cyproheptadine has been researched along with Benign Neoplasms in 20 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 9.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| "Cyproheptadine was given orally 12 to 14 hours before and again immediately before cisplatin administration." | 6.67 | Evaluation of butorphanol and cyproheptadine for prevention of cisplatin-induced vomiting in dogs. ( Berg, J; Dennis, RA; L'Heureux, DA; Moore, AS; Rand, WM, 1994) |
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 5.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "Cachexia occurs in the majority of cancer patients before death." | 3.77 | Clinical management of anorexia and cachexia in patients with advanced cancer. ( Bruera, E, 1992) |
| "Anorexia and cachexia are common clinical problems of many patients with advanced cancer." | 3.76 | Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group. ( Burch, PA; Ellison, NM; Goldberg, RM; Loprinzi, CL; Michalak, JC, 1990) |
| "Cyproheptadine was given orally 12 to 14 hours before and again immediately before cisplatin administration." | 2.67 | Evaluation of butorphanol and cyproheptadine for prevention of cisplatin-induced vomiting in dogs. ( Berg, J; Dennis, RA; L'Heureux, DA; Moore, AS; Rand, WM, 1994) |
| "Cachexia is a frequent and devastating complication of advanced cancer." | 2.39 | Anorexia and cachexia in advanced cancer patients. ( Bruera, E; Vigano, A; Watanabe, S, 1994) |
| "Cancer cachexia is highly prevalent in patients with advanced cancer." | 2.38 | Is the pharmacological treatment of cancer cachexia possible? ( Bruera, E, 1993) |
| "Cancer cachexia is one of the most prevalent and devastating syndromes associated with advanced cancer." | 2.38 | Current pharmacological management of anorexia in cancer patients. ( Bruera, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Chiang, CH | 3 |
| Peng, CY | 1 |
| Hsia, YP | 1 |
| See, XY | 1 |
| Horng, CS | 1 |
| Chang, YC | 1 |
| Shen, XE | 1 |
| Wang, SS | 1 |
| Tsai, TC | 1 |
| Chen, YJ | 1 |
| Ma, KS | 1 |
| Chen, BS | 1 |
| Luan, YZ | 1 |
| Tay, ST | 1 |
| Shen, CH | 1 |
| Chung, KC | 1 |
| Peng, CM | 1 |
| Kasvis, P | 1 |
| Vigano, M | 1 |
| Vigano, A | 2 |
| Couluris, M | 1 |
| Mayer, JL | 1 |
| Freyer, DR | 1 |
| Sandler, E | 1 |
| Xu, P | 1 |
| Krischer, JP | 1 |
| Ladas, EJ | 1 |
| CATER, DB | 1 |
| SCHOENIGER, EL | 1 |
| WATKINSON, DA | 2 |
| SJOERDSMA, A | 1 |
| MELMON, KL | 1 |
| AATER, DB | 1 |
| PETRIE, C | 1 |
| Moore, AS | 1 |
| Rand, WM | 1 |
| Berg, J | 1 |
| L'Heureux, DA | 1 |
| Dennis, RA | 1 |
| Bruera, E | 4 |
| Watanabe, S | 1 |
| Jatoi, A | 1 |
| Loprinzi, CL | 4 |
| Irsy, G | 1 |
| Szatlóczky, E | 1 |
| Thirlby, RC | 1 |
| Kardinal, CG | 1 |
| Schaid, DJ | 1 |
| Hass, AC | 1 |
| Dose, AM | 2 |
| Athmann, LM | 1 |
| Mailliard, JA | 1 |
| McCormack, GW | 1 |
| Gerstner, JB | 1 |
| Schray, MF | 1 |
| Ellison, NM | 1 |
| Goldberg, RM | 1 |
| Michalak, JC | 1 |
| Burch, PA | 1 |
| Miser, AW | 1 |
| Kardinal, C | 1 |
| Everson, LK | 1 |
| Ahlquist, DA | 1 |
| Moertel, CG | 1 |
| Hilt, G | 1 |
| Bungeroth, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia[NCT00066248] | Phase 2 | 70 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders[NCT02568007] | Phase 4 | 4 participants (Actual) | Interventional | 2015-12-31 | Terminated (stopped due to Unable to enroll adequate participants) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for cyproheptadine and Benign Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
Health-related quality of life across cancer cachexia stages.
Topics: Adrenal Cortex Hormones; Anorexia; Appetite Stimulants; Cachexia; Cannabinoids; Cyproheptadine; Fema | 2019 |
Is the pharmacological treatment of cancer cachexia possible?
Topics: Adrenal Cortex Hormones; Anorexia; Antineoplastic Agents; Cachexia; Cannabinoids; Clinical Protocols | 1993 |
Anorexia and cachexia in advanced cancer patients.
Topics: Adrenal Cortex Hormones; Animals; Anorexia; Antineoplastic Agents; Cachexia; Cannabinoids; Clinical | 1994 |
An update: cancer-associated anorexia as a treatment target.
Topics: Animals; Anorexia; Appetite; Appetite Regulation; Clinical Trials as Topic; Cyproheptadine; Dexameth | 2001 |
Clinical management of anorexia and cachexia in patients with advanced cancer.
Topics: Anorexia; Cachexia; Cannabinoids; Cyproheptadine; Humans; Hydrazines; Megestrol; Megestrol Acetate; | 1992 |
Current pharmacological management of anorexia in cancer patients.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Cachexia; Cannabinoids; Cyproheptadine; Humans; Hydr | 1992 |
Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.
Topics: Anorexia; Cachexia; Cyproheptadine; Dexamethasone; Double-Blind Method; Humans; Hydrazines; Neoplasm | 1990 |
7 trials available for cyproheptadine and Benign Neoplasms
| Article | Year |
|---|---|
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
Evaluation of butorphanol and cyproheptadine for prevention of cisplatin-induced vomiting in dogs.
Topics: Animals; Butorphanol; Cisplatin; Cyproheptadine; Dog Diseases; Dogs; Dose-Response Relationship, Dru | 1994 |
Clinical management of anorexia and cachexia in patients with advanced cancer.
Topics: Anorexia; Cachexia; Cannabinoids; Cyproheptadine; Humans; Hydrazines; Megestrol; Megestrol Acetate; | 1992 |
A controlled trial of cyproheptadine in cancer patients with anorexia and/or cachexia.
Topics: Adult; Aged; Aged, 80 and over; Anorexia; Appetite; Cachexia; Cyproheptadine; Double-Blind Method; F | 1990 |
Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.
Topics: Anorexia; Cachexia; Cyproheptadine; Dexamethasone; Double-Blind Method; Humans; Hydrazines; Neoplasm | 1990 |
Cancer control research in the North Central Cancer Treatment Group (NCCTG).
Topics: Allopurinol; Anorexia; Antineoplastic Agents; Cachexia; Clinical Trials as Topic; Colorectal Neoplas | 1989 |
[Increase of appetite by Nuran in liver diseases].
Topics: Adolescent; Adult; Aged; Appetite; Appetite Regulation; Body Weight; Cyproheptadine; Fatty Liver; Fe | 1971 |
7 other studies available for cyproheptadine and Benign Neoplasms
| Article | Year |
|---|---|
Efficacy of cationic amphiphilic antihistamines on outcomes of patients treated with immune checkpoint inhibitors.
Topics: Cohort Studies; Cyproheptadine; Histamine Antagonists; Humans; Immune Checkpoint Inhibitors; Neoplas | 2022 |
Future directions in evaluating cancer-associated cachexia.
Topics: Cachexia; Cyproheptadine; Humans; Neoplasms; Serotonin Antagonists | 2009 |
EFFECT OF BREATHING HIGH PRESSURE OXYGEN UPON TISSUE OXYGEN TENSION IN RAT AND MOUSE TUMOURS.
Topics: Animals; Carcinoma, Hepatocellular; Cyproheptadine; Hypoxia; Liver Neoplasms; Mammary Neoplasms, Ani | 1963 |
THE CARCINOID SPECTRUM.
Topics: 5-Hydroxytryptophan; Angiotensins; Antineoplastic Agents; Bronchial Neoplasms; Carcinoid Tumor; Chlo | 1964 |
EFFECT OF 5-HYDROXYTRYPTAMINE AND CYPROHEPTADINE ON TUMOUR BLOOD FLOW; ESTIMATION BY RATE OF COOLING AFTER MICROWAVE DIATHERMY.
Topics: Animals; Blood Circulation; Cyproheptadine; Diathermy; Hyperthermia, Induced; Metabolism; Mice; Micr | 1965 |
Effect of Peritol in stimulating appetite and promoting weight gain.
Topics: Adult; Aged; Animals; Appetite; Body Weight; Child; Cyproheptadine; Female; Humans; Male; Middle Age | 1977 |
Toward a treatment for anorexia and cachexia in patients with cancer.
Topics: Anorexia; Appetite Regulation; Cachexia; Cyproheptadine; Dexamethasone; Humans; Megestrol; Megestrol | 1991 |