Compounds > cyclosporine

cyclosporine and Brain Injuries

cyclosporine has been researched along with Brain Injuries in 74 studies

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (12.16)18.2507
2000's42 (56.76)29.6817
2010's22 (29.73)24.3611
2020's1 (1.35)2.80

Authors

AuthorsStudies
Elmér, E; Hansson, MJ1
Damaskos, C; Daskalopoulou, A; Dimopoulos, C; Garmpis, N; Georgopoulos, S; Kontzoglou, K; Moraitis, S; Nikiteas, N; Papadakis, M; Papaspirou, I; Perrea, D1
Alves, OL; Brar, S; Brophy, GM; Bullock, R; Bunnell, K; Gilman, C; Hayes, RL; Karnes, T; Mazzeo, AT1
Elmér, E; Hansson, MJ; Hatakeyama, K; Morota, S; Nishiyama, T; Suzuki, M; Taguchi, C; Tanoue, T; Uchino, H; Usui, D1
Jablonska, A; Janowski, M; Lukomska, B1
Bullock, MR; Gajavelli, S; Mazzeo, AT; Yokobori, S1
Biagi, E; Biondi, A; Citerio, G; D'Amico, G; Dander, E; De Simoni, MG; Pischiutta, F; Zanier, ER1
Dai, Y; Hu, Y; Shi, J; Sun, Q; Zhang, X; Zhou, M1
Byro, M; Costine, BA; Duhaime, AC; Kilbaugh, T; Margulies, SS; Propert, K; Saliga, K; Smith, C; Sullivan, S1
Palzur, E; Sharon, A; Shehadeh, M; Soustiel, JF1
Heuer, A; Jönsson, ME; Kirkeby, A; Parmar, M; Pfisterer, U1
Carrico, KM; Hall, ED; Mbye, LH; Saatman, KE; Singh, IN1
Alves, OL; Gilman, CB; Hayes, RL; Mazzeo, AT; Niki Kunene, K; Ross Bullock, M; Tolias, C1
Empey, P; Hatton, J; Kryscio, R; Rosbolt, B; Young, B1
Brinker, T; Hotop, A; Klinge, PM; Knapp, WH; Korkmaz, Z; Meyer, GJ; Mirzayan, MJ; Samii, A; Samii, M; Ude, S1
Nimmo, AJ; Vink, R1
Caryk, M; Janeczko, K; Setkowicz, Z; Szafraniec, M; Zmudzińska, A1
Cook, AM; Hatton, J; Whitlow, J; Young, B1
Curè, J; Flanagan, C; Kline, L1
Alves, OL; Brophy, GM; Bullock, MR; Gilman, CB; Hayes, RL; Mazzeo, AT; Povlishock, JT; Robles, JR1
Aal-Shaya, WA; Al-Faridi, K; Halawani, MM; Taha, WS; Tawfeeq, NA1
Colley, BS; Phillips, LL; Reeves, TM1
Chen, Y; Dou, KF; Qian, NS; Wang, YY; Xu, XP; Yang, YL1
Erlandsson, A; Lin, CH; Morshead, CM; Yu, F1
Beskonakli, E; Bodur, E; Eroglu, H; Gurcan, O; Oner, L; Sargon, MF; Turkoglu, OF1
Hall, ED; Sebastian, AH; Sullivan, PG1
Bhandare, S; Kilbaugh, TJ; Lorom, DH; Margulies, SS; Robertson, CL; Saraswati, M1
Bae, EC; Borlongan, CV; Burns, J; Lulic, D; van Loveren, H1
Lauritzen, M; Piilgaard, H; Rasmussen, P; Witgen, BM1
Borlongan, CV; Glover, L; Lau, T; Lulic, D; Osman, MM; Stahl, CE; van Loveren, H1
McEwen, ML; Pandya, JD; Pauly, JR; Readnower, RD; Springer, JE; Sullivan, PG1
Valeri, CR; VanItallie, TB; Veech, RL1
Cheng, Y; Deng, J; Huang, Q; Lei, B; Shen, W; Wu, M; Xie, Z1
Alessandri, B; Bullock, MR; DeFord, M; Hamm, RJ; Levasseur, J; Rice, AC1
Adamchik, Y; Carlen, PL; Frantseva, M; Perez Velazquez, JL; Tonkikh, A1
Friberg, H; Grady, MS; Janmey, P; Lifshitz, J; McIntosh, TK; Neumar, RW; Raghupathi, R; Saatman, KE; Welsh, FA; Wieloch, T1
Helm, GA; Melon, DE; Mutlu, LK; Okonkwo, DO; Pellicane, AJ; Rubin, DG; Stone, JR1
Day, JR; Ewing, AG; Frank, AT; Goetting-Minesky, MP; Krady, JK; Lang, MG; Milner, RJ; Patel, SP; Price, M; Silviera, ML1
Marmarou, A1
Dunbar, JG; Fukui, S; Marmarou, A; Signoretti, S1
Amorini, AM; Dunbar, J; Lazzarino, G; Marmarou, A; Signoretti, S; Tavazzi, B; Vagnozzi, R1
Van Den Heuvel, C; Vink, R1
Bodian, CA; Griepp, RB; Haldenwang, PL; Spielvogel, D; Strauch, JT; Tatton, NA; Weisz, D; Zhang, N1
Fugaccia, I; Gabbita, SP; Menard, RM; Roberts, K; Scheff, SW; Zemlan, FP1
Blumbergs, PC; Donkin, JJ; Finnie, JW; Jones, NR; Koszyca, B; Kuchel, T; Manavis, J; Reilly, PL; Van Den Heuvel, C; Vink, R1
Fandrey, J; Härting, M; Kou, W; Niemi, MB; Pacheco-López, G; Schedlowski, M1
Empey, PE; Hatton, J; McNamara, PJ; Rosbolt, MB; Young, B1
Bullock, R; Merenda, A1
Ikeda, Y; Ishii, N; Kudo, Y; Morota, S; Shibasaki, F; Siesjö, BK; Takahashi, T; Uchino, H1
Ikeda, Y; Ishii, N; Ishikawa, Y; Li, C; Morota, S; Shibasaki, F; Takahashi, T; Uchino, H1
Bullock, MR; Gilman, CB; Hafez, N; Hamm, RJ; Kunene, NK; Mazzeo, AT1
Bullock, R; Gilman, C; Kunene, N; Mazzeo, A; Samuelson, R; Young, HF1
Hall, ED; Mbye, LH; Singh, IN; Springer, JE; Sullivan, PG1
Guzik, R; Setkowicz, Z1
Elmér, E; Lindvall, O; Siesjö, BK; Uchino, H; Uchino, K1
Gogarten, W; Marcus, M; Meyer, J; Moskopp, D; Roos, N; Schleef, J; Van Aken, H1
Okonkwo, DO; Povlishock, JT1
Büki, A; Okonkwo, DO; Povlishock, JT; Siman, R1
Büki, A; Okonkwo, DO; Povlishock, JT1
Siesjö, BK; Yoshimoto, T1
Scheff, SW; Sullivan, PG1
Scheff, SW; Sullivan, PG; Thompson, MB1
Scheff, SW; Sullivan, PG; Thompson, M1
Albensi, BC; Mattson, MP; Scheff, SW; Sullivan, PG; Thompson, MB1
Gold, BG1
Fletcher-Turner, A; Gibson, TR; Hicks, RR; Rabchevsky, AG; Scheff, SW; Sullivan, PG1
Povlishock, JT; Suehiro, E1
Bullock, R; Clausen, T1
Bareyre, FM; Cheney, JA; Grady, MS; Lifshitz, J; McIntosh, TK; Neugebauer, E; Raghupathi, R; Riess, P; Saatman, KE1
Cernak, I; Nimmo, AJ; Vink, R1
Griepp, RB; Hagl, C; Insolia, S; Khaladj, N; Nandor, S; Spielvogel, D; Tatton, NA; Weisz, DJ; Zhang, N1
Jayakumar, AR; Norenberg, MD; Panickar, KS1
Büki, A; Dóczi, T; Farkas, O; Kövér, F1
Kogure, K; Matsuo, Y; Onodera, H; Shiga, Y1

Reviews

17 review(s) available for cyclosporine and Brain Injuries

ArticleYear
Cyclosporine as Therapy for Traumatic Brain Injury.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2023, Volume: 20, Issue:6

    Topics: Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Cyclosporine; Humans; Neuroprotective Agents

2023
Cyclophilin-D inhibition in neuroprotection: dawn of a new era of mitochondrial medicine.
    Acta neurochirurgica. Supplement, 2013, Volume: 118

    Topics: Animals; Arsenicals; Brain Injuries; Calcium; Cyclophilins; Cyclosporine; Enzyme Inhibitors; Humans; Ischemia; Mitochondria; Neuroprotective Agents; Peptidyl-Prolyl Isomerase F

2013
Mitochondrial neuroprotection in traumatic brain injury: rationale and therapeutic strategies.
    CNS & neurological disorders drug targets, 2014, Volume: 13, Issue:4

    Topics: Animals; Brain Injuries; Cyclosporine; Humans; Lactic Acid; Mitochondria; Neuroprotective Agents; Randomized Controlled Trials as Topic

2014
Multifunctional drugs for head injury.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2009, Volume: 6, Issue:1

    Topics: Animals; Brain Edema; Brain Injuries; Cyclosporine; Dronabinol; Erythropoietin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinins; Magnesium; Minocycline; Mitochondria; Neuroprotective Agents; Oxidative Stress; Progesterone; Psychotropic Drugs; Thyrotropin-Releasing Hormone; Toll-Like Receptors

2009
Cyclosporine A for neuroprotection: establishing dosing guidelines for safe and effective use.
    Expert opinion on drug safety, 2009, Volume: 8, Issue:4

    Topics: Animals; Brain Injuries; Cyclosporine; Drug Administration Schedule; Humans; Models, Biological; Neuroprotective Agents

2009
Cerebral blindness.
    International ophthalmology clinics, 2009,Summer, Volume: 49, Issue:3

    Topics: Alzheimer Disease; Blindness, Cortical; Brain Diseases; Brain Injuries; Cerebral Infarction; Creutzfeldt-Jakob Syndrome; Cyclosporine; Electrodiagnosis; Humans; Immunosuppressive Agents; Occipital Lobe; Seizures; Tacrolimus; Visual Cortex

2009
Traumatic brain injury: neuroprotective anaesthetic techniques, an update.
    Injury, 2009, Volume: 40 Suppl 4

    Topics: Adolescent; Adult; Brain Injuries; Cell Death; Central Nervous System Depressants; Craniocerebral Trauma; Cyclosporine; Dexmedetomidine; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Intracranial Hypotension; Isoflurane; Middle Aged; Neuroprotective Agents; Nitrous Oxide; Perioperative Care; Propofol; Resuscitation; Saline Solution, Hypertonic; Xenon; Young Adult

2009
A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury.
    Neurosurgery, 2011, Volume: 68, Issue:5

    Topics: Animals; Brain Injuries; Clinical Trials as Topic; Cyclosporine; Disease Models, Animal; Humans; Neuroprotective Agents; Treatment Outcome

2011
Cyclosporine-A as a neuroprotective agent against stroke: its translation from laboratory research to clinical application.
    Neuropeptides, 2011, Volume: 45, Issue:6

    Topics: Animals; Brain Injuries; Cell Death; Clinical Trials as Topic; Cyclosporine; Humans; Immunosuppressive Agents; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Molecular Structure; Neuroprotective Agents; Stroke; Treatment Outcome

2011
Neurotrauma/neurodegeneration and mitochondrial dysfunction.
    Progress in brain research, 2002, Volume: 137

    Topics: Animals; Brain Injuries; Cell Death; Cyclosporine; Humans; Hypoxia; Ischemia; Mitochondria; Nerve Degeneration; Ruthenium Compounds

2002
Pathophysiology of traumatic brain edema: current concepts.
    Acta neurochirurgica. Supplement, 2003, Volume: 86

    Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cyclosporine; Diffusion Magnetic Resonance Imaging; Humans; Neuroprotective Agents; Sodium; Water

2003
Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury.
    Expert opinion on investigational drugs, 2004, Volume: 13, Issue:10

    Topics: Animals; Brain Injuries; Cyclosporine; Dexamethasone; Dronabinol; Humans; Magnesium; Mitochondria; Neuroprotective Agents; Oxidative Stress; Progesterone

2004
Clinical treatments for mitochondrial dysfunctions after brain injury.
    Current opinion in critical care, 2006, Volume: 12, Issue:2

    Topics: Blood Pressure; Brain Injuries; Calcium Channel Blockers; Critical Care; Cyclosporine; Humans; Immunosuppressive Agents; Mitochondrial Diseases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Reactive Oxygen Species

2006
Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders.
    Expert opinion on investigational drugs, 2000, Volume: 9, Issue:10

    Topics: Animals; Brain Injuries; Carpal Tunnel Syndrome; Cyclosporine; Humans; Immunophilins; Immunosuppressive Agents; Ligands; Nerve Regeneration; Nervous System Diseases; Spinal Cord Injuries; Tacrolimus; Tacrolimus Binding Protein 1A

2000
Medical treatment and neuroprotection in traumatic brain injury.
    Current pharmaceutical design, 2001, Volume: 7, Issue:15

    Topics: Brain Injuries; Calcium Channel Blockers; Critical Care; Cyclosporine; Excitatory Amino Acid Antagonists; Forecasting; Free Radical Scavengers; Humans; Neuroprotective Agents

2001
An overview of new and novel pharmacotherapies for use in traumatic brain injury.
    Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:11

    Topics: Brain Injuries; Clinical Trials as Topic; Cyclosporine; Gonadal Steroid Hormones; Humans; Magnesium; Substance P

2001
[Therapeutic possibilities in axonal injury caused by head trauma].
    Orvosi hetilap, 2002, Mar-10, Volume: 143, Issue:10

