middle Aged; Platelet Acti | 2009 |
[ON THE EFFECT OF PERIACTIN ON CHRONIC URTICARIA AND VARIOUS SKIN TESTS].
Topics: Chronic Disease; Cyproheptadine; Erythema; Humans; Pharmacology; Serotonin; Skin Tests; Urticaria | 1964 |
Pharmacological characterization of a chronic pruritus model induced by multiple application of 2,4,6-trinitrochlorobenzene in NC mice.
Topics: Animals; Antipruritics; Cell Degranulation; Chronic Disease; Cromolyn Sodium; Cyproheptadine; Dermat | 2007 |
Cyproheptadine in treatment-resistant chronic schizophrenics with prior negative response to fluoxetine.
Topics: Adult; Aged; Antipsychotic Agents; Chronic Disease; Cyproheptadine; Depressive Disorder; Drug Therap | 1994 |
[The effect of the one-time and long-term administration of preparations acting on biogenic amine metabolism on the blood level of pressor peptide hormones].
Topics: Adolescent; Adult; Angiotensin II; Biogenic Amines; Blood Pressure; Bromocriptine; Chronic Disease; | 1993 |
An algorithmic approach to chronic cough.
Topics: Adolescent; Adult; Aged; Algorithms; Asthma; Bronchial Provocation Tests; Chi-Square Distribution; C | 1993 |
Treatment of chronic idiopathic urticaria with combined H1 and H2 blockers.
Topics: Adult; Chronic Disease; Cimetidine; Cyproheptadine; Drug Therapy, Combination; Female; Histamine H1 | 1978 |
Cerebrospinal fluid monoamine metabolites and cyclic nucleotides in chronic schizophrenic patients with tardive dyskinesia or drug-induced tremor.
Topics: Adult; Chronic Disease; Cyclic AMP; Cyclic GMP; Cyproheptadine; Dyskinesia, Drug-Induced; Female; Ho | 1979 |
Urticaria and angio-oedema.
Topics: Acute Disease; Angioedema; Chronic Disease; Cyproheptadine; Humans; Hydroxyzine; Urticaria | 1978 |
Ice cube test in children with cold urticaria.
Topics: Child; Child, Preschool; Chronic Disease; Cold Temperature; Cyproheptadine; False Positive Reactions | 1992 |
Computed phonetograms in adult patients with benign voice disorders before and after treatment with a nonsedating antihistamine (loratadine).
Topics: Adult; Aged; Chronic Disease; Cyproheptadine; Female; Histamine Antagonists; Humans; Laryngitis; Lor | 1991 |
[Clinical remission in Cushing's disease through treatment with sodium valproate and bromocriptine].
Topics: Bromocriptine; Chronic Disease; Cushing Syndrome; Cyproheptadine; Drug Therapy, Combination; Female; | 1991 |
[Peritol in exacerbated chronic pancreatitis].
Topics: Adult; Chronic Disease; Cyproheptadine; Drug Evaluation; Female; Humans; Male; Middle Aged; Pancreat | 1988 |
[Blood viscosity indicators in patients with gastric and duodenal diseases].
Topics: Adolescent; Adult; Blood Viscosity; Chronic Disease; Cimetidine; Cyproheptadine; Duodenal Ulcer; Fem | 1985 |
Effects of antihistamines, acetylsalicylic acid and prednisone on cutaneous reactions to kallikrein and prostaglandin E1.
Topics: Adult; Aspirin; Bradykinin; Chronic Disease; Cyproheptadine; Drug Hypersensitivity; Eczema; Female; | 1970 |
Effect of cortisol and cyproheptadine on anaphylactoid and arthritic responses of the rat to dextran.
Topics: Acute Disease; Anaphylaxis; Animals; Arthritis; Chronic Disease; Cyproheptadine; Dextrans; Disease M | 1973 |
[Treatment of idiopathic thrombocytopenic purpura in chronic phase with cyproheptadine].
Topics: Child; Chronic Disease; Cyproheptadine; Humans; Male; Purpura, Thrombocytopenic | 1971 |
Recurrent non-scarring pressure panniculitis.
Topics: Adult; Chronic Disease; Cyproheptadine; Female; Humans; Methysergide; Panniculitis, Nodular Nonsuppu | 1969 |