cyprodime and Feeding-and-Eating-Disorders

Buprenorphine (BPN), a mixed opioid drug with high affinity for mu (MOR) and kappa (KOR) opioid receptors, has been shown to produce behavioral responses in rodents that are similar to those of antidepressant and anxiolytic drugs. Although recent studies have identified KORs as a primary mediator of BPN's effects in rodent models of depressive-like behavior, the role of MORs in BPN's behavioral effects has not been as well explored. The current studies investigated the role of MORs in mediating conditioned approach behavior in the novelty-induced hypophagia (NIH) test, a behavioral measure previously shown to be sensitive to chronic treatment with antidepressant drugs. The effects of BPN were evaluated in the NIH test 24h post-administration in mice with genetic deletion of the MOR (Oprm1

Topics: Animals; Antidepressive Agents; Behavior, Animal; Buprenorphine; Feeding and Eating Disorders; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu