Compounds > cyclosporine

cyclosporine and Cholestasis

cyclosporine has been researched along with Cholestasis in 73 studies

Research

Studies (73)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's41 (56.16)18.2507
2000's14 (19.18)29.6817
2010's17 (23.29)24.3611
2020's1 (1.37)2.80

Authors

AuthorsStudies
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Han, X; Lu, Y; Qin, Y; Tan, J; Wang, N; Zhai, X1
Honda, H; Ito, Y; Kawamoto, T; Morita, O1
Brauers, K; Coonen, MLJ; Jennen, D; Kleinjans, JCS; Olde Damink, SWM; Schaap, FG; Van den Hof, WFPM; van Herwijnen, M1
González-Diéguez, ML; Houghton, RF; Mendoza Pacas, GE; Viso Vidal, D1
Kienhuis, AS; Luijten, M; Pennings, JL; Pronk, TE; Roodbergen, M; Speksnijder, EN; van Delft, JH; van der Ven, LT; Vitins, AP1
Groot, MJ; Hendriksen, PJ; Peijnenburg, AA; Stoopen, G; Szalowska, E1
Andress, EJ; Dixon, PH; Linton, KJ; Naik, S; Nicolaou, M; Romero, MR; Williamson, C1
Al-Attrache, H; Azzi, PB; Guguen-Guillouzo, C; Guillouzo, A; Humbert, L; Rainteau, D; Savary, CC; Sharanek, A1
Bitetto, D; Bulajic, M; Cmet, S; Cussigh, A; Fabris, C; Falleti, E; Toniutto, P; Vadalà, S; Zilli, M1
Aoki, S; Horie, T; Ito, K; Ogimura, E; Oizumi, K; Sekine, S; Susukida, T1
Gore, E; Groothuis, GM; Olinga, P; Pennings, JL; Vatakuti, S1
Annaert, P; Bachellier, P; Baze, A; Heyd, B; Oorts, M; Richert, L; Zacharias, T1
Groothuis, GMM; Olinga, P; Pennings, JLA; Vatakuti, S1
de Kok, TM; Jennen, DG; Kleinjans, JC; Schaap, FG; Theunissen, DH; van Breda, SG; Van den Hof, WF; van Herwijnen, MH; Wolters, JE1
Currin, RT; Giri, S; Kim, I; Lemasters, JJ; Ramshesh, VK; Rehman, H; Theruvath, TP; Zhong, Z1
Aoki, T; Asai, N; Inomata, A; Ishihara, K; Katsutani, N; Sawada, K; Suganuma, A; Uemura, Y; Yokoi, T1
Honma, Y; Ichikawa, M; Kawamata, R; Koike, Y; Kono, Y; Momoi, MY; Takahashi, N; Yada, Y; Yotsumoto, S1
Casadio, C; Gaddoni, G; Giacomoni, P; Lanzanova, G; Maio, V; Patrizi, A; Savoia, F; Spadola, G; Tabanelli, M; Zago, S1
Aït-Slimane, T; Delaunay, JL; Delautier, D; Durand-Schneider, AM; Gabillet, J; Gautherot, J; Housset, C; Maurice, M; Rada, A1
Deters, M; Kaever, V; Klabunde, T; Meyer, H; Resch, K1
Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R1
Bjøro, K; Bjøro, T; Bollerslev, J; Brandsaeter, B; Godang, K; Schrumpf, E; Wiencke, K1
Benkoël, L; Chanussot, F1
Höckerstedt, K; Lalla, M; Salmela, K; Tötterman, A1
Albani, J; Burdelski, M; Ganschow, R; Grabhorn, E; Richter, A1
Akita, H; Hayashi, H; Hofmann, AF; Mita, S; Onuki, R; Sugiyama, Y; Suzuki, H1
Day, C; Hewins, P; Kilby, M; Lipkin, G; McPake, D; Sheikh, L1
Klöters-Plachky, P; Sauer, P; Stiehl, A1
Kattner, A; Manns, M; Oldhafer, K; Pichlmayr, R; Ringe, B; Schneider, A; Wietholtz, H; Winkler, M1
Fernández, E; Galán, AI; González-Buitrago, JM; Jiménez, R; Morán, D; Muñoz, ME1
Bismuth, H; Cabiac, MD; Farges, O; Girault, D; Haddad, N; Samuel, D1
Ballardie, FW; Bhatnagar, D; Chalmers, RJ; Durrington, PN; Edwards, BD; Gokal, R; Mackness, MI1
Eckfeldt, J; Levitt, MD; Pieper-Bigelow, C1
Bloomer, JR; Bowers, LD; Lacerda, MA; Payne, WD; Snover, DC1
Friman, S; Holmberg, SB; Svensson, G1
Grant, D; Levy, G1
Banks, L; Engel, K; Freeman, D; Grant, D; Levy, G; Roach, C; Rochon, J; Wong, PY1
Böhme, M; Jedlitschky, G; Keppler, D; Leier, I; Müller, M1
Bertault-Peres, P; Durand, A; Guitaoui, M; Mesdjian, E; Montet, JC; Queneau, PE1
al-Quaiz, MN; O'Grady, JG; Tredger, JM; Williams, R1
Färber, L; Maibücher, A; Manns, M; Pichlmayr, R; Ringe, B; Schneider, K; Wietholtz, H; Winkler, M1
Bertault-Perès, P; Durand, A; Mesdjian, E; Montet, JC; Queneau, PE1
Badr, KF; Bluhm, RE; Frazer, MG; Pinson, CW; Vore, M1
Arias, IM1
Bonfissuto, G; Calabrese, S; Caputo, F; Carroccio, A; Montalto, G; Pisciotta, G; Soresi, M; Sparacino, V1
Morales, JM1
Alberti, D; de Ville de Goyet, J; Falchetti, D; Otte, JB; Panzali, A; Reding, R; Rigamonti, W; Sokal, E; Wallemacq, P1
Chipman, JK; Coleman, R; Stone, V; Wilton, JC1
Bernard, B; Bouvier, E; Cabrol, A; Cadranel, JF; Dorent, R; Gandjbakhch, I; Gerhardt, M; Ghoussoub, JJ; Lunel, F; Myara, A; Opolon, P; Trivin, F1
Gosland, M; Hoffman, T; Huang, L; Liu, Y; Vore, M1
Adachi, Y; Kamisako, T1
Chan, FK; Shaffer, EA1
Almogy, N; Fiodorov, D; Nakache, R; Weinbroum, A1
Deters, M; Strubelt, O; Younes, M1
Clement de Clety, S; De Backer, M; de Ville de Goyet, J; Otte, JB; Reding, R; Sokal, EM; Van Leeuw, V; Wallemacq, PE1
Bährle, S; Dengler, TJ; Kübler, W; Stiehl, A; Szabó, G; Theilmann, L; Zimmermann, R1
De Buitrago, JM; Fernández, E; Galán, AI; Jiménez, R; Morán, D; Muñoz, ME1
Calmus, Y; Conti, F; Gaulard, P; Houssin, D; Louvel, A; Rouer, E; Zafrani, ES1
Alvaro, D; Benedetti, A; Bini, A; Delle Monache, MD; Di Cosimo, E; Fraioli, F; Francia, C; Gigliozzi, A; Jezequel, AM; Marucci, L; Papa, E1
Deters, M; Hänsel, W; Muhl, P; Siegers, C1
Deters, M; Hänsel, W; Hennighausen, G; Schneider, KP; Siegers, C1
Chayama, K; Kajiyama, G; Ochi, H; Tazuma, S; Yasumiba, S1
McDonald, GB; Shulman, HM; Strasser, SI1
Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP1
Bangert, K; Bramow, S; Dalhoff, K; Ott, P; Thomsen Nielsen, F; Tygstrup, N1
Deters, M; Kaever, V; Kirchner, G; Nolte, K; Resch, K1
Aitio, ML; Aranko, K1
Cava, F; Esteller, A; Galán, AI; Gonzalez-Buitrago, JM; Jimenez, R; Muñoz, ME; Román, ID1
Arvieux, C; Boucher, E; Calmus, Y; Gane, P; Nordlinger, B; Poupon, R; Rouger, P1
Duane, WC; Eckfeldt, JH; Furne, J; Hillstrom, J; Levitt, MD1
Black, DL; Bluhm, RE; Branch, R; Rodgers, WH; Wilkinson, GR1
Almeida, VM; Bleck, JS; Budniak, J; Christians, U; Deters, M; Kohlhaw, K; Pichlmayr, R; Schlitt, HJ; Schottmann, R; Wonigeit, K1

Reviews

6 review(s) available for cyclosporine and Cholestasis

ArticleYear
Prevention by dietary (n-6) polyunsaturated phosphatidylcholines of intrahepatic cholestasis induced by cyclosporine A in animals.
    Life sciences, 2003, Jun-13, Volume: 73, Issue:4

    Topics: Actins; Adenosine Triphosphatases; Adenosine Triphosphate; Animal Feed; Animals; Biological Transport; Calcium; Cell Membrane; Cholestasis; Cyclosporine; Hypolipidemic Agents; Lipid Metabolism; Liver; Liver Diseases; Magnesium; Male; Models, Biological; Phosphatidylcholines; Phospholipids; Rats; Rats, Wistar

2003
Potential for CsA-Neoral in organ transplantation.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Administration, Oral; Adult; Child; Cholestasis; Cyclosporine; Graft Rejection; Heart Transplantation; Humans; Kidney Transplantation; Liver Transplantation; Randomized Controlled Trials as Topic; Transplantation Immunology

1994
Hepatobiliary function and toxicity in vitro using isolated hepatocyte couplets.
    General pharmacology, 1995, Volume: 26, Issue:7

    Topics: Animals; Bile Acids and Salts; Bile Canaliculi; Cell Communication; Cell Separation; Cells, Cultured; Cholestasis; Cyclosporine; Hemostatics; Immunosuppressive Agents; In Vitro Techniques; Liver; Rats; Tight Junctions; Vacuoles; Vitamin K

1995
[Intrahepatic cholestasis].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:3

    Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cholestasis; Cholestasis, Intrahepatic; Cyclosporine; Endotoxins; Humans; Liver; S-Adenosylmethionine

1996
Cholestasis after hematopoietic cell transplantation.
    Clinics in liver disease, 1999, Volume: 3, Issue:3

    Topics: Cholestasis; Cyclosporine; Cytomegalovirus Infections; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Hemolysis; Humans; Parenteral Nutrition, Total; Sepsis

1999
[Problems in cyclosporin medication].
    Duodecim; laaketieteellinen aikakauskirja, 1992, Volume: 108, Issue:6

    Topics: Acute Kidney Injury; Cholestasis; Cyclosporine; Drug Interactions; Humans; Immunologic Deficiency Syndromes; Liver; Tissue Transplantation

1992

Trials

2 trial(s) available for cyclosporine and Cholestasis

ArticleYear
Cyclosporine Neoral in liver transplant recipients.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Antilymphocyte Serum; Cholestasis; Cyclosporine; Female; Graft Rejection; Humans; Immunosuppression Therapy; Intestinal Absorption; Liver Transplantation; Male; Metabolic Clearance Rate; Methylprednisolone; Middle Aged; Muromonab-CD3; Postoperative Complications

1994
Clinical pharmacokinetics of Neoral in pediatric recipients of primary liver transplants.
    Transplant international : official journal of the European Society for Organ Transplantation, 1997, Volume: 10, Issue:6

    Topics: Administration, Oral; Child, Preschool; Cholestasis; Cyclosporine; Diarrhea; Dose-Response Relationship, Drug; Fluoroimmunoassay; Humans; Immunosuppressive Agents; Infant; Liver Transplantation; Time Factors

1997

Other Studies

65 other study(ies) available for cyclosporine and Cholestasis

ArticleYear
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Effects of Yinzhihuang on Alleviating Cyclosporine A-Induced Cholestatic Liver Injury via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Vitro and in Vivo.
    Biological & pharmaceutical bulletin, 2023, Volume: 46, Issue:12

    Topics: Animals; Bile Acids and Salts; Bilirubin; Cholestasis; Cyclosporine; Liver; Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear

2023
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:4

    Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; Dose-Response Relationship, Drug; Flutamide; Gene Expression; Humans; Imipramine; Inflammation; Ketoconazole; Liver; Methyltestosterone; Oxidative Stress; Rats; Risk Assessment; Sulindac; Tamoxifen; Toxicogenetics

2017
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 44

    Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Cyclosporine; Ethinyl Estradiol; Hep G2 Cells; Hepatocytes; Humans; Liver; Mice; Transcriptome

2017
Tacrolimus-Induced Cholestatic Hepatitis in a Patient With Liver Transplant.
    Transplantation, 2018, Volume: 102, Issue:10

    Topics: Allografts; Biopsy; Carcinoma, Hepatocellular; Cholestasis; Cyclosporine; Graft Rejection; Hepatitis; Humans; Immunosuppressive Agents; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Tacrolimus; Ultrasonography, Doppler

2018
Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.
    Toxicology letters, 2013, Aug-29, Volume: 221, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Cholestasis; Cholesterol; Cyclosporine; Gene Expression; Gene Expression Profiling; Hep G2 Cells; Histocytochemistry; Humans; Male; Mice; Mice, Inbred C57BL; Phenotype; Specific Pathogen-Free Organisms; Toxicogenetics

2013
Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes.
    BMC medical genomics, 2013, Oct-10, Volume: 6

    Topics: Animals; Biomarkers; Chlorpromazine; Cholestasis; Cyclosporine; Cytotoxins; Down-Regulation; Gene Expression Profiling; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Signal Transduction

2013
Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:5

    Topics: ATP Binding Cassette Transporter, Subfamily B; Cholestasis; Cyclosporine; Female; HEK293 Cells; Humans; Male; Polymorphism, Single Nucleotide; Proteasome Inhibitors; Protein Folding; Protein Transport

2014
Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 141, Issue:1

    Topics: Actins; Cell Line, Tumor; Cell Survival; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Gene Expression; Humans; Immunosuppressive Agents; Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Taurocholic Acid; Time-Lapse Imaging

2014
Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine treated.
    International journal of surgery (London, England), 2014, Volume: 12, Issue:10

    Topics: Adult; Aged; Anastomotic Leak; Cholestasis; Cyclosporine; Female; Genetic Variation; Genotype; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Interferons; Interleukins; Liver Transplantation; Male; Middle Aged; Retrospective Studies; Risk Factors; Tacrolimus

2014
Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Culture Techniques; Cells, Cultured; Cholestasis; Cyclosporine; HEK293 Cells; Hepatocytes; Humans; Multidrug Resistance-Associated Proteins; Propionates; Quinidine; Quinolines; Rats, Sprague-Dawley

2015
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
    Chemical research in toxicology, 2016, Mar-21, Volume: 29, Issue:3

    Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis; Colchicine; Cyclosporine; Diethylnitrosamine; Drug-Related Side Effects and Adverse Reactions; Ethinyl Estradiol; Female; Gene Expression Profiling; Hepatocytes; Humans; Liver; Male; Methyltestosterone; Middle Aged; Necrosis; Phenotype; Toxicogenetics; Young Adult

2016
Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 34

    Topics: Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cyclosporine; Hepatocytes; Humans; Risk Assessment; Urea

2016
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: 1-Naphthylisothiocyanate; Aged; Chlorpromazine; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Gene Expression Profiling; Humans; Liver; Male; Methyltestosterone; Middle Aged; Signal Transduction; Transcriptome; Young Adult

2017
Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.
    Chemical research in toxicology, 2016, 12-19, Volume: 29, Issue:12

    Topics: Cells, Cultured; Cholestasis; Cyclosporine; DNA Methylation; Genomics; Hepatocytes; Humans; Immunosuppressive Agents; Oligonucleotide Array Sequence Analysis; Transcriptome

2016
NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:3

    Topics: Animals; Cell Death; Cholestasis; Collagen; Cyclosporine; Fibrosis; Hepatocytes; Membrane Potentials; Mice; Mitochondrial Membranes; Permeability

2008
Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:3

    Topics: 1-Naphthylisothiocyanate; Aniline Compounds; Animals; Biomarkers; Cholestasis; Cyclosporine; Disease Models, Animal; Kidney; Magnetic Resonance Spectroscopy; Male; Metabolomics; Rats; Rats, Sprague-Dawley

2009
Selectively high levels of serum interleukin 17 in a newborn infant with progressive severe cholestasis.
    Pediatrics, 2010, Volume: 126, Issue:1

    Topics: Biomarkers; Cholestasis; Cyclosporine; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Humans; Infant, Newborn; Interleukin-17; Interleukin-8; Macrophage Inflammatory Proteins; Male; Risk Assessment; Severity of Illness Index; Steroids; Treatment Outcome

2010
Prurigo nodularis as the first manifestation of a chronic autoimmune cholestatic hepatitis.
    International journal of dermatology, 2011, Volume: 50, Issue:12

    Topics: Alkaline Phosphatase; Antibodies, Antinuclear; Azathioprine; Cholestasis; Cyclosporine; Dermatologic Agents; Female; gamma-Glutamyltransferase; Hepatitis, Autoimmune; Humans; Middle Aged; Prurigo; Ursodeoxycholic Acid

2011
Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
    The Journal of biological chemistry, 2012, Feb-10, Volume: 287, Issue:7

    Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calnexin; Cholestasis; Cryoprotective Agents; Cyclosporine; Dogs; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Silencing; Glycerol; Hep G2 Cells; HSC70 Heat-Shock Proteins; Humans; Mutation, Missense; Phenylbutyrates; Protein Transport; Thapsigargin

2012
Effects of curcumin on cyclosporine-induced cholestasis and hypercholesterolemia and on cyclosporine metabolism in the rat.
    Planta medica, 2003, Volume: 69, Issue:4

    Topics: Administration, Oral; Animals; Bile; Bile Acids and Salts; Biliary Fistula; Cholagogues and Choleretics; Cholestasis; Cholesterol; Curcuma; Curcumin; Cyclosporine; Disease Models, Animal; Hypercholesterolemia; Hypolipidemic Agents; Immunosuppressive Agents; Injections, Intraperitoneal; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Triglycerides

2003
Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2003, Volume: 22, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Calcium; Cardiovascular Diseases; Cholestasis; Chronic Disease; Cyclosporine; Disease Models, Animal; Female; Fibrosis; Liver Diseases; Mitochondria, Heart; Oxidative Stress; Rats; Rats, Wistar

2003
Secondary osteoporosis in liver transplant recipients: a longitudinal study in patients with and without cholestatic liver disease.
    Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:3

    Topics: Adult; Aged; Alkaline Phosphatase; Biomarkers; Bone Density; Bone Resorption; Cholestasis; Collagen; Collagen Type I; Cyclosporine; Female; Femur Neck; Follow-Up Studies; Forearm; Fractures, Bone; Glucocorticoids; Humans; Immunosuppressive Agents; Liver Diseases; Liver Transplantation; Longitudinal Studies; Lumbar Vertebrae; Male; Middle Aged; Norway; Osteocalcin; Osteoporosis; Peptide Fragments; Peptides; Postoperative Complications; Survival Analysis; Tacrolimus; Treatment Outcome; Waiting Lists

2003
Cholestasis and kidney dysfunction in liver transplant patients reduces cyclosporine metabolite excretion.
    Transplant international : official journal of the European Society for Organ Transplantation, 1992, Volume: 5 Suppl 1

    Topics: Adult; Aged; Cholestasis; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Diseases; Liver Transplantation; Male; Middle Aged; Postoperative Period; Regression Analysis; Time Factors

1992
Tacrolimus-induced cholestatic syndrome following pediatric liver transplantation and steroid-resistant graft rejection.
    Pediatric transplantation, 2006, Volume: 10, Issue:2

    Topics: Adolescent; Child; Cholestasis; Cyclosporine; Graft Rejection; Humans; Immunosuppressive Agents; Infant; Liver; Liver Transplantation; Postoperative Complications; Pruritus; Retrospective Studies; Tacrolimus

2006
Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluoresceins; Kinetics; LLC-PK1 Cells; Organic Anion Transporters, Sodium-Dependent; Oxadiazoles; Rifampin; Rifamycins; Swine; Symporters; Taurocholic Acid; Transfection

2006
Cholestasis in pregnancy associated with ciclosporin therapy in renal transplant recipients.
    Transplant international : official journal of the European Society for Organ Transplantation, 2006, Volume: 19, Issue:12

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Canaliculi; Cholestasis; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Pregnancy; Pregnancy Complications

2006
Inhibition of ileal bile acid transport by cyclosporin A in rat.
    European journal of clinical investigation, 1995, Volume: 25, Issue:9

    Topics: Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Cyclosporine; Ileum; Immunosuppressive Agents; Intestinal Absorption; Male; Perfusion; Rats; Rats, Wistar

1995
Conversion from CyA to CyA-NOF in a cholestatic liver grafted patient with CyA malabsorption.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Administration, Oral; Biopsy; Cholestasis; Cyclosporine; Humans; Immunosuppression Therapy; Intestinal Absorption; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Tacrolimus

1994
Reversal of cyclosporine A-induced alterations in biliary secretion by S-adenosyl-L-methionine in rats.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Animals; Bile Acids and Salts; Biliary Tract; Cholestasis; Cholesterol; Cyclosporine; Drug Administration Schedule; Drug Interactions; Immunosuppressive Agents; Liver; Male; Phospholipids; Proteins; Rats; Rats, Wistar; S-Adenosylmethionine

