cyproheptadine has been researched along with Asthma in 14 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a randomized, double-blind, crossover study, we evaluated the effects of loratadine, 10 and 20 mg, and placebo administered once daily for 3 days on the skin-wheal responses to histamine, the airway responses to inhaled histamine and methacholine, and the skin-wheal and airway responses to allergen in 12 subjects with asthma." | 9.06 | Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma. ( Holgate, ST; Town, GI, 1990) |
| "Seventeen patients with perennial asthma, stable on a moderate dose of inhaled steroid, participated in a crossover study comparing the clinical effect of a non-sedative, potent and highly selective H1 antagonist (loratadine 10 mg) with placebo." | 9.06 | Effect of a non-sedative antihistaminic (loratadine) in moderate asthma. A double-blind controlled clinical crossover-trial. ( Dirksen, A; Engel, T; Frølund, L; Heinig, JH; Svendsen, UG; Weeke, B, 1989) |
| "Rupatadine had a beneficial effect on histologic changes in a chronic murine model of asthma." | 7.79 | The effect of rupatadine on lung histopathology in a murine model of chronic asthma. ( Bagriyanik, AH; Firinci, F; Karaman, M; Karaman, O; Kiray, M; Tuncel, T; Uysal, P; Uzuner, N; Yilmaz, O, 2013) |
| "To determine whether oral administration of cyproheptadine or cetirizine blocks the action of serotonin and histamine, respectively, and results in diminished eosinophilic airway inflammation in cats with experimentally induced asthma." | 7.74 | Effects of cyproheptadine and cetirizine on eosinophilic airway inflammation in cats with experimentally induced asthma. ( Jiji, RD; McGee Turner, JB; Reinero, CR; Schooley, EK; Spinka, CM, 2007) |
| "To compare the effects of an orally administered corticosteroid (prednisone), an inhaled corticosteroid (flunisolide), a leukotriene-receptor antagonist (zafirlukast), an antiserotonergic drug (cyproheptadine), and a control substance on the asthmatic phenotype in cats with experimentally induced asthma." | 5.11 | Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma. ( Berghaus, LJ; Berghaus, RD; Byerly, JR; Decile, KC; Gershwin, LJ; Hyde, DM; Reinero, CR; Schelegle, ES; Walby, WE, 2005) |
| " In a randomized, double-blind, crossover study, we evaluated the effects of loratadine, 10 and 20 mg, and placebo administered once daily for 3 days on the skin-wheal responses to histamine, the airway responses to inhaled histamine and methacholine, and the skin-wheal and airway responses to allergen in 12 subjects with asthma." | 5.06 | Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma. ( Holgate, ST; Town, GI, 1990) |
| "Seventeen patients with perennial asthma, stable on a moderate dose of inhaled steroid, participated in a crossover study comparing the clinical effect of a non-sedative, potent and highly selective H1 antagonist (loratadine 10 mg) with placebo." | 5.06 | Effect of a non-sedative antihistaminic (loratadine) in moderate asthma. A double-blind controlled clinical crossover-trial. ( Dirksen, A; Engel, T; Frølund, L; Heinig, JH; Svendsen, UG; Weeke, B, 1989) |
| "Rupatadine had a beneficial effect on histologic changes in a chronic murine model of asthma." | 3.79 | The effect of rupatadine on lung histopathology in a murine model of chronic asthma. ( Bagriyanik, AH; Firinci, F; Karaman, M; Karaman, O; Kiray, M; Tuncel, T; Uysal, P; Uzuner, N; Yilmaz, O, 2013) |
| "To determine whether oral administration of cyproheptadine or cetirizine blocks the action of serotonin and histamine, respectively, and results in diminished eosinophilic airway inflammation in cats with experimentally induced asthma." | 3.74 | Effects of cyproheptadine and cetirizine on eosinophilic airway inflammation in cats with experimentally induced asthma. ( Jiji, RD; McGee Turner, JB; Reinero, CR; Schooley, EK; Spinka, CM, 2007) |
| "The 18% incidence of recurrence highlights the fact that cough often is the manifestation of a chronic or recurring process that requires chronic or episodic therapy." | 1.29 | An algorithmic approach to chronic cough. ( Akers, S; Bartter, T; DuBois, J; Pratter, MR, 1993) |
| "Pretreatment with cyproheptadine significantly inhibited the fall in FEV1." | 1.28 | [The inhibitory effects of anti-asthmatic agents on ethanol-induced bronchoconstriction in Japanese asthmatic patients]. ( Asai, S; Hara, K; Inuyama, M; Kiya, T; Miura, N; Sakamoto, Y; Shimoda, T; Tomonaga, H; Watanabe, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tuncel, T | 1 |
| Karaman, M | 1 |
| Firinci, F | 1 |
| Uysal, P | 1 |
| Kiray, M | 1 |
| Bagriyanik, AH | 1 |
| Yilmaz, O | 1 |
| Karaman, O | 1 |
| Uzuner, N | 1 |
| OSHIMA, Y | 1 |
| MIYAMOTO, T | 1 |
| TAKEDA, H | 1 |
| MATSUMURA, T | 1 |
| KUROUME, Y | 1 |
| TATENO, K | 1 |
| BERGEN, SS | 1 |
| FUNCKE, AB | 1 |
| MULDER, D | 1 |
| DEJONGE, MC | 1 |
| TERSTEEGE, HM | 1 |
| HARMS, AF | 1 |
| NAUTA, WT | 1 |
| DONNER, R | 1 |
| RUEMKE, CL | 1 |
| LAVENSTEIN, AF | 1 |
| DACANEY, EP | 1 |
| LASAGNA, L | 1 |
| VANMETRE, TE | 1 |
| Reinero, CR | 2 |
| Decile, KC | 1 |
| Byerly, JR | 1 |
| Berghaus, RD | 1 |
| Walby, WE | 1 |
| Berghaus, LJ | 1 |
| Hyde, DM | 1 |
| Schelegle, ES | 1 |
| Gershwin, LJ | 1 |
| Schooley, EK | 1 |
| McGee Turner, JB | 1 |
| Jiji, RD | 1 |
| Spinka, CM | 1 |
| Furukawa, CT | 1 |
| Pratter, MR | 1 |
| Bartter, T | 1 |
| Akers, S | 1 |
| DuBois, J | 1 |
| Watanabe, T | 1 |
| Tomonaga, H | 1 |
| Inuyama, M | 1 |
| Miura, N | 1 |
| Shimoda, T | 1 |
| Sakamoto, Y | 1 |
| Kiya, T | 1 |
| Hara, K | 1 |
| Asai, S | 1 |
| Town, GI | 1 |
| Holgate, ST | 1 |
| Dirksen, A | 1 |
| Engel, T | 1 |
| Frølund, L | 1 |
| Heinig, JH | 1 |
| Svendsen, UG | 1 |
| Weeke, B | 1 |
| Göschke, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders[NCT02568007] | Phase 4 | 4 participants (Actual) | Interventional | 2015-12-31 | Terminated (stopped due to Unable to enroll adequate participants) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for cyproheptadine and Asthma
| Article | Year |
|---|---|
Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.
Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Spasm; Bronchoalveolar Lavage F | 2005 |
Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma.
Topics: Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Cyproheptadine; Female; Histamine; H | 1990 |
Effect of a non-sedative antihistaminic (loratadine) in moderate asthma. A double-blind controlled clinical crossover-trial.
Topics: Adult; Asthma; Bronchi; Clinical Trials as Topic; Cyproheptadine; Double-Blind Method; Female; Force | 1989 |
11 other studies available for cyproheptadine and Asthma
| Article | Year |
|---|---|
The effect of rupatadine on lung histopathology in a murine model of chronic asthma.
Topics: Animals; Asthma; Cyproheptadine; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; His | 2013 |
[ON THE ACTION OF PERIACTIN ON ASTHMATIC SYMPTOMS CAUSED BY SEROTONIN].
Topics: Acetylcholine; Asthma; Biomedical Research; Cyproheptadine; Injections, Subcutaneous; Pharmacology; | 1964 |
[ON THE THERAPEUTIC EFFECT OF SEROTONIN INHIBITORS ON ALLERGIC DISEASES IN CHILDREN].
Topics: Adolescent; Asthma; Bronchitis; Child; Common Cold; Cyproheptadine; Dermatology; Eczema; Exanthema; | 1964 |
APPETITE STIMULATING PROPERTIES OF CYPROHEPTADINE.
Topics: Adolescent; Appetite; Asthma; Biomedical Research; Blood Glucose; Child; Cyproheptadine; Feeding and | 1964 |
INVESTIGATION OF 3-(10,11-DIHYDRO-5H-DIBENZO (A,D) CYCLOHEPTEN-5-YLOXY) TROPANE CITRATE (DIBENZHEPTROPINE CITRATE, BRONTINE). I. PHARMACOLOGICAL PROPERTIES. II. TOXICOLOGICAL PROPERTIES.
Topics: Acetylcholine; Albumins; Animals; Asthma; Atropine; Bronchi; Citric Acid; Cyproheptadine; Diphenhydr | 1964 |
Effect of cyproheptadine on asthmatic children. Study of appetite, weight gain, and linear growth.
Topics: Antihypertensive Agents; Appetite; Asthma; Body Weight; Child; Cyproheptadine; Growth; Histamine H1 | 1962 |
Effects of cyproheptadine and cetirizine on eosinophilic airway inflammation in cats with experimentally induced asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cat Diseases; Cats; Cetirizine; Cross-Over Studies; C | 2007 |
Other pharmacologic agents that may affect bronchial hyperreactivity.
Topics: Adrenergic alpha-Antagonists; Asthma; Asthma, Exercise-Induced; Benzothiazoles; Budesonide; Calcium | 1984 |
An algorithmic approach to chronic cough.
Topics: Adolescent; Adult; Aged; Algorithms; Asthma; Bronchial Provocation Tests; Chi-Square Distribution; C | 1993 |
[The inhibitory effects of anti-asthmatic agents on ethanol-induced bronchoconstriction in Japanese asthmatic patients].
Topics: Adult; Aged; Alcohol Drinking; Asthma; Atropine; Bronchoconstriction; Cromolyn Sodium; Cyproheptadin | 1992 |
[Drug therapy of the carcinoid syndrome].
Topics: Asthma; Carcinoid Tumor; Chlorpromazine; Cyclophosphamide; Cyproheptadine; Diarrhea; Humans; Methyse | 1968 |