Page last updated: 2024-10-25

cyproheptadine and Aging

cyproheptadine has been researched along with Aging in 10 studies

Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with cyproheptadine and vinblastine, however, prevented only the increased permeability of the blood-brain barrier; the plasma and level of 5-HT in brain continued to remain high."1.27Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. ( Dey, PK; Sharma, HS, 1986)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19905 (50.00)18.7374
1990's4 (40.00)18.2507
2000's1 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Petrascheck, M1
Ye, X1
Buck, LB1
Wedderburn, JF1
Sillar, KT1
Sharma, HS2
Westman, J1
Navarro, JC1
Dey, PK2
Nyberg, F1
Moyanova, S1
Kortenska, L1
Kirov, R1
Dunn, CJ1
Willoughby, DA1
Blackford, SP1
Little, PJ1
Kuhn, CM3
Bero, LA2
Kuhn, C1
Bero, L1
Ignar, D1
Lurie, S1
Field, E1

Other Studies

10 other studies available for cyproheptadine and Aging

ArticleYear
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
    Nature, 2007, Nov-22, Volume: 450, Issue:7169

    Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit

2007
Modulation of rhythmic swimming activity in post-embryonic Xenopus laevis tadpoles by 5-hydroxytryptamine acting at 5HT1a receptors.
    Proceedings. Biological sciences, 1994, Jul-22, Volume: 257, Issue:1348

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Cyproheptadine; Ergolines; Ketanserin; Metam

1994
Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat.
    Behavioural brain research, 1995, Dec-14, Volume: 72, Issue:1-2

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Antineoplastic Agents, Phytogenic; Blood Pressure; Blood-Br

1995
High-voltage electroencephalogram spindles in rats, aging and 5-HT2 antagonism.
    Brain research, 1998, Mar-09, Volume: 786, Issue:1-2

    Topics: Aging; Alpha Rhythm; Animals; Cyproheptadine; Electroencephalography; Ketanserin; Male; Rats; Rats,

1998
The response of the newborn rat to intraleural dextran: vascular and cellular aspects.
    Agents and actions, 1975, Volume: 5, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Dextrans; Edema; Exudates and Transudates; Hindlim

1975
Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.
    Endocrinology, 1992, Volume: 131, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Ani

1992
Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:3

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Cyproheptadine; Hydroxyindoleacetic Acid;

1987
Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.
    Neuropharmacology, 1986, Volume: 25, Issue:2

    Topics: Aging; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Cyproheptadine; Diazepam; Fem

1986
Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Corticosterone; Cyproheptadine; Fluoxetine; G

1987
Endocrine consequences of perinatal methadone exposure.
    NIDA research monograph, 1987, Volume: 78

    Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Disease Models, Animal; Hypothalamo-Hypophyseal Sy

1987