cyclosporine and Brain Ischemia

cyclosporine has been researched along with Brain Ischemia in 46 studies

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (10.87)18.2507
2000's24 (52.17)29.6817
2010's14 (30.43)24.3611
2020's3 (6.52)2.80

Authors

AuthorsStudies
Cheng, Y; Huan, M; Ji, Q; Liu, D; Liu, M; Mei, Q; Zhang, B; Zhou, S1
Dimopoulos, C; Kontzoglou, K; Nikiteas, N; Papadakis, M; Perrea, D1
Chen, L; Deng, H; Feng, H; Ge, H; Liu, L; Zhang, S1
Cao, M; Jia, J; Luan, H; Lv, J; Ma, L; Niu, W; Tian, J; Tu, W; Xi, W; Yang, S1
Bakulin, DA; Filina, IS; Kurkin, DV; Tyurenkov, IN; Volotova, EV1
Damaskos, C; Daskalopoulou, A; Dimopoulos, C; Garmpis, N; Georgopoulos, S; Kontzoglou, K; Moraitis, S; Nikiteas, N; Papadakis, M; Papaspirou, I; Perrea, D1
Forsse, A; Gramsbergen, JB; Nielsen, TH; Nordström, CH; Nygaard, KH; Poulsen, FR1
Amaz, C; Ameli, R; Berner, LP; Berthezene, Y; Cho, TH; Cornut, L; Eker, O; Mewton, N; Nighoghossian, N; Ovize, M1
Anderson, RA; Panickar, KS; Qin, B1
Amarenco, P; Béjot, Y; Berthezène, Y; Bodiguel, E; Cakmak, S; Chauveau, F; Cho, TH; Derex, L; Desal, H; Domigo, V; Giroud, M; Guillon, B; Guiraud, V; Hosseini, H; Jacquin, A; Lamy, C; Mahagne, MH; Mas, JL; Mechtouff, L; Mewton, N; Nighoghossian, N; Ong, E; Oppenheim, C; Ovize, M; Philippeau, F; Rheims, S; Ricolfi, F; Ritzenthaler, T; Sevin-Allouet, M; Sibon, I; Turc, G1
Cho, TH; Mewton, N; Nighoghossian, N; Ong, E; Ovize, M1
Amani, A; Dehpour, AR; Gilani, K; Mehr, SE; Nasoohi, S; Partoazar, A; Rahimi, N; Rezayat, SM1
Jiang, YM; Yin, L; Zhang, H1
Hosaka, M; Hou, N; Imai, H; Saito, N; Takeuchi, T; Torii, S; Yamaguchi, R; Yoshimoto, Y1
Anderson, RA; Graves, DJ; Panickar, KS; Polansky, MM; Urban, JF1
Dong, H; Hou, L; Luan, Q; Song, W; Sun, J; Xie, K; Xiong, L1
Hasegawa, E; Ikeda, Y; Kudo, Y; Ohta, S; Omi, A; Tanoue, T; Uchino, H; Yokoyama, T1
Kristián, T; Minamikawa-Tachino, R; Narazaki, M; Perkins, G; Shibasaki, F; Siesjö, BK; Uchino, H1
Cavalheiro, EA; Coimbra, C; Sinigaglia-Coimbra, R1
Chen, PM; Fuh, JL; Hsiao, LT; Lin, JT; Lirng, JF; Wang, SJ1
Kurahashi, K; Midorikawa, H; Nishie, M; Ogawa, M; Yoshida, Y1
Bennett, JP; Dennis, J; Jenkins, R; Keeney, PM; Kindler, DD; Kostecki, V; Solenski, NJ; Thiffault, C1
Ishii, N; Shibasaki, F; Uchino, H1
Buzañska, L; Domañska-Janik, K; Dłuzniewska, J; Kozłowska, H; Sarnowska, A; Zabłocka, B1
Miyake, H; Nakai, A; Oya, A; Shibazaki, Y; Takeshita, T; Taniuchi, Y1
Borlongan, CV; Hess, DC; Yu, G1
Han, BH; Ju, C; Kim, HC; Kim, HS; Kim, WK; Oh, YJ1
Gabryel, B; Małecki, A; Toborek, T1
Mei, HS; Wang, C; Wang, YL; Zhang, YJ1
Akdemir, G; Albayrak, L; Dağlioğlu, E; Ergüngör, MF; Kilinç, K; Sezer, M1
Ikeda, Y; Ishii, N; Kudo, Y; Morota, S; Shibasaki, F; Siesjö, BK; Takahashi, T; Uchino, H1
Chalimoniuk, M; Gabryel, B; Langfort, J; Malecki, A; Stolecka, A; Waniek, K1
Craddock, SD; Korde, AS; Maragos, WF; Pettigrew, LC; Pocernich, CB; Waldmeier, PC1
Carlen, PL; Feeney, CJ; Frantseva, MV; Mills, LR; Pennefather, PS; Shniffer, C; Shulyakova, N1
Butcher, SP; Sharkey, J1
Bronster, DJ; Lidov, M; Lorberboym, M; Pandit, N1
Folbergrová, J; Li, PA; Siesjö, BK; Smith, ML; Uchino, H1
Akiguchi, I; Tomimoto, H1
Shibasaki, F1
Kobayashi, T1
He, QP; Li, PA; Siesjö, BK1
Hutchison, J; Monette, R; Smith, C; Stanimirovic, DB; Zhang, W1
Isshiki, A; Miyata, K; Omori, N; Shibasaki, F; Uchino, H; Yamaguchi, T1
Carlen, PL; Frantseva, MV; Perez Velazquez, JL1
Hou, YY; Lan, W; Liu, GQ; Liu, XD; Pan, GY; Su, Q; Xie, L1
Cano, F; Delucchi, A; Rodríguez, E1

Reviews

3 review(s) available for cyclosporine and Brain Ischemia

ArticleYear
Cyclosporine A, a Potential Therapy of Ischemic Reperfusion Injury. A Common History for Heart and Brain.
    Cerebrovascular diseases (Basel, Switzerland), 2016, Volume: 42, Issue:5-6

    Topics: Animals; Brain; Brain Ischemia; Cyclosporine; Disease Models, Animal; Humans; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Neuroprotective Agents; Signal Transduction; Stroke

2016
[The role of immunologic reactions in the pathogenesis in Binswanger's disease; a clue to therapeutic approach].
    Rinsho shinkeigaku = Clinical neurology, 1999, Volume: 39, Issue:1

    Topics: Animals; Antithrombins; Arginine; Blood Coagulation Factors; Brain; Brain Ischemia; Cyclosporine; Dementia, Vascular; Humans; Immunosuppressive Agents; Neuroglia; Pipecolic Acids; Sulfonamides; Thrombin

1999
[New aspects of physiological roles of serine/threonine phosphatase 2B, calcineurin].
    Seikagaku. The Journal of Japanese Biochemical Society, 2000, Volume: 72, Issue:7

    Topics: Animals; Apoptosis; Biological Transport; Brain Ischemia; Calcineurin; Calcium; Cell Death; Cell Membrane Permeability; Cell Nucleus; Cyclosporine; DNA-Binding Proteins; Humans; Immunosuppressive Agents; Mitochondria; Neurons; NFATC Transcription Factors; Nuclear Proteins; Transcription Factors

2000

Trials

1 trial(s) available for cyclosporine and Brain Ischemia

ArticleYear
Cyclosporine in acute ischemic stroke.
    Neurology, 2015, Jun-02, Volume: 84, Issue:22

    Topics: Aged; Aged, 80 and over; Brain Ischemia; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Single-Blind Method; Stroke; Thrombolytic Therapy

2015

Other Studies

42 other study(ies) available for cyclosporine and Brain Ischemia

ArticleYear
Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice.
    Journal of nanobiotechnology, 2022, Jun-03, Volume: 20, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Cyclosporine; Inflammation; Ischemia; Ischemic Stroke; Mice; Mitochondrial Permeability Transition Pore; Nanoparticles; Reactive Oxygen Species; Reperfusion Injury

2022
The Effect of Cyclosporine and the Consequences in Hepatic and Renal Function Following Ischemic Stroke in a Rats' Model.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020, Volume: 29, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Brain Ischemia; Cyclosporine; Disease Models, Animal; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Rats, Wistar; Stroke; Time Factors

2020
The effect of cyclosporin a on ischemia-reperfusion damage in a mouse model of ischemic stroke.
    Neurological research, 2020, Volume: 42, Issue:9

    Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Ischemia; Cyclosporine; Disease Models, Animal; Ischemic Stroke; Male; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reperfusion Injury

2020
Inhibition of mitochondrial permeability transition pore opening contributes to cannabinoid type 1 receptor agonist ACEA-induced neuroprotection.
    Neuropharmacology, 2018, Volume: 135

    Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Arachidonic Acids; Atractyloside; Brain Ischemia; Cell Survival; Cyclosporine; Cytochromes c; L-Lactate Dehydrogenase; Male; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neuroprotective Agents; Primary Cell Culture; Superoxide Dismutase; Superoxides

2018
NEUROPROTECTIVE ACTION OF PHENIBUT AND NEUROGLUTAM IN EXPERIMENTAL CEREBRAL ISCHEMIA ON THE BACKGROUND OF ALTERED IMMUNOREACTIVITY.
    Eksperimental'naia i klinicheskaia farmakologiia, 2016, Volume: 79, Issue:4

    Topics: Animals; Animals, Outbred Strains; Biomarkers; Brain Ischemia; Carotid Artery, Common; Cerebrovascular Circulation; Cyclosporine; gamma-Aminobutyric Acid; Glutamic Acid; Immunity, Innate; Immunosuppression Therapy; Immunosuppressive Agents; Ligation; Lipopolysaccharides; Locomotion; Male; Muscle Strength; Myelin Basic Protein; Neuroprotective Agents; Orientation, Spatial; Phosphopyruvate Hydratase; Rats; Survival Analysis

2016
Expression of S100B Protein in Ischemia/Reperfusion-Induced Brain Injury After Cyclosporine Therapy: A Biochemical Serum Marker with Prognostic Value?
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Mar-03, Volume: 25

    Topics: Animals; Biomarkers; Brain; Brain Injuries; Brain Ischemia; Cerebral Infarction; Cyclosporine; Male; Neuroprotective Agents; Prognosis; Rats; Rats, Wistar; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit

2019
Cyclosporin A ameliorates cerebral oxidative metabolism and infarct size in the endothelin-1 rat model of transient cerebral ischaemia.
    Scientific reports, 2019, 03-06, Volume: 9, Issue:1

    Topics: Animals; Brain Ischemia; Cell Respiration; Cyclosporine; Endothelin-1; Infarction; Ischemic Attack, Transient; Male; Microdialysis; Mitochondria; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stroke

2019
Impact of Collateral Status on Neuroprotective Effect of Cyclosporine A in Acute Ischemic Stroke.
    Current neurovascular research, 2019, Volume: 16, Issue:2

    Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Collateral Circulation; Cyclosporine; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroprotective Agents; Stroke; Treatment Outcome

2019
Ischemia-induced endothelial cell swelling and mitochondrial dysfunction are attenuated by cinnamtannin D1, green tea extract, and resveratrol in vitro.
    Nutritional neuroscience, 2015, Volume: 18, Issue:7

    Topics: Animals; Antioxidants; Brain Ischemia; Calcium; Cell Line; Chemokine CCL2; Cyclosporine; Egtazic Acid; Endothelial Cells; Glucose; Hypoxia; Interleukin-6; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Plant Extracts; Polyphenols; Proanthocyanidins; Reactive Oxygen Species; Resveratrol; Stilbenes; Tea; Tumor Necrosis Factor-alpha

2015
Nanoliposome containing cyclosporine A reduced neuroinflammation responses and improved neurological activities in cerebral ischemia/reperfusion in rat.
    Fundamental & clinical pharmacology, 2017, Volume: 31, Issue:2

    Topics: Animals; Brain Ischemia; Cyclosporine; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Liposomes; Male; Nanoparticles; Neuroprotective Agents; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Stroke; Time Factors; Tumor Necrosis Factor-alpha

2017
Effect of CIPC and intervention of Ca(2+)-regulated factors on CaN, cbl-b and p-AKT expression in neurons.
    Brain research, 2011, May-10, Volume: 1389

    Topics: Animals; Blotting, Western; Brain Ischemia; Calcineurin; Calcium; Calcium Signaling; Cyclosporine; Dizocilpine Maleate; Hippocampus; In Situ Nick-End Labeling; Ischemic Preconditioning; Male; Neurons; Neuroprotective Agents; Nimodipine; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction

2011
Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages.
    Brain research, 2011, Jun-23, Volume: 1397

    Topics: Adenoviridae; Animals; Binding, Competitive; Brain Ischemia; Calcineurin; Calcium; Carrier Proteins; Cell Line; Cyclophilin C; Cyclophilins; Cyclosporine; Extracellular Matrix Proteins; Immunohistochemistry; Infarction, Middle Cerebral Artery; Macrophage Activation; Macrophages; Male; Mice; Nerve Tissue Proteins; NFATC Transcription Factors; Phagocytosis; Phosphoric Monoester Hydrolases; Protein Transport; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Up-Regulation

2011
A procyanidin type A trimer from cinnamon extract attenuates glial cell swelling and the reduction in glutamate uptake following ischemia-like injury in vitro.
    Neuroscience, 2012, Jan-27, Volume: 202

    Topics: Adenosine Triphosphate; Biflavonoids; Brain Ischemia; Calcium; Catechin; Cell Size; Cells, Cultured; Cinnamomum zeylanicum; Cyclosporine; Glucose; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Hypoxia; Membrane Potentials; Mitochondrial Membranes; Neuroglia; Plant Extracts; Proanthocyanidins; Reactive Nitrogen Species; Reactive Oxygen Species

2012
Inhibition of mitochondrial permeability transition pore opening contributes to the neuroprotective effects of ischemic postconditioning in rats.
    Brain research, 2012, Feb-03, Volume: 1436

    Topics: Animals; Atractyloside; Brain Ischemia; Cyclosporine; Ischemic Postconditioning; Male; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Random Allocation; Rats; Rats, Sprague-Dawley

2012
Evaluation of the protective effects of cyclosporin a and FK506 on abnormal cytosolic and mitochondrial Ca²⁺ dynamics during ischemia and exposure to high glutamate concentration in mouse brain slice preparations.
    Journal of pharmacological sciences, 2012, Volume: 120, Issue:3

    Topics: Animals; Brain; Brain Edema; Brain Ischemia; Brain Mapping; CA1 Region, Hippocampal; Calcium Signaling; Cerebral Cortex; Cyclosporine; Cytosol; Glutamic Acid; Immunosuppressive Agents; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Neuroprotective Agents; Osmolar Concentration; Tacrolimus

2012
Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition.
    Neurobiology of disease, 2002, Volume: 10, Issue:3

    Topics: Animals; Brain Ischemia; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Ion Channels; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Neuroprotective Agents; Prosencephalon; Rats; Rats, Wistar; Tacrolimus

2002
Protective effect of systemic treatment with cyclosporine A after global ischemia in rats.
    Journal of the neurological sciences, 2002, Nov-15, Volume: 203-204

