cyclosporine and Keratoconjunctivitis Sicca

cyclosporine has been researched along with Keratoconjunctivitis Sicca in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	16 (26.67)	18.2507
2000's	23 (38.33)	29.6817
2010's	17 (28.33)	24.3611
2020's	4 (6.67)	2.80

Authors

Authors	Studies
Gupta, PK; Karpecki, P; Mitchell, B; Toyos, M	1
Basu, S; Batra, N; Chauhan, T; Gupta, A; Gupta, V; Mukherjee, S; Rao, AT; Sangwan, VS; Sharma, N	1
Geyer, HL; Juthani, V; Kitsis, EA; Napier, F	1
Jacobi, C; Paulsen, F; Schneider, E	1
Hoy, SM	1
Ahn, HK; Cho, SM; Choi, HJ; Kang, S; Kim, YJ; Lee, HB; Son, WC; Song, YJ	1
Balicki, I; Radziejewski, K; Szadkowski, M	1
Bacharach, J; Darby, C; Devries, DK; Kabat, A; Karpecki, P; Luchs, J; Malhotra, R; Ogundele, A; Schechter, BA; Shen Lee, B; Shettle, L; Smyth-Medina, R	1
Bacharach, J; Darby, C; Justice, A; Kannarr, S; Luchs, J; Malhotra, R; Ogundele, A; Sheppard, J	1
Davis, RM; Grubbs, J; Huynh, K; Liu, KC	1
Barachetti, L; Gilger, BC; Mortellaro, CM; Rampazzo, A; Scevola, S	1
Alkan, F; Celik, I; Erol, M; Izci, C; Sur, E	1
Acharya, NR; Cuddapah, PA; Lietman, TM; Liu, MP; O'Brien, KS; Rose-Nussbaumer, J; Sy, A	1
Carslake, HB; Kent, RJ; Mackenzie, CJ; Malalana, F; Robin, M	1
Balicki, I; Radziejewski, K	1
Attar, M; Kass, PH; Maggs, DJ; Murphy, CJ; Park, SA; Sebbag, L	1
Nell, B; Sallmutter, T; Schwarz, BC	1
Williams, DL	2
Cursiefen, C; Jacobi, C; Kruse, F; Schrell, C	1
Fiscella, RG	1
Bozdağ Pehlivan, S; Unlü, N; Yavuz, B	1
Bové, A; Brito-Zerón, P; Kostov, BA; Ramos-Casals, M; Sisó-Almirall, A	1
Acheampong, A; Berdy, G; Epstein, R; Foerster, R; Forstot, L; Reis, B; Small, DS; Stern, K; Stewart, W; Tang-Liu, DD	1
Baudouin, C; Brignole, F; De Jean, MS; Goguel, A; Pisella, PJ	1
Baudouin, C; Brignole, F; Galatoire, O; Pisella, PJ	1
Sheppard, JD	1
Wilson, SE	1
Donnenfeld, ED; Perry, HD	1
Pflugfelder, SC	1
Farley, W; Pflugfelder, SC; Stern, ME; Strong, B	1
Gross, RH; Kerney, DL; Perry, HD; Stonecipher, K	1
Ang, H; Liu, C; Sun, J; Zhang, Y	1
Chuck, RS; Lekhanont, K; Leyngold, IM; Rangsin, R; Suwan-Apichon, O	1
Katsev, D; Kerney, D; Trattler, W	1
Acton, AE; Beale, AB; Gilger, BC; Stoskopf, MK	1
Allgoewer, I; Graenitz, U; Lambrou, GN; Latour, E; Ofri, R; Pena, TM; Spiess, BM	1
Bounous, DI; Fullard, RJ; Hirsh, SG; Kaswan, RM	1
Brown, J; Kaswan, RL; Salisbury, MA	1
Gündüz, K; Ozdemir, O	1
Kaswan, R	1
Andriano, K; Laibovitz, RA; O'Connell, M; Silverman, MH; Solch, S	1
Beech, J; Reilly, L	1
Barnett, KC; Clerc, B; de Haas, V; Jegou, JP; Neumann, W; Sansom, J; Schulte-Neumann, A; Weingarten, A	1
Andrews, J; Gilger, BC; Lairmore, MD; Wilkie, DA; Wyman, M	1
Tauber, J	1
Bounous, DI; Hirsh, SG; Kaswan, RL; Krenzer, KL	1
Acheampong, A; Lam, S; Rudewicz, P; Shackleton, M; Tang-Liu, D	1
Addeo, JV; Gao, J; Ghosn, CR; Schwalb, TA; Stern, ME	1
Baudouin, C; Brignole, F; De Saint Jean, M; Goguel, A; Goldschild, M; Pisella, PJ	2
McHugh, J; Moore, CP; Phillips, TE	1
McHugh, JB; Moore, CP; Phillips, TE; Thorne, JG	1
Baltatzis, S; Foster, CS; Merayo-Lloves, J	1
Alkan, F; Celik, I; Ceylan, C; Izci, C; Ogurtan, Z; Ozkan, Y; Sur, E	1
Bryan, GM	1
Davidson, MG; English, RV; Gerig, TM; Jamieson, VE; Nasisse, MP; Olivero, DK	1
Abrams, KL; Morgan, RV	1

Reviews

11 review(s) available for cyclosporine and Keratoconjunctivitis Sicca

Article	Year
The Effect of OTX-101 on Tear Production in Patients with Severe Tear-deficient Dry Eye Disease: A Pooled Analysis of Phase 2b/3 and Phase 3 Studies. Current eye research, 2022, Volume: 47, Issue:2 Topics: Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclosporine; Dry Eye Syndromes; Humans; Keratoconjunctivitis Sicca; Ophthalmic Solutions; Randomized Controlled Trials as Topic; Tears	2022
Ciclosporin Ophthalmic Emulsion 0.1%: A Review in Severe Dry Eye Disease. Drugs, 2017, Volume: 77, Issue:17 Topics: Administration, Ophthalmic; Anti-Inflammatory Agents; Cyclosporine; Dose-Response Relationship, Drug; Emulsions; Humans; Keratoconjunctivitis Sicca; Treatment Outcome	2017
Autoimmunity in the pathogenesis and treatment of keratoconjunctivitis sicca. Current allergy and asthma reports, 2014, Volume: 14, Issue:1 Topics: Animals; Antigen-Presenting Cells; Apoptosis; Autoantibodies; Autoimmunity; Cyclosporine; Genetic Predisposition to Disease; Humans; Immunity, Cellular; Immunity, Humoral; Keratoconjunctivitis Sicca; Molecular Mimicry; Quinuclidines; Sjogren's Syndrome; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thiophenes	2014
Understanding dry eye disease: a managed care perspective. The American journal of managed care, 2011, Volume: 17 Suppl 16 Topics: Adrenal Cortex Hormones; Aging; Clinical Trials as Topic; Cyclosporine; Dietary Supplements; Eye; Fatty Acids, Essential; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Managed Care Programs; Ophthalmic Solutions; Practice Guidelines as Topic; Quality of Life	2011
An overview on dry eye treatment: approaches for cyclosporin a delivery. TheScientificWorldJournal, 2012, Volume: 2012 Topics: Cyclosporine; Dosage Forms; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca	2012
Primary Sjögren syndrome: an update on current pharmacotherapy options and future directions. Expert opinion on pharmacotherapy, 2013, Volume: 14, Issue:3 Topics: Cyclosporine; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Molecular Targeted Therapy; Ophthalmic Solutions; Saliva, Artificial; Sjogren's Syndrome	2013
Medications for dry eye syndrome: a drug-therapy review. Managed care (Langhorne, Pa.), 2003, Volume: 12, Issue:12 Suppl Topics: Adrenal Cortex Hormones; Cyclosporine; Drugs, Generic; Humans; Inflammation; Keratoconjunctivitis Sicca; Ophthalmic Solutions; Tears; United States	2003
Antiinflammatory therapy for dry eye. American journal of ophthalmology, 2004, Volume: 137, Issue:2 Topics: Anti-Inflammatory Agents; Cyclosporine; Dacryocystitis; Dry Eye Syndromes; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca	2004
[Keratoconjunctivitis sicca (KCS) in dogs]. Tijdschrift voor diergeneeskunde, 2005, Nov-15, Volume: 130, Issue:22 Topics: Animals; Anti-Bacterial Agents; Blindness; Cyclosporine; Dog Diseases; Dogs; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Treatment Failure; Treatment Outcome	2005
Characteristics of a canine model of KCS: effective treatment with topical cyclosporine. Advances in experimental medicine and biology, 1994, Volume: 350 Topics: Administration, Topical; Animals; Cyclosporine; Disease Models, Animal; Dogs; Female; Keratoconjunctivitis Sicca; Ophthalmic Solutions	1994
A comparative approach to topical cyclosporine therapy. Eye (London, England), 1997, Volume: 11 ( Pt 4) Topics: Administration, Topical; Animals; Cats; Corneal Diseases; Corneal Transplantation; Cyclosporine; Dog Diseases; Dogs; Graft Rejection; Immunosuppressive Agents; Keratoconjunctivitis Sicca	1997

Trials

19 trial(s) available for cyclosporine and Keratoconjunctivitis Sicca

Article	Year
Efficacy and safety of 0.05% micellar nano-particulate (MNP) cyclosporine ophthalmic emulsion in the treatment of moderate-to-severe keratoconjunctivitis sicca: a 12-week, multicenter, randomized, active-controlled trial. BMC ophthalmology, 2023, Mar-27, Volume: 23, Issue:1 Topics: Cyclosporine; Double-Blind Method; Dry Eye Syndromes; Emulsions; Humans; Keratoconjunctivitis Sicca; Micelles; Ophthalmic Solutions; Tears; Treatment Outcome	2023
