cyhalothrin and Infertility--Male

The objective of the current study was to analyze the reproductive toxicity caused by lambda-cyhalothrin (LCT) in male rabbits, and to evaluate the possible protective effect of vitamin E (Vit. E) as antioxidant. Animals were orally administered their respective doses of LCT every other day and given drinking water supplemented with vitamin E for 16 weeks. Results showed that semen quality was deteriorated following treatment with LCT. Also, testosterone levels, body weight (BW), feed intake (FI), and relative testes (RTW) and epididymis (REW) weights were significantly decreased. Concentrations of thiobarbituric acid-reactive substances (TBARS) were significantly increased in seminal plasma of rabbits treated with LCT compared with control. While, activities of glutathione S-transferase (GST), transaminases and acid phosphatase (AcP) were significantly decreased. Vitamin E alone significantly increased testosterone levels, BW, FI, RTW, REW, semen characteristics and seminal plasma enzymes, and decreased the levels of TBARS. Also, the present study showed that vitamin E might be effective against LCT-induced reproductive toxicity. It was suggested that LCT exerted a significant adverse effect on reproductive performance of male rabbits. Furthermore, vitamin E antagonized the toxic effects of LCT and improved semen quality of male rabbit.

Topics: Animals; Antioxidants; Body Weight; Enzymes; Epididymis; Fungicides, Industrial; Infertility, Male; Male; Nitriles; Organ Size; Oxidative Stress; Pyrethrins; Rabbits; Semen; Sperm Motility; Spermatozoa; Testis; Testosterone; Thiobarbituric Acid Reactive Substances; Vitamin E

To assess the effect of ICON (trade name of lambda-cyhalothrin) on sexual competence and fertility of male rats.. Male rats were gavaged daily for 7 consecutive days with different doses of ICON (63 mg/kg and 100 mg/kg) or vehicle (distilled water). Their sexual behaviour and fertility were evaluated at different time points during treatment and post-treatment using receptive females.. Treatment had no effect on fertility, but sexual competence was seriously impaired: libido (assessed in terms of pre-coital sexual behaviour, and numbers of mounting, intromission and ejaculation), sexual arousability/motivation (in terms of latencies for mounting, intromission and ejaculation), sexual vigour (judged by frequencies of mounting and intromission or copulatory efficiency). In addition, ICON suppressed intromission ratio, indicating erectile dysfunction. These effects on sexual function had a rapid onset and was reversible. ICON-induced sexual dysfunction was mediated by multiple mechanisms, mainly toxicity, stress, sedation and possibly via GABA and dopaminergic systems.. Exposure to ICON may cause sexual dysfunction in male rats.

Topics: Animals; Body Temperature; Body Weight; Copulation; Drinking; Eating; Erythrocyte Count; Female; Hypnotics and Sedatives; Infertility, Male; Insecticides; Male; Muscle Contraction; Nitriles; Pyrethrins; Rats; Rats, Inbred Strains; Salivation