    Topics: Animals; Apoptosis; Body Temperature; Brain Ischemia; Cerebral Cortex; Cyclosporine; Hippocampus; Immunosuppressive Agents; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar

2002
Prolonged reversible vasospasm in cyclosporin A-induced encephalopathy.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:1

    Topics: Adult; Anemia, Hemolytic, Autoimmune; Brain Edema; Brain Ischemia; Cerebral Cortex; Cyclosporine; Diffusion Magnetic Resonance Imaging; Female; Humans; Magnetic Resonance Angiography; Middle Cerebral Artery; Myelodysplastic Syndromes; Neurologic Examination; Posterior Cerebral Artery; Vasospasm, Intracranial

2003
Posterior encephalopathy subsequent to cyclosporin A presenting as irreversible abulia.
    Internal medicine (Tokyo, Japan), 2003, Volume: 42, Issue:8

    Topics: Akinetic Mutism; Brain; Brain Ischemia; Cyclosporine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurotoxicity Syndromes; Tomography, Emission-Computed, Single-Photon

2003
Neurotoxic nitric oxide rapidly depolarizes and permeabilizes mitochondria by dynamically opening the mitochondrial transition pore.
    Molecular and cellular neurosciences, 2003, Volume: 23, Issue:4

    Topics: Animals; bcl-X Protein; Brain Ischemia; Calcium Channels; Calcium-Binding Proteins; Caspase 3; Caspases; Cell Death; Cell Membrane Permeability; Cyclosporine; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Intracellular Membranes; Ion Channels; Membrane Potentials; Mitochondria; Nerve Degeneration; Neurons; Nitric Oxide; Proto-Oncogene Proteins c-bcl-2; Rats; Rhodamines; Ruthenium Compounds; Triazenes; Tumor Cells, Cultured

2003
Calcineurin and cyclophilin D are differential targets of neuroprotection by immunosuppressants CsA and FK506 in ischemic brain damage.
    Acta neurochirurgica. Supplement, 2003, Volume: 86

    Topics: Animals; bcl-Associated Death Protein; Brain; Brain Ischemia; Calcineurin; Calcineurin Inhibitors; Calcium; Carrier Proteins; Cyclophilins; Cyclosporine; Cytochromes c; Immunosuppressive Agents; Mitochondrial Swelling; Neuroprotective Agents; Peptidyl-Prolyl Isomerase F; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Tacrolimus

2003
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm.
    Brain research. Molecular brain research, 2004, Feb-05, Volume: 121, Issue:1-2

    Topics: Analysis of Variance; Animals; Biological Transport; Blotting, Western; Brain Ischemia; Cell Count; Cell Death; Cerebral Cortex; Cyclosporine; Cytochromes c; Cytoplasm; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Gerbillinae; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Immunosuppressive Agents; In Vitro Techniques; Ischemic Attack, Transient; Male; Microscopy, Confocal; Rats; Rats, Wistar; Staurosporine; Tacrolimus; Time Factors; Tubulin

2004
Role of mitochondrial permeability transition in fetal brain damage in rats.
    Pediatric neurology, 2004, Volume: 30, Issue:4

    Topics: Animals; Apoptosis; Brain Damage, Chronic; Brain Ischemia; Cerebral Cortex; Cyclosporine; Energy Metabolism; Female; Fetal Hypoxia; Ion Channels; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Pregnancy; Rats; Rats, Wistar; Reperfusion Injury

2004
Combined cyclosporine-A and methylprednisolone treatment exerts partial and transient neuroprotection against ischemic stroke.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: Animals; Brain Ischemia; Cerebral Infarction; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Functional Laterality; Infarction, Middle Cerebral Artery; Male; Methylprednisolone; Movement Disorders; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Treatment Outcome

2004
Intracellular pH-dependent peroxynitrite-evoked synergistic death of glucose-deprived astrocytes.
    Free radical biology & medicine, 2004, Oct-15, Volume: 37, Issue:8

    Topics: Amiloride; Ammonium Chloride; Anaerobiosis; Animals; Astrocytes; Brain Ischemia; Caspases; Cyclosporine; Glucose; Glutathione; Hydrogen-Ion Concentration; Intracellular Fluid; Intracellular Membranes; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sodium Acetate; Sodium-Hydrogen Exchangers

2004
Immunosuppressive immunophilin ligands attenuate damage in cultured rat astrocytes depleted of glutathione and exposed to simulated ischemia in vitro. Comparison with N-acetylcysteine.
    Neurotoxicology, 2005, Volume: 26, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; Astrocytes; Benzimidazoles; Brain Ischemia; Cell Separation; Cells, Cultured; Cyclosporine; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Immunophilins; Immunosuppressive Agents; Ligands; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Tacrolimus; Tetrazolium Salts; Thiazoles

2005
Involvement of nuclear factor of activated T-cells (NFATc) in calcineurin-mediated ischemic brain damage in vivo.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:4

    Topics: Animals; Brain Ischemia; Calcineurin; Cyclosporine; DNA-Binding Proteins; Fas Ligand Protein; Female; Hippocampus; Membrane Glycoproteins; Neurons; NF-kappa B; NFATC Transcription Factors; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factors

2005
Therapeutic efficacy of intraventricular cyclosporine A and methylprednisolone on a global cerebral ischemia model in rats.
    Neurological research, 2005, Volume: 27, Issue:8

    Topics: Animals; Brain Ischemia; Cyclosporine; Drug Evaluation, Preclinical; Free Radical Scavengers; Hippocampus; Immunosuppressive Agents; Ion Channels; Lipid Peroxidation; Male; Methylprednisolone; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2005
A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins.
    Acta neurochirurgica. Supplement, 2006, Volume: 96

    Topics: Animals; Brain Injuries; Brain Ischemia; Calcineurin; Cyclophilins; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neuroprotective Agents; Prosencephalon; Rats; Rats, Wistar; Treatment Outcome

2006
Inhibition of arachidonic acid release by cytosolic phospholipase A2 is involved in the antiapoptotic effect of FK506 and cyclosporin a on astrocytes exposed to simulated ischemia in vitro.
    Journal of pharmacological sciences, 2006, Volume: 102, Issue:1

    Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Arachidonic Acid; Astrocytes; Blotting, Western; Brain Ischemia; Calcineurin; Cell Survival; Cells, Cultured; Cyclosporine; Cytosol; Immunophilins; Immunosuppressive Agents; Membrane Potentials; Oxidative Stress; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Receptor Cross-Talk; Signal Transduction; Tacrolimus

2006
Protective effects of NIM811 in transient focal cerebral ischemia suggest involvement of the mitochondrial permeability transition.
    Journal of neurotrauma, 2007, Volume: 24, Issue:5

    Topics: Animals; Brain Infarction; Brain Ischemia; Calcium Signaling; Cell Death; Cyclosporine; Cytochromes c; Disease Models, Animal; Energy Metabolism; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Treatment Outcome

2007
Vulnerability of glial cells to hydrogen peroxide in cultured hippocampal slices.
    Brain research, 2008, Mar-10, Volume: 1198

    Topics: Animals; Animals, Newborn; Antioxidants; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Energy Metabolism; Fluorescent Dyes; Free Radicals; Hippocampus; Hydrogen Peroxide; Mitochondrial Membranes; Necrosis; Nerve Degeneration; Neuroglia; Organ Culture Techniques; Oxidative Stress; Pyramidal Cells; Rats; Time Factors

2008
Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia.
    Nature, 1994, Sep-22, Volume: 371, Issue:6495

    Topics: Animals; Brain Ischemia; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Cyclosporine; Heat-Shock Proteins; Humans; Immunosuppressive Agents; Male; Polyenes; Rats; Rats, Sprague-Dawley; Sirolimus; Tacrolimus; Tacrolimus Binding Proteins

1994
Reversible cerebral perfusion abnormalities associated with cyclosporine therapy in orthotopic liver transplantation.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1996, Volume: 37, Issue:3

    Topics: Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclosporine; Female; Humans; Immunosuppression Therapy; Liver Transplantation; Middle Aged; Occipital Lobe; Organotechnetium Compounds; Oximes; Parietal Lobe; Seizures; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

1996
Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects.
    Experimental brain research, 1997, Volume: 114, Issue:1

    Topics: Animals; Brain Ischemia; Cyclosporine; Energy Metabolism; Hippocampus; Hyperglycemia; Male; Mitochondria; Necrosis; Permeability; Prosencephalon; Rats; Rats, Wistar

1997
[The roles of mitochondrial permeability transition in brain ischemia].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 2000, Volume: 75, Issue:4

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclosporine; Gerbillinae; Male; Mitochondria; Oxidative Stress; Rats; Rats, Wistar

2000
Effects of intracarotid arterial injection of cyclosporin A and spontaneous hypothermia on brain damage incurred after a long period of global ischemia.
    Brain research, 2001, Feb-02, Volume: 890, Issue:2

    Topics: Animals; Blood Glucose; Brain Infarction; Brain Ischemia; Cardiovascular Physiological Phenomena; Carotid Arteries; Cyclosporine; Hypothermia, Induced; Immunosuppressive Agents; Injections, Intra-Arterial; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Respiratory Physiological Phenomena; Survival Rate; Time Factors

2001
Indomethacin and cyclosporin a inhibit in vitro ischemia-induced expression of ICAM-1 and chemokines in human brain endothelial cells.
    Acta neurochirurgica. Supplement, 2000, Volume: 76

    Topics: Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Chemokines; Cyclosporine; Endothelium, Vascular; Humans; Indomethacin; Intercellular Adhesion Molecule-1; Leukocytes

2000
Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotecive effect of cyclosporin A in forebrain ischemia.
    Neuroscience, 2001, Volume: 105, Issue:3

    Topics: Animals; Blotting, Western; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Cyclosporine; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphorylation; Rats; Rats, Wistar; Receptor, trkB; RNA, Messenger; Transcription, Genetic; Up-Regulation

2001
Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons.
    Free radical biology & medicine, 2001, Nov-15, Volume: 31, Issue:10

    Topics: Aniline Compounds; Animals; Brain Ischemia; Calcium; Calcium Channels; Calcium-Binding Proteins; Culture Techniques; Cyclosporine; Electron Transport Complex I; Fluorescent Dyes; Free Radicals; Heterocyclic Compounds, 3-Ring; Hippocampus; Intracellular Fluid; Mitochondria; NADH, NADPH Oxidoreductases; Niacinamide; Pyramidal Cells; Rats; Rats, Wistar; Reperfusion Injury; Rhodamines; Rotenone; Ruthenium Compounds; Xanthenes

2001
Cyclosporin A enhanced protection of nimodipine against brain damage induced by hypoxia-ischemia in mice and rats.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Ischemia; Calcium Channel Blockers; Cerebral Cortex; Cyclosporine; L-Lactate Dehydrogenase; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Neuroprotective Agents; Nimodipine; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2002
[Neurotoxicity caused by cyclosporin A in renal transplantation in children].
    Revista medica de Chile, 1992, Volume: 120, Issue:3

    Topics: Brain Ischemia; Child; Cushing Syndrome; Cyclosporine; Diplopia; Epilepsy, Tonic-Clonic; Female; Humans; Kidney Transplantation; Male; Postoperative Complications; Pseudotumor Cerebri; Subarachnoid Hemorrhage; Vasculitis

1992
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