Compounds > cyclosporine

cyclosporine and Bile Duct Obstruction

cyclosporine has been researched along with Bile Duct Obstruction in 73 studies

Research

Studies (73)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's41 (56.16)18.2507
2000's14 (19.18)29.6817
2010's17 (23.29)24.3611
2020's1 (1.37)2.80

Authors

AuthorsStudies
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Han, X; Lu, Y; Qin, Y; Tan, J; Wang, N; Zhai, X1
Honda, H; Ito, Y; Kawamoto, T; Morita, O1
Brauers, K; Coonen, MLJ; Jennen, D; Kleinjans, JCS; Olde Damink, SWM; Schaap, FG; Van den Hof, WFPM; van Herwijnen, M1
González-Diéguez, ML; Houghton, RF; Mendoza Pacas, GE; Viso Vidal, D1
Kienhuis, AS; Luijten, M; Pennings, JL; Pronk, TE; Roodbergen, M; Speksnijder, EN; van Delft, JH; van der Ven, LT; Vitins, AP1
Groot, MJ; Hendriksen, PJ; Peijnenburg, AA; Stoopen, G; Szalowska, E1
Andress, EJ; Dixon, PH; Linton, KJ; Naik, S; Nicolaou, M; Romero, MR; Williamson, C1
Al-Attrache, H; Azzi, PB; Guguen-Guillouzo, C; Guillouzo, A; Humbert, L; Rainteau, D; Savary, CC; Sharanek, A1
Bitetto, D; Bulajic, M; Cmet, S; Cussigh, A; Fabris, C; Falleti, E; Toniutto, P; Vadalà, S; Zilli, M1
Aoki, S; Horie, T; Ito, K; Ogimura, E; Oizumi, K; Sekine, S; Susukida, T1
Gore, E; Groothuis, GM; Olinga, P; Pennings, JL; Vatakuti, S1
Annaert, P; Bachellier, P; Baze, A; Heyd, B; Oorts, M; Richert, L; Zacharias, T1
Groothuis, GMM; Olinga, P; Pennings, JLA; Vatakuti, S1
de Kok, TM; Jennen, DG; Kleinjans, JC; Schaap, FG; Theunissen, DH; van Breda, SG; Van den Hof, WF; van Herwijnen, MH; Wolters, JE1
Currin, RT; Giri, S; Kim, I; Lemasters, JJ; Ramshesh, VK; Rehman, H; Theruvath, TP; Zhong, Z1
Aoki, T; Asai, N; Inomata, A; Ishihara, K; Katsutani, N; Sawada, K; Suganuma, A; Uemura, Y; Yokoi, T1
Honma, Y; Ichikawa, M; Kawamata, R; Koike, Y; Kono, Y; Momoi, MY; Takahashi, N; Yada, Y; Yotsumoto, S1
Casadio, C; Gaddoni, G; Giacomoni, P; Lanzanova, G; Maio, V; Patrizi, A; Savoia, F; Spadola, G; Tabanelli, M; Zago, S1
Aït-Slimane, T; Delaunay, JL; Delautier, D; Durand-Schneider, AM; Gabillet, J; Gautherot, J; Housset, C; Maurice, M; Rada, A1
Deters, M; Kaever, V; Klabunde, T; Meyer, H; Resch, K1
Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP; Santos, MS; Seiça, R1
Bjøro, K; Bjøro, T; Bollerslev, J; Brandsaeter, B; Godang, K; Schrumpf, E; Wiencke, K1
Benkoël, L; Chanussot, F1
Höckerstedt, K; Lalla, M; Salmela, K; Tötterman, A1
Albani, J; Burdelski, M; Ganschow, R; Grabhorn, E; Richter, A1
Akita, H; Hayashi, H; Hofmann, AF; Mita, S; Onuki, R; Sugiyama, Y; Suzuki, H1
Day, C; Hewins, P; Kilby, M; Lipkin, G; McPake, D; Sheikh, L1
Klöters-Plachky, P; Sauer, P; Stiehl, A1
Kattner, A; Manns, M; Oldhafer, K; Pichlmayr, R; Ringe, B; Schneider, A; Wietholtz, H; Winkler, M1
Fernández, E; Galán, AI; González-Buitrago, JM; Jiménez, R; Morán, D; Muñoz, ME1
Bismuth, H; Cabiac, MD; Farges, O; Girault, D; Haddad, N; Samuel, D1
Ballardie, FW; Bhatnagar, D; Chalmers, RJ; Durrington, PN; Edwards, BD; Gokal, R; Mackness, MI1
Eckfeldt, J; Levitt, MD; Pieper-Bigelow, C1
Bloomer, JR; Bowers, LD; Lacerda, MA; Payne, WD; Snover, DC1
Friman, S; Holmberg, SB; Svensson, G1
Grant, D; Levy, G1
Banks, L; Engel, K; Freeman, D; Grant, D; Levy, G; Roach, C; Rochon, J; Wong, PY1
Böhme, M; Jedlitschky, G; Keppler, D; Leier, I; Müller, M1
Bertault-Peres, P; Durand, A; Guitaoui, M; Mesdjian, E; Montet, JC; Queneau, PE1
al-Quaiz, MN; O'Grady, JG; Tredger, JM; Williams, R1
Färber, L; Maibücher, A; Manns, M; Pichlmayr, R; Ringe, B; Schneider, K; Wietholtz, H; Winkler, M1
Bertault-Perès, P; Durand, A; Mesdjian, E; Montet, JC; Queneau, PE1
Badr, KF; Bluhm, RE; Frazer, MG; Pinson, CW; Vore, M1
Arias, IM1
Bonfissuto, G; Calabrese, S; Caputo, F; Carroccio, A; Montalto, G; Pisciotta, G; Soresi, M; Sparacino, V1
Morales, JM1
Alberti, D; de Ville de Goyet, J; Falchetti, D; Otte, JB; Panzali, A; Reding, R; Rigamonti, W; Sokal, E; Wallemacq, P1
Chipman, JK; Coleman, R; Stone, V; Wilton, JC1
Bernard, B; Bouvier, E; Cabrol, A; Cadranel, JF; Dorent, R; Gandjbakhch, I; Gerhardt, M; Ghoussoub, JJ; Lunel, F; Myara, A; Opolon, P; Trivin, F1
Gosland, M; Hoffman, T; Huang, L; Liu, Y; Vore, M1
Adachi, Y; Kamisako, T1
Chan, FK; Shaffer, EA1
Almogy, N; Fiodorov, D; Nakache, R; Weinbroum, A1
Deters, M; Strubelt, O; Younes, M1
Clement de Clety, S; De Backer, M; de Ville de Goyet, J; Otte, JB; Reding, R; Sokal, EM; Van Leeuw, V; Wallemacq, PE1
Bährle, S; Dengler, TJ; Kübler, W; Stiehl, A; Szabó, G; Theilmann, L; Zimmermann, R1
De Buitrago, JM; Fernández, E; Galán, AI; Jiménez, R; Morán, D; Muñoz, ME1
Calmus, Y; Conti, F; Gaulard, P; Houssin, D; Louvel, A; Rouer, E; Zafrani, ES1
Alvaro, D; Benedetti, A; Bini, A; Delle Monache, MD; Di Cosimo, E; Fraioli, F; Francia, C; Gigliozzi, A; Jezequel, AM; Marucci, L; Papa, E1
Deters, M; Hänsel, W; Muhl, P; Siegers, C1
Deters, M; Hänsel, W; Hennighausen, G; Schneider, KP; Siegers, C1
Chayama, K; Kajiyama, G; Ochi, H; Tazuma, S; Yasumiba, S1
McDonald, GB; Shulman, HM; Strasser, SI1
Moreno, AJ; Oliveira, PJ; Palmeira, CM; Rolo, AP1
Bangert, K; Bramow, S; Dalhoff, K; Ott, P; Thomsen Nielsen, F; Tygstrup, N1
Deters, M; Kaever, V; Kirchner, G; Nolte, K; Resch, K1
Aitio, ML; Aranko, K1
Cava, F; Esteller, A; Galán, AI; Gonzalez-Buitrago, JM; Jimenez, R; Muñoz, ME; Román, ID1
Arvieux, C; Boucher, E; Calmus, Y; Gane, P; Nordlinger, B; Poupon, R; Rouger, P1
Duane, WC; Eckfeldt, JH; Furne, J; Hillstrom, J; Levitt, MD1
Black, DL; Bluhm, RE; Branch, R; Rodgers, WH; Wilkinson, GR1
Almeida, VM; Bleck, JS; Budniak, J; Christians, U; Deters, M; Kohlhaw, K; Pichlmayr, R; Schlitt, HJ; Schottmann, R; Wonigeit, K1

