cyclosporine has been researched along with Alloxan Diabetes in 96 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (2.08) | 18.7374 |
1990's | 50 (52.08) | 18.2507 |
2000's | 27 (28.13) | 29.6817 |
2010's | 14 (14.58) | 24.3611 |
2020's | 3 (3.13) | 2.80 |
Authors | Studies |
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Arnstein, M; Cooper, ME; Coughlan, MT; Forbes, JM; Granata, C; Henstridge, DC; Higgins, GC; Lindblom, RSJ; Nguyen, TV; Snelson, M; Thallas-Bonke, V | 1 |
Chen, F; Wang, P; Zhang, X | 1 |
Min, SN; Yu, GY; Zhu, YY | 1 |
Acebes, A; Brito-Casillas, Y; Cuesto, G; De Vries, APJ; Porrini, E; Rodriguez-Rodriguez, AE; Salido, E; Torres, A; Triñanes, J; Wagner, A | 1 |
Bondan, EF; Monteiro Martins, Mde F | 1 |
Angaswamy, N; Banan, B; Benshoff, N; Chapman, W; Mohanakumar, T; Tiriveedhi, V | 1 |
Díez-Fuentes, ML; Fumero, C; Luis Lima, S; Porrini, E; Rodríguez-Rodríguez, AE; Salido, E; Torres, A; Triñanes, J; Vega-Prieto, MJ; Velázquez-García, S | 1 |
Alimoradi, H; Asgari, M; Barzegar-Fallah, A; Dehpour, AR; Razmi, A; Shafiei, M | 1 |
Cui, J; Li, DQ; Qiu, MC; Zhang, JS; Zhang, P; Zhang, X | 2 |
Borlak, J; Niehof, M | 1 |
Amann, K; Daniel, C; Hugo, C; Stief, A; Vogelbacher, R; Wittmann, S | 1 |
Carmines, PK; Foster, JM; Pollock, JS | 1 |
Ghee, JY; Han, DH; Kim, J; Kim, SH; Li, C; Piao, SG; Song, HK; Song, JH; Yang, CW; Yoon, HE | 1 |
Gooch, JL; Knotts, TL; Molkentin, JD; Price, SR; Reddy, RN; Roberts, BR | 1 |
Alkharfy, KM | 1 |
Agardh, CD; Agardh, E; Fredrikson, GN; Gomez, MF; González Bosc, LV; Hultgårdh-Nilsson, A; Nilsson, J; Nilsson-Berglund, LM; Nilsson-Ohman, J; Salehi, A; Sigvardsson, M; Smith, ML; Wamhoff, BR; Zetterqvist, AV | 1 |
Bouwman, E; Rijkelijkhuizen, JK; Terpstra, OT; Töns, A | 1 |
Cui, SH; Li, F; Liu, S; Luo, B; Sun, HC; Sun, JB; Xin, MJ | 1 |
Ahmadiasl, N; Badalzadeh, R; Ebrahimi, H; Farajnia, S; Mohammadi, M; Najafi, M | 1 |
Bostian, PA; Brown, DA; Frasier, CR; Lust, RM; Moukdar, F; Patel, HD; Sloan, RC | 1 |
Chen, XM; Fang, YH; Lei, B; Shen, Q; Zhang, XD; Zong, YJ | 1 |
Byun, Y; Hwang, JW; Jeong, JH; Jung, MJ; Lee, DY; Moon, HT; Yook, S | 1 |
Abboud, HE; Barnes, JL; Garcia, S; Gooch, JL | 1 |
Ha, JC; Han, DJ; Jeong, YL; Kim, SC; Lee, AY; Lee, HK; Lee, SK; Wee, YM | 1 |
Biessels, GJ; Gispen, WH; Kamal, A; Ramakers, GM | 1 |
Bennet, W; Goto, M; Groth, CG; Korsgren, O; Maeda, A; Wennberg, L; Zhang, J | 1 |
Deng, S; Li, X; Wang, Y; Zhao, G | 1 |
Cetkovic-Cvrlje, M; Dragt, AL; Uckun, FM | 1 |
Corsi, M; Ferrero, ME; Gaja, G; Marni, A; Parise, M; Salari, PC | 1 |
Amaratunga, A; Khoury, P; Tuch, BE; Wang, L; Williams, L | 1 |
Christians, U; Colvin, RB; Graham, M; Hering, BJ; Ingulli, E; Kirchhof, N; Schuurman, HJ; Wijkstrom, M | 1 |
Coombes, JD; Couser, WG; Pippin, JW; Rangan, GK | 1 |
Dufour, JM; Kin, T; Kobayashi, T; Korbutt, GS; Rajotte, RV | 1 |
Antonakis, PT; Flogeras, D; Fotiadis, C; Karampela, E; Papalois, AE; Sfiniadakis, I; Xekouki, P; Zografos, G | 1 |
Najjar, TA; Saad, SY | 1 |
Ahn, KO; Choi, YH; Chung, BH; Ito, S; Kim, J; Li, C; Lim, SW; Sugawara, A; Sun, BK; Yang, CW; Yang, JH; Yoon, KH | 1 |
Byun, Y; Lee, DY; Nam, JH; Park, SJ | 2 |
Fox, M; Greaves, M; Johnson, BF; Preston, FE; Raftery, AT; Wiley, KN | 1 |
Cook, HW; Fraser, RB; Kapoor, S; Wright, JR | 1 |
Borel, JF; Lu, X | 1 |
Carotenuto, P; Leslie, RD; Pozzilli, P | 1 |
Ar'Rajab, A; Dawidson, IJ; Harris, RB; Sentementes, JT | 1 |
Cheung, SS; Tai, J; Tze, WJ | 2 |
Kearns, H; Wright, JR | 1 |
Kearns, H; McDonald, AS; Wright, JR | 1 |
Epstein, S; Jee, WS; Joffe, II; Katz, IA; Ke, HZ; Li, M; Liang, XG; Romero, DF; Stein, B; Takizawa, M | 1 |
Chou, TC; Field, JF; Gores, PF; Sutherland, DE | 1 |
Bonthuis, F; Bouwman, E; Ijzermans, JN; Kouwenhoven, E; Marquet, RL; Scheringa, M; van Rooijen, N; Wolvekamp, MC | 1 |
Gores, PF; Hower, C; Lloveras, JK; Soon-Shiong, P; Stephanian, E; Sutherland, DE; Wahoff, DC | 1 |
Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Suzuki, T | 1 |
Andersson, A; Groth, CG; Korsgren, O; Sandberg, JO | 1 |
Barrera, J; Demetriou, AA; Lebow, LT; Morsiani, E; Rozga, J; Young, JD | 1 |
Cheung, SS; Tai, J; Tsang, A; Tze, WJ | 1 |
Andereggen, E; Bubloz, C; Bühler, L; Deng, S; Fournier, B; Morel, P | 1 |
Chick, WL; Ecker, DM; Kühtreiber, WM; Lanza, RP; Marsh, JP; Staruk, JE | 1 |
Gruessner, AC; Gruessner, RW; Matas, AJ; Moon, C; Nakhleh, RE; Papalois, BE; Troppmann, C | 1 |
Chen, H; Daloze, P; Qi, S; Xu, D | 1 |
Gruessner, AC; Gruessner, RW; Matas, AJ; Moon, C; Nakhleh, RE; Papalois, BE; Sehgal, SN; Troppmann, C | 1 |
Gupta, RC; Mathur, AK; Prasad, N; Sharma, P | 1 |
Chen, S; Li, JW; Ma, SX; Wang, Y; Yan, YH | 1 |
Kristal, BS; Matsuda, M; Yu, BP | 1 |
Cíhalová, E; Kazdová, L; Nozicková, M; Ruzbarský, V; Saudek, F; Vrána, A | 1 |
Hikichi, N; Iizuka, Y; Murata, R; Ogata, M | 1 |
Bartlett, ST; Delatorre, A; Hadley, GA; Johnson, LB; Kuo, PC; Schweitzer, EJ | 1 |
Cheung, SC; Tai, J; Tze, WJ | 1 |
Chong, AS; Foster, P; Guo, Z; Jensik, S; McChesney, L; Mital, D; Sankary, H; Shen, J; Tian, Y; Williams, JW; Yin, D | 1 |
Chong, AS; Foster, PF; Fu, Z; Guo, Z; Jensik, S; McChesney, LP; Mital, D; Sankary, HN; Shen, J; Tian, Y; Williams, JW | 1 |
Hikichi, N; Iizuka, Y; Murata, R; Ogata, M; Suzuki, S; Toyota, T; Uchimura, T | 1 |
Arita, S; Atiya, A; Kasraie, A; Mullen, Y; Ohtsuka, S; Shevlin, L; Une, S | 1 |
Cheung, S; Tai, J; Tsang, A; Tze, WJ | 1 |
du Toit, D; Louw, J; Muller, C; Page, B | 1 |
Choi, HS; Chun, YC; Ha, JH; Kang, JS; Kim, DS; Kim, JH; Lee, CH; Shin, IC | 1 |
Erley, CM; Heyne, N; Merten, S; Osswald, H; Petersen, P; Risler, T; Schöber, W; Wolf, S | 1 |
Fujimura, A; Green, M; Kamada, N; Kobayashi, E; Lord, R; Miyata, M; Toyama, N | 1 |
Davaris, P; Golematis, B; Karamanos, V; Lykoudis, E; Nikolaou, A; Nikolaou, C; Papadimitriou, L; Papalois, A; Papalois, B; Pataryas, T; Smyrniotis, V; Tountas, C | 1 |
Fujimura, A; Green, M; Kamada, N; Kobayashi, E; Lord, R; Uchida, H; Walker, NI | 1 |
Bari, S; Bennet, W; Groth, CG; Korsgren, O; Nava, S; Song, Z; Sundberg, B; Wennberg, L; Zhang, J | 2 |
Jeon, SD; Moon, CK; So, DS; Yang, KM | 1 |
Carmo, A; Carvalho, AP; Cunha-Vaz, JG; Lopes, MC | 1 |
Auchincloss , H; Boskovic, S; C Ko, DS; Colvin, RB; Cosimi, AB; Kawai, T; Koulmanda, M; O'Neil, JJ; Sachs, DH; Smith, RN; Sogawa, H; Sykes, M; Wee, SL | 1 |
Demetriou, AA; Fogli, L; Lanza, G; Lebow, LT; Morsiani, E; Rozga, J | 1 |
Breim, LC; De-Macedo, AR; Machado, JL; Mercadante, MC; Spadella, CT | 1 |
Baker, H; DeAngelis, B; Frank, O; Jyothirmayi, GN; Khalil, M; Leevy, CB; Reddi, AS | 1 |
Hisanaga, M; Nakajima, Y; Nakano, H; Segawa, M; Ueno, M; Yabuuchi, H; Yoshimura, A | 1 |
Ji-ning, L; Shao-Wen, H; Xi-yuan, Z | 1 |
Ketchum, RJ; Moore, WV; Moyer, C; Su, HC | 1 |
Dietze, O; Habringer, C; Klima, G; Königsrainer, A; Krausler, R; Margreiter, R | 1 |
Barker, CF; Berezniak, R; Dafoe, DC; Posselt, A; Tafra, L; Wang, X | 1 |
Duhault, J; Goranova, I; Jablenska, R; Marquie, G; Petkov, P; Popov, A; Vassileva, E; Zafirova, M | 1 |
Baker, H; DeAngelis, B; Frank, O; Jyothirmayi, GN; Kabaria, V; Reddi, AS | 1 |
Diamantstein, T; Dunger, A; Hahn, HJ; Kauert, C; Kuttler, B | 1 |
Atlef, N; Doll, N; Hermitte, L; Payan, MJ; Scheimann, A; Vague, P; Vialettes, B | 1 |
1 review(s) available for cyclosporine and Alloxan Diabetes
Article | Year |
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New developments in non-specific and semi-specific immunosuppression in type I diabetes.
Topics: Animals; Antilymphocyte Serum; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Insulin; Lymphokines; Photopheresis; Prediabetic State | 1993 |
95 other study(ies) available for cyclosporine and Alloxan Diabetes
Article | Year |
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Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D.
Topics: Albuminuria; Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hydrogen Peroxide; Kidney; Kidney Diseases; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Peptidyl-Prolyl Isomerase F; Proton-Translocating ATPases | 2020 |
Cyclosporine-a attenuates retinal inflammation by inhibiting HMGB-1 formation in rats with type 2 diabetes mellitus.
Topics: Animals; Anti-Inflammatory Agents; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Retinopathy; HMGB1 Protein; Interleukin-1beta; Intravitreal Injections; Male; Rats, Sprague-Dawley; Retina; Tumor Necrosis Factor-alpha | 2020 |
[Effect of topical injection of cyclosporine A on saliva secretion and inflammation in the submandibular gland of non-obese diabetic mice].
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Inflammation; Mice; Mice, Inbred NOD; Saliva; Sjogren's Syndrome; Submandibular Gland | 2021 |
Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells.
Topics: Animals; Calcineurin; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Immunosuppressive Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Nerve Tissue Proteins; NFATC Transcription Factors; Obesity; Rats; Rats, Zucker; Tacrolimus; Thinness | 2017 |
Cyclosporine improves remyelination in diabetic rats submitted to a gliotoxic demyelinating model in the brainstem.
Topics: Animals; Brain Stem; Cyclosporine; Demyelinating Diseases; Diabetes Mellitus, Experimental; Disease Models, Animal; Ethidium; Nerve Regeneration; Neuroprotective Agents; Rats; Rats, Wistar; Treatment Outcome | 2013 |
Synergism of a natural plant product, oleanolic acid with calcineurin inhibitor in prolonging islet allograft survival.
Topics: Allografts; Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Diabetes Mellitus, Experimental; Drug Synergism; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Mice; Mice, Inbred BALB C; Oleanolic Acid; T-Lymphocytes | 2013 |
Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus.
Topics: Animals; Apoptosis; Calcineurin Inhibitors; Carbohydrate Metabolism; Cell Division; Cyclosporine; Diabetes Mellitus, Experimental; Drug Substitution; Glucose; Glucose Tolerance Test; Homeostasis; Insulin Resistance; Insulin-Secreting Cells; Obesity; Proinsulin; Rats; Rats, Zucker; Tacrolimus | 2015 |
Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Matrix; Fibronectins; Hypertrophy; Indoles; Kidney Glomerulus; Male; Protective Agents; Rats; Streptozocin; Transcription Factors; Tropisetron | 2015 |
[The effects of cyclosporine A on immunoglobulins deposition in retina of streptozotocin-induced diabetic rats].
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Retina; Streptozocin | 2008 |
HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus.
Topics: Animals; Base Sequence; Blotting, Western; Cell Line; Cyclosporine; Diabetes Mellitus, Experimental; DNA Primers; Electrophoretic Mobility Shift Assay; Hepatocyte Nuclear Factor 4; Humans; Phosphorylation; Promoter Regions, Genetic; Rats | 2009 |
Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA Primers; Fibronectins; Immunosuppressive Agents; Laminin; Male; Nephrogenic Fibrosing Dermopathy; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sirolimus; Vascular Endothelial Growth Factor A | 2009 |
PP2B-dependent NO production in the medullary thick ascending limb during diabetes.
Topics: Amidines; Animals; Benzylamines; Calcineurin; Calcineurin Inhibitors; Cell Survival; Cyclic N-Oxides; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Kidney Medulla; Loop of Henle; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Ornithine; Phosphorylation; Rats; Rats, Sprague-Dawley; Spin Labels; Up-Regulation | 2009 |
Influence of sirolimus on cyclosporine-induced pancreas islet dysfunction in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Cyclosporine; Deoxyguanosine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glycated Hemoglobin; Immunohistochemistry; Immunosuppressive Agents; Insulin; Islets of Langerhans; Male; Rats; Rats, Sprague-Dawley; Sirolimus | 2009 |
Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney.
Topics: Albumins; Animals; Blood Urea Nitrogen; Calcineurin; Cyclosporine; Diabetes Mellitus, Experimental; Extracellular Matrix; Glomerular Filtration Rate; Glucose; Hypertrophy; Insulin-Secreting Cells; JNK Mitogen-Activated Protein Kinases; Kidney; MAP Kinase Signaling System; Mice; Mice, Knockout; NFATC Transcription Factors; TOR Serine-Threonine Kinases; Transforming Growth Factor beta | 2011 |
Influence of overt diabetes mellitus on cyclosporine pharmacokinetics in a canine model.
Topics: Alloxan; Animals; Area Under Curve; Blood Glucose; Cholesterol; Cyclosporine; Diabetes Mellitus, Experimental; Dogs; Hypoglycemia; Immunosuppressive Agents; Kinetics; Lipoproteins, LDL; Models, Statistical; Streptozocin | 2009 |
Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia.
Topics: Animals; Apyrase; Arteries; Binding Sites; Blood Glucose; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Disease Models, Animal; Enzyme Inhibitors; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Jurkat Cells; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NFATC Transcription Factors; Osteopontin; Promoter Regions, Genetic; Pyrazoles; RNA, Messenger; Signal Transduction; Time Factors; Transcriptional Activation; Transfection; Uridine Triphosphate | 2010 |
Transplantation of long-term cultured porcine islets in the rat: prolonged graft survival and recipient growth on reduced immunosuppression.
Topics: Animals; Anti-Inflammatory Agents; Cyclophosphamide; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Gadolinium; Graft Rejection; Graft Survival; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Male; Models, Animal; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous | 2010 |
Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Glucose Tolerance Test; Graft Rejection; Graft Survival; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Phenanthrenes; Time Factors; Transplantation, Homologous; Weight Gain | 2010 |
[The protective effects of cyclosporine A on aortic immunological injuries in STZ-induced diabetic rats].
Topics: Animals; Aorta; Aortic Diseases; Cyclosporine; Diabetes Mellitus, Experimental; Endothelium, Vascular; Immunosuppressive Agents; Rats; Rats, Sprague-Dawley | 2010 |
The additive effects of ischemic postconditioning and cyclosporine-A on nitric oxide activity and functions of diabetic myocardium injured by ischemia/reperfusion.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide; Rats; Rats, Wistar; Streptozocin | 2012 |
Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cardiotonic Agents; Cyclosporine; Diabetes Mellitus, Experimental; Glutathione; Glutathione Disulfide; Heart; Hemodynamics; In Vitro Techniques; Male; Minocycline; Mitochondria, Heart; Mitochondrial ADP, ATP Translocases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Oligopeptides; Oxidation-Reduction; Permeability; Rats; Rats, Sprague-Dawley | 2012 |
[The protective effects on the function and structure of retinae in diabetic rats by intravitreal injection of cyclosporin A].
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Intravitreal Injections; Male; Rats; Rats, Sprague-Dawley; Retina | 2012 |
Synergistic effect of surface modification with poly(ethylene glycol) and immunosuppressants on repetitive pancreatic islet transplantation into antecedently sensitized rat.
Topics: Animals; Antibodies, Monoclonal; Biomarkers; Blood Glucose; Coculture Techniques; Cyclosporine; Diabetes Mellitus, Experimental; Drug Synergism; Drug Therapy, Combination; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; L-Lactate Dehydrogenase; Male; Polyethylene Glycols; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Spleen; Time Factors; Tissue Culture Techniques | 2013 |
Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Gene Expression; Hypertrophy; Kidney Glomerulus; Male; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2003 |
Tautomycetin as a novel immunosuppressant in transplantation.
Topics: Animals; Antifungal Agents; Cyclosporine; Diabetes Mellitus, Experimental; Furans; Graft Survival; Heart Transplantation; Histocompatibility Testing; Immunosuppressive Agents; Islets of Langerhans Transplantation; Lipids; Rats; Rats, Inbred Lew; Rats, Wistar; Transplantation, Homologous | 2003 |
Effects of a phorbol ester and cyclosporin A on hippocampal synaptic plasticity in streptozotocin-induced-diabetic rats: reduced sensitivity to phorbol esters.
Topics: Alkaloids; Animals; Benzophenanthridines; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Synaptic Transmission | 2003 |
Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats.
Topics: Animals; Blood Cell Count; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Female; Fingolimod Hydrochloride; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoantibodies; Mice; Mice, Nude; Propylene Glycols; Rats; Rats, Inbred Lew; Sphingosine; Swine; Transplantation, Heterologous | 2003 |
[Short-term effects of cyclosporine A on the function of pancreatic islet cells in normal and spontaneous diabetic Chinese hamsters].
Topics: Animals; Cells, Cultured; Cricetinae; Cyclosporine; Diabetes Mellitus, Experimental; Glucagon; Immunosuppressive Agents; Insulin; Insulin Secretion; Islets of Langerhans | 2003 |
Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1).
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Enzyme Inhibitors; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Janus Kinase 3; Major Histocompatibility Complex; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein-Tyrosine Kinases; Quinazolines | 2003 |
Cyclosporine-induced insulin release in rats is related to an increase in plasma lipid levels.
Topics: Animals; Blood Glucose; Cholesterol; Cyclosporine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose Intolerance; Insulin; Insulin Secretion; Male; Rats; Rats, Wistar; Streptozocin; Triglycerides | 1992 |
Porcine pancreatic icosapeptide as a marker of graft survival and rejection in xenotransplantation.
Topics: Animals; Biomarkers; C-Peptide; Cyclosporine; Diabetes Mellitus, Experimental; Female; Graft Rejection; Graft Survival; Immunosuppressive Agents; Insulin; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Pancreas Transplantation; Pancreatic Polypeptide; Peptide Fragments; Swine; Transplantation, Heterologous | 2003 |
Cyclosporine toxicity in immunosuppressed streptozotocin-diabetic nonhuman primates.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Synergism; Female; Immunocompromised Host; Immunosuppressive Agents; Islets of Langerhans Transplantation; Macaca fascicularis; Male; Renal Insufficiency; Streptozocin | 2005 |
C5b-9 does not mediate chronic tubulointerstitial disease in the absence of proteinuria.
Topics: Animals; Chronic Disease; Complement Membrane Attack Complex; Cyclosporine; Diabetes Mellitus, Experimental; Extracellular Matrix Proteins; Female; Immunohistochemistry; Kidney Tubules; Nephritis, Interstitial; Proteinuria; Rats; Streptozocin; Ureteral Obstruction | 2005 |
Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.
Topics: Animals; Animals, Newborn; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Feasibility Studies; Female; Glucose Tolerance Test; Immunosuppressive Agents; Insulin; Islets of Langerhans Transplantation; Liver; Male; Pancreatectomy; Portal Vein; Sirolimus; Swine; Time Factors | 2005 |
Effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mycophenolic Acid; Rats; Rats, Wistar | 2005 |
Effects of STZ-induced diabetes and its treatment with vanadyl sulphate on cyclosporine A-induced nephrotoxicity in rats.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Glutathione; Hypoglycemic Agents; Immunosuppressive Agents; Kidney; Kidney Diseases; Kidney Function Tests; Male; Malondialdehyde; Organ Size; Rats; Rats, Wistar; Vanadium Compounds | 2005 |
Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats.
Topics: Angiotensin II; Animals; Apoptosis; Cyclosporine; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents; Immunosuppressive Agents; Insulin; Islets of Langerhans; Kidney; Osteopontin; Pancreatic Diseases; Rats; Rats, Sprague-Dawley; Rosiglitazone; Sialoglycoproteins; Thiazolidinediones; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Excipients; Glucose Tolerance Test; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Nephrectomy; Polyethylene Glycols; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Surface Properties | 2006 |
A new strategy toward improving immunoprotection in cell therapy for diabetes mellitus: long-functioning PEGylated islets in vivo.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Polyethylene Glycols; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Tissue Engineering | 2006 |
Urinary thromboxane and 6-keto-prostaglandin F1 alpha are early markers of acute rejection in experimental pancreas transplantation.
Topics: 6-Ketoprostaglandin F1 alpha; Amylases; Animals; Biomarkers; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Graft Rejection; Pancreas Transplantation; Radioimmunoassay; Rats; Thromboxane B2; Transplantation, Homologous; Transplantation, Isogeneic | 1994 |
Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in naive and cyclosporin-treated low-responder murine strains.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Disease Susceptibility; Fatty Acids, Essential; Islets of Langerhans; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Species Specificity; Streptozocin; Time Factors | 1995 |
Prolongation of islet xenograft survival with combined treatment of 15-deoxyspergualin or cyclosporine and anti-CD4 monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; CD4 Antigens; Cells, Cultured; Combined Modality Therapy; Cricetinae; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Guanidines; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Mesocricetus; Mice; Mice, Inbred CBA; Transplantation, Heterologous | 1995 |
Immune privilege of the testis for islet xenotransplantation (rat to mouse).
Topics: Animals; Blood Glucose; Cells, Cultured; Cryptorchidism; Cyclosporine; Diabetes Mellitus, Experimental; Injections, Intraperitoneal; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Male; Mice; Rats; Rats, Inbred WF; Testis; Transplantation, Heterologous | 1994 |
In vivo studies of UV-B-irradiated adult pig islets in diabetic mice.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Glucagon; Graft Survival; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Mice; Mice, Inbred Strains; Swine; Time Factors; Transplantation, Heterologous; Ultraviolet Rays | 1994 |
Immunomodulation and fish-to-mouse islet xenograft survival.
Topics: Animals; Blood Glucose; Cells, Cultured; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, Inbred BALB C; Mice, Nude; Tilapia; Transplantation, Heterologous | 1994 |
Leflunomide and cyclosporin-A prolong fish-to-mouse islet xenograft survival in BALB/C mice.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred BALB C; Tilapia; Transplantation, Heterologous | 1994 |
Effect of cyclosporin A on bone mineral metabolism in experimental diabetes mellitus in the rat.
Topics: Animals; Blood Glucose; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Calcitriol; Calcium; Cyclosporine; Diabetes Mellitus, Experimental; Male; Minerals; Osteocalcin; Osteogenesis; Parathyroid Hormone; Rats; Rats, Sprague-Dawley | 1994 |
Synergistic interaction of 15-deoxyspergualin and cyclosporine to prolong the survival of rat islet allografts.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Synergism; Graft Survival; Guanidines; Immunosuppressive Agents; Islets of Langerhans Transplantation; Rats; Rats, Inbred Lew; Rats, Inbred WF; Regression Analysis; Transplantation, Homologous | 1994 |
Local immunologic factors determine the occurrence of primary nonfunction of islet xenografts.
Topics: Animals; Blood Glucose; Clodronic Acid; Cricetinae; Cyclosporine; Diabetes Mellitus, Experimental; Gamma Rays; Graft Survival; Immunosuppression Therapy; Islets of Langerhans Transplantation; Macrophages; Mesocricetus; Rats; Rats, Inbred Lew; Transplantation, Heterologous; Whole-Body Irradiation | 1994 |
Intraperitoneal transplantation of microencapsulated canine islet allografts with short-term, low-dose cyclosporine for treatment of pancreatectomy-induced diabetes in dogs.
Topics: Animals; Azathioprine; Blood Glucose; Capsules; Cyclosporine; Diabetes Mellitus, Experimental; Dogs; Glucose Tolerance Test; Graft Survival; Islets of Langerhans Transplantation; Pancreatectomy; Peritoneal Cavity; Transplantation, Heterotopic; Transplantation, Homologous | 1994 |
The effects of cyclosporine on morphine-induced antinociception in diabetic mice.
Topics: Analgesics; Animals; Cyclosporine; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Pain Threshold; Spleen | 1993 |
15-Deoxyspergualin prolongs pancreatic islet allo- and xenograft survival in mice.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Graft Rejection; Graft Survival; Guanidines; Immunosuppressive Agents; Islets of Langerhans Transplantation; Mice; Mice, Inbred C57BL; Transplantation, Heterologous; Transplantation, Homologous | 1993 |
Repeated intrahepatic islet allografts restore normoglycemia in cyclosporine-immunosuppressed diabetic pigs.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Female; Immunosuppressive Agents; Islets of Langerhans Transplantation; Liver; Reoperation; Swine; Swine, Miniature; Tissue Donors; Transplantation, Heterotopic; Transplantation, Homologous | 1995 |
In vivo function of pig islet xenografts in immunosuppressed diabetic mice.
Topics: Animals; Antilymphocyte Serum; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Mice; Swine; Tacrolimus; Transplantation, Heterologous | 1995 |
Immunohistological study of islet xenograft rejection in immunosuppressed recipients.
Topics: Animals; CD3 Complex; CD4 Antigens; CD8 Antigens; Cyclosporine; Diabetes Mellitus, Experimental; Graft Rejection; Graft Survival; Guanidines; Immunoglobulins; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans Transplantation; Macrophage-1 Antigen; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-2; Tacrolimus; Transplantation, Heterologous | 1996 |
A simple method for xenotransplanting cells and tissues into rats using uncoated alginate microreactors.
Topics: Alginates; Animals; Antibodies, Heterophile; Biocompatible Materials; Blood Glucose; Cattle; Cyclosporine; Diabetes Mellitus, Experimental; Glucuronic Acid; Hexuronic Acids; Islets of Langerhans Transplantation; Microspheres; Rats; Rats, Inbred Lew; Species Specificity; Swine; Transplantation, Heterologous | 1996 |
Impact of antipassenger lymphocyte globulin on functional graft survival of discordant xenoislet grafts from a large animal donor.
Topics: Animals; Antilymphocyte Serum; Cyclosporine; Diabetes Mellitus, Experimental; Dogs; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Polyenes; Rabbits; Rats; Rats, Inbred Lew; Sirolimus; Time Factors; Transplantation, Heterologous | 1996 |
Prolongation of pancreas allograft survival by mycophenolate mofetil in the rat.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Graft Rejection; Graft Survival; Immunosuppressive Agents; Male; Mycophenolic Acid; Pancreas Transplantation; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Homologous | 1996 |
Perioperative immunosuppression as a critical determinant of early outcome after discordant xenoislet transplantation: a comparative study.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Dogs; Drug Administration Schedule; Drug Therapy, Combination; Graft Survival; Guanidines; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Tacrolimus; Transplantation, Heterologous | 1996 |
Pancreatic xenotransplantation in rabbits.
Topics: Animals; Azathioprine; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Goats; Graft Survival; Immunosuppressive Agents; Pancreas Transplantation; Prednisolone; Rabbits; Transplantation, Heterologous | 1996 |
Effect of new thromboxane A2 synthesis inhibitor tetramethyl-pyrazine on pancreatic transplantation in diabetic rats.
Topics: Albuminuria; Animals; Benzofurans; beta 2-Microglobulin; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Immunosuppressive Agents; Kidney; Organ Size; Pancreas Transplantation; Pyrazines; Rats; Rats, Wistar; Thromboxane A2; Thromboxane-A Synthase; Transplantation, Isogeneic | 1996 |
Abnormalities in the mitochondrial permeability transition in diabetic rats.
Topics: Animals; Blood Glucose; Calcium; Calcium Phosphates; Cyclosporine; Diabetes Mellitus, Experimental; Kinetics; Mitochondria, Liver; Permeability; Peroxides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; tert-Butylhydroperoxide | 1996 |
The effect of combination therapy with cyclosporine A and hydrocortisone on glucose metabolism in diabetic rats following pancreatic islet transplantation.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Carbon Radioisotopes; Creatinine; Cyclosporine; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Therapy, Combination; Fasting; Glucose; Glucose Tolerance Test; Hydrocortisone; Immunosuppressive Agents; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Kidney; Lipid Metabolism; Liver; Portal Vein; Rats; Rats, Wistar | 1995 |
Effect of streptozotocin-induced diabetes on cyclosporin A disposition in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Chromatography, High Pressure Liquid; Cyclosporine; Diabetes Mellitus, Experimental; Gastric Emptying; Gastrointestinal Transit; Immunosuppressive Agents; Injections, Intravenous; Intestinal Absorption; Lymphatic System; Male; Rats; Rats, Wistar | 1996 |
Prevention of autoimmune islet allograft destruction by engraftment of donor T cells.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Flow Cytometry; Graft Rejection; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Lymph Nodes; Lymphocyte Transfusion; Male; Rats; Rats, Inbred BB; Rats, Inbred BN; Rats, Inbred WF; T-Lymphocyte Subsets; T-Lymphocytes; Time Factors; Transplantation, Homologous | 1997 |
Effect of molecular weight exclusion of polysulfone fibers on macroencapsulated pig islet xenograft function in diabetic mice.
Topics: Animals; Biocompatible Materials; Blood Glucose; C-Peptide; Cyclosporine; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Immunosuppressive Agents; Insulin; Islets of Langerhans Transplantation; Membranes, Artificial; Mice; Polymers; Subrenal Capsule Assay; Sulfones; Swine; Time Factors; Transplantation, Heterologous | 1997 |
Effect of leflunomide and cyclosporine on concordant xenogeneic islet transplantation in streptozotocin-induced and autoimmune diabetic mice.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Rats; Rats, Sprague-Dawley; Species Specificity; Transplantation, Heterologous | 1997 |
Successful xenotransplantation of adult porcine islets in NOD and BALB/c mice with leflunomide and cyclosporine.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Graft Survival; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Swine; Transplantation, Heterologous | 1997 |
Effect of non-insulin dependent diabetes on cyclosporin A disposition in Goto-Kakizaki (GK) rats.
Topics: Administration, Oral; Animals; Biological Availability; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastric Emptying; Gastrointestinal Transit; Immunosuppressive Agents; Injections, Intravenous; Lymphatic System; Rats; Rats, Inbred Strains; Rats, Wistar | 1997 |
Pravastatin and low-dose cyclosporine treatment prevent islet allograft rejection in mice.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Graft Rejection; Graft Survival; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Islets of Langerhans Transplantation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pravastatin; Transplantation, Homologous | 1998 |
Xenotransplantation of adult porcine islets in diabetic mice. A study of UVB irradiation, cryopreservation and immunosuppression on graft survival time.
Topics: Animals; Blood Glucose; Cryopreservation; Cyclosporine; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Kinetics; Mice; Swine; Transplantation, Heterologous; Ultraviolet Rays | 1998 |
Foetal rat pancreatic transplantation: posttransplantation development of foetal pancreatic iso- and allografts and suppression of rejection with mycophenolate mofetil (MMF) and cyclosporine based immunesuppression.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Fetal Tissue Transplantation; Graft Rejection; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans; Mycophenolic Acid; Pancreas; Pancreas Transplantation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Transplantation, Homologous; Transplantation, Isogeneic | 1998 |
Effect of cyclosporine on glucose tolerance in streptozotocin-diabetic rats: cyclosporine may deteriorate insulin sensitivity.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Rats; Rats, Sprague-Dawley; Streptozocin | 1999 |
Adenosine receptor antagonism in the prevention of acute cyclosporine A-nephrotoxicity in normal, diabetic and hypertensive rats.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Hypertension; Immunosuppressive Agents; Kidney; Purinergic P1 Receptor Antagonists; Rats; Streptozocin | 1999 |
The fate of donor splenic lymphocytes in a long-surviving host after combined pancrea/spleen transplantation in the rat.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Flow Cytometry; Graft Survival; Immunosuppressive Agents; Lymphocyte Transfusion; Pancreas Transplantation; Rats; Rats, Inbred Strains; Spleen; Transplantation, Homologous | 1999 |
The role of triple immunosuppressive treatment in the successful implantation of islet grafts.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azathioprine; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Glucose Tolerance Test; Immunosuppressive Agents; Islets of Langerhans Transplantation; Prednisolone; Swine; Transplantation, Homologous | 1999 |
Detection of membrane-bound and soluble-form MHC class I antigen from rat pancreas/spleen grafts during ongoing rejection.
Topics: Animals; Cell Membrane; Cyclosporine; Diabetes Mellitus, Experimental; Graft Rejection; Graft Survival; Histocompatibility Antigens Class I; Immunosuppressive Agents; Liver; Lymphocytes; Pancreas Transplantation; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Sirolimus; Spleen; Transplantation, Homologous | 1999 |
Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous | 2000 |
Brazilin augments cellular immunity in multiple low dose streptozotocin (MLD-STZ) induced type I diabetic mice.
Topics: Adjuvants, Immunologic; Animals; Benzopyrans; Cell Division; Concanavalin A; Cyclosporine; Diabetes Mellitus, Experimental; Hypersensitivity, Delayed; Hypoglycemic Agents; Immunity, Cellular; Interleukin-2; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred C57BL; Receptors, Interleukin-2; Spleen; T-Lymphocytes, Regulatory | 2000 |
Effect of cyclosporin-A on the blood--retinal barrier permeability in streptozotocin-induced diabetes.
Topics: Animals; Blood-Retinal Barrier; Cyclooxygenase 2; Cyclosporine; Diabetes Mellitus, Experimental; Immunosuppressive Agents; Interleukin-1; Isoenzymes; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Permeability; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Streptozocin | 2000 |
Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days.
Topics: Animals; Antibodies, Heterophile; Blood Glucose; C-Peptide; Cell Culture Techniques; Cell Separation; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Female; Graft Survival; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Macrophages; Mice; Mice, Nude; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous | 2001 |
Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor.
Topics: ABO Blood-Group System; Animals; Antilymphocyte Serum; Blood Glucose; Bone Marrow Transplantation; C-Peptide; Cell Separation; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Histocompatibility Testing; Immunosuppression Therapy; Insulin; Islets of Langerhans; Macaca fascicularis; Major Histocompatibility Complex; Male; Splenectomy; Transplantation, Homologous; Whole-Body Irradiation | 2001 |
Long-term insulin independence following repeated islet transplantation in totally pancreatectomized diabetic pigs.
Topics: Animals; Blood Glucose; Cells, Cultured; Cyclosporine; Diabetes Mellitus, Experimental; Feasibility Studies; Female; Glucose Tolerance Test; Immunosuppressive Agents; Injections, Intravenous; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Pancreatectomy; Portal Vein; Swine, Miniature; Time Factors; Transplantation, Isogeneic | 2002 |
Effects of cyclosporin A immunosuppression on pancreaticoduodenal transplantation in alloxan-diabetic rats.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Evaluation; Duodenum; Female; Immunohistochemistry; Immunosuppression Therapy; Islets of Langerhans Transplantation; Male; Pancreas; Random Allocation; Rats; Rats, Wistar; Time Factors | 1992 |
Effect of cyclosporine treatment on carnitine and myo-inositol in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Carnitine; Cyclosporine; Diabetes Mellitus, Experimental; Eating; