cyclosporine and Cardiomegaly

cyclosporine has been researched along with Cardiomegaly in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (19.23)	18.2507
2000's	32 (61.54)	29.6817
2010's	10 (19.23)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cheng, JT; Cheng, KC; Cheng, YZ; Kuo, SC; Lee, WJ; Li, Y	1
Cai, Y; Chen, S; Feng, X; Gao, S; Huang, X; Li, H; Li, Q; Liu, P; Liu, Z; Lu, J; Ye, J	1
Bin, J; Cao, S; Chen, C; Huang, X; Kitakaze, M; Li, G; Li, X; Liao, Y; Shen, L; Xu, D; Xuan, W; Zhang, J	1
Bao, Y; Cai, B; Chen, S; Gao, J; Jiang, J; Le, K; Li, R; Liu, P; Zhang, F	1
Ascah, A; Bourcier-Lucas, C; Burelle, Y; Deschepper, CF; Marcil, M; Matas, J; Young, NT	1
Brum, PC; Ferreira, JC; Gomes, ER; Guatimosim, S; Medeiros, A; Oliveira, RS; Paixão, NA; Rolim, NP	1
Benito, B; Nattel, S	1
Erikson, JM; Lindsey, ML; Zhang, J	1
Bian, ZY; Cao, F; Huang, H; Jiang, H; Li, H; Liu, C; Shen, DF; Tang, QZ; Wang, L; Yan, L; Zhu, LH	1
Chen, C; Chu, X; Dong, DL; Hu, JT; Huang, W; Huo, R; Li, Z; Tu, YJ; Wang, N; Yang, BF	1
Hu, WC; Liu, XH; Rong, F; Wu, XD; Zhang, ZY	1
Dai, J; Gomes, AP; Hafner, AV; Palmeira, CM; Rosenzweig, A; Sinclair, DA; Xiao, CY	1
Dhandapany, PS; Fabris, F; Gelb, BD; Hajjar, RJ; Illaste, A; Karakikes, I; Lebeche, D; Sheng, J; Sobie, EA; Sorourian, M; Tartaglia, M; Tonk, R	1
Bupha-Intr, T; Haizlip, KM; Janssen, PM	1
Radio, SJ; Roberts, CA; Stern, DL	1
Hudnall, SD	1
Duff, HJ; Kryski, AJ; Molkentin, JD; Semeniuk, LM; Severson, DL; Swirp, SL	1
Jordan, MC; Nicholas, SB; Philipson, KD; Quednau, BD; Roos, KP; Ross, RS	1
Boerrigter, G; Burnett, JC; Cataliotti, A; Costello-Boerrigter, LC; Jougasaki, M; Lee, SC; McGregor, CG; Nordstrom, LJ; Salz-Gilman, L; Tsuruda, T	1
Dollinger, MM; Flapan, AD; Hayes, PC; Plevris, JN; Therapondos, G	1
Fu, M; Liu, N; Pang, Y; Tang, C; Xu, S; Zhang, J	1
Bauer, A; Becker, R; Katus, HA; Kelemen, K; Kraft, P; Schoels, W; Schreiner, KD; Senges, JC; Voss, F; Zehelein, J	1
Han, Z; Xiang, J; Yang, Y; Zhang, K	1
Feng, W; Jiang, Y; Kang, YJ; Merten, KE	1
Dong, LF; Wang, YL; Zhang, YJ	1
Barinaga, M	1
Colbert, MC; Gualberto, A; Gude, N; Lim, HW; Molkentin, JD; Olson, EN; Robbins, J; Sussman, MA; Taigen, T; Wieczorek, DF	1
Gualberto, A; Luo, Z; Shyu, KG; Walsh, K	1
Crabtree, GR	1
Horiuchi, M; Jalil, A; Kobayashi, K; Nomoto, M; Saheki, T	1
Choukroun, G; Force, T; Hajjar, R; Rosenzweig, A	1
McKinsey, TA; Olson, EN	1
McCullagh, KJ; Musarò, A; Naya, FJ; Olson, EN; Rosenthal, N	1
Condorelli, G; De Windt, LJ; Dorn, GW; Kitsis, RN; Lim, HW; Molkentin, JD; Taigen, T; Wencker, D	1
De Windt, LJ; Kimball, TR; Lim, HW; Mante, J; Molkentin, JD; Sussman, MA; Witt, SA	1
De Windt, LJ; Kimball, TR; Lim, HW; Molkentin, JD; Steinberg, L; Taigen, T; Witt, SA	1
Attramadal, H; Bjørnerheim, R; Clausen, OP; Oie, E	1
Davisson, RL; Hill, JA; Karimi, M; Kerber, RE; Kutschke, W; Wang, Z; Weiss, RM; Zimmerman, K	1
Fu, M; Liu, N; Pang, Y; Su, J; Tang, C; Xu, S; Zhang, J	1
Brenot, R; Charve, P; David, M; Eicher, JC; Fenot, P; Gomez, MC; Jazayeri, S; Tatou, E	1
Brunner, HR; Murat, A; Pedrazzini, T; Pellieux, C	1
Molkentin, JD	1
Honda, R; Lalli, MJ; Molkentin, JD; Tymitz, KM; Yatani, A	1
Leinwand, LA	1
Han, J; Lim, HW; Molkentin, JD; New, L	1
Fu, MG; Jiang, ZS; Liu, NK; Pang, YZ; Tang, CS; Wang, XH	1
Hill, JA; Karimi, M; Kutschke, W; Richardson, KE; Wang, Z	1
Bauerlein, R; Bodine, SC; Glass, DJ; Gonzalez, M; Kline, WO; Lawrence, JC; Scrimgeour, A; Stitt, TN; Stover, GL; Yancopoulos, GD; Zlotchenko, E	1
Buttrick, PM; Geenen, DL; Goldspink, PH; Kimball, VA; McKinney, RD	1
Demura, M; Mabuchi, H; Takeda, Y; Usukura, M; Yoneda, T	1
Bueno, OF; De Windt, LJ; Doevendans, PA; Molkentin, JD; van Rooij, E	1