    Topics: Accidents, Traffic; Animals; Axons; Brain Injuries; Calpain; Caspases; Craniocerebral Trauma; Cyclosporine; Humans; Hypothermia, Induced; Magnetic Resonance Imaging; Tomography, X-Ray Computed

2002

Trials

6 trial(s) available for cyclosporine and Brain Injuries

ArticleYear
Exposure of cyclosporin A in whole blood, cerebral spinal fluid, and brain extracellular fluid dialysate in adults with traumatic brain injury.
    Journal of neurotrauma, 2013, Sep-01, Volume: 30, Issue:17

    Topics: Adolescent; Adult; Brain; Brain Injuries; Cyclosporine; Extracellular Fluid; Female; Humans; Infusions, Intravenous; Male; Microdialysis; Middle Aged; Neuroprotective Agents; Prospective Studies; Ventriculostomy; Young Adult

2013
Brain metabolic and hemodynamic effects of cyclosporin A after human severe traumatic brain injury: a microdialysis study.
    Acta neurochirurgica, 2008, Volume: 150, Issue:10

    Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Cyclosporine; Double-Blind Method; Energy Metabolism; Extracellular Fluid; Female; Glucose; Humans; Male; Microdialysis; Middle Aged; Mitochondria; Neuroprotective Agents; Placebos; Pyruvic Acid; Treatment Outcome; Young Adult

2008
Dosing and safety of cyclosporine in patients with severe brain injury.
    Journal of neurosurgery, 2008, Volume: 109, Issue:4

    Topics: Acute Disease; Adult; Brain Injuries; Cyclosporine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Immunosuppressive Agents; Injections, Intravenous; Male; Middle Aged; Neuroprotective Agents; Placebos; Prospective Studies; Treatment Outcome

2008
Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: results from a prospective randomized trial.
    Journal of neurotrauma, 2009, Volume: 26, Issue:12

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Biomarkers; Blood Urea Nitrogen; Brain Injuries; Creatinine; Cyclosporine; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Kidney; Leukocyte Count; Male; Middle Aged; Neuroprotective Agents; Placebos; Prospective Studies; Treatment Outcome; Young Adult

2009
Cyclosporin A disposition following acute traumatic brain injury.
    Journal of neurotrauma, 2006, Volume: 23, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Brain; Brain Injuries; Cohort Studies; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neuroprotective Agents; Placebos; Prospective Studies; Time Factors

2006
Severe human traumatic brain injury, but not cyclosporin a treatment, depresses activated T lymphocytes early after injury.
    Journal of neurotrauma, 2006, Volume: 23, Issue:6

    Topics: Adult; Aging; Brain; Brain Injuries; CD3 Complex; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cyclosporine; Female; Glasgow Coma Scale; Humans; Immunity, Cellular; Immunosuppressive Agents; Lymphocyte Count; Male; Pilot Projects; Prospective Studies; T-Lymphocytes

2006

Other Studies

51 other study(ies) available for cyclosporine and Brain Injuries

ArticleYear
Expression of S100B Protein in Ischemia/Reperfusion-Induced Brain Injury After Cyclosporine Therapy: A Biochemical Serum Marker with Prognostic Value?
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Mar-03, Volume: 25

    Topics: Animals; Biomarkers; Brain; Brain Injuries; Brain Ischemia; Cerebral Infarction; Cyclosporine; Male; Neuroprotective Agents; Prognosis; Rats; Rats, Wistar; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit

2019
Different methods of immunosuppresion do not prolong the survival of human cord blood-derived neural stem cells transplanted into focal brain-injured immunocompetent rats.
    Acta neurobiologiae experimentalis, 2013, Volume: 73, Issue:1

    Topics: Analysis of Variance; Animals; Antigens, CD; Brain Injuries; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Fetal Blood; Graft Rejection; Graft Survival; Humans; Immunocompetence; Immunosuppressive Agents; Male; Nerve Tissue Proteins; Neural Stem Cells; Ouabain; Rats; Rats, Wistar; Stem Cell Transplantation; Time Factors; Transplantation, Heterologous

2013
Immunosuppression does not affect human bone marrow mesenchymal stromal cell efficacy after transplantation in traumatized mice brain.
    Neuropharmacology, 2014, Volume: 79

    Topics: Animals; Brain; Brain Injuries; Cyclosporine; Gene Expression; Graft Rejection; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Recovery of Function; Treatment Outcome

2014
Cyclosporin A ameliorates early brain injury after subarachnoid hemorrhage through inhibition of a Nur77 dependent apoptosis pathway.
    Brain research, 2014, Mar-27, Volume: 1556

