cyproheptadine has been researched along with Carcinoid Tumor in 23 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixteen patients with metastatic neuroendocrine tumors and the malignant carcinoid syndrome were treated with cyproheptadine (Periactin, Merck, Sharp & Dohme, West Point, PA) at maximum tolerable doses that ranged from 12 to 48 mg daily." | 9.07 | A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome. ( Kvols, LK; Moertel, CG; Rubin, J, 1991) |
| "Sixteen patients with metastatic neuroendocrine tumors and the malignant carcinoid syndrome were treated with cyproheptadine (Periactin, Merck, Sharp & Dohme, West Point, PA) at maximum tolerable doses that ranged from 12 to 48 mg daily." | 5.07 | A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome. ( Kvols, LK; Moertel, CG; Rubin, J, 1991) |
| "A myopathy, which improved with cyproheptadine hydrochloride therapy, developed in a patient with carcinoid syndrome of ten years' duration." | 3.65 | Carcinoid myopathy. Serotonin-induced muscle weakness in man? ( Davidson, AR; Fox, KP; Swash, M, 1975) |
| "Malignant carcinoid tumors are remarkably varied in their biologic behavior." | 2.66 | Metastatic carcinoid tumors and the carcinoid syndrome. A selective review of chemotherapy and hormonal therapy. ( Kvols, LK, 1986) |
| "Ectopic secretion of GH by the carcinoid hepatic metastases was documented by both RIA and immunohistochemical techniques." | 1.26 | Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor. ( Buckley, PJ; Daughaday, WH; Deschryver, K; Greider, MH; Jaffe, BM; Leveston, SA; McKeel, DW, 1981) |
| "Both groups of carcinoid patients had a comparable decrease in their insulinogenic index." | 1.25 | Glucose intolerance in the carcinoid syndrome. ( Bivens, CH; Feldman, JM; Lebovitz, HE; Plonk, JW, 1975) |
| "Six patients with actively secreting carcinoid tumors responded to standard metyrapone testing with a mean increment of 22." | 1.25 | Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine. ( Feldman, JM; Plank, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (82.61) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| JULIAR, B | 1 |
| SJOERDSMA, A | 1 |
| MELMON, KL | 1 |
| Modlin, IM | 3 |
| Leveston, SA | 1 |
| McKeel, DW | 1 |
| Buckley, PJ | 1 |
| Deschryver, K | 1 |
| Greider, MH | 1 |
| Jaffe, BM | 1 |
| Daughaday, WH | 1 |
| Harris, AL | 1 |
| Smith, IE | 1 |
| Lawton, GP | 1 |
| Tang, LH | 1 |
| Geibel, J | 1 |
| Abraham, R | 1 |
| Darr, U | 1 |
| Kvols, LK | 3 |
| Kumar, RR | 1 |
| Soroka, CJ | 1 |
| Ahlman, H | 1 |
| Nilsson, O | 1 |
| Goldenring, JR | 1 |
| Feldman, JM | 3 |
| Plonk, JW | 2 |
| Bivens, CH | 1 |
| Lebovitz, HE | 1 |
| May, B | 1 |
| Swash, M | 1 |
| Fox, KP | 1 |
| Davidson, AR | 1 |
| Plank, J | 1 |
| Moertel, CG | 1 |
| Rubin, J | 1 |
| Leitner, SP | 1 |
| Greenberg, P | 1 |
| Danieu, LA | 1 |
| Michaelson, RA | 1 |
| Bates, GJ | 1 |
| Luscombe, FE | 1 |
| Solares, G | 1 |
| Blanco, E | 1 |
| Pulgar, S | 1 |
| Diago, C | 1 |
| Ramos, F | 1 |
| Orr, KB | 1 |
| Bivens, CE | 1 |
| Brune, GG | 1 |
| Sill, V | 1 |
| Simpson, AJ | 1 |
| Martin, RG | 1 |
| Göschke, H | 1 |
3 reviews available for cyproheptadine and Carcinoid Tumor
| Article | Year |
|---|---|
Metastatic carcinoid tumors and the malignant carcinoid syndrome.
Topics: Biomarkers, Tumor; Carcinoid Heart Disease; Carcinoid Tumor; Cisplatin; Combined Modality Therapy; C | 1994 |
[Carcinoid: diagnosis and therapy].
Topics: Aprotinin; Bradykinin; Carcinoid Heart Disease; Carcinoid Tumor; Cyproheptadine; Diagnosis, Differen | 1975 |
The carcinoid tumor, syndrome and spectrum. A review of the literature.
Topics: Antineoplastic Agents; Carcinoid Tumor; Cyproheptadine; Dihydroxyphenylalanine; Epinephrine; Ergolin | 1969 |
2 trials available for cyproheptadine and Carcinoid Tumor
| Article | Year |
|---|---|
A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome.
Topics: Adult; Aged; Carcinoid Tumor; Cyproheptadine; Endocrine System Diseases; Female; Humans; Male; Malig | 1991 |
Metastatic carcinoid tumors and the carcinoid syndrome. A selective review of chemotherapy and hormonal therapy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Clinical Tri | 1986 |
18 other studies available for cyproheptadine and Carcinoid Tumor
| Article | Year |
|---|---|
CARCINOID SYNDROME: REPORT OF CASE.
Topics: Carcinoid Tumor; Chlorpromazine; Cyproheptadine; Geriatrics; Humans; Hydroxyindoleacetic Acid; Malig | 1963 |
THE CARCINOID SPECTRUM.
Topics: 5-Hydroxytryptophan; Angiotensins; Antineoplastic Agents; Bronchial Neoplasms; Carcinoid Tumor; Chlo | 1964 |
Carcinoid syndrome.
Topics: Antineoplastic Agents; Apudoma; Carcinoid Tumor; Cyproheptadine; Fenclonine; Gastrointestinal Motili | 1980 |
Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor.
Topics: Abdominal Neoplasms; Acromegaly; Adolescent; Adrenocorticotropic Hormone; Carcinoid Tumor; Cushing S | 1981 |
Regression of carcinoid tumour with cyproheptadine.
Topics: Adult; Aged; Apudoma; Carcinoid Tumor; Cyproheptadine; Humans; Male; Pancreatic Neoplasms; Tomograph | 1982 |
The mastomys gastric carcinoid: aspects of enterochromaffin-like cell function.
Topics: Animals; Calcium; Carcinoid Tumor; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; | 1994 |
Histamine as an intermediate growth factor in genesis of gastric ECLomas associated with hypergastrinemia in mastomys.
Topics: Animals; Carcinoid Tumor; Cell Count; Cyproheptadine; Enterochromaffin Cells; Gastric Acid; Gastric | 1994 |
Glucose intolerance in the carcinoid syndrome.
Topics: Adult; Aged; Carcinoid Tumor; Cyproheptadine; Diabetes Mellitus; Female; Fenclonine; Glucose; Glucos | 1975 |
Carcinoid myopathy. Serotonin-induced muscle weakness in man?
Topics: Adult; Carcinoid Tumor; Cyproheptadine; Electromyography; Female; Humans; Intestinal Neoplasms; Musc | 1975 |
Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Aged; Carcinoid Tumor; Circadian Rhythm; Cyproheptadine; | 1975 |
Partial remission of carcinoid tumor in response to cyproheptadine.
Topics: Aged; Aged, 80 and over; Carcinoid Tumor; Cyproheptadine; Female; Humans; Hydroxyindoleacetic Acid; | 1989 |
Carcinoid metastasis in the middle ear: anaesthetic and surgical management.
Topics: Carcinoid Tumor; Cyproheptadine; Ear Neoplasms; Ear, Middle; Fenclonine; Humans; Ileal Neoplasms; Ke | 1989 |
Carcinoid syndrome and intravenous cyproheptadine.
Topics: Aged; Anesthesia, General; Carcinoid Tumor; Cyproheptadine; Humans; Hypertension; Intraoperative Com | 1987 |
The carcinoid syndrome: An example due to an ileal polyp.
Topics: Autopsy; Carcinoid Tumor; Cyanosis; Cyproheptadine; Diarrhea; Female; Humans; Hydroxyindoleacetic Ac | 1970 |
Alterations of pituitary-gonadal function in the carcinoid syndrome.
Topics: Aged; Bronchial Neoplasms; Carcinoid Tumor; Cyproheptadine; Erectile Dysfunction; Female; Genitalia, | 1974 |
[Carcinoid syndrome. Tryptophan metabolism--pathogenesis of concomitant symptoms--combination of tumours].
Topics: Adenocarcinoma; Aprotinin; Carcinoid Tumor; Chondroma; Colonic Neoplasms; Cyproheptadine; Humans; Hy | 1972 |
Management of carcinoid tumors.
Topics: Carcinoid Tumor; Cyproheptadine; Female; Humans; Male; Malignant Carcinoid Syndrome; Methysergide; N | 1970 |
[Drug therapy of the carcinoid syndrome].
Topics: Asthma; Carcinoid Tumor; Chlorpromazine; Cyclophosphamide; Cyproheptadine; Diarrhea; Humans; Methyse | 1968 |