Efficacy of HL036 versus Cyclosporine A in the Treatment of Naturally Occurring Canine Keratoconjunctivitis Sicca. Current eye research, 2018, Volume: 43, Issue:7 Topics: Administration, Topical; Animals; Conjunctiva; Cyclosporine; Disease Models, Animal; Dogs; Female; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Ophthalmic Solutions; Random Allocation; Treatment Outcome; Tumor Necrosis Factor-alpha	2018
Effect of OTX-101, a Novel Nanomicellar Formulation of Cyclosporine A, on Corneal Staining in Patients With Keratoconjunctivitis Sicca: A Pooled Analysis of Phase 2b/3 and Phase 3 Studies. Cornea, 2019, Volume: 38, Issue:10 Topics: Cornea; Cyclosporine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Micelles; Middle Aged; Ophthalmic Solutions; Ophthalmoscopy; Staining and Labeling; Treatment Outcome; Visual Acuity	2019
Efficacy and Safety of OTX-101, a Novel Nanomicellar Formulation of Cyclosporine A, for the Treatment of Keratoconjunctivitis Sicca: Pooled Analysis of a Phase 2b/3 and Phase 3 Study. Eye & contact lens, 2020, Volume: 46 Suppl 1 Topics: Cyclosporine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Middle Aged; Ophthalmic Solutions; Tears; Treatment Outcome	2020
Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. Acta veterinaria Hungarica, 2016, Volume: 64, Issue:3 Topics: Administration, Topical; Animals; Cyclosporine; Dog Diseases; Dogs; Female; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Ophthalmic Solutions; Tacrolimus	2016
[Topical cyclosporine A 0.05% in the treatment of keratoconjunctivitis sicca]. Klinische Monatsblatter fur Augenheilkunde, 2012, Volume: 229, Issue:5 Topics: Administration, Topical; Cyclosporine; Female; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Middle Aged; Treatment Outcome	2012
Blood concentrations of cyclosporin a during long-term treatment with cyclosporin a ophthalmic emulsions in patients with moderate to severe dry eye disease. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2002, Volume: 18, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chromatography, High Pressure Liquid; Cyclosporine; Double-Blind Method; Emulsions; Female; Humans; Instillation, Drug; Keratoconjunctivitis Sicca; Male; Middle Aged; Ophthalmic Solutions	2002
Flow cytometric analysis of the inflammatory marker HLA DR in dry eye syndrome: results from 12 months of randomized treatment with topical cyclosporin A. Advances in experimental medicine and biology, 2002, Volume: 506, Issue:Pt B Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Conjunctiva; Cyclosporine; Double-Blind Method; Drug Administration Schedule; Epithelial Cells; Flow Cytometry; HLA-DR Antigens; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Middle Aged	2002
[Flow cytometry in impression cytology during keratoconjunctivitis sicca: effects of topical cyclosporin A on HLA DR expression]. Journal francais d'ophtalmologie, 2003, Volume: 26, Issue:4 Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Cyclosporine; Double-Blind Method; Emulsions; Female; Flow Cytometry; Fluorescent Antibody Technique, Indirect; HLA-DR Antigens; Humans; Keratoconjunctivitis Sicca; Male; Middle Aged; Ophthalmic Solutions; Pharmaceutical Vehicles; Prospective Studies; Sjogren's Syndrome; Treatment Outcome	2003
The impact of topical cyclosporine A emulsion 0.05% on the outcomes of patients with keratoconjunctivitis sicca. Current medical research and opinion, 2005, Volume: 21, Issue:7 Topics: Administration, Topical; Cyclosporine; Emulsions; Female; Humans; Keratoconjunctivitis Sicca; Male; Middle Aged; Treatment Outcome	2005
Self-reported compliance with topical cyclosporine emulsion 0.05% and onset of the effects of increased tear production as assessed through patient surveys. Clinical therapeutics, 2006, Volume: 28, Issue:11 Topics: Adult; Aged; Cyclosporine; Data Collection; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Middle Aged; Ophthalmic Solutions; Patient Compliance; Recovery of Function; Time Factors	2006
Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: a comparison with cyclosporine A. Veterinary journal (London, England : 1997), 2009, Volume: 179, Issue:1 Topics: Administration, Topical; Animals; Cyclosporine; Dog Diseases; Dogs; Female; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Ophthalmic Solutions; Tacrolimus; Treatment Outcome	2009
Topical cyclosporin treatment of keratoconjunctivitis sicca in secondary Sjögren's syndrome. Acta ophthalmologica, 1994, Volume: 72, Issue:4 Topics: Administration, Topical; Cyclosporine; Double-Blind Method; Epithelium; Female; Humans; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Male; Middle Aged; Ophthalmic Solutions; Rose Bengal; Sjogren's Syndrome; Tears	1994
Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. Cornea, 1993, Volume: 12, Issue:4 Topics: Adult; Aged; Cyclosporine; Double-Blind Method; Female; Humans; Keratoconjunctivitis Sicca; Lactoferrin; Male; Middle Aged; Ointments; Ophthalmic Solutions; Pilot Projects; Placebos; Tears	1993
Treatment of keratoconjunctivitis sicca in dogs with cyclosporine ophthalmic ointment: a European clinical field trial. The Veterinary record, 1995, Nov-11, Volume: 137, Issue:20 Topics: Animals; Conjunctiva; Corneal Edema; Cyclosporine; Dog Diseases; Dogs; Europe; Female; Hypertrophy; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Ointments	1995
A dose-ranging clinical trial to assess the safety and efficacy of cyclosporine ophthalmic emulsion in patients with keratoconjunctivitis sicca. The Cyclosporine Study Group. Advances in experimental medicine and biology, 1998, Volume: 438 Topics: Administration, Topical; Cyclosporine; Dose-Response Relationship, Drug; Double-Blind Method; Emulsions; Humans; Keratoconjunctivitis Sicca	1998
Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; CD40 Antigens; CD40 Ligand; Conjunctiva; Cyclosporine; Double-Blind Method; Epithelial Cells; Eye Proteins; fas Receptor; Female; Flow Cytometry; Fluorescent Antibody Technique, Indirect; HLA-DR Antigens; Homeodomain Proteins; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Membrane Glycoproteins; Middle Aged; Xenopus Proteins	2000
Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A. Investigative ophthalmology & visual science, 2001, Volume: 42, Issue:1 Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; CD40 Antigens; CD40 Ligand; Cornea; Cyclosporine; Double-Blind Method; fas Receptor; Female; Flow Cytometry; HLA-DR Antigens; Homeodomain Proteins; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Middle Aged; Ophthalmic Solutions; Xenopus Proteins	2001
Clinical evaluation of 1% cyclosporine for topical treatment of keratoconjunctivitis sicca in dogs. Journal of the American Veterinary Medical Association, 1991, Oct-15, Volume: 199, Issue:8 Topics: Administration, Topical; Animals; Cyclosporine; Dog Diseases; Dogs; Double-Blind Method; Keratoconjunctivitis Sicca; Ophthalmic Solutions	1991

Other Studies

30 other study(ies) available for cyclosporine and Keratoconjunctivitis Sicca

Article	Year
