cyproheptadine has been researched along with Acute Liver Injury, Drug-Induced in 7 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a patient in whom cyproheptadine-induced hepatitis was followed by prolonged cholestasis marked by elevation of serum alkaline phosphatase levels, gammaglutamyltransferase and bile acid levels, and disappearance of small bile ducts." | 7.67 | Prolonged cholestasis after cyproheptadine-induced acute hepatitis. ( Benhamou, JP; Degott, C; Geneve, J; Larrey, D; Machayekhi, JP; Pessayre, D, 1987) |
| "We report a patient in whom cyproheptadine-induced hepatitis was followed by prolonged cholestasis marked by elevation of serum alkaline phosphatase levels, gammaglutamyltransferase and bile acid levels, and disappearance of small bile ducts." | 3.67 | Prolonged cholestasis after cyproheptadine-induced acute hepatitis. ( Benhamou, JP; Degott, C; Geneve, J; Larrey, D; Machayekhi, JP; Pessayre, D, 1987) |
| "5-fluorouracil (5-FU) is a widely used chemotherapeutic drug, but its hepatotoxicity challenges its clinical use." | 1.72 | Role of Platelet-activating factor and HO-1 in mediating the protective effect of rupatadine against 5-fluorouracil-induced hepatotoxicity in rats. ( Abdalla, AM; Abdelbaky, FAF; Abdelzaher, WY; Hafez, SMNA; Khalaf, HM; Welson, NN, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Khalaf, HM | 1 |
| Hafez, SMNA | 1 |
| Abdalla, AM | 1 |
| Welson, NN | 1 |
| Abdelzaher, WY | 1 |
| Abdelbaky, FAF | 1 |
| Chan, TY | 1 |
| Tang, CH | 1 |
| Critchley, JA | 1 |
| Miyazawa, Y | 1 |
| Tsutsui, H | 1 |
| Mizuhara, H | 1 |
| Fujiwara, H | 1 |
| Kaneda, K | 1 |
| Larrey, D | 1 |
| Geneve, J | 1 |
| Pessayre, D | 1 |
| Machayekhi, JP | 1 |
| Degott, C | 1 |
| Benhamou, JP | 1 |
1 review available for cyproheptadine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
6 other studies available for cyproheptadine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Role of Platelet-activating factor and HO-1 in mediating the protective effect of rupatadine against 5-fluorouracil-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced | 2022 |
Poisoning due to an over-the-counter hypnotic, Sleep-Qik (hyoscine, cyproheptadine, valerian).
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cyproheptadine; Drug Combinations; Female | 1995 |
Involvement of intrasinusoidal hemostasis in the development of concanavalin A-induced hepatic injury in mice.
Topics: Animals; Antibodies, Monoclonal; CD3 Complex; Chemical and Drug Induced Liver Injury; Concanavalin A | 1998 |
Prolonged cholestasis after cyproheptadine-induced acute hepatitis.
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Cyproheptadine; Female; H | 1987 |