Reviews

6 review(s) available for cyclosporine and Cardiomegaly

Article	Year
[Hypertrophy of the heart: calcineurin-NFAT pathway may be a new therapeutic target]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:10 Topics: Animals; Calcineurin; Cardiomegaly; Cyclosporine; Gene Expression; Humans; Immunosuppressive Agents; NFATC Transcription Factors; Signal Transduction; Tacrolimus	2006
Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell, 1999, Mar-05, Volume: 96, Issue:5 Topics: Amino Acid Sequence; Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Calcium Signaling; Cardiomegaly; Cyclosporine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Immunosuppressive Agents; Mice; Models, Biological; Molecular Sequence Data; Multigene Family; Myocardium; NFATC Transcription Factors; Nuclear Proteins; Organ Specificity; Protein Isoforms; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Tacrolimus; Transcription Factors; Transfection	1999
Cardiac hypertrophy: sorting out the circuitry. Current opinion in genetics & development, 1999, Volume: 9, Issue:3 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; DNA-Binding Proteins; Humans; MAP Kinase Signaling System; NFATC Transcription Factors; Nuclear Proteins; Transcription Factors	1999
Calcineurin and beyond: cardiac hypertrophic signaling. Circulation research, 2000, Oct-27, Volume: 87, Issue:9 Topics: Amino Acid Sequence; Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Cell Nucleus; Cyclosporine; Cytoplasm; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Immunosuppressive Agents; Mice; Mice, Transgenic; Models, Animal; Molecular Sequence Data; NFATC Transcription Factors; Nuclear Proteins; Signal Transduction; T-Lymphocytes; Tacrolimus; Transcription Factors; Transcription, Genetic	2000
Calcineurin inhibition and cardiac hypertrophy: a matter of balance. Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6 Topics: A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Carrier Proteins; Cyclosporine; DNA-Binding Proteins; Humans; Immunosuppressive Agents; Intracellular Signaling Peptides and Proteins; Muscle Proteins; Phosphoproteins; Tacrolimus	2001
Calcineurin and hypertrophic heart disease: novel insights and remaining questions. Cardiovascular research, 2002, Volume: 53, Issue:4 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Heart Failure; Humans; Signal Transduction; Tacrolimus	2002

Trials

1 trial(s) available for cyclosporine and Cardiomegaly

Article	Year
Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart. Regulatory peptides, 2003, Apr-15, Volume: 112, Issue:1-3 Topics: Adolescent; Adrenomedullin; Adult; Aged; Biopsy; Blood Pressure; Cardiomegaly; Cell Size; Cyclosporine; Female; Graft Rejection; Heart Transplantation; Heart Ventricles; Humans; Immunohistochemistry; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Peptides	2003

Article

Year

Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart.

Regulatory peptides, 2003, Apr-15, Volume: 112, Issue:1-3

Topics: Adolescent; Adrenomedullin; Adult; Aged; Biopsy; Blood Pressure; Cardiomegaly; Cell Size; Cyclosporine; Female; Graft Rejection; Heart Transplantation; Heart Ventricles; Humans; Immunohistochemistry; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Peptides

2003

Other Studies

45 other study(ies) available for cyclosporine and Cardiomegaly

Article	Year
Molecular mechanisms regarding potassium bromate‑induced cardiac hypertrophy without apoptosis in H9c2 cells. Molecular medicine reports, 2018, Volume: 18, Issue:5 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Apoptosis; Bromates; Calcineurin; Cardiomegaly; Cell Line; Cell Size; Cyclosporine; Gene Expression Regulation; Humans; Myocytes, Cardiac; Myosin Heavy Chains; Natriuretic Peptide, Brain; Rats; Reactive Oxygen Species; Signal Transduction	2018
COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3. Molecular and cellular endocrinology, 2014, Feb-15, Volume: 382, Issue:2 Topics: Animals; Animals, Newborn; Calcineurin; Cardiomegaly; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclosporine; Dinoprostone; Endothelin-1; Gene Expression Regulation; Myocytes, Cardiac; Natriuretic Peptide, Brain; NFATC Transcription Factors; Nitrobenzenes; Primary Cell Culture; Promoter Regions, Genetic; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sulfonamides; Transcription, Genetic	2014
Cytosolic CARP promotes angiotensin II- or pressure overload-induced cardiomyocyte hypertrophy through calcineurin accumulation. PloS one, 2014, Volume: 9, Issue:8 Topics: Adenoviridae; Angiotensin II; Animals; Animals, Newborn; Aorta; Atrial Natriuretic Factor; Calcineurin; Calpain; Cardiomegaly; Constriction, Pathologic; Cyclosporine; Gene Expression Regulation; Genetic Vectors; Glycoproteins; Imidazoles; Mice; Muscle Proteins; Myocytes, Cardiac; Myosin Heavy Chains; Nuclear Proteins; Primary Cell Culture; Protein Transport; Rats; Repressor Proteins; RNA, Small Interfering; Signal Transduction; Tetrazoles	2014
Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway. Molecular and cellular biochemistry, 2008, Volume: 317, Issue:1-2 Topics: Animals; Animals, Newborn; Calcineurin; Cardiomegaly; Cell Nucleus; Cell Size; Cyclosporine; Endothelin-1; Myocytes, Cardiac; NFATC Transcription Factors; PPAR gamma; Protein Biosynthesis; Protein Transport; Rats; Rats, Sprague-Dawley; Rosiglitazone; Signal Transduction; Surface Properties; Thiazolidinediones	2008
Blockade of calcineurin reverses cardiac hypertrophy and induces the down-regulation of JNK mRNA expression in renovascular hypertensive rats. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2008, Volume: 9, Issue:3 Topics: Animals; Blood Pressure; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Diastole; Down-Regulation; Heart Function Tests; Heart Ventricles; Hypertension, Renovascular; JNK Mitogen-Activated Protein Kinases; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Systole	2008
Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy. Journal of molecular and cellular cardiology, 2009, Volume: 46, Issue:3 Topics: Animals; Cardiomegaly; Cell Death; Cell Survival; Cyclophilins; Cyclosporine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxygen Consumption; Peptidyl-Prolyl Isomerase F; Protein Binding; Protein Transport; Rats; Reactive Oxygen Species; Stress, Physiological	2009
Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice. The Journal of physiology, 2009, Aug-01, Volume: 587, Issue:Pt 15 Topics: Animals; Calcineurin; Cardiomegaly; Carrier Proteins; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Exercise Tolerance; Heart Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NFATC Transcription Factors; Phosphotransferases (Alcohol Group Acceptor); Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; Receptors, Adrenergic, alpha-2; Signal Transduction; TOR Serine-Threonine Kinases; Ventricular Remodeling	2009
Exercise training as a treatment for heart failure: potential mechanisms and clinical implications. The Journal of physiology, 2009, Nov-01, Volume: 587, Issue:Pt 21 Topics: Animals; Calcineurin; Cardiomegaly; Carrier Proteins; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Exercise Tolerance; Heart Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NFATC Transcription Factors; Phosphotransferases (Alcohol Group Acceptor); Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; Receptors, Adrenergic, alpha-2; Signal Transduction; TOR Serine-Threonine Kinases; Ventricular Remodeling	2009
Going out on a LIM and cysteine-rich domains 1 limb: a new way to block calcineurin activity. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:2 Topics: Animals; Binding Sites; Calcineurin; Cardiomegaly; Cyclosporine; Cysteine; Disease Models, Animal; DNA-Binding Proteins; Gene Expression Regulation; Homeodomain Proteins; Humans; Male; Mice	2010
LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:2 Topics: Animals; Blotting, Northern; Blotting, Western; Calcineurin; Cardiomegaly; Cells, Cultured; Cyclosporine; Disease Models, Animal; Drug Delivery Systems; Gene Expression Regulation; Homeodomain Proteins; LIM-Homeodomain Proteins; Mice; Mice, Transgenic; Myocytes, Cardiac; NFATC Transcription Factors; Random Allocation; RNA, Messenger; Signal Transduction; Transcription Factors; Transfection	2010
Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy: a novel mechanism for progressive cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:4 Topics: Analysis of Variance; Animals; Blotting, Western; Calcineurin; Cardiomegaly; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Mice; MicroRNAs; Myocardium; Myocytes, Cardiac; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Statistics, Nonparametric; Transfection	2010
The calcineurin-myocyte enhancer factor 2c pathway mediates cardiac hypertrophy induced by endoplasmic reticulum stress in neonatal rat cardiomyocytes. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:5 Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcineurin; Calcium; Cardiomegaly; Cell Size; Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Antibody Technique; L-Lactate Dehydrogenase; MEF2 Transcription Factors; Myocytes, Cardiac; Myogenic Regulatory Factors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Thapsigargin; Tunicamycin	2010
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging, 2010, Volume: 2, Issue:12 Topics: Acetylation; Age Factors; Aging; Amino Acid Sequence; Animals; Cardiomegaly; Cyclophilins; Cyclosporine; Disease Models, Animal; Humans; Lysine; Mice; Mice, 129 Strain; Mice, Knockout; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Myocytes, Cardiac; Peptidyl-Prolyl Isomerase F; Protein Conformation; Sirtuin 3; Structure-Activity Relationship; Time Factors	2010
Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:1 Topics: Adenoviridae; Animals; Animals, Newborn; Calcineurin; Calcium Signaling; Cardiomegaly; Cardiomyopathy, Hypertrophic; Cyclosporine; Disease Models, Animal; LEOPARD Syndrome; Mutation; Myocytes, Cardiac; Noonan Syndrome; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; T-Lymphocytes	2011
Role of endothelin in the induction of cardiac hypertrophy in vitro. PloS one, 2012, Volume: 7, Issue:8 Topics: Analysis of Variance; Animals; Benzylamines; Boron Compounds; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cyclosporine; Endothelins; Immunoblotting; In Vitro Techniques; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; Myocardial Contraction; NFATC Transcription Factors; Rabbits; Signal Transduction; Sulfonamides; Thiourea; Time Factors	2012
Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine A after liver transplant. Transplantation, 2002, Sep-27, Volume: 74, Issue:6 Topics: Adult; Autopsy; Body Weight; Cardiomegaly; Child; Cyclosporine; Female; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Organ Size; Tacrolimus	2002
Cardiac hypertrophy postliver transplantation: a role for FK506 and cyclosporine A? Transplantation, 2002, Sep-27, Volume: 74, Issue:6 Topics: Adrenal Cortex Hormones; Autopsy; Cardiomegaly; Cyclosporine; Humans; Hypertension; Immunosuppressive Agents; Liver Transplantation; Tacrolimus	2002
Time-dependent systolic and diastolic function in mice overexpressing calcineurin. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:2 Topics: Animals; Calcineurin; Cardiomegaly; Cyclosporine; Death, Sudden, Cardiac; Diastole; Disease Progression; Echocardiography; Heart; Heart Ventricles; Mice; Mice, Transgenic; Survival Analysis; Systole; Time Factors	2003
Cyclosporin A regulates sodium-calcium exchanger (NCX1) gene expression in vitro and cardiac hypertrophy in NCX1 transgenic mice. Annals of the New York Academy of Sciences, 2002, Volume: 976 Topics: Animals; Atrial Natriuretic Factor; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Gene Expression Regulation; Humans; In Vitro Techniques; Mice; Mice, Transgenic; Myosin Heavy Chains; Promoter Regions, Genetic; Rats; Recombinant Proteins; Sequence Deletion; Sodium-Calcium Exchanger	2002
Cardiac hypertrophy in liver transplant recipients: tacrolimus, cyclosporine or both? Transplantation, 2003, Jul-27, Volume: 76, Issue:2 Topics: Cardiomegaly; Cyclosporine; Graft Rejection; Humans; Immunosuppressive Agents; Liver Transplantation; Tacrolimus	2003
Role of calcineurin in angiotensin II-induced cardiac myocyte hypertrophy of rats. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2001, Volume: 16, Issue:1 Topics: Angiotensin II; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcineurin; Cardiomegaly; Cells, Cultured; Cyclosporine; Myocytes, Cardiac; Rats; Rats, Wistar; RNA, Messenger	2001
Biventricular hypertrophy in dogs with chronic AV block: effects of cyclosporin A on morphology and electrophysiology. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:6 Topics: Animals; Cardiomegaly; Cyclosporine; Dogs; Electrocardiography; Enzyme Inhibitors; Heart Block; Torsades de Pointes; Ventricular Premature Complexes	2004
Effects of cyclosporine A on angiotensin II-induced cardiomyocyte hypertrophy in neonatal rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2005, Volume: 25, Issue:5 Topics: Angiotensin II; Animals; Animals, Newborn; Calcium; Cardiomegaly; Cells, Cultured; Cyclosporine; Myocytes, Cardiac; Proto-Oncogene Proteins c-fos; Rats	2005
Calcineurin activation is not necessary for Doxorubicin-induced hypertrophy in H9c2 embryonic rat cardiac cells: involvement of the phosphoinositide 3-kinase-Akt pathway. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:2 Topics: Animals; Calcineurin; Cardiomegaly; Cell Line; Cyclosporine; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; Myocytes, Cardiac; NFATC Transcription Factors; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Tacrolimus	2006
Signaling path may lead to better heart-failure therapies. Science (New York, N.Y.), 1998, Apr-17, Volume: 280, Issue:5362 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cardiomegaly; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; GATA4 Transcription Factor; Heart Failure; Humans; Mice; Myocardium; NFATC Transcription Factors; Nuclear Proteins; Signal Transduction; Tacrolimus; Transcription Factors	1998
Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science (New York, N.Y.), 1998, Sep-11, Volume: 281, Issue:5383 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cardiac Myosins; Cardiomegaly; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Carrier Proteins; Cyclosporine; Female; Mice; Mice, Transgenic; Microfilament Proteins; Models, Cardiovascular; Myocardium; Myosin Light Chains; Rats; Signal Transduction; Tacrolimus; Tropomodulin; Tropomyosin	1998
Calcineurin inhibitors and cardiac hypertrophy. Nature medicine, 1998, Volume: 4, Issue:10 Topics: Animals; Aorta; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Immunosuppressive Agents; Ligation; Male; Rats; Rats, Sprague-Dawley; Tacrolimus	1998
Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency. Life sciences, 1999, Volume: 64, Issue:13 Topics: Adrenergic Antagonists; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Carnitine; Cyclosporine; Disease Models, Animal; Mice; Microtubule-Associated Proteins; Muscle Proteins; Norepinephrine; RNA, Messenger	1999
Calcineurin inhibitors and cardiac hypertrophy. Lancet (London, England), 1999, Apr-17, Volume: 353, Issue:9161 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Humans; Immunosuppressive Agents; Mice; Mice, Transgenic	1999
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature, 1999, Aug-05, Volume: 400, Issue:6744 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Cell Line; Cyclosporine; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Expression Regulation; Hypertrophy; Insulin-Like Growth Factor I; Mice; Mice, Transgenic; Muscle, Skeletal; Myocardium; NFATC Transcription Factors; Nuclear Proteins; Signal Transduction; Transcription Factors	1999
Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure. Circulation research, 2000, Feb-18, Volume: 86, Issue:3 Topics: Adenoviridae; Animals; Animals, Newborn; Apoptosis; Calcineurin; Cardiac Output, Low; Cardiomegaly; Cells, Cultured; Cyclosporine; Gene Transfer Techniques; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Heart; Humans; Mice; Mice, Transgenic; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Ultrasonography	2000
Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition. Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:4 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Carrier Proteins; Cyclosporine; Disease Models, Animal; DNA-Binding Proteins; Enzyme Inhibitors; Mice; Mice, Transgenic; Microfilament Proteins; NFATC Transcription Factors; Nuclear Proteins; Phenotype; Transcription Factors; Tropomodulin	2000
Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation, 2000, May-23, Volume: 101, Issue:20 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Disease Progression; Female; Hypertension; Immunosuppressive Agents; Rats; Rats, Sprague-Dawley	2000
Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:6 Topics: Animals; Apoptosis; Cardiomegaly; Cyclosporine; Echocardiography; Fibrosis; Gene Expression; Heart; Heart Failure; Male; Myocardial Infarction; Myocardium; Pressure; Rats; Rats, Wistar; Renin; Ventricular Function, Left; Ventricular Remodeling	2000
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation, 2000, Jun-20, Volume: 101, Issue:24 Topics: Acute Disease; Adaptation, Physiological; Animals; Aorta, Thoracic; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Echocardiography; Enzyme Inhibitors; Hemodynamics; Hypertension; Ligation; Male; Mice; Mice, Inbred C57BL	2000
Involvement of calcineurin in angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibroblast hyperplasia of rats. Heart and vessels, 1999, Volume: 14, Issue:6 Topics: Angiotensin II; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcineurin; Calcineurin Inhibitors; Calcium; Cardiomegaly; Cell Division; Cells, Cultured; Cyclosporine; DNA; Fibroblasts; Fura-2; Hyperplasia; Losartan; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Signal Transduction	1999
[Long-term hemodynamic function of the transplanted heart]. Archives des maladies du coeur et des vaisseaux, 2000, Volume: 93, Issue:6 Topics: Cardiomegaly; Cyclosporine; Female; Follow-Up Studies; Heart Rate; Heart Transplantation; Hemodynamics; Humans; Immunosuppressive Agents; Male; Middle Aged; Ventricular Function, Left	2000
Calcineurin blockade prevents cardiac mitogen-activated protein kinase activation and hypertrophy in renovascular hypertension. The Journal of biological chemistry, 2000, Dec-29, Volume: 275, Issue:52 Topics: Angiotensin II; Animals; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Cyclosporine; Enzyme Activation; Hypertension, Renovascular; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardium; Protein Kinase C	2000
Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:2 Topics: Animals; Blotting, Western; Calcineurin; Calcineurin Inhibitors; Calcium; Calcium Channels; Cardiomegaly; Cyclosporine; Electrophysiology; Isoproterenol; Kinetics; Mice; Mice, Transgenic; Myocardium; Protein Structure, Tertiary; Ryanodine	2001
Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19 Topics: Animals; Animals, Newborn; Calcimycin; Calcineurin; Cardiomegaly; Cell Cycle Proteins; Cell Line; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cyclosporine; Dual Specificity Phosphatase 1; Fibroblasts; Gene Expression Regulation, Enzymologic; Heart; Immediate-Early Proteins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transfection	2001
[Involvement of calcineurin-dependent signal pathway in the angiotensin II-induced cardiac myocyte hypertrophy]. Sheng li xue bao : [Acta physiologica Sinica], 1999, Volume: 51, Issue:5 Topics: Angiotensin II; Animals; Calcineurin; Cardiomegaly; Cells, Cultured; Cyclosporine; Myocardium; Rats; Signal Transduction	1999
Electrical remodeling in pressure-overload cardiac hypertrophy: role of calcineurin. Circulation, 2001, Oct-02, Volume: 104, Issue:14 Topics: Action Potentials; Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cardiomegaly; Cells, Cultured; Cyclosporine; Electric Conductivity; Male; Mice; Mice, Inbred C57BL; Myocardium; Patch-Clamp Techniques; Potassium; Pressure; Ventricular Function, Left; Ventricular Remodeling	2001
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nature cell biology, 2001, Volume: 3, Issue:11 Topics: Animals; Calcineurin; Cardiomegaly; Cyclosporine; Enzyme Inhibitors; Female; Muscle, Skeletal; Muscular Atrophy; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases	2001
Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult rats. Molecular and cellular biochemistry, 2001, Volume: 226, Issue:1-2 Topics: Angiotensin II; Animals; Blotting, Northern; Body Weight; Calcineurin; Calcium; Cardiomegaly; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hypertrophy; Myocardium; Organ Size; Rats; Rats, Wistar; RNA; Signal Transduction; Up-Regulation	2001
Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy. Circulation, 2002, Feb-12, Volume: 105, Issue:6 Topics: Aldosterone; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Natriuretic Factor; Body Weight; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Collagen Type III; Cyclosporine; Enzyme Inhibitors; Fibrosis; Heart; Immunosuppressive Agents; Losartan; Male; Mineralocorticoids; Myocardium; Nephrectomy; Organ Size; Rats; Rats, Inbred WKY; RNA, Messenger; Sodium Chloride, Dietary; Tacrolimus	2002