cyproheptadine has been researched along with Cachexia in 11 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 9.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 5.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| "Cachexia occurs in the majority of cancer patients before death." | 3.77 | Clinical management of anorexia and cachexia in patients with advanced cancer. ( Bruera, E, 1992) |
| "Anorexia and cachexia are common clinical problems of many patients with advanced cancer." | 3.76 | Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group. ( Burch, PA; Ellison, NM; Goldberg, RM; Loprinzi, CL; Michalak, JC, 1990) |
| "Cachexia is a frequent and devastating complication of advanced cancer." | 2.39 | Anorexia and cachexia in advanced cancer patients. ( Bruera, E; Vigano, A; Watanabe, S, 1994) |
| "Cancer cachexia is highly prevalent in patients with advanced cancer." | 2.38 | Is the pharmacological treatment of cancer cachexia possible? ( Bruera, E, 1993) |
| "Cancer cachexia is one of the most prevalent and devastating syndromes associated with advanced cancer." | 2.38 | Current pharmacological management of anorexia in cancer patients. ( Bruera, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 7 (63.64) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasvis, P | 1 |
| Vigano, M | 1 |
| Vigano, A | 2 |
| Couluris, M | 1 |
| Mayer, JL | 1 |
| Freyer, DR | 1 |
| Sandler, E | 1 |
| Xu, P | 1 |
| Krischer, JP | 1 |
| Ladas, EJ | 1 |
| Bruera, E | 4 |
| Watanabe, S | 1 |
| Thirlby, RC | 1 |
| Kardinal, CG | 1 |
| Loprinzi, CL | 3 |
| Schaid, DJ | 1 |
| Hass, AC | 1 |
| Dose, AM | 2 |
| Athmann, LM | 1 |
| Mailliard, JA | 1 |
| McCormack, GW | 1 |
| Gerstner, JB | 1 |
| Schray, MF | 1 |
| Ellison, NM | 1 |
| Goldberg, RM | 1 |
| Michalak, JC | 1 |
| Burch, PA | 1 |
| Miser, AW | 1 |
| Kardinal, C | 1 |
| Everson, LK | 1 |
| Ahlquist, DA | 1 |
| Moertel, CG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia[NCT00066248] | Phase 2 | 70 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders[NCT02568007] | Phase 4 | 4 participants (Actual) | Interventional | 2015-12-31 | Terminated (stopped due to Unable to enroll adequate participants) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for cyproheptadine and Cachexia
| Article | Year |
|---|---|
Health-related quality of life across cancer cachexia stages.
Topics: Adrenal Cortex Hormones; Anorexia; Appetite Stimulants; Cachexia; Cannabinoids; Cyproheptadine; Fema | 2019 |
Is the pharmacological treatment of cancer cachexia possible?
Topics: Adrenal Cortex Hormones; Anorexia; Antineoplastic Agents; Cachexia; Cannabinoids; Clinical Protocols | 1993 |
Anorexia and cachexia in advanced cancer patients.
Topics: Adrenal Cortex Hormones; Animals; Anorexia; Antineoplastic Agents; Cachexia; Cannabinoids; Clinical | 1994 |
Clinical management of anorexia and cachexia in patients with advanced cancer.
Topics: Anorexia; Cachexia; Cannabinoids; Cyproheptadine; Humans; Hydrazines; Megestrol; Megestrol Acetate; | 1992 |
Current pharmacological management of anorexia in cancer patients.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Cachexia; Cannabinoids; Cyproheptadine; Humans; Hydr | 1992 |
Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.
Topics: Anorexia; Cachexia; Cyproheptadine; Dexamethasone; Double-Blind Method; Humans; Hydrazines; Neoplasm | 1990 |
5 trials available for cyproheptadine and Cachexia
| Article | Year |
|---|---|
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
Clinical management of anorexia and cachexia in patients with advanced cancer.
Topics: Anorexia; Cachexia; Cannabinoids; Cyproheptadine; Humans; Hydrazines; Megestrol; Megestrol Acetate; | 1992 |
A controlled trial of cyproheptadine in cancer patients with anorexia and/or cachexia.
Topics: Adult; Aged; Aged, 80 and over; Anorexia; Appetite; Cachexia; Cyproheptadine; Double-Blind Method; F | 1990 |
Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.
Topics: Anorexia; Cachexia; Cyproheptadine; Dexamethasone; Double-Blind Method; Humans; Hydrazines; Neoplasm | 1990 |
Cancer control research in the North Central Cancer Treatment Group (NCCTG).
Topics: Allopurinol; Anorexia; Antineoplastic Agents; Cachexia; Clinical Trials as Topic; Colorectal Neoplas | 1989 |
2 other studies available for cyproheptadine and Cachexia
| Article | Year |
|---|---|
Future directions in evaluating cancer-associated cachexia.
Topics: Cachexia; Cyproheptadine; Humans; Neoplasms; Serotonin Antagonists | 2009 |
Toward a treatment for anorexia and cachexia in patients with cancer.
Topics: Anorexia; Appetite Regulation; Cachexia; Cyproheptadine; Dexamethasone; Humans; Megestrol; Megestrol | 1991 |