Association of Sjögren's syndrome with myotonic dystrophy type 1. BMJ case reports, 2019, Aug-28, Volume: 12, Issue:8 Topics: Antibodies, Antinuclear; Cyclosporine; Diagnosis, Differential; Electromyography; Female; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Middle Aged; Myotonic Dystrophy; Myotonin-Protein Kinase; Protein Kinases; Sjogren's Syndrome; Treatment Outcome	2019
[Assessment of Langerhans Cells in the Central Cornea as Tool for Monitoring Inflammatory Changes in Patients with Keratoconjunctivitis sicca under Topical Therapy with Cyclosporine A 0.05% Eye Drops]. Klinische Monatsblatter fur Augenheilkunde, 2020, Volume: 237, Issue:5 Topics: Cornea; Cyclosporine; Dry Eye Syndromes; Female; Humans; Keratoconjunctivitis Sicca; Langerhans Cells; Male; Ophthalmic Solutions; Prospective Studies; Quality of Life; Tears	2020
Assessment of corneal and conjunctival metaplasia by impression cytology during the treatment of canine keratoconjunctivitis sicca. Acta veterinaria Hungarica, 2018, Volume: 66, Issue:2 Topics: Administration, Topical; Animals; Conjunctiva; Cornea; Cyclosporine; Dog Diseases; Dogs; Female; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Metaplasia; Ophthalmic Solutions; Tacrolimus	2018
Use of episcleral cyclosporine implants in dogs with keratoconjunctivitis sicca: pilot study. Veterinary ophthalmology, 2015, Volume: 18, Issue:3 Topics: Animals; Conjunctiva; Cyclosporine; Dog Diseases; Dogs; Female; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Prostheses and Implants; Retrospective Studies	2015
Clinical and light microscopic studies of the conjunctival tissues of dogs with bilateral keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine. Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2015, Volume: 90, Issue:3 Topics: Administration, Topical; Animals; Biopsy; Conjunctiva; Cyclosporine; Dog Diseases; Dogs; Female; Immunity, Mucosal; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Lymphocyte Subsets; Male; Mast Cells	2015
Expert opinion in the management of aqueous Deficient Dry Eye Disease (DED). BMC ophthalmology, 2015, Oct-13, Volume: 15 Topics: Anti-Allergic Agents; Aqueous Humor; Cyclosporine; Doxycycline; Expert Testimony; Flax; Fluorometholone; Glucocorticoids; Health Care Surveys; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Loteprednol Etabonate; Practice Patterns, Physicians'; Prosthesis Implantation; Serum; Sjogren's Syndrome	2015
Episcleral cyclosporine A implants for the management of unilateral keratoconjunctivitis sicca in an 8-year-old mare. Veterinary ophthalmology, 2017, Volume: 20, Issue:1 Topics: Administration, Ophthalmic; Animals; Cyclosporine; Drug Implants; Female; Horse Diseases; Horses; Keratoconjunctivitis Sicca; Sclera	2017
Assessment of tear film osmolarity using the TearLab Veterinary ophthalmology, 2017, Volume: 20, Issue:4 Topics: Animals; Cyclosporine; Dog Diseases; Dogs; Female; Humans; Keratoconjunctivitis Sicca; Osmolar Concentration; Reproducibility of Results; Tears	2017
Keratoconjunctivitis sicca attributable to parasympathetic facial nerve dysfunction associated with hypothyroidism in a horse. Journal of the American Veterinary Medical Association, 2008, Dec-01, Volume: 233, Issue:11 Topics: Animals; Autonomic Nervous System Diseases; Cyclosporine; Diagnosis, Differential; Facial Nerve Diseases; Horse Diseases; Horses; Hypothyroidism; Keratoconjunctivitis Sicca; Male; Thyroxine; Treatment Outcome	2008
Lack of effects on lymphocyte function from chronic topical ocular cyclosporine medication: a prospective study. Veterinary ophthalmology, 2010, Volume: 13, Issue:5 Topics: Animals; Cyclosporine; Dog Diseases; Dogs; Drug Administration Schedule; Instillation, Drug; Keratoconjunctivitis Sicca; Lymphocyte Activation; Lymphocytes	2010
