Page last updated: 2024-10-25

cyclothiazide and Epilepsy

cyclothiazide has been researched along with Epilepsy in 5 studies

cyclothiazide: inhibits the desensitization of AMPA-type receptors; structure
cyclothiazide : 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sun, Y2
Wu, Z1
Kong, S3
Jiang, D1
Pitre, A1
Wang, Y3
Chen, G3
Qi, JS1
Fan, J1
Jiang, M1
Qian, B1
Liu, J1
Fan, M1
Seifert, G1
Hüttmann, K1
Schramm, J1
Steinhäuser, C1
Addae, JI1
Ali, N1
Youssef, FF1
Stone, TW1

Other Studies

5 other studies available for cyclothiazide and Epilepsy

ArticleYear
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
    Molecular brain, 2013, May-01, Volume: 6

    Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells

2013
BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide.
    Neuropharmacology, 2009, Volume: 57, Issue:1

    Topics: Action Potentials; Analysis of Variance; Animals; Antibodies; Antihypertensive Agents; Benzothiadiaz

2009
Cyclothiazide induces seizure behavior in freely moving rats.
    Brain research, 2010, Oct-08, Volume: 1355

    Topics: Animals; Antihypertensive Agents; Behavior, Animal; Benzothiadiazines; Brain; Convulsants; Disease M

2010
Enhanced relative expression of glutamate receptor 1 flip AMPA receptor subunits in hippocampal astrocytes of epilepsy patients with Ammon's horn sclerosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Feb-25, Volume: 24, Issue:8

    Topics: Alternative Splicing; Astrocytes; Benzothiadiazines; Cell Separation; Epilepsy; Hippocampus; Humans;

2004
AMPA receptor activation reduces epileptiform activity in the rat neocortex.
    Brain research, 2007, Jul-16, Volume: 1158

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim

2007