1995
Conversion from cyclosporine Sandimmun to cyclosporine neoral in liver transplant patients with cholestasis or external biliary drainage.
    Transplantation proceedings, 1995, Volume: 27, Issue:4

    Topics: Administration, Oral; Adult; Autoimmune Diseases; Bile; Cholestasis; Cyclosporine; Drainage; Female; Hepatitis C; Humans; Injections, Intravenous; Intestinal Absorption; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged

1995
Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis.
    QJM : monthly journal of the Association of Physicians, 1995, Volume: 88, Issue:2

    Topics: Biomarkers; Cholestasis; Cholesterol, LDL; Cyclosporine; Drug Administration Schedule; Humans; Lipoproteins; Liver Function Tests; Psoriasis

1995
Sensitivity of HPLC and conventional bilirubin measurements in the detection of early cholestasis.
    The Journal of laboratory and clinical medicine, 1995, Volume: 125, Issue:5

    Topics: Animals; Bile Ducts; Bilirubin; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Ethinyl Estradiol; Guinea Pigs; Ligation; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity

1995
Hepatic levels of cyclosporine and metabolites in patients after liver transplantation.
    Clinical transplantation, 1995, Volume: 9, Issue:1

    Topics: Adult; Bilirubin; Biopsy; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Female; Humans; Immunosuppression Therapy; Liver; Liver Transplantation; Male; Mass Spectrometry

1995
Influence of liver transplantation and cyclosporin on bile secretion--an experimental study in the rat.
    Transplant international : official journal of the European Society for Organ Transplantation, 1995, Volume: 8, Issue:1

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cyclosporine; Female; Injections, Intraperitoneal; Liver; Liver Transplantation; Models, Biological; Organ Size; Rats; Rats, Inbred WF

1995
Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver.
    Gastroenterology, 1994, Volume: 107, Issue:1

    Topics: Adenosine Triphosphate; Animals; Bile Acids and Salts; Bile Canaliculi; Biological Transport; Carbon Radioisotopes; Cell Membrane; Cholestasis; Cyclosporine; Cyclosporins; In Vitro Techniques; Leukotriene C4; Liver; Male; Rats; Rats, Wistar; Taurocholic Acid; Time Factors

1994
Improvement of cyclosporin A-induced cholestasis by tauroursodeoxycholate in a long-term study in the rat.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:7

    Topics: Animals; Cholestasis; Cyclosporine; Isomerism; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Taurochenodeoxycholic Acid

1994
Variable effect of ursodeoxycholic acid on cyclosporin absorption after orthotopic liver transplantation.
    Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7, Issue:3

    Topics: Absorption; Adolescent; Adult; Aged; Biological Availability; Cholestasis; Cyclosporine; Female; Graft Rejection; Half-Life; Humans; Liver; Liver Transplantation; Male; Middle Aged; Transplantation, Homologous; Ursodeoxycholic Acid

1994
Enhanced bioavailability of cyclosporine using a new oral formulation (Sandimmun optoral) in a liver-grafted patient with severe cholestasis.
    Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7, Issue:2

    Topics: Administration, Oral; Biological Availability; Cholestasis; Cyclosporine; Emulsions; Graft Rejection; Humans; Intestinal Absorption; Liver Transplantation; Male; Middle Aged

1994
Diminution of an acute cyclosporin-induced cholestasis by tauroursodeoxycholate in the rat.
    Transplantation, 1993, Volume: 56, Issue:3

    Topics: Animals; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis; Cyclosporine; Male; Rats; Rats, Sprague-Dawley; Solutions; Taurine; Ursodeoxycholic Acid; Viscosity

1993
Endothelins 1 and 3: potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine.
    Hepatology (Baltimore, Md.), 1993, Volume: 18, Issue:4

    Topics: Animals; Cholestasis; Cyclosporine; Drug Synergism; Endothelins; Liver; Male; Rats; Rats, Sprague-Dawley

1993
Cyclosporin, the biology of the bile canaliculus, and cholestasis.
    Gastroenterology, 1993, Volume: 104, Issue:5

    Topics: Adenosine Triphosphate; Animals; Anions; Bile Canaliculi; Biological Transport; Cholestasis; Cyclosporine; Humans

1993
[Effects of cyclosporin A on various indices of cholestasis in kidney transplant recipients].
    Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 1995, Volume: 47, Issue:2

    Topics: Adult; Cholelithiasis; Cholestasis; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Liver Function Tests; Male; Middle Aged; Postoperative Complications

1995
Drug-induced hepatotoxicity.
    The New England journal of medicine, 1996, Mar-28, Volume: 334, Issue:13

    Topics: Azathioprine; Cholestasis; Cyclosporine; Humans

1996
Microemulsion formulation of cyclosporine in pediatric liver transplantation.
    Transplantation, 1996, Feb-15, Volume: 61, Issue:3

    Topics: Administration, Oral; Biological Availability; Child; Child, Preschool; Cholestasis; Chronic Disease; Cyclosporine; Diarrhea; Emulsions; Female; Graft Rejection; Humans; Immunosuppressive Agents; Intestinal Absorption; Liver Transplantation; Short Bowel Syndrome

1996
Cyclosporin A-mediated cholestasis in patients with chronic hepatitis after heart transplantation.
    European journal of gastroenterology & hepatology, 1996, Volume: 8, Issue:3

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cholestasis; Cholic Acid; Cholic Acids; Chromatography, High Pressure Liquid; Cyclosporine; Fasting; Female; Glycocholic Acid; Heart Transplantation; Hepatitis, Chronic; Humans; Immunosuppressive Agents; Lithocholic Acid; Male; Middle Aged; Spectrophotometry, Ultraviolet; Taurocholic Acid; Ursodeoxycholic Acid

1996
MDR1 substrates/modulators protect against beta-estradiol-17beta-D-glucuronide cholestasis in rat liver.
    Cancer research, 1996, Nov-01, Volume: 56, Issue:21

    Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Carrier Proteins; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Daunorubicin; Estradiol; Male; Paclitaxel; Rats; Rats, Sprague-Dawley

1996
Cholestatic effects of cyclosporine in the rat.
    Transplantation, 1997, Jun-15, Volume: 63, Issue:11

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cholesterol; Cyclosporine; Immunosuppressive Agents; Liver; Male; Organ Size; Polyethylene Glycols; Rats; Rats, Inbred Lew

1997
Vasoactive effect of cyclosporine on the rat peribiliary capillary plexus: relationship with cholestasis and hyperbilirubinemia.
    Transplantation proceedings, 1997, Volume: 29, Issue:6

    Topics: Animals; Capillaries; Cholestasis; Cyclosporine; Hyperbilirubinemia; Immunosuppressive Agents; In Vitro Techniques; Liver; Rats; Vasoconstriction

1997
Reevaluation of cyclosporine induced hepatotoxicity in the isolated perfused rat liver.
    Toxicology, 1997, Dec-05, Volume: 123, Issue:3

    Topics: Alanine Transaminase; Animals; Antioxidants; Bile; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Drug Evaluation; Glutamate Dehydrogenase; Immunosuppressive Agents; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Oxygen Consumption; Perfusion; Rats; Rats, Wistar

1997
Adjuvant treatment with ursodeoxycholic acid may reduce the incidence of acute cardiac allograft rejection.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1998, Volume: 17, Issue:6

    Topics: Acute Disease; Cholestasis; Cyclosporine; Female; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Retrospective Studies; Ursodeoxycholic Acid

1998
Inhibition of biliary glutathione secretion by cyclosporine A in the rat: possible mechanisms and role in the cholestasis induced by the drug.
    Journal of hepatology, 1998, Volume: 29, Issue:1

    Topics: Animals; Bile Acids and Salts; Biliary Tract; Cholestasis; Cyclosporine; Glutathione; Immunosuppressive Agents; Male; Rats; Rats, Wistar

1998
Increased expression of interleukin-4 during liver allograft rejection.
    Journal of hepatology, 1999, Volume: 30, Issue:5

    Topics: Acute Disease; Adult; Cholestasis; Chronic Disease; Cyclosporine; Female; Gene Expression Regulation; Graft Rejection; Humans; Immunohistochemistry; Immunosuppression Therapy; Interleukin-2; Interleukin-4; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Receptors, Interleukin-2; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Transplantation, Homologous

1999
Effect of pharmacological modulation of liver P-glycoproteins on cyclosporin A biliary excretion and cholestasis: a study in isolated perfused rat liver.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:11

    Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B; Bile; Cholestasis; Cyclosporine; Immunosuppressive Agents; Liver; Male; Perfusion; Rats; Rats, Wistar; Time Factors; Verapamil

1999
Choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat.
    Planta medica, 1999, Volume: 65, Issue:7

    Topics: Animals; Bile; Cholagogues and Choleretics; Cholestasis; Coumaric Acids; Curcumin; Cyclosporine; Diarylheptanoids; Immunosuppressive Agents; Male; Rats; Rats, Wistar

1999
Influence of curcumin on cyclosporin-induced reduction of biliary bilirubin and cholesterol excretion and on biliary excretion of cyclosporin and its metabolites.
    Planta medica, 2000, Volume: 66, Issue:5

    Topics: Animals; Bile; Bilirubin; Cholagogues and Choleretics; Cholestasis; Cholesterol; Curcumin; Cyclosporine; Injections, Intravenous; Male; Rats; Rats, Wistar

2000
Cyclosporin A reduces canalicular membrane fluidity and regulates transporter function in rats.
    The Biochemical journal, 2001, Mar-15, Volume: 354, Issue:Pt 3

    Topics: Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Blotting, Western; Carrier Proteins; Cholestasis; Cholesterol; Cyclosporine; Immunosuppressive Agents; Male; Membrane Fluidity; Phospholipids; Rats; Rats, Sprague-Dawley

2001
Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria.
    Bioscience reports, 2001, Volume: 21, Issue:1

    Topics: Animals; Calcium; Chenodeoxycholic Acid; Cholestasis; Cyclosporine; Enzyme Inhibitors; Gastrointestinal Agents; Indicators and Reagents; Liver; Male; Membrane Potentials; Mitochondria, Liver; Osmosis; Permeability; Rats; Rats, Wistar; Ruthenium Red; Subcellular Fractions

2001
Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine A and sirolimus (Rapamycin).
    Pharmacology & toxicology, 2001, Volume: 89, Issue:3

    Topics: Animals; Carrier Proteins; Cholestasis; Cyclosporine; Cytochrome P-450 Enzyme System; Drug Interactions; Gene Expression Regulation; Glutathione; Immunosuppressive Agents; Liver; Liver Function Tests; Liver Transplantation; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sirolimus

2001
Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus-tacrolimus combinations on bile flow in the rat.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:10

    Topics: Animals; Bile Acids and Salts; Biliary Fistula; Biliary Tract; Cholestasis; Cyclosporine; Disease Models, Animal; Drug Combinations; Immunosuppressive Agents; Male; Rats; Rats, Wistar; Sirolimus; Tacrolimus

2001
Inhibition of biliary lipid and protein secretion by cyclosporine A in the rat.
    Biochemical pharmacology, 1992, Sep-25, Volume: 44, Issue:6

    Topics: Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Cholestasis; Cholesterol; Cyclosporine; Fat Emulsions, Intravenous; Liver; Male; Phospholipids; Proteins; Rats; Rats, Wistar

1992
Cholestasis induces major histocompatibility complex class I expression in hepatocytes.
    Gastroenterology, 1992, Volume: 102, Issue:4 Pt 1

    Topics: Aged; Animals; Cholestasis; Cyclosporine; Female; Flow Cytometry; Fluorescent Antibody Technique; Histocompatibility Antigens Class I; Humans; Liver; Male; Middle Aged; Rats; Rats, Inbred Lew

1992
Lack of benefit of ursodeoxycholic acid in drug-induced cholestasis in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 200, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cyclosporine; Ethinyl Estradiol; Male; Rats; Rats, Inbred Strains; Ursodeoxycholic Acid

1992
Cholestasis in transplant patients--what is the role of cyclosporin?
    Alimentary pharmacology & therapeutics, 1992, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anti-Bacterial Agents; Aspartate Aminotransferases; Bilirubin; Biopsy; Child; Child, Preschool; Cholestasis; Chromatography, High Pressure Liquid; Creatinine; Cross Reactions; Cyclosporine; Female; Fluorescence Polarization Immunoassay; Humans; Hyperbilirubinemia; Infant; L-Lactate Dehydrogenase; Liver; Male; Prognosis; Time Factors; Transplantation

1992
Ciclosporin metabolite pattern in blood and urine of liver graft recipients. II. Influence of cholestasis and rejection.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:4

    Topics: Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Graft Rejection; Humans; Liver Transplantation; Postoperative Complications; Radioimmunoassay; Time Factors

1991