Ophthalmic cyclosporine (Restasis) for dry eye disease. The Medical letter on drugs and therapeutics, 2003, May-26, Volume: 45, Issue:1157 Topics: Cyclosporine; Dose-Response Relationship, Drug; Humans; Keratoconjunctivitis Sicca; Ophthalmic Solutions; Randomized Controlled Trials as Topic	2003
Dry eye moves beyond palliative therapy. Managed care (Langhorne, Pa.), 2003, Volume: 12, Issue:12 Suppl Topics: Age Factors; Aged; Anti-Inflammatory Agents; Cyclosporine; Female; Formularies as Topic; Health Care Costs; Humans; Keratoconjunctivitis Sicca; Managed Care Programs; Middle Aged; Palliative Care; Patient Satisfaction; Quality of Life	2003
Inflammation: a unifying theory for the origin of dry eye syndrome. Managed care (Langhorne, Pa.), 2003, Volume: 12, Issue:12 Suppl Topics: Aged; Anti-Inflammatory Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclosporine; Humans; Inflammation; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Middle Aged; Tears; United States	2003
Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea, 2005, Volume: 24, Issue:1 Topics: Administration, Topical; Animals; Apoptosis; Caspase 3; Caspases; Cell Count; Conjunctiva; Cyclosporine; Disease Models, Animal; Epithelial Cells; Goblet Cells; Immunoenzyme Techniques; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Mice; Mice, Inbred C57BL; Ophthalmic Solutions; Scopolamine	2005
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2005, Volume: 25, Issue:6 Topics: Animals; Aquaporin 3; Cyclosporine; Female; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Mice; Mice, Inbred BALB C; Ophthalmic Solutions; Pertussis Vaccine; Random Allocation	2005
Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model. Cornea, 2007, Volume: 26, Issue:1 Topics: Administration, Topical; Animals; Blinking; Botulinum Toxins; Botulinum Toxins, Type A; Cornea; Cyclosporine; Disease Models, Animal; Drug Therapy, Combination; Female; Fluorescent Dyes; Fluorometholone; Keratoconjunctivitis Sicca; Mice; Mice, Inbred CBA; Ophthalmic Solutions; Sodium Chloride; Staining and Labeling; Tears	2007
Sustained release cyclosporine therapy for bilateral keratoconjunctivitis sicca in a red wolf (Canis rufus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2006, Volume: 37, Issue:4 Topics: Animals; Cyclosporine; Drug Implants; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Treatment Outcome; Wolves	2006
Tear protein profiles vs. clinical characteristics of untreated and cyclosporine-treated canine KCS. Journal of the American Optometric Association, 1995, Volume: 66, Issue:7 Topics: Animals; Conjunctiva; Cornea; Cyclosporine; Dog Diseases; Dogs; Eye Proteins; Female; Immunoglobulins; Keratoconjunctivitis Sicca; Male; Peroxidase; Tears	1995
Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. American journal of veterinary research, 1995, Volume: 56, Issue:7 Topics: Animals; Bacteria; Cornea; Cyclosporine; Dog Diseases; Dogs; Fungi; Keratoconjunctivitis Sicca; Opportunistic Infections; Reference Values; Staphylococcus; Streptococcus	1995
Bilateral keratoconjunctivitis sicca in a horse. Equine veterinary journal, 1994, Volume: 26, Issue:2 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Cyclosporine; Female; Gentamicins; Horse Diseases; Horses; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Miconazole	1994
Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine. Veterinary immunology and immunopathology, 1995, Volume: 49, Issue:3 Topics: Administration, Topical; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Dog Diseases; Dogs; Female; Immunity, Cellular; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Lymphocyte Activation; Lymphocyte Count; Male; Ophthalmic Solutions	1995
