cyclosporine and Chemical and Drug Induced Liver Injury

cyclosporine has been researched along with Chemical and Drug Induced Liver Injury in 110 studies

Research

Studies (110)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.91)	18.7374
1990's	23 (20.91)	18.2507
2000's	28 (25.45)	29.6817
2010's	44 (40.00)	24.3611
2020's	14 (12.73)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Norman, BH	1
Callegaro, G; den Hollander, W; Furlong, L; Grosdidier, S; Guney, E; Kunnen, SJ; Mollon, J; Niemeijer, M; Piñero Gonzalez, J; Saez-Rodriguez, J; Stevens, JL; Sutherland, JJ; Trairatphisan, P; van de Water, B; Webster, YW	1
El-Sayed, NM; Faheem, SA; Hazem, RM; Moustafa, YM; Saeed, NM	1
Cao, Z; Huang, L; Liao, X; Liu, F; Liu, J; Lu, H; Wan, M; Wang, Y; Xiao, J; Xiong, G; Yang, D; Zhang, S	1
Ahmed, YM; Elsayed, NM; Faheem, SA; Hazem, RM; Saeed, NM	1
Matsukawa, T; Miyagishima, T; Nagai, J; Oshimi, K; Suto, K	1
Bekpinar, S; Bingul, I; Olgac, V; Uysal, M	1
Li, T; Luo, Z; Wei, Y; Wu, Q; Xiao, W; Yu, Y; Zhou, K	1
Bajaj, P; Harada, K; Kohara, H; Matsui, T; Miyamoto, K; Miyawaki, A; Okai, Y; Shinozawa, T; Wagoner, M; Yamanaka, K	1
Das, P; Kumar, VL; Vangaveti, S	1
Enver Ozan, İ; Erdem Güzel, E; Gül, M; Kavak Balgetir, M; Kaya Tektemur, N; Ozan Kocamüftüoğlu, G; Özcan Yıldırım, S; Tektemur, A; Yalçın, T	1
Abdelmageed, ME; Nader, MA; Serrya, MS	1
Adebayo, A; Adefegha, SA; Babatola, LJ; Dada, FA; Oyeleye, SI	1
Aylı, M; Caliskan, E; Coban, SN; Esme, P; Ugur, B	1
Brauers, K; Coonen, MLJ; Jennen, D; Kleinjans, JCS; Olde Damink, SWM; Schaap, FG; Van den Hof, WFPM; van Herwijnen, M	1
Berti, E; Damiani, G; Fiore, M; Leone, S; Maraolo, AE	1
Dawson, N; Kassab, L; Patel, A; Ton, A	1
Caballero, D; Caballero-Velázquez, T; Castilla-Llorente, C; Encinas, C; Heras, I; López-Corral, L; Martino, R; Pérez-Simón, JA; Rosiñol, L; Sampol, A; San Miguel, J; Serrano, D	1
Huang, H; Li, YQ; Liu, HM; Wu, XC; Xin, HW; Yu, AR; Zhang, L	1
Brauers, K; Coonen, ML; Kleinjans, JC; Lommen, A; Van den Hof, WF; van Herwijnen, M; Van Summeren, A; Wodzig, WK	1
Akbulut, S; Dogan, Z; Elbe, H; Eris, C; Otan, E; Toprak, G; Turkoz, Y; Yalcin, E	1
Driessen, M; Kienhuis, AS; Pennings, JL; van der Ven, LT; Vitins, AP; Water, Bv	1
Brauers, K; Coonen, ML; Gaj, S; Jennen, DG; Kleinjans, JC; Ruiz-Aracama, A; van Delft, JH; Van den Hof, WF; Van Summeren, A; Wodzig, WK	1
Choi, YH; Jung, SH; Kim, HS; Kim, SG; Ko, MS; Lee, CH; Lee, JS	1
Almeida, JM; Camargo, C; de Freitas, KM; Diamante, MA; Dolder, H; Jorge, MH; Monteiro, JC; Vale, JS	1
Akool, el-S	1
Chen, CJ; Cheng, TT; Lin, JC; Lin, KM	1
Bašić-Jukić, N; Ivandić, E	1
Funakami, Y; Kato, Y; Nagai, N; Tanino, T	1
Aamdal, S; Andersson, Y; Brunsvig, P; Dueland, S; Engebraaten, O; Fodstad, Ø; Juell, S	1
El-Sherbeeny, NA; Nader, MA	1
Hu, J; Jaeschke, H; Lemasters, JJ; McGill, MR; Ramshesh, VK	1
Akküçük, S; Karaboğa, I; Motor, S; Nacar, A; Nacar, E; Okuyan, HM; Ozkan, OV; Sefil, NK	1
Diem, S; Larkin, J; Spain, L	1
Annaert, P; Bachellier, P; Baze, A; Heyd, B; Oorts, M; Richert, L; Zacharias, T	1
Cai, P; Li, J; Liu, F; Metushi, I; Nakayawa, T; Uetrecht, J; Vega, L	1
Exton, LS; Kirby, B; Mohd Mustapa, MF; Smith, CH; Warren, RB; Weatherhead, SC; Yesudian, PD	1
Almario, EE; Borlak, J; Chen, M; Suzuki, A	1
Akimaru, K; Ishikawa, Y; Kakinuma, D; Kanada, T; Mamada, Y; Mizuguchi, Y; Tajiri, T; Taniai, N; Yoshida, H	1
Pari, L; Sivasankari, R	1
Catarsi, P; Ghiggeri, GM; Ginevri, F; Gusmano, R; Magnasco, A; Perfumo, F; Rossi, A	1
Azarpira, N; Baghban, M; Jamshidzadeh, A; Mohammadi Bardbori, A; Niknahad, H	1
Cederbaum, AI; Zhuge, J	1
Allen, CE; Horton, T; Jones, JY; McClain, KL; Thompson, PA; Vinks, AA	1
Atasever, A; Esrefoglu, M; Kurus, M; Sogutlu, G	1
Andrade, RJ; Cotta, J; Lucena, MA; Robles, M; Toscano, E	1
El-Dayem, WA; Eladl, M; Elgalaly, H; Kamel, M; Maarouf, AM; Radwan, M; Salem, EA; Salem, NA	1
Bayrak, R; Delibasi, T; Ekiz, F; Erarslan, E; Koca, C; Turkcu, UO; Uz, B	1
Bouwman, FG; Kleinjans, JC; Mariman, EC; Noben, JP; Renes, J; van Delft, JH; Van Summeren, A	1
Chaudhuri, S; Hennings, L; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Simpson, PM	1
Jaeschke, H; McGill, MR; Ramachandran, A	1
Couch, L; Fang, JL; Guo, L; Higuchi, M; Li, Y	1
Burton, L; Chiuzan, C; Garrett-Mayer, E; Heath, TS; Hudspeth, MP; Nista, E; Ragucci, D	1
Chen, XC; Xu, Q	1
Ducloux, D	1
De Carlis, LG; De Gasperi, A; Mancini, V; Marbello, L; Morra, E; Muti, G; Nosari, A	1
Hagar, HH	1
Arduino, JM; Chodakewitz, J; Hachem, R; Kartsonis, N; Lipka, CJ; Marr, KA; Ngai, AL; Papanicolaou, G; Sable, C; Somani, J	1
Armstrong, JS; Cheung, NS; Halliwell, B; Rose, P; Siau, JL; Tan, GS; Whiteman, M	1
Bianchi, R; Buffoli, B; Rezzani, R; Rodella, L; Stacchiotti, A	1
Niemczyk, M; Paczek, L; Perkowska, A; Porowski, D; Wyzgał, J	1
Fujiwara, M; Hori, A; Kami, M; Kanda, Y; Komatsu, T; Koyama, R; Kusumi, E; Masuoka, K; Matsumura, T; Miyakoshi, S; Murashige, N; Seki, K; Tanaka, Y; Taniguchi, S; Wake, A; Yuji, K	1
Durgut, R; Duru, M; Kaya, H; Koc, A; Sogut, S; Uz, E; Yilmaz, HR	1
Aoyama, T; Arai, K; Ikejima, K; Kon, K; Lemasters, JJ; Okumura, K; Sato, N; Takei, Y	1
Lai, FF; Ma, KF; Qi, LY	1
Amudha, G; Josephine, A; Nithya, K; Preetha, SP; Varalakshmi, P; Veena, CK	1
Behre, G; Christopeit, M; Eikam, M	1
Anderle, SK; Geratz, JD; Pryzwansky, KB; Tidwell, RR	1
Greenberg, E; Moore, RA; Tangen, L	1
Caraceni, P; Cooper, DK; Deal, S; Fagiuoli, S; Gavaler, J; Jazzar, A; Sisson, S; Van Thiel, DH; Wright, HI; Zuhdi, N	1
Wood, P; Yin, JA	1
Holzer, H; Horina, JH; Kenner, L; Krejs, GJ; Wirnsberger, GH	1
Kahan, BD; Lindholm, A	1
Bouvier, R; Cochat, P; Dubourg-Derain, L; Philippe, N; Vial, T; Vinot, O	1
Lemasters, JJ; Trost, LC	1
Demetris, AJ; Felekouras, ES; Fung, JJ; Jain, AB; Lee, RG; Tsamandas, AC	1
Brooks, RH; Pincus, T; Stein, CM	1
Fritsche, H; Ippoliti, C; Khouri, I; Körbling, M; Przepiorka, D; Warkentin, D; Woo, M	1
Crespo Valadés, E; González Fernández, MR; Jimeno Torres, B; Robles Pérez, NR	1
Asakura, W; Hara, K; Kobayashi, T; Nakano, Y; Okamoto, T; Tsuzuike, N	1
Kobayashi, T; Okamoto, T	1
Hara, A; Hitomi, Y; Okamoto, T	1
Cartner, S; Contreras, JL; Eckhoff, DE; Frenette, L; Neville, DM; Robbin, ML; Thomas, FT; Thomas, JM	1
Agranat, O; Freimark, D; Gruberg, L; Har-Zahav, Y	1
Sato, S; Suzuki, K; Takikawa, Y	1
Cartier, VA; Chousterman, M; Gordin, J; Hagège, H; Lons, T; Ngo, MD; Rosa, I	1
DeCicco, LA; Rikans, LE; Yamano, T	1
Chicharro, Mf; Guarner, L; Malagelada, J; Planas, M; Vilaseca, J	1
Busca, A; Lanino, E; Manfredini, L; Messina, C; Miniero, R; Nicolini, B; Rabusin, M; Saroglia, EM; Uderzo, C	1
Kubota, T; Lynch, SV; Matsunami, H; Morioka, D; Nakatani, Y; Sekido, H; Shimada, H; Strong, RW; Takeda, K; Togo, S	1
Enomoto, N; Ikejima, K; Kolinsky, M; Li, X; Raleigh, JA; Thurman, RG; von Frankenberg, M; Yamashina, S; Zhong, Z	1
Jiang, XL; Li, WB; Quan, QZ; Sun, ZQ; Wang, D; Wang, YJ; Zhang, XL	1
Berg, U; Ingelman-Sundberg, M; Lytton, SD; Nemeth, A	1
Abu-Elmagd, K; Alessiani, M; Demetris, AJ; Fung, JJ; Jain, A; McCauley, J; Starzl, TE; Takaya, S; Todo, S; Van Thiel, DH	1
Fung, J; Gavaler, JS; Starzl, TE; Van Thiel, DH; Wright, HI	1
García, R; Henríquez La Roche, C; Herrera, J; Marín, C; Rodríguez-Iturbe, B; Rubio, L	1
Adorno, D; Casciani, CU; Cervelli, V; Cesarini, A; Filingeri, V; Iacona, A; Orsini, D; Rossetti, A	1
Baldwin, JC; Billingham, ME; Jamieson, SW; Ogunnaike, HO; Porter, KA; Starkey, TD	1

Reviews

9 review(s) available for cyclosporine and Chemical and Drug Induced Liver Injury

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies. Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20 Topics: Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Discovery; Drug Evaluation, Preclinical; Hepatocytes; Humans; Liver; Mitochondria, Liver; Pharmaceutical Preparations; Risk Assessment; Tissue Distribution	2020
Liver Illness and Psoriatic Patients. BioMed research international, 2018, Volume: 2018 Topics: Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Inflammation; Liver; Liver Diseases; Methotrexate; Psoriasis	2018
Management of toxicities of immune checkpoint inhibitors. Cancer treatment reviews, 2016, Volume: 44 Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antilymphocyte Serum; Antineoplastic Agents; Carcinoma, Renal Cell; Chemical and Drug Induced Liver Injury; Colitis; CTLA-4 Antigen; Cyclosporine; Diarrhea; Drug Eruptions; Humans; Immunosuppressive Agents; Infliximab; Ipilimumab; Kidney Neoplasms; Lung Neoplasms; Melanoma; Mycophenolic Acid; Neoplasms; Nivolumab; Pituitary Diseases; Programmed Cell Death 1 Receptor; Skin Neoplasms; Tacrolimus; Thyroiditis	2016
Cyclosporin and organ specific toxicity: clinical aspects, pharmacogenetics and perspectives. Current clinical pharmacology, 2008, Volume: 3, Issue:3 Topics: Brain; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Immunosuppressive Agents; Kidney; Neurotoxicity Syndromes; Organ Specificity; Pharmacogenetics	2008
Is cyclosporine withdrawal a therapeutic option in renal transplant recipients with chronic allograft dysfunction? Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 2003, Volume: 55, Issue:1 Topics: Calcineurin Inhibitors; Chemical and Drug Induced Liver Injury; Chronic Disease; Clinical Trials as Topic; Cyclosporine; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation	2003
Oxymetholone hepatotoxicity enhanced by concomitant use of cyclosporin A in a bone marrow transplant patient. Clinical and laboratory haematology, 1994, Volume: 16, Issue:2 Topics: Adolescent; Bone Marrow Transplantation; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Synergism; Humans; Male; Oxymetholone	1994
Toxicities of tacrolimus and cyclosporin A after allogeneic blood stem cell transplantation. Bone marrow transplantation, 1997, Volume: 20, Issue:12 Topics: Acute Kidney Injury; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cyclosporine; Female; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Humans; Hyperglycemia; Hyperkalemia; Hypertension; Immunosuppressive Agents; Incidence; Infections; Male; Methylprednisolone; Middle Aged; Patient Compliance; Retrospective Studies; Seizures; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous; Treatment Outcome; Whole-Body Irradiation	1997
[Physiopathology and therapy of fulminant hepatitis]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1999, Sep-10, Volume: 88, Issue:9 Topics: Chemical and Drug Induced Liver Injury; Cyclosporine; Hemofiltration; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Immunosuppressive Agents; Liver Failure; Plasma Exchange; T-Lymphocytes, Cytotoxic; Tumor Necrosis Factor-alpha	1999

Trials

7 trial(s) available for cyclosporine and Chemical and Drug Induced Liver Injury

Article	Year
Phase II clinical trial for the evaluation of bortezomib within the reduced intensity conditioning regimen (RIC) and post-allogeneic transplantation for high-risk myeloma patients. British journal of haematology, 2013, Volume: 162, Issue:4 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Cyclosporine; Drug Synergism; Female; Graft vs Host Disease; Hematologic Diseases; Humans; Immunosuppressive Agents; Maintenance Chemotherapy; Male; Melphalan; Middle Aged; Multiple Myeloma; Peripheral Blood Stem Cell Transplantation; Peripheral Nervous System Diseases; Protease Inhibitors; Pyrazines; Remission Induction; Reoperation; Salvage Therapy; T-Lymphocyte Subsets; Transplantation Conditioning; Transplantation, Autologous; Transplantation, Homologous; Vidarabine	2013
Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin. British journal of cancer, 2015, Dec-01, Volume: 113, Issue:11 Topics: Adult; Aged; Alanine Transaminase; Animals; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Bone Marrow Neoplasms; Carcinoma; Cell Adhesion Molecules; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Interactions; Epithelial Cell Adhesion Molecule; Female; Half-Life; Humans; Immunoconjugates; Infusions, Intravenous; Lethal Dose 50; Macaca fascicularis; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasm Micrometastasis; Neoplasms; Treatment Outcome	2015
Incidence and etiology of hepatic dysfunction in heart transplant recipients receiving a cyclosporine-based triple immunosuppressive therapy. Transplantation proceedings, 1994, Volume: 26, Issue:5 Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Heart Transplantation; Humans; Immunosuppression Therapy; Liver Diseases; Liver Function Tests; Time Factors	1994
Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation. Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:2 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Monitoring; Female; Follow-Up Studies; Graft Rejection; Humans; Kidney Diseases; Kidney Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Racial Groups; Regression Analysis	1993
Effect of combination therapy with cyclosporine and methotrexate on liver function test results in rheumatoid arthritis. Arthritis and rheumatism, 1997, Volume: 40, Issue:9 Topics: Alkaline Phosphatase; Antirheumatic Agents; Arthritis, Rheumatoid; Bilirubin; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Humans; Liver; Liver Diseases; Liver Function Tests; Methotrexate	1997
Mycophenolate mofetil (MMF) as therapy for refractory chronic GVHD (cGVHD) in children receiving bone marrow transplantation. Bone marrow transplantation, 2000, Volume: 25, Issue:10 Topics: Adolescent; Adrenal Cortex Hormones; Bone Marrow Transplantation; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Combined Modality Therapy; Cyclosporine; Drug Resistance; Female; Gastrointestinal Diseases; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Mycophenolic Acid; Opportunistic Infections; Prodrugs; PUVA Therapy; Safety; Transplantation, Homologous; Treatment Outcome	2000
Interferon therapy of hepatitis following liver transplantation under FK 506 or cyclosporine. Transplantation proceedings, 1991, Volume: 23, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Interferon Type I; Liver Transplantation; Tacrolimus; Transplantation, Homologous; Treatment Outcome	1991

Other Studies

94 other study(ies) available for cyclosporine and Chemical and Drug Induced Liver Injury

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment. Archives of toxicology, 2021, Volume: 95, Issue:12 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Datasets as Topic; Endoplasmic Reticulum Stress; Gene Expression Profiling; Gene Regulatory Networks; Hepatocytes; Humans; Oxidative Stress; Rats; Risk Assessment; Species Specificity; Toxicogenetics; Tunicamycin	2021
Pyrvinium pamoate ameliorates cyclosporin A- induced hepatotoxicity via the modulation of Wnt/β-catenin signaling and upregulation of PPAR-γ. International immunopharmacology, 2022, Volume: 104 Topics: Animals; beta Catenin; Chemical and Drug Induced Liver Injury; Cyclosporine; Immunosuppressive Agents; Interleukin-1beta; Liver; Male; Mice; NF-kappa B; PPAR gamma; Protective Agents; Pyrvinium Compounds; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Up-Regulation; Wnt Signaling Pathway	2022
Cyclosporine A induces hepatotoxicity in zebrafish larvae via upregulating oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2023, Volume: 266 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Larva; Oxidative Stress; Zebrafish	2023
Niclosamide modulates cyclosporin A-induced hepatotoxicity in a mouse model: PPAR-γ and Wnt/β-catenin crosstalk. International immunopharmacology, 2023, Volume: 117 Topics: Animals; beta Catenin; Chemical and Drug Induced Liver Injury; Cyclosporine; Male; Mice; Niclosamide; PPAR gamma; Wnt Signaling Pathway	2023
[Aplastic anemia following drug-induced liver injury]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2019, Volume: 60, Issue:7 Topics: Adolescent; Anemia, Aplastic; Antilymphocyte Serum; Chemical and Drug Induced Liver Injury; Cyclosporine; Hemoglobinuria, Paroxysmal; Humans; Immunosuppressive Agents; Male	2019
The protective effect of resveratrol against cyclosporine A-induced oxidative stress and hepatotoxicity. Archives of physiology and biochemistry, 2021, Volume: 127, Issue:6 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclosporine; Lipid Peroxidation; Liver; Oxidative Stress; Rats; Resveratrol; Thiobarbituric Acid Reactive Substances	2021
Natural product research, 2021, Volume: 35, Issue:17 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Drugs, Chinese Herbal; Ions; Kidney; Liver; NF-E2-Related Factor 2; Rats; Schisandra; Signal Transduction	2021
High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice. Toxicological sciences : an official journal of the Society of Toxicology, 2020, 02-01, Volume: 173, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Bile Canaliculi; Chemical and Drug Induced Liver Injury; Cyclosporine; Gene Expression; Hepatocytes; High-Throughput Screening Assays; Humans; Mice; Mice, Transgenic	2020
Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation. Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Inflammation; Kidney Diseases; Male; Metformin; Oxidation-Reduction; Rats; Rats, Wistar; Silymarin	2021
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice. Ultrastructural pathology, 2021, Jan-02, Volume: 45, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Liver; Mice	2021
Hepatoprotective effect of the tyrosine kinase inhibitor nilotinib against cyclosporine-A induced liver injury in rats through blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling pathway. Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:6 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochromes c; Male; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction	2021
Evaluation of different almond ( Journal of complementary & integrative medicine, 2021, Apr-13, Volume: 18, Issue:4 Topics: Acetylcholinesterase; Animals; Antioxidants; Brain; Chemical and Drug Induced Liver Injury; Cyclosporine; Lipid Peroxidation; Liver; Male; Oxidative Stress; Plant Extracts; Prunus dulcis; Rats; Rats, Wistar; Terminalia	2021
A case of psoriasis successfully treated by extracorporeal photopheresis during COVID-19 pandemic. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2021, Volume: 60, Issue:5 Topics: Acitretin; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Contraindications, Drug; COVID-19; Cyclosporine; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Nails; Pandemics; Photopheresis; Psoriasis; Quality of Life; SARS-CoV-2; Severity of Illness Index; Ultraviolet Therapy	2021
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis. Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 44 Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Cyclosporine; Ethinyl Estradiol; Hep G2 Cells; Hepatocytes; Humans; Liver; Mice; Transcriptome	2017
Severe acute hepatitis in drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome resolved following cyclosporine. The journal of allergy and clinical immunology. In practice, 2020, Volume: 8, Issue:1 Topics: Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Hypersensitivity Syndrome; Eosinophilia; Hepatitis; Humans	2020
Association of CYP3A418B and CYP3A53 polymorphism with cyclosporine-related liver injury in Chinese renal transplant recipients. International journal of clinical pharmacology and therapeutics, 2014, Volume: 52, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Chemical and Drug Induced Liver Injury; Chi-Square Distribution; China; Cyclosporine; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Incidence; Kidney Transplantation; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Risk Factors; Time Factors; Young Adult	2014
Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity. Toxicology, 2014, Oct-03, Volume: 324 Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclosporine; Gene Expression Profiling; Gene Expression Regulation; Genetic Markers; Genomics; Hepatocytes; Immunosuppressive Agents; Liver; Male; Metabolomics; Mice; Mice, Inbred C57BL; MicroRNAs; Primary Cell Culture; Protein Interaction Mapping; Protein Interaction Maps; Proteomics; Risk Assessment; RNA, Messenger; Systems Biology	2014
Effects of antioxidant agents against cyclosporine-induced hepatotoxicity. The Journal of surgical research, 2015, Volume: 193, Issue:2 Topics: Alanine Transaminase; Alkaline Phosphatase; Allopurinol; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Body Weight; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Evaluation, Preclinical; Liver; Male; Melatonin; Random Allocation; Rats, Sprague-Dawley; Ursodeoxycholic Acid; Xanthine Oxidase	2015
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen. Toxicology letters, 2015, Jan-22, Volume: 232, Issue:2 Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cyclosporine; Embryo, Nonmammalian; Gene Expression; Hepatocytes; Humans; Immunosuppressive Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Rats; Transcriptome; Zebrafish	2015
Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:3 Topics: Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Gene Expression Profiling; Hep G2 Cells; Humans; Immunosuppressive Agents; In Vitro Techniques; Metabolomics; MicroRNAs; RNA, Messenger; Transcriptome	2015
Tacrolimus therapy causes hepatotoxicity in patients with a history of liver disease. International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Monitoring; Electronic Health Records; Female; Humans; Immunosuppressive Agents; Liver Diseases; Male; Middle Aged; Republic of Korea; Retrospective Studies; Risk Factors; Tacrolimus; Time Factors; Young Adult	2015
The effects of cyclosporin A and Heteropterys tomentosa on the rat liver. Anais da Academia Brasileira de Ciencias, 2015, Volume: 87, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Immunosuppressive Agents; Liver; Male; Malpighiaceae; Plant Extracts; Rats; Rats, Wistar; Time Factors	2015
Molecular mechanisms of the protective role of wheat germ oil against cyclosporin A-induced hepatotoxicity in rats. Pharmaceutical biology, 2015, Volume: 53, Issue:9 Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Interleukin-2; Lipid Peroxidation; Liver; Male; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Phytotherapy; Plant Oils; Plants, Medicinal; Rats, Wistar; Reactive Oxygen Species; Triticum	2015
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study. Clinical rheumatology, 2015, Volume: 34, Issue:6 Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Hepatitis C, Chronic; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha	2015
[Liver damage caused by atorvastatin and cyclosporine in patients with renal transplant]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2014, Volume: 68, Issue:2 Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Cyclosporine; Graft Rejection; Graft Survival; Heptanoic Acids; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Liver; Male; Middle Aged; Pyrroles	2014
Cyclosporin A-sensitive cytotoxicity of flurbiprofen non-stereoselectively mediated by cytochrome P450 metabolism in three-dimensional cultured rat hepatocytes. The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:10 Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochrome P-450 Enzyme System; Flurbiprofen; Hepatocytes; Ibuprofen; L-Lactate Dehydrogenase; Male; Mitochondria; Naproxen; Phenylpropionates; Rats; Rats, Wistar; Stereoisomerism	2015
The protective effect of vildagliptin in chronic experimental cyclosporine A-induced hepatotoxicity. Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:3 Topics: Adamantane; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Nitriles; Oxidative Stress; Protective Agents; Pyrrolidines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vildagliptin	2016
Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 150, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Mitochondria, Liver	2016
Investigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods. Turkish journal of medical sciences, 2015, Volume: 45, Issue:6 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclosporine; Expectorants; Glutathione Peroxidase; Immunosuppressive Agents; Liver; Male; Malondialdehyde; Microscopy; Random Allocation; Rats, Wistar; Superoxide Dismutase; Thioglycolates; Thiophenes	2015
Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 34 Topics: Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cyclosporine; Hepatocytes; Humans; Risk Assessment; Urea	2016
Exploring an animal model of amodiaquine-induced liver injury in rats and mice. Journal of immunotoxicology, 2016, Volume: 13, Issue:5 Topics: Agranulocytosis; Amodiaquine; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytokines; Disease Models, Animal; Humans; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred BN; Remission, Spontaneous; Spinocerebellar Degenerations; T-Lymphocytes, Regulatory; Th17 Cells; Tretinoin	2016
British Association of Dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease 2016. The British journal of dermatology, 2016, Volume: 175, Issue:1 Topics: Adult; Alcohol Drinking; Biological Products; Bone Marrow Diseases; Checklist; Chemical and Drug Induced Liver Injury; Chickenpox; Child; Counseling; Cyclosporine; Dermatologic Agents; Drug Administration Routes; Drug Administration Schedule; Drug Approval; Drug Interactions; Drug Monitoring; Drug Overdose; Evidence-Based Medicine; Female; Hepatitis, Viral, Human; HIV Infections; Humans; Intraoperative Complications; Kidney Diseases; Lung Diseases; Methotrexate; Nausea; Neoplasms; Off-Label Use; Patient Education as Topic; Patient Safety; Pregnancy; Pregnancy Complications; Retinoids; Skin Diseases; Tuberculosis; Ultraviolet Rays; Vaccination	2016
Drug-Induced Liver Injury. BioMed research international, 2017, Volume: 2017 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Disease Models, Animal; Humans; Medicine, Chinese Traditional; Valproic Acid; Zebrafish	2017
Hepatotoxicity caused by both tacrolimus and cyclosporine after living donor liver transplantation. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2008, Volume: 75, Issue:3 Topics: Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Immunosuppressive Agents; Jaundice, Obstructive; Liver Transplantation; Living Donors; Male; Middle Aged; Tacrolimus	2008
Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundamental & clinical pharmacology, 2008, Volume: 22, Issue:4 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Antagonism; Ellagic Acid; Glutathione Transferase; Immunosuppressive Agents; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances	2008
Effects of tomato extract on oxidative stress induced toxicity in different organs of rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:12 Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione; Immunosuppressive Agents; Kidney Diseases; Lipid Peroxidation; Lung Diseases; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Solanum lycopersicum	2008
Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice. Free radical biology & medicine, 2009, Feb-01, Volume: 46, Issue:3 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclosporine; Lipid Peroxidation; Lipopolysaccharides; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitogen-Activated Protein Kinase 9; Necrosis; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Signal Transduction	2009
Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis. Pediatric blood & cancer, 2009, Volume: 52, Issue:5 Topics: Adolescent; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclosporine; Female; Humans; Infant; Liver Diseases; Lymphohistiocytosis, Hemophagocytic; Magnetic Resonance Imaging; Male; Models, Biological	2009
Melatonin prevents cyclosporine-induced hepatotoxicity in rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2009, Volume: 18, Issue:5 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Disease Models, Animal; Free Radical Scavengers; Immunosuppressive Agents; Male; Melatonin; Rats	2009
[Hepatotoxicity induced by new immunosuppressants]. Gastroenterologia y hepatologia, 2010, Volume: 33, Issue:1 Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha	2010
Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats. Renal failure, 2010, Volume: 32, Issue:8 Topics: Animals; Arginine; Chemical and Drug Induced Liver Injury; Cyclosporine; Immunosuppressive Agents; Kidney Diseases; Male; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Trapidil; Vasodilator Agents	2010
Effects of erdosteine on cyclosporine-A-induced hepatotoxicity in rats. Drug and chemical toxicology, 2011, Volume: 34, Issue:1 Topics: Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione Peroxidase; Immunosuppressive Agents; Liver; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thioglycolates; Thiophenes	2011
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 120, Issue:1 Topics: Acetaminophen; Amiodarone; Blotting, Western; Cell Survival; Chemical and Drug Induced Liver Injury; Cluster Analysis; Cyclosporine; Drug-Related Side Effects and Adverse Reactions; Electrophoresis, Gel, Two-Dimensional; Hep G2 Cells; Humans; Pharmaceutical Preparations; Protein Biosynthesis; Protein Processing, Post-Translational; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry	2011
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia. Toxicology and applied pharmacology, 2011, May-01, Volume: 252, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitroimidazoles; Oxidative Stress; Statistics, Nonparametric	2011
Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 121, Issue:2 Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclosporine; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Proteomics	2011
Mitochondrial dysfunction induced by sertraline, an antidepressant agent. Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 127, Issue:2 Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Bongkrekic Acid; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Electron Transport Chain Complex Proteins; Energy Metabolism; Hepatocytes; L-Lactate Dehydrogenase; Male; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Mitochondrial Diseases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Risk Assessment; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors	2012
Folinic acid administration after MTX GVHD prophylaxis in pediatric allo-SCT. Bone marrow transplantation, 2013, Volume: 48, Issue:1 Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclosporine; Drug Monitoring; Drug Therapy, Combination; Female; Folic Acid Antagonists; Graft vs Host Disease; Humans; Immunosuppressive Agents; Infant; Leucovorin; Male; Methotrexate; Mucositis; Retrospective Studies; Severity of Illness Index; Stem Cell Transplantation; Survival Analysis; Transplantation, Homologous; Vitamin B Complex	2013
CD4 T lymphocytes cause hepatocyte apoptosis by releasing Th1 cytokines in cellular immunological liver injury. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:9 Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Cyclosporine; Ear Diseases; Edema; Female; Hepatocytes; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Liver Diseases; Mice; Mice, Inbred BALB C; Picryl Chloride; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha	2002
Bone marrow hypoplasia complicating tacrolimus (FK506) therapy. International journal of hematology, 2004, Volume: 79, Issue:2 Topics: Adolescent; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cyclosporine; Female; Humans; Immunosuppressive Agents; Liver Transplantation; N-Methyl-3,4-methylenedioxyamphetamine; Tacrolimus	2004
The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Toxicology letters, 2004, Jul-15, Volume: 151, Issue:2 Topics: Administration, Oral; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Antagonism; Immunosuppressive Agents; Injections, Subcutaneous; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Taurine; Thiobarbituric Acid Reactive Substances; Water Supply	2004
Retrospective study of the hepatic safety profile of patients concomitantly treated with caspofungin and cyclosporin A. Transplant infectious disease : an official journal of the Transplantation Society, 2004, Volume: 6, Issue:3 Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antifungal Agents; Aspartate Aminotransferases; Caspofungin; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Echinocandins; Female; Humans; Immunosuppressive Agents; Lipopeptides; Male; Middle Aged; Peptides, Cyclic; Retrospective Studies	2004
Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition. Free radical biology & medicine, 2005, Jun-15, Volume: 38, Issue:12 Topics: Animals; Apoptosis; Bongkrekic Acid; Carcinoma, Hepatocellular; Caspase 3; Caspase 7; Caspases; Cell Line; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochromes c; Humans; Hypochlorous Acid; Liver; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Permeability; Rats	2005
Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver. International immunopharmacology, 2005, Volume: 5, Issue:9 Topics: Animals; Antioxidants; Chaperonin 60; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Immunosuppressive Agents; Liver; Liver Diseases; Male; Malondialdehyde; Melatonin; Membrane Proteins; Metallothionein; Oxidative Stress; Rats; Rats, Wistar	2005
Sirolimus-associated hepatotoxicity in the kidney graft recipient. Transplant international : official journal of the European Society for Organ Transplantation, 2005, Volume: 18, Issue:11 Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mycophenolic Acid; Sirolimus; Steroids	2005