    Topics: Analysis of Variance; Animals; Apoptosis; Brain Edema; Brain Injuries; Caspase 3; Cyclosporine; Disease Models, Animal; Immunosuppressive Agents; Male; Neurologic Examination; Nuclear Receptor Subfamily 4, Group A, Member 1; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Subarachnoid Hemorrhage

2014
Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development: Using Cyclosporin A as a Case Study.
    Brain pathology (Zurich, Switzerland), 2015, Volume: 25, Issue:3

    Topics: Animals; Brain Injuries; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mitochondria; Neurologic Examination; Neuroprotective Agents; Swine; Time Factors; Translational Research, Biomedical; Treatment Outcome

2015
Investigation of the mechanisms of neuroprotection mediated by Ro5-4864 in brain injury.
    Neuroscience, 2016, 08-04, Volume: 329

    Topics: Animals; Benzodiazepinones; Brain Injuries; Brain-Derived Neurotrophic Factor; Carrier Proteins; Cyclosporine; Disease Models, Animal; Drug Evaluation, Preclinical; Fluorescent Antibody Technique; Interleukin-1beta; Male; Neuroglia; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Receptors, GABA-A; Tumor Necrosis Factor-alpha

2016
hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation.
    Experimental neurology, 2016, Volume: 282

    Topics: Animals; Animals, Newborn; Antigens, CD; Blood-Brain Barrier; Brain Injuries; Cell Line, Transformed; Cyclosporine; Desensitization, Immunologic; Disease Models, Animal; Female; Graft Rejection; Green Fluorescent Proteins; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Nerve Tissue Proteins; Neural Cell Adhesion Molecules; Oxidopamine; Pregnancy; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Sympatholytics; Time Factors; Transplantation, Heterologous

2016
Comparative neuroprotective effects of cyclosporin A and NIM811, a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:1

    Topics: Animals; Brain Injuries; Calpain; Cyclosporine; Cytoskeleton; Immunosuppressive Agents; Male; Mice; Motor Activity; Neuroprotective Agents; Physical Conditioning, Animal; Spectrin

2009
Modified calcium accumulation after controlled cortical impact under cyclosporin A treatment: a 45Ca autoradiographic study.
    Neurological research, 2008, Volume: 30, Issue:5

    Topics: Animals; Autoradiography; Brain; Brain Injuries; Calcium; Calcium Radioisotopes; Cyclosporine; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2008
Tacrolimus (FK506) and cyclosporin A reduce macrophage recruitment to the rat brain injured at perinatal and early postnatal periods.
    Neurological research, 2009, Volume: 31, Issue:10

    Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Brain Injuries; Cell Count; Cell Proliferation; Cyclosporine; Dose-Response Relationship, Drug; Immunosuppressive Agents; Inflammation; Macrophage Activation; Macrophages; Male; Neurons; Rats; Rats, Wistar; Statistics, Nonparametric; Tacrolimus

2009
The effects of cyclosporin-A on axonal conduction deficits following traumatic brain injury in adult rats.
    Experimental neurology, 2010, Volume: 224, Issue:1

    Topics: Action Potentials; Analysis of Variance; Animals; Axons; Brain Injuries; Corpus Callosum; Cyclosporine; Cytoprotection; Electrophysiology; Male; Nerve Fibers, Myelinated; Neural Conduction; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function

2010
Protective effect of cyclosporin A on brain injury in rats with acute necrotic pancreatitis.
    Life sciences, 2010, Jul-03, Volume: 87, Issue:1-2

    Topics: Animals; Body Water; Brain Injuries; Cyclosporine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Immunosuppressive Agents; Interleukin-10; Interleukin-1beta; Male; Malondialdehyde; Pancreatitis, Acute Necrotizing; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha

2010
Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury.
    Experimental neurology, 2011, Volume: 230, Issue:1

    Topics: Animals; Brain Injuries; Cell Movement; Cerebral Cortex; Cyclosporine; Disease Models, Animal; Glial Fibrillary Acidic Protein; Immunosuppression Therapy; Immunosuppressive Agents; Ischemia; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Motor Activity; Multipotent Stem Cells; Neural Stem Cells; Neurogenesis; Recovery of Function; Regeneration

2011
Local administration of chitosan microspheres after traumatic brain injury in rats: a new challenge for cyclosporine--a delivery.
    British journal of neurosurgery, 2010, Volume: 24, Issue:5

    Topics: Animals; Brain Injuries; Chitosan; Cyclosporine; Disease Models, Animal; Male; Microspheres; Mitochondria; Rats; Rats, Sprague-Dawley

2010
Therapeutic window analysis of the neuroprotective effects of cyclosporine A after traumatic brain injury.
    Journal of neurotrauma, 2011, Volume: 28, Issue:2

    Topics: Animals; Brain Injuries; Cyclosporine; Disease Models, Animal; Drug Administration Schedule; Immunosuppressive Agents; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Time Factors

2011
Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and piglet.
    Journal of neurotrauma, 2011, Volume: 28, Issue:5

    Topics: Animals; Brain Injuries; Cell Respiration; Cerebrovascular Circulation; Cyclosporine; Female; Immunosuppressive Agents; Microdialysis; Mitochondria; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Swine

2011
Cyclosporine A, FK506, and NIM811 ameliorate prolonged CBF reduction and impaired neurovascular coupling after cortical spreading depression.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011, Volume: 31, Issue:7

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Brain; Brain Injuries; Cerebrovascular Circulation; Cortical Spreading Depression; Cyclosporine; Enzyme Inhibitors; Immunosuppressive Agents; Male; Oxygen; Rats; Rats, Wistar; Tacrolimus; Vasoconstrictor Agents

2011
Post-injury administration of the mitochondrial permeability transition pore inhibitor, NIM811, is neuroprotective and improves cognition after traumatic brain injury in rats.
    Journal of neurotrauma, 2011, Volume: 28, Issue:9

    Topics: Animals; Brain Injuries; Cognition; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Maze Learning; Mitochondria; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley

2011
The mitochondrial permeability transition pore provides a key to the diagnosis and treatment of traumatic brain injury.
    IUBMB life, 2012, Volume: 64, Issue:2

    Topics: Animals; Brain; Brain Injuries; Cyclosporine; Humans; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Molecular Targeted Therapy; Spectrophotometry, Infrared

2012
Neuroprotective effect of Cyclosporin A on the development of early brain injury in a subarachnoid hemorrhage model: a pilot study.
    Brain research, 2012, Sep-07, Volume: 1472

    Topics: Animals; Apoptosis; Blood-Brain Barrier; Blotting, Western; Brain Edema; Brain Injuries; Capillary Permeability; Cyclosporine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; In Situ Nick-End Labeling; Male; Neuroprotective Agents; Pilot Projects; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage

2012
Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats.
    Journal of neurotrauma, 2002, Volume: 19, Issue:7

    Topics: Animals; Brain; Brain Injuries; Cognition; Cyclosporine; Learning; Male; Mitochondria; Oxygen Consumption; Rats; Rats, Sprague-Dawley

2002
Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:2

    Topics: Adenosine Triphosphate; Animals; Body Water; Brain; Brain Injuries; Calcium; Cerebral Cortex; Cyclosporine; Enzymes; Hippocampus; Male; Mitochondria; Mitochondrial Proteins; Oxygen Consumption; Permeability; Rats; Rats, Sprague-Dawley

2003
Dose-response of cyclosporin A in attenuating traumatic axonal injury in rat.
    Neuroreport, 2003, Mar-03, Volume: 14, Issue:3

    Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Brain Injuries; Cyclosporine; Dose-Response Relationship, Drug; Immunohistochemistry; Injections, Intravenous; Male; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Seizures; Wounds, Nonpenetrating

2003
Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury.
    Brain research. Molecular brain research, 2003, Sep-10, Volume: 117, Issue:1

    Topics: Animals; Animals, Newborn; Blotting, Northern; Brain; Brain Injuries; Calcineurin; Cell Division; Cell Size; Cells, Cultured; Cloning, Molecular; Colchicine; Cyclosporine; Disease Models, Animal; DNA, Complementary; Enzyme Inhibitors; Gene Library; Hippocampus; Immunohistochemistry; In Situ Hybridization; Neurites; Neurons; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synapsins; Time Factors

2003
The effect of cyclosporin A on brain edema formation following experimental cortical contusion.
    Acta neurochirurgica. Supplement, 2003, Volume: 86

    Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Cyclosporine; Dose-Response Relationship, Drug; Infusions, Intravenous; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2003
The protective effect of cyclosporin A upon N-acetylaspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury.
    Journal of neurotrauma, 2004, Volume: 21, Issue:9

    Topics: Animals; Aspartic Acid; Brain Injuries; Cyclosporine; Drug Administration Schedule; Infusions, Intravenous; Injections, Spinal; Male; Mitochondria; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2004
Cooling to 10 degrees C and treatment with Cyclosporine A improve cerebral recovery following prolonged hypothermic circulatory arrest in a chronic porcine model.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2005, Volume: 27, Issue:1

    Topics: Animals; Apoptosis; Brain Injuries; Cell Nucleus; Chronic Disease; Cyclosporine; Disease Models, Animal; Electroencephalography; Evoked Potentials; Female; Heart Arrest; Hemodynamics; Hippocampus; Hypothermia, Induced; Intracranial Pressure; Necrosis; Random Allocation; Swine

