cyclothiazide has been researched along with Seizures in 9 studies
cyclothiazide: inhibits the desensitization of AMPA-type receptors; structure
cyclothiazide : 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "02% propylthiouracil (PTU) through mother's milk showed a high incidence of audiogenic seizures after maturation." | 3.70 | [Running fit and generalized tonic-clonic seizure are differently controlled by different subtype receptors in the brainstem]. ( Higashiyama, A; Ishida, N; Kato, N; Yasuda, S, 1998) |
| "Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons." | 1.40 | Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model. ( Cheng, Z; Kong, S; Liu, J; Wang, Y, 2014) |
| "KA induced seizure in hippocampus is different to that of both CTA and PTZ." | 1.37 | Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats. ( Chen, L; Kong, S; Qian, B; Sun, Y; Wan, L; Wang, Y; Wang, ZY; Wu, Z; Zhang, B; Zhang, F, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Wan, L | 3 |
| Chen, L | 2 |
| Yu, J | 1 |
| Wang, G | 1 |
| Wu, Z | 4 |
| Qian, B | 2 |
| Liu, X | 2 |
| Wang, Y | 5 |
| Sun, Y | 2 |
| Kong, S | 4 |
| Jiang, D | 1 |
| Pitre, A | 1 |
| Chen, G | 1 |
| Cheng, Z | 1 |
| Liu, J | 1 |
| Ren, W | 1 |
| Dargham, RA | 1 |
| Cheng, L | 1 |
| Zhang, B | 1 |
| Zhang, F | 1 |
| Wang, ZY | 1 |
| Cheung, EC | 1 |
| Melanson-Drapeau, L | 1 |
| Cregan, SP | 1 |
| Vanderluit, JL | 1 |
| Ferguson, KL | 1 |
| McIntosh, WC | 1 |
| Park, DS | 1 |
| Bennett, SA | 1 |
| Slack, RS | 1 |
| Lasztóczi, B | 1 |
| Kardos, J | 1 |
| Yasuda, S | 2 |
| Ishida, N | 2 |
| Higashiyama, A | 2 |
| Kato, N | 2 |
| Morinobu, S | 1 |
9 other studies available for cyclothiazide and Seizures
| Article | Year |
|---|---|
Coordinated downregulation of KCC2 and GABA
Topics: Animals; Benzothiadiazines; Brain; Cells, Cultured; Disease Models, Animal; Down-Regulation; Gene Kn | 2020 |
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells | 2013 |
Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model.
Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Benzothiadiazines; Brain-Derived Neurotroph | 2014 |
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agoni | 2014 |
Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats.
Topics: Animals; Benzothiadiazines; Convulsants; Electrophysiology; Excitatory Postsynaptic Potentials; Hipp | 2011 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Fac | 2005 |
Cyclothiazide prolongs low [Mg2+]-induced seizure-like events.
Topics: 4-Aminopyridine; Animals; Benzodiazepines; Benzothiadiazines; Diuretics; Excitatory Amino Acid Antag | 2006 |
[Running fit and generalized tonic-clonic seizure are differently controlled by different subtype receptors in the brainstem].
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1998 |
Characterization of audiogenic-like seizures in naive rats evoked by activation of AMPA and NMDA receptors in the inferior colliculus.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Su | 2000 |