Hepatic injury following reduced intensity unrelated cord blood transplantation for adult patients with hematological diseases. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:12 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Busulfan; Chemical and Drug Induced Liver Injury; Cholangitis; Cord Blood Stem Cell Transplantation; Cyclosporine; Female; Hematologic Diseases; Hematologic Neoplasms; Hepatic Veno-Occlusive Disease; Humans; Hyperbilirubinemia; Immunosuppressive Agents; Incidence; Infant, Newborn; Liver Diseases; Liver Function Tests; Male; Melphalan; Middle Aged; Postoperative Complications; Risk Factors; Tacrolimus; Tissue Donors; Transplantation Conditioning; Vidarabine; Whole-Body Irradiation	2006
The protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in rats. Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione Peroxidase; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Wistar; Superoxide Dismutase	2008
Role of apoptosis in acetaminophen hepatotoxicity. Journal of gastroenterology and hepatology, 2007, Volume: 22 Suppl 1 Topics: Acetaminophen; Animals; Apoptosis; Cell Membrane Permeability; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione; Mice; Microscopy, Confocal; Mitochondria, Liver; Necrosis; Oxidative Stress	2007
[Gene expressions of LTC4 synthase homologs in Con A-induced mouse hepatitis and regulative effect of cyclosporine A]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2007, Volume: 36, Issue:3 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Concanavalin A; Cyclosporine; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Hepatitis, Animal; Immunosuppressive Agents; Injections, Intravenous; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction	2007
Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats. BMC pharmacology, 2008, Feb-20, Volume: 8 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Immunosuppressive Agents; Liver; Male; Oxidative Stress; Polysaccharides; Rats; Rats, Wistar; Sargassum; Sulfates	2008
Comedication of caspofungin acetate and cyclosporine A after allogeneic haematopoietic stem cell transplantation leads to negligible hepatotoxicity. Mycoses, 2008, Volume: 51 Suppl 1 Topics: Antifungal Agents; Caspofungin; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Echinocandins; Female; Germany; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Lipopeptides; Male; Mycoses; Postoperative Complications; Retrospective Studies; Treatment Outcome	2008
Control of glucan-induced systemic granulomatosis by cyclosporine A. Inflammation, 1995, Volume: 19, Issue:2 Topics: Animals; Chemical and Drug Induced Liver Injury; Chemotaxis; Cyclosporine; Female; Glucans; Granuloma, Foreign-Body; Liver Diseases; Lung Diseases; Macrophages; Rats; Rats, Inbred Lew; Splenic Diseases	1995
Cyclosporine-induced worsening of hepatic dysfunction in a patient with Crohn's disease and enterocutaneous fistula. Southern medical journal, 1995, Volume: 88, Issue:8 Topics: Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Crohn Disease; Cutaneous Fistula; Cyclosporine; Humans; Intestinal Fistula; Liver Diseases; Male	1995
Increased susceptibility for CsA-induced hepatotoxicity in kidney graft recipients with chronic viral hepatitis C. Transplantation, 1993, Volume: 56, Issue:5 Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Cyclosporine; Disease Susceptibility; Hepatitis C; Humans; Kidney Transplantation; Liver Function Tests; Retrospective Studies	1993
Jaundice associated with concomitant use of norethandrolone and cyclosporine. Transplantation, 1993, Volume: 56, Issue:2 Topics: Adolescent; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Female; Humans; Jaundice; Norethandrolone	1993
The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3 Topics: Animals; Aspirin; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cyclosporine; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Rats; Rats, Sprague-Dawley; Reye Syndrome; Ruthenium Red; Structure-Activity Relationship; Valproic Acid	1996
Central venulitis in the allograft liver: a clinicopathologic study. Transplantation, 1997, Jul-27, Volume: 64, Issue:2 Topics: Adult; Chemical and Drug Induced Liver Injury; Cyclosporine; Female; Graft Rejection; Hepatic Veins; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Tacrolimus; Time Factors; Transplantation, Homologous; Treatment Outcome; Vasculitis; Venules	1997
[Acute nephrotoxicity resolved by cyclosporine A, induced by simultaneous administration of colchicine]. Medicina clinica, 1998, Mar-14, Volume: 110, Issue:9 Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Colchicine; Cyclosporine; Gout Suppressants; Humans; Immunosuppressive Agents; Male; Middle Aged	1998
Expression of cytokine mRNA in extrahepatic organs in a mouse concanavalin A-hepatitis model. Japanese journal of pharmacology, 1998, Volume: 77, Issue:3 Topics: Animals; CD4 Antigens; CD8 Antigens; Chemical and Drug Induced Liver Injury; Concanavalin A; Cyclosporine; Cytokines; Disease Models, Animal; Female; Liver; Lung; Mice; Mice, Inbred BALB C; RNA, Messenger; Spleen	1998
Effects of immunosuppressants on concanavalin A-induced interleukin-2 mRNA expression in mouse liver. Japanese journal of pharmacology, 1998, Volume: 77, Issue:3 Topics: Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Cyclosporine; Dexamethasone; Female; Gene Expression Regulation; Immunosuppressive Agents; Interleukin-2; Liver; Mice; Mice, Inbred BALB C; RNA, Messenger	1998
The protective effect of cyclosporine A on anti-Fas antibody-induced hepatitis in mice. Japanese journal of pharmacology, 1999, Volume: 79, Issue:4 Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Caspase 3; Caspases; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytokines; Dose-Response Relationship, Drug; fas Receptor; Female; Gene Expression Regulation; Immunosuppressive Agents; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; RNA, Messenger	1999
Tolerability and side effects of anti-CD3-immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients. Transplantation, 1999, Jul-27, Volume: 68, Issue:2 Topics: Animals; Capillary Leak Syndrome; CD3 Complex; Chemical and Drug Induced Liver Injury; Cyclosporine; Immune Tolerance; Immunotoxins; Islets of Langerhans Transplantation; Kidney Function Tests; Kidney Transplantation; Liver Function Tests; Macaca mulatta; Male; Methylprednisolone; Transplantation Conditioning	1999
Acute myopathy induced by colchicine in a cyclosporine treated heart transplant recipient: possible role of the multidrug resistance transporter. Transplantation proceedings, 1999, Volume: 31, Issue:5 Topics: Acute Disease; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chemical and Drug Induced Liver Injury; Colchicine; Cyclosporine; Drug Resistance, Multiple; Drug Therapy, Combination; Gastrointestinal Diseases; Gout Suppressants; Heart Transplantation; Humans; Immunosuppressive Agents; Kidney Diseases; Male; Middle Aged; Muscular Diseases; Syndrome	1999
[Acute hepatitis in the course of cyclosporine therapy of Crohn's disease]. Presse medicale (Paris, France : 1983), 1999, Nov-06, Volume: 28, Issue:34 Topics: Adult; Chemical and Drug Induced Liver Injury; Crohn Disease; Cyclosporine; Female; Humans; Treatment Outcome	1999
Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of Kupffer cells and inflammatory cytokines. Toxicology and applied pharmacology, 2000, Jan-01, Volume: 162, Issue:1 Topics: Age Factors; Alanine Transaminase; Animals; Cadmium; Carbon; Chemical and Drug Induced Liver Injury; Chemotaxis; Cyclosporine; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Gadolinium; Inflammation Mediators; Interleukin-1; Kupffer Cells; L-Iditol 2-Dehydrogenase; Male; Neutrophil Infiltration; Phagocytosis; Rats; Rats, Inbred F344; Time Factors	2000
Does cyclosporin A worsen liver function in patients with inflammatory bowel disease and total parenteral nutrition? Revista espanola de enfermedades digestivas, 2000, Volume: 92, Issue:2 Topics: Adult; Chemical and Drug Induced Liver Injury; Cyclosporine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Liver Diseases; Liver Function Tests; Male; Parenteral Nutrition, Total; Retrospective Studies	2000
Successful conversion from cyclosporine to tacrolimus for immunosuppression. Transplantation proceedings, 2000, Volume: 32, Issue:7 Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Cyclosporine; Diabetes Mellitus, Type 1; Female; Humans; Immunosuppressive Agents; Inflammation; Insulin; Liver Function Tests; Liver Transplantation; Male; Neutrophils; Tacrolimus	2000
Cyclosporin A causes a hypermetabolic state and hypoxia in the liver: prevention by dietary glycine. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:3 Topics: Animals; Body Weight; Calcium; Chemical and Drug Induced Liver Injury; Cyclosporine; Dietary Supplements; Dinoprostone; Eating; Glycine; Hypoxia; Immunosuppressive Agents; Kupffer Cells; Liver Diseases; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Urea	2001
Protective effects of cyclosporine A on T-cell dependent ConA-induced liver injury in Kunming mice. World journal of gastroenterology, 2001, Volume: 7, Issue:4 Topics: Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Cyclosporine; Disease Models, Animal; Immunosuppressive Agents; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; T-Lymphocytes; Tumor Necrosis Factor-alpha	2001
Autoantibodies against cytochrome P450s in sera of children treated with immunosuppressive drugs. Clinical and experimental immunology, 2002, Volume: 127, Issue:2 Topics: Adolescent; Adult; Antibody Specificity; Aryl Hydrocarbon Hydroxylases; Autoantibodies; Autoantigens; Azathioprine; Blotting, Western; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclosporine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Epitopes; Female; Graft Rejection; Humans; Immunoglobulin G; Immunosuppressive Agents; Infant; Isoenzymes; Kidney Diseases; Kidney Transplantation; Liver Cirrhosis, Biliary; Liver Transplantation; Male; Middle Aged; Mixed Function Oxygenases; Postoperative Complications; Prednisone; Recombinant Fusion Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tacrolimus	2002
Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients. Transplantation, 1992, Volume: 53, Issue:5 Topics: Adolescent; Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chronic Disease; Cyclosporine; Female; Graft Rejection; Hepatic Artery; Hepatitis; Humans; Immunity, Cellular; Infant; Liver; Liver Diseases; Liver Transplantation; Male; Middle Aged; Tacrolimus	1992
[Usefulness of ketoconazole combined with cyclosporin in renal transplantation]. Investigacion clinica, 1991, Volume: 32, Issue:3 Topics: Adolescent; Adult; Azathioprine; Biotransformation; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Drug Therapy, Combination; Female; Humans; Immunosuppression Therapy; Ketoconazole; Kidney Diseases; Kidney Transplantation; Liver Function Tests; Male; Middle Aged; Prednisone	1991
Reduced nephrotoxicity and hepatoxicity in cyclosporin A therapy by enalapril and spironolactone in rats. Drugs under experimental and clinical research, 1991, Volume: 17, Issue:10-11 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Enalapril; Kidney Diseases; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Spironolactone	1991
An assessment of Nva2-cyclosporine in primate cardiac transplantation. Transplantation, 1987, Volume: 43, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Cyclosporins; Heart Transplantation; Immunosuppression Therapy; Kidney Diseases; Macaca fascicularis; Myocardium; Time Factors	1987