2005
Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury.
    Journal of neurotrauma, 2005, Volume: 22, Issue:1

    Topics: Animals; Brain; Brain Damage, Chronic; Brain Injuries; Cyclosporine; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors; Trauma Severity Indices

2005
Downregulation of amyloid precursor protein (APP) expression following post-traumatic cyclosporin-A administration.
    Journal of neurotrauma, 2004, Volume: 21, Issue:11

    Topics: Amyloid beta-Protein Precursor; Animals; Brain; Brain Injuries; Cyclosporine; Disease Models, Animal; Down-Regulation; Female; Immunohistochemistry; Injections, Spinal; Nerve Degeneration; Neuroprotective Agents; RNA, Messenger; Sheep; Time Factors; Up-Regulation

2004
Neural substrates for behaviorally conditioned immunosuppression in the rat.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-02, Volume: 25, Issue:9

    Topics: Amygdala; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain Injuries; Brain Mapping; Cell Proliferation; Cerebral Cortex; Conditioning, Classical; Cyclosporine; Cytokines; Flow Cytometry; Hypothalamus, Middle; Immunity, Cellular; Immunosuppression Therapy; Immunosuppressive Agents; Leukocyte Count; Lymphocytes; Male; N-Methylaspartate; Neurons; Rats; Time Factors

2005
A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins.
    Acta neurochirurgica. Supplement, 2006, Volume: 96

    Topics: Animals; Brain Injuries; Brain Ischemia; Calcineurin; Cyclophilins; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neuroprotective Agents; Prosencephalon; Rats; Rats, Wistar; Treatment Outcome

2006
Search for novel gene markers of traumatic brain injury by time differential microarray analysis.
    Acta neurochirurgica. Supplement, 2006, Volume: 96

    Topics: Animals; Biomarkers; Brain; Brain Injuries; Cyclosporine; Gene Expression Profiling; Gene Expression Regulation; Genetic Markers; Male; Nerve Tissue Proteins; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Prognosis; Rats; Rats, Wistar; Tacrolimus; Time Factors; Treatment Outcome

2006
Synthes Award For Resident Research On Craniofacial And Brain Injury: effect of cyclosporin A, topiramate, or 100% oxygen as proposed "neuroprotective" therapies on the neurochemical analytes in patients with severe traumatic brain injury.
    Clinical neurosurgery, 2006, Volume: 53

    Topics: Adult; Awards and Prizes; Brain Injuries; Case-Control Studies; Cohort Studies; Cyclosporine; Fructose; Glucose; Glutamic Acid; Humans; Lactic Acid; Microdialysis; Neuroprotective Agents; Oxygen Inhalation Therapy; Pyruvic Acid; Topiramate

2006
Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog.
    Experimental neurology, 2008, Volume: 209, Issue:1

    Topics: Acute Disease; Aldehydes; Animals; Biomarkers; Brain Injuries; Cyclosporine; Dose-Response Relationship, Drug; Immunoblotting; Lipid Peroxidation; Male; Mice; Mitochondrial Diseases; Oxidative Stress; Oxygen Consumption; Structure-Activity Relationship; Tyrosine

2008
Injections of vehicle, but not cyclosporin A or tacrolimus (FK506), afford neuroprotection following injury in the developing rat brain.
    Acta neurobiologiae experimentalis, 2007, Volume: 67, Issue:4

    Topics: Animals; Brain; Brain Injuries; Calbindin 2; Cell Count; Chemistry, Pharmaceutical; Cyclosporine; Epilepsy; Female; Immunosuppressive Agents; Neurons; Neuroprotective Agents; Organ Size; Parvalbumins; Pregnancy; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Staining and Labeling; Tacrolimus

2007
Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat.
    Acta physiologica Scandinavica, 1995, Volume: 155, Issue:4

    Topics: Amino Acid Isomerases; Animals; Brain Injuries; Carrier Proteins; Cyclosporine; Hippocampus; Immunosuppressive Agents; Ischemic Attack, Transient; Mitochondria; Peptidylprolyl Isomerase; Rats

1995
A case of severe cerebral trauma in a patient under chronic treatment with cyclosporine A.
    Journal of neurosurgical anesthesiology, 1998, Volume: 10, Issue:2

    Topics: Adolescent; Brain Injuries; Cyclosporine; Glasgow Coma Scale; Graft Rejection; Humans; Immunosuppressive Agents; Liver Transplantation; Magnetic Resonance Imaging; Male; Tomography, X-Ray Computed

1998
An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, Volume: 19, Issue:4

    Topics: Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Axons; Brain Injuries; Cyclosporine; Immunohistochemistry; Injections, Spinal; Male; Mitochondria; Neuroprotective Agents; Permeability; Rats; Rats, Sprague-Dawley

1999
Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury.
    Neuroreport, 1999, Feb-05, Volume: 10, Issue:2

    Topics: Animals; Axons; Biomarkers; Brain; Brain Injuries; Calcium; Calpain; Cyclosporine; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Peptide Hydrolases; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Spectrin

1999
Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury.
    Journal of neurotrauma, 1999, Volume: 16, Issue:6

    Topics: Amyloid beta-Protein Precursor; Animals; Axons; Biomarkers; Brain Injuries; Brain Stem; Calcium; Calpain; Cyclosporine; Disease Models, Animal; Disease Progression; Male; Neural Pathways; Neurofilament Proteins; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spectrin

1999
Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia.
    Brain research, 1999, Aug-28, Volume: 839, Issue:2

    Topics: Animals; Blood Glucose; Blood-Brain Barrier; Body Temperature; Brain Injuries; Carbon Dioxide; Carotid Arteries; Cyclosporine; Diuretics, Osmotic; Hydrogen-Ion Concentration; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Injections, Intra-Arterial; Ischemic Attack, Transient; Male; Mannitol; Osmosis; Oxygen; Rats; Rats, Wistar; Sodium Chloride; Tacrolimus; Wounds, Stab

1999
Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents.
    Journal of neurotrauma, 1999, Volume: 16, Issue:9

    Topics: Animals; Brain Injuries; Cerebral Cortex; Cyclosporine; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley

1999
Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.
    Experimental neurology, 1999, Volume: 160, Issue:1

    Topics: Animals; Brain Injuries; Calcium; Cyclosporine; Drug Evaluation, Preclinical; Intracellular Membranes; Male; Mitochondria; Necrosis; Neuroprotective Agents; Peptidylprolyl Isomerase; Permeability; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Synaptosomes

1999
Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury.
    Experimental neurology, 2000, Volume: 161, Issue:2

    Topics: Animals; Brain Injuries; Cerebral Cortex; Cyclosporine; Infusions, Parenteral; Injections, Intraperitoneal; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Time Factors

2000
Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity.
    Experimental neurology, 2000, Volume: 162, Issue:2

    Topics: Action Potentials; Animals; Brain Injuries; Contusions; Cyclosporine; Electric Stimulation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Mitochondria; Neural Inhibition; Neuronal Plasticity; Rats; Synapses; Synaptic Transmission

2000
Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats.
    Neuroscience, 2000, Volume: 101, Issue:2

    Topics: Animals; Blood-Brain Barrier; Brain Injuries; Cell Death; Cerebral Cortex; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Nerve Degeneration; Neuroprotective Agents; Percussion; Rats; Rats, Sprague-Dawley

2000
Exacerbation of traumatically induced axonal injury by rapid posthypothermic rewarming and attenuation of axonal change by cyclosporin A.
    Journal of neurosurgery, 2001, Volume: 94, Issue:3

    Topics: Amyloid beta-Protein Precursor; Animals; Axons; Body Temperature; Brain Injuries; Cyclosporine; Hypothermia, Induced; Immunohistochemistry; Immunosuppressive Agents; Male; Rats; Rats, Sprague-Dawley; Time Factors

2001
Effects of chronic, post-injury Cyclosporin A administration on motor and sensorimotor function following severe, experimental traumatic brain injury.
    Restorative neurology and neuroscience, 2001, Volume: 18, Issue:1

    Topics: Animals; Behavior, Animal; Brain Injuries; Cognition; Cyclosporine; Immunosuppressive Agents; Male; Maze Learning; Motor Activity; Motor Neurons; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Recovery of Function

2001
Involvement of apoptosis in neurological injury after hypothermic circulatory arrest: a new target for therapeutic intervention?
    The Annals of thoracic surgery, 2001, Volume: 72, Issue:5

    Topics: Animals; Apoptosis; Behavior, Animal; Brain Injuries; Cyclosporine; Female; Heart Arrest, Induced; Neurodegenerative Diseases; Neuroprotective Agents; Swine

2001
Differential response of neural cells to trauma-induced free radical production in vitro.
    Neurochemical research, 2002, Volume: 27, Issue:1-2

    Topics: Animals; Astrocytes; Brain Injuries; Calcineurin Inhibitors; Cells, Cultured; Cyclosporine; Free Radicals; Intracellular Membranes; Microglia; Mitochondria; Neurons; Permeability; Rats; Reference Values; Tacrolimus; Time Factors

2002
Cyclosporin A protects against ischemia-reperfusion injury in the brain.
    Brain research, 1992, Nov-06, Volume: 595, Issue:1

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Brain Edema; Brain Injuries; Cerebral Arteries; Cyclosporine; Male; Rats; Rats, Wistar; Reperfusion Injury

1992