Conjunctival impression cytology from dogs with keratoconjunctivitis sicca. Pre- and post-treatment with topical cyclosporine. Advances in experimental medicine and biology, 1998, Volume: 438 Topics: Administration, Topical; Animals; Conjunctiva; Cyclosporine; Dog Diseases; Dogs; Keratins; Keratoconjunctivitis Sicca; Metaplasia	1998
Cyclosporine distribution into the conjunctiva, cornea, lacrimal gland, and systemic blood following topical dosing of cyclosporine to rabbit, dog, and human eyes. Advances in experimental medicine and biology, 1998, Volume: 438 Topics: Administration, Topical; Animals; Conjunctiva; Cornea; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Humans; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Metabolic Clearance Rate; Rabbits; Tissue Distribution	1998
The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapy. Cornea, 1998, Volume: 17, Issue:6 Topics: Administration, Topical; Animals; Apoptosis; Conjunctiva; Cyclosporine; DNA; Dog Diseases; Dogs; Fas Ligand Protein; fas Receptor; Female; Immunoenzyme Techniques; Immunosuppressive Agents; In Situ Nick-End Labeling; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Male; Membrane Glycoproteins; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Tumor Suppressor Protein p53	1998
Cyclosporine has a direct effect on the differentiation of a mucin-secreting cell line. Journal of cellular physiology, 2000, Volume: 184, Issue:3 Topics: Calmodulin; Cell Differentiation; Cell Division; Cell Line; Colitis, Ulcerative; Cyclosporine; Cyclosporins; Glycoproteins; Goblet Cells; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Mucins; Prolactin; Prostaglandin-Endoperoxide Synthases	2000
Effect of cyclosporine on conjunctival mucin in a canine keratoconjunctivitis sicca model. Investigative ophthalmology & visual science, 2001, Volume: 42, Issue:3 Topics: Administration, Topical; Animals; Conjunctiva; Cyclosporine; Dogs; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Models, Animal; Mucins; Ophthalmic Solutions	2001
Epstein-Barr virus dacryoadenitis resulting in keratoconjunctivitis sicca in a child. American journal of ophthalmology, 2001, Volume: 132, Issue:6 Topics: Acyclovir; Antiviral Agents; Child; Cyclosporine; Dacryocystitis; Drug Therapy, Combination; Epstein-Barr Virus Infections; Eye Infections, Viral; Glucocorticoids; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Male; Nasolacrimal Duct; Prednisone	2001
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. American journal of veterinary research, 2002, Volume: 63, Issue:5 Topics: Administration, Topical; Animals; Biopsy; Cyclosporine; Dog Diseases; Dogs; Female; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Lymphocyte Count; Lymphocyte Subsets; Male; Naphthol AS D Esterase; Nictitating Membrane; Random Allocation; Tears	2002
Perspective, patience, and cyclosporine. Journal of the American Veterinary Medical Association, 1992, Jan-15, Volume: 200, Issue:2 Topics: Animals; Cyclosporine; Dog Diseases; Dogs; Keratoconjunctivitis Sicca; Ophthalmic Solutions	1992
Topical administration of cyclosporine for treatment of keratoconjunctivitis sicca in dogs. Journal of the American Veterinary Medical Association, 1991, Oct-15, Volume: 199, Issue:8 Topics: Administration, Topical; Animals; Breeding; Chronic Disease; Cyclosporine; Dog Diseases; Dogs; Female; Follow-Up Studies; Keratoconjunctivitis Sicca; Male; Ophthalmic Solutions; Tears; Treatment Outcome	1991