Reviews

6 review(s) available for cyclosporine and Bile Duct Obstruction

ArticleYear
Prevention by dietary (n-6) polyunsaturated phosphatidylcholines of intrahepatic cholestasis induced by cyclosporine A in animals.
    Life sciences, 2003, Jun-13, Volume: 73, Issue:4

    Topics: Actins; Adenosine Triphosphatases; Adenosine Triphosphate; Animal Feed; Animals; Biological Transport; Calcium; Cell Membrane; Cholestasis; Cyclosporine; Hypolipidemic Agents; Lipid Metabolism; Liver; Liver Diseases; Magnesium; Male; Models, Biological; Phosphatidylcholines; Phospholipids; Rats; Rats, Wistar

2003
Potential for CsA-Neoral in organ transplantation.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Administration, Oral; Adult; Child; Cholestasis; Cyclosporine; Graft Rejection; Heart Transplantation; Humans; Kidney Transplantation; Liver Transplantation; Randomized Controlled Trials as Topic; Transplantation Immunology

1994
Hepatobiliary function and toxicity in vitro using isolated hepatocyte couplets.
    General pharmacology, 1995, Volume: 26, Issue:7

    Topics: Animals; Bile Acids and Salts; Bile Canaliculi; Cell Communication; Cell Separation; Cells, Cultured; Cholestasis; Cyclosporine; Hemostatics; Immunosuppressive Agents; In Vitro Techniques; Liver; Rats; Tight Junctions; Vacuoles; Vitamin K

1995
[Intrahepatic cholestasis].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:3

    Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cholestasis; Cholestasis, Intrahepatic; Cyclosporine; Endotoxins; Humans; Liver; S-Adenosylmethionine

1996
Cholestasis after hematopoietic cell transplantation.
    Clinics in liver disease, 1999, Volume: 3, Issue:3

    Topics: Cholestasis; Cyclosporine; Cytomegalovirus Infections; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Hemolysis; Humans; Parenteral Nutrition, Total; Sepsis

1999
[Problems in cyclosporin medication].
    Duodecim; laaketieteellinen aikakauskirja, 1992, Volume: 108, Issue:6

    Topics: Acute Kidney Injury; Cholestasis; Cyclosporine; Drug Interactions; Humans; Immunologic Deficiency Syndromes; Liver; Tissue Transplantation

1992

Trials

2 trial(s) available for cyclosporine and Bile Duct Obstruction

ArticleYear
Cyclosporine Neoral in liver transplant recipients.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Antilymphocyte Serum; Cholestasis; Cyclosporine; Female; Graft Rejection; Humans; Immunosuppression Therapy; Intestinal Absorption; Liver Transplantation; Male; Metabolic Clearance Rate; Methylprednisolone; Middle Aged; Muromonab-CD3; Postoperative Complications

1994
Clinical pharmacokinetics of Neoral in pediatric recipients of primary liver transplants.
    Transplant international : official journal of the European Society for Organ Transplantation, 1997, Volume: 10, Issue:6

    Topics: Administration, Oral; Child, Preschool; Cholestasis; Cyclosporine; Diarrhea; Dose-Response Relationship, Drug; Fluoroimmunoassay; Humans; Immunosuppressive Agents; Infant; Liver Transplantation; Time Factors

1997

Other Studies

65 other study(ies) available for cyclosporine and Bile Duct Obstruction

ArticleYear
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Effects of Yinzhihuang on Alleviating Cyclosporine A-Induced Cholestatic Liver Injury via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Vitro and in Vivo.
    Biological & pharmaceutical bulletin, 2023, Volume: 46, Issue:12

    Topics: Animals; Bile Acids and Salts; Bilirubin; Cholestasis; Cyclosporine; Liver; Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear

2023
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:4

    Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; Dose-Response Relationship, Drug; Flutamide; Gene Expression; Humans; Imipramine; Inflammation; Ketoconazole; Liver; Methyltestosterone; Oxidative Stress; Rats; Risk Assessment; Sulindac; Tamoxifen; Toxicogenetics

2017
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 44

    Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Cyclosporine; Ethinyl Estradiol; Hep G2 Cells; Hepatocytes; Humans; Liver; Mice; Transcriptome

2017
Tacrolimus-Induced Cholestatic Hepatitis in a Patient With Liver Transplant.
    Transplantation, 2018, Volume: 102, Issue:10

    Topics: Allografts; Biopsy; Carcinoma, Hepatocellular; Cholestasis; Cyclosporine; Graft Rejection; Hepatitis; Humans; Immunosuppressive Agents; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Tacrolimus; Ultrasonography, Doppler

2018
Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.
    Toxicology letters, 2013, Aug-29, Volume: 221, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Bilirubin; Cholestasis; Cholesterol; Cyclosporine; Gene Expression; Gene Expression Profiling; Hep G2 Cells; Histocytochemistry; Humans; Male; Mice; Mice, Inbred C57BL; Phenotype; Specific Pathogen-Free Organisms; Toxicogenetics

2013
Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes.
    BMC medical genomics, 2013, Oct-10, Volume: 6

    Topics: Animals; Biomarkers; Chlorpromazine; Cholestasis; Cyclosporine; Cytotoxins; Down-Regulation; Gene Expression Profiling; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Signal Transduction

2013
Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:5

    Topics: ATP Binding Cassette Transporter, Subfamily B; Cholestasis; Cyclosporine; Female; HEK293 Cells; Humans; Male; Polymorphism, Single Nucleotide; Proteasome Inhibitors; Protein Folding; Protein Transport

2014
Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 141, Issue:1

    Topics: Actins; Cell Line, Tumor; Cell Survival; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Gene Expression; Humans; Immunosuppressive Agents; Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Taurocholic Acid; Time-Lapse Imaging

2014
Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine treated.
    International journal of surgery (London, England), 2014, Volume: 12, Issue:10

    Topics: Adult; Aged; Anastomotic Leak; Cholestasis; Cyclosporine; Female; Genetic Variation; Genotype; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Interferons; Interleukins; Liver Transplantation; Male; Middle Aged; Retrospective Studies; Risk Factors; Tacrolimus

2014
Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Culture Techniques; Cells, Cultured; Cholestasis; Cyclosporine; HEK293 Cells; Hepatocytes; Humans; Multidrug Resistance-Associated Proteins; Propionates; Quinidine; Quinolines; Rats, Sprague-Dawley

2015
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
    Chemical research in toxicology, 2016, Mar-21, Volume: 29, Issue:3

    Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis; Colchicine; Cyclosporine; Diethylnitrosamine; Drug-Related Side Effects and Adverse Reactions; Ethinyl Estradiol; Female; Gene Expression Profiling; Hepatocytes; Humans; Liver; Male; Methyltestosterone; Middle Aged; Necrosis; Phenotype; Toxicogenetics; Young Adult

2016
Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 34

    Topics: Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis; Cyclosporine; Hepatocytes; Humans; Risk Assessment; Urea

2016
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: 1-Naphthylisothiocyanate; Aged; Chlorpromazine; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Gene Expression Profiling; Humans; Liver; Male; Methyltestosterone; Middle Aged; Signal Transduction; Transcriptome; Young Adult

2017
Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.
    Chemical research in toxicology, 2016, 12-19, Volume: 29, Issue:12

    Topics: Cells, Cultured; Cholestasis; Cyclosporine; DNA Methylation; Genomics; Hepatocytes; Humans; Immunosuppressive Agents; Oligonucleotide Array Sequence Analysis; Transcriptome

2016
NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:3

    Topics: Animals; Cell Death; Cholestasis; Collagen; Cyclosporine; Fibrosis; Hepatocytes; Membrane Potentials; Mice; Mitochondrial Membranes; Permeability

2008
Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:3

    Topics: 1-Naphthylisothiocyanate; Aniline Compounds; Animals; Biomarkers; Cholestasis; Cyclosporine; Disease Models, Animal; Kidney; Magnetic Resonance Spectroscopy; Male; Metabolomics; Rats; Rats, Sprague-Dawley

2009
Selectively high levels of serum interleukin 17 in a newborn infant with progressive severe cholestasis.
    Pediatrics, 2010, Volume: 126, Issue:1

    Topics: Biomarkers; Cholestasis; Cyclosporine; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Humans; Infant, Newborn; Interleukin-17; Interleukin-8; Macrophage Inflammatory Proteins; Male; Risk Assessment; Severity of Illness Index; Steroids; Treatment Outcome

2010
Prurigo nodularis as the first manifestation of a chronic autoimmune cholestatic hepatitis.
    International journal of dermatology, 2011, Volume: 50, Issue:12

    Topics: Alkaline Phosphatase; Antibodies, Antinuclear; Azathioprine; Cholestasis; Cyclosporine; Dermatologic Agents; Female; gamma-Glutamyltransferase; Hepatitis, Autoimmune; Humans; Middle Aged; Prurigo; Ursodeoxycholic Acid

2011
Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
    The Journal of biological chemistry, 2012, Feb-10, Volume: 287, Issue:7

    Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calnexin; Cholestasis; Cryoprotective Agents; Cyclosporine; Dogs; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Silencing; Glycerol; Hep G2 Cells; HSC70 Heat-Shock Proteins; Humans; Mutation, Missense; Phenylbutyrates; Protein Transport; Thapsigargin

2012
Effects of curcumin on cyclosporine-induced cholestasis and hypercholesterolemia and on cyclosporine metabolism in the rat.
    Planta medica, 2003, Volume: 69, Issue:4

    Topics: Administration, Oral; Animals; Bile; Bile Acids and Salts; Biliary Fistula; Cholagogues and Choleretics; Cholestasis; Cholesterol; Curcuma; Curcumin; Cyclosporine; Disease Models, Animal; Hypercholesterolemia; Hypolipidemic Agents; Immunosuppressive Agents; Injections, Intraperitoneal; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Triglycerides

2003
Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2003, Volume: 22, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Calcium; Cardiovascular Diseases; Cholestasis; Chronic Disease; Cyclosporine; Disease Models, Animal; Female; Fibrosis; Liver Diseases; Mitochondria, Heart; Oxidative Stress; Rats; Rats, Wistar

2003
Secondary osteoporosis in liver transplant recipients: a longitudinal study in patients with and without cholestatic liver disease.
    Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:3

    Topics: Adult; Aged; Alkaline Phosphatase; Biomarkers; Bone Density; Bone Resorption; Cholestasis; Collagen; Collagen Type I; Cyclosporine; Female; Femur Neck; Follow-Up Studies; Forearm; Fractures, Bone; Glucocorticoids; Humans; Immunosuppressive Agents; Liver Diseases; Liver Transplantation; Longitudinal Studies; Lumbar Vertebrae; Male; Middle Aged; Norway; Osteocalcin; Osteoporosis; Peptide Fragments; Peptides; Postoperative Complications; Survival Analysis; Tacrolimus; Treatment Outcome; Waiting Lists

2003
Cholestasis and kidney dysfunction in liver transplant patients reduces cyclosporine metabolite excretion.
    Transplant international : official journal of the European Society for Organ Transplantation, 1992, Volume: 5 Suppl 1

    Topics: Adult; Aged; Cholestasis; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Diseases; Liver Transplantation; Male; Middle Aged; Postoperative Period; Regression Analysis; Time Factors

1992
Tacrolimus-induced cholestatic syndrome following pediatric liver transplantation and steroid-resistant graft rejection.
    Pediatric transplantation, 2006, Volume: 10, Issue:2

    Topics: Adolescent; Child; Cholestasis; Cyclosporine; Graft Rejection; Humans; Immunosuppressive Agents; Infant; Liver; Liver Transplantation; Postoperative Complications; Pruritus; Retrospective Studies; Tacrolimus

2006
Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluoresceins; Kinetics; LLC-PK1 Cells; Organic Anion Transporters, Sodium-Dependent; Oxadiazoles; Rifampin; Rifamycins; Swine; Symporters; Taurocholic Acid; Transfection

2006
Cholestasis in pregnancy associated with ciclosporin therapy in renal transplant recipients.
    Transplant international : official journal of the European Society for Organ Transplantation, 2006, Volume: 19, Issue:12

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Canaliculi; Cholestasis; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Pregnancy; Pregnancy Complications

2006
Inhibition of ileal bile acid transport by cyclosporin A in rat.
    European journal of clinical investigation, 1995, Volume: 25, Issue:9

    Topics: Animals; Bile Acids and Salts; Biological Transport; Cholestasis; Cyclosporine; Ileum; Immunosuppressive Agents; Intestinal Absorption; Male; Perfusion; Rats; Rats, Wistar

1995
Conversion from CyA to CyA-NOF in a cholestatic liver grafted patient with CyA malabsorption.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Administration, Oral; Biopsy; Cholestasis; Cyclosporine; Humans; Immunosuppression Therapy; Intestinal Absorption; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Tacrolimus

1994
Reversal of cyclosporine A-induced alterations in biliary secretion by S-adenosyl-L-methionine in rats.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Animals; Bile Acids and Salts; Biliary Tract; Cholestasis; Cholesterol; Cyclosporine; Drug Administration Schedule; Drug Interactions; Immunosuppressive Agents; Liver; Male; Phospholipids; Proteins; Rats; Rats, Wistar; S-Adenosylmethionine

1995
Conversion from cyclosporine Sandimmun to cyclosporine neoral in liver transplant patients with cholestasis or external biliary drainage.
    Transplantation proceedings, 1995, Volume: 27, Issue:4

    Topics: Administration, Oral; Adult; Autoimmune Diseases; Bile; Cholestasis; Cyclosporine; Drainage; Female; Hepatitis C; Humans; Injections, Intravenous; Intestinal Absorption; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged

1995
Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis.
    QJM : monthly journal of the Association of Physicians, 1995, Volume: 88, Issue:2

    Topics: Biomarkers; Cholestasis; Cholesterol, LDL; Cyclosporine; Drug Administration Schedule; Humans; Lipoproteins; Liver Function Tests; Psoriasis

1995
Sensitivity of HPLC and conventional bilirubin measurements in the detection of early cholestasis.
    The Journal of laboratory and clinical medicine, 1995, Volume: 125, Issue:5

    Topics: Animals; Bile Ducts; Bilirubin; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Ethinyl Estradiol; Guinea Pigs; Ligation; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity

1995
Hepatic levels of cyclosporine and metabolites in patients after liver transplantation.
    Clinical transplantation, 1995, Volume: 9, Issue:1

    Topics: Adult; Bilirubin; Biopsy; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Female; Humans; Immunosuppression Therapy; Liver; Liver Transplantation; Male; Mass Spectrometry

1995
Influence of liver transplantation and cyclosporin on bile secretion--an experimental study in the rat.
    Transplant international : official journal of the European Society for Organ Transplantation, 1995, Volume: 8, Issue:1

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cyclosporine; Female; Injections, Intraperitoneal; Liver; Liver Transplantation; Models, Biological; Organ Size; Rats; Rats, Inbred WF

1995
Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver.
    Gastroenterology, 1994, Volume: 107, Issue:1

    Topics: Adenosine Triphosphate; Animals; Bile Acids and Salts; Bile Canaliculi; Biological Transport; Carbon Radioisotopes; Cell Membrane; Cholestasis; Cyclosporine; Cyclosporins; In Vitro Techniques; Leukotriene C4; Liver; Male; Rats; Rats, Wistar; Taurocholic Acid; Time Factors

1994
Improvement of cyclosporin A-induced cholestasis by tauroursodeoxycholate in a long-term study in the rat.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:7

    Topics: Animals; Cholestasis; Cyclosporine; Isomerism; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Taurochenodeoxycholic Acid

1994
Variable effect of ursodeoxycholic acid on cyclosporin absorption after orthotopic liver transplantation.
    Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7, Issue:3

    Topics: Absorption; Adolescent; Adult; Aged; Biological Availability; Cholestasis; Cyclosporine; Female; Graft Rejection; Half-Life; Humans; Liver; Liver Transplantation; Male; Middle Aged; Transplantation, Homologous; Ursodeoxycholic Acid

1994
Enhanced bioavailability of cyclosporine using a new oral formulation (Sandimmun optoral) in a liver-grafted patient with severe cholestasis.
    Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7, Issue:2

    Topics: Administration, Oral; Biological Availability; Cholestasis; Cyclosporine; Emulsions; Graft Rejection; Humans; Intestinal Absorption; Liver Transplantation; Male; Middle Aged

1994
Diminution of an acute cyclosporin-induced cholestasis by tauroursodeoxycholate in the rat.
    Transplantation, 1993, Volume: 56, Issue:3

    Topics: Animals; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis; Cyclosporine; Male; Rats; Rats, Sprague-Dawley; Solutions; Taurine; Ursodeoxycholic Acid; Viscosity

1993
Endothelins 1 and 3: potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine.
    Hepatology (Baltimore, Md.), 1993, Volume: 18, Issue:4

    Topics: Animals; Cholestasis; Cyclosporine; Drug Synergism; Endothelins; Liver; Male; Rats; Rats, Sprague-Dawley

1993
Cyclosporin, the biology of the bile canaliculus, and cholestasis.
    Gastroenterology, 1993, Volume: 104, Issue:5

    Topics: Adenosine Triphosphate; Animals; Anions; Bile Canaliculi; Biological Transport; Cholestasis; Cyclosporine; Humans

1993
[Effects of cyclosporin A on various indices of cholestasis in kidney transplant recipients].
    Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 1995, Volume: 47, Issue:2

    Topics: Adult; Cholelithiasis; Cholestasis; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Liver Function Tests; Male; Middle Aged; Postoperative Complications

1995
Drug-induced hepatotoxicity.
    The New England journal of medicine, 1996, Mar-28, Volume: 334, Issue:13

    Topics: Azathioprine; Cholestasis; Cyclosporine; Humans

1996
Microemulsion formulation of cyclosporine in pediatric liver transplantation.
    Transplantation, 1996, Feb-15, Volume: 61, Issue:3

    Topics: Administration, Oral; Biological Availability; Child; Child, Preschool; Cholestasis; Chronic Disease; Cyclosporine; Diarrhea; Emulsions; Female; Graft Rejection; Humans; Immunosuppressive Agents; Intestinal Absorption; Liver Transplantation; Short Bowel Syndrome

1996
Cyclosporin A-mediated cholestasis in patients with chronic hepatitis after heart transplantation.
    European journal of gastroenterology & hepatology, 1996, Volume: 8, Issue:3

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Bile Acids and Salts; Bilirubin; Chenodeoxycholic Acid; Cholestasis; Cholic Acid; Cholic Acids; Chromatography, High Pressure Liquid; Cyclosporine; Fasting; Female; Glycocholic Acid; Heart Transplantation; Hepatitis, Chronic; Humans; Immunosuppressive Agents; Lithocholic Acid; Male; Middle Aged; Spectrophotometry, Ultraviolet; Taurocholic Acid; Ursodeoxycholic Acid

1996
MDR1 substrates/modulators protect against beta-estradiol-17beta-D-glucuronide cholestasis in rat liver.
    Cancer research, 1996, Nov-01, Volume: 56, Issue:21

    Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Carrier Proteins; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Daunorubicin; Estradiol; Male; Paclitaxel; Rats; Rats, Sprague-Dawley

1996
Cholestatic effects of cyclosporine in the rat.
    Transplantation, 1997, Jun-15, Volume: 63, Issue:11

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cholesterol; Cyclosporine; Immunosuppressive Agents; Liver; Male; Organ Size; Polyethylene Glycols; Rats; Rats, Inbred Lew

1997
Vasoactive effect of cyclosporine on the rat peribiliary capillary plexus: relationship with cholestasis and hyperbilirubinemia.
    Transplantation proceedings, 1997, Volume: 29, Issue:6

    Topics: Animals; Capillaries; Cholestasis; Cyclosporine; Hyperbilirubinemia; Immunosuppressive Agents; In Vitro Techniques; Liver; Rats; Vasoconstriction

1997
Reevaluation of cyclosporine induced hepatotoxicity in the isolated perfused rat liver.
    Toxicology, 1997, Dec-05, Volume: 123, Issue:3

    Topics: Alanine Transaminase; Animals; Antioxidants; Bile; Cholestasis; Cyclosporine; Dose-Response Relationship, Drug; Drug Evaluation; Glutamate Dehydrogenase; Immunosuppressive Agents; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Oxygen Consumption; Perfusion; Rats; Rats, Wistar

1997
Adjuvant treatment with ursodeoxycholic acid may reduce the incidence of acute cardiac allograft rejection.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1998, Volume: 17, Issue:6

    Topics: Acute Disease; Cholestasis; Cyclosporine; Female; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Retrospective Studies; Ursodeoxycholic Acid

1998
Inhibition of biliary glutathione secretion by cyclosporine A in the rat: possible mechanisms and role in the cholestasis induced by the drug.
    Journal of hepatology, 1998, Volume: 29, Issue:1

    Topics: Animals; Bile Acids and Salts; Biliary Tract; Cholestasis; Cyclosporine; Glutathione; Immunosuppressive Agents; Male; Rats; Rats, Wistar

1998
Increased expression of interleukin-4 during liver allograft rejection.
    Journal of hepatology, 1999, Volume: 30, Issue:5

    Topics: Acute Disease; Adult; Cholestasis; Chronic Disease; Cyclosporine; Female; Gene Expression Regulation; Graft Rejection; Humans; Immunohistochemistry; Immunosuppression Therapy; Interleukin-2; Interleukin-4; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Receptors, Interleukin-2; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Transplantation, Homologous

1999
Effect of pharmacological modulation of liver P-glycoproteins on cyclosporin A biliary excretion and cholestasis: a study in isolated perfused rat liver.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:11

    Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B; Bile; Cholestasis; Cyclosporine; Immunosuppressive Agents; Liver; Male; Perfusion; Rats; Rats, Wistar; Time Factors; Verapamil

1999
Choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat.
    Planta medica, 1999, Volume: 65, Issue:7

    Topics: Animals; Bile; Cholagogues and Choleretics; Cholestasis; Coumaric Acids; Curcumin; Cyclosporine; Diarylheptanoids; Immunosuppressive Agents; Male; Rats; Rats, Wistar

1999
Influence of curcumin on cyclosporin-induced reduction of biliary bilirubin and cholesterol excretion and on biliary excretion of cyclosporin and its metabolites.
    Planta medica, 2000, Volume: 66, Issue:5

    Topics: Animals; Bile; Bilirubin; Cholagogues and Choleretics; Cholestasis; Cholesterol; Curcumin; Cyclosporine; Injections, Intravenous; Male; Rats; Rats, Wistar

2000
Cyclosporin A reduces canalicular membrane fluidity and regulates transporter function in rats.
    The Biochemical journal, 2001, Mar-15, Volume: 354, Issue:Pt 3

    Topics: Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Blotting, Western; Carrier Proteins; Cholestasis; Cholesterol; Cyclosporine; Immunosuppressive Agents; Male; Membrane Fluidity; Phospholipids; Rats; Rats, Sprague-Dawley

2001
Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria.
    Bioscience reports, 2001, Volume: 21, Issue:1

    Topics: Animals; Calcium; Chenodeoxycholic Acid; Cholestasis; Cyclosporine; Enzyme Inhibitors; Gastrointestinal Agents; Indicators and Reagents; Liver; Male; Membrane Potentials; Mitochondria, Liver; Osmosis; Permeability; Rats; Rats, Wistar; Ruthenium Red; Subcellular Fractions

2001
Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine A and sirolimus (Rapamycin).
    Pharmacology & toxicology, 2001, Volume: 89, Issue:3

    Topics: Animals; Carrier Proteins; Cholestasis; Cyclosporine; Cytochrome P-450 Enzyme System; Drug Interactions; Gene Expression Regulation; Glutathione; Immunosuppressive Agents; Liver; Liver Function Tests; Liver Transplantation; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sirolimus

2001
Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus-tacrolimus combinations on bile flow in the rat.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:10

    Topics: Animals; Bile Acids and Salts; Biliary Fistula; Biliary Tract; Cholestasis; Cyclosporine; Disease Models, Animal; Drug Combinations; Immunosuppressive Agents; Male; Rats; Rats, Wistar; Sirolimus; Tacrolimus

2001
Inhibition of biliary lipid and protein secretion by cyclosporine A in the rat.
    Biochemical pharmacology, 1992, Sep-25, Volume: 44, Issue:6

    Topics: Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Cholestasis; Cholesterol; Cyclosporine; Fat Emulsions, Intravenous; Liver; Male; Phospholipids; Proteins; Rats; Rats, Wistar

1992
Cholestasis induces major histocompatibility complex class I expression in hepatocytes.
    Gastroenterology, 1992, Volume: 102, Issue:4 Pt 1

    Topics: Aged; Animals; Cholestasis; Cyclosporine; Female; Flow Cytometry; Fluorescent Antibody Technique; Histocompatibility Antigens Class I; Humans; Liver; Male; Middle Aged; Rats; Rats, Inbred Lew

1992
Lack of benefit of ursodeoxycholic acid in drug-induced cholestasis in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 200, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Cholestasis; Cyclosporine; Ethinyl Estradiol; Male; Rats; Rats, Inbred Strains; Ursodeoxycholic Acid

1992
Cholestasis in transplant patients--what is the role of cyclosporin?
    Alimentary pharmacology & therapeutics, 1992, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anti-Bacterial Agents; Aspartate Aminotransferases; Bilirubin; Biopsy; Child; Child, Preschool; Cholestasis; Chromatography, High Pressure Liquid; Creatinine; Cross Reactions; Cyclosporine; Female; Fluorescence Polarization Immunoassay; Humans; Hyperbilirubinemia; Infant; L-Lactate Dehydrogenase; Liver; Male; Prognosis; Time Factors; Transplantation

1992
Ciclosporin metabolite pattern in blood and urine of liver graft recipients. II. Influence of cholestasis and rejection.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:4

    Topics: Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Graft Rejection; Humans; Liver Transplantation; Postoperative Complications; Radioimmunoassay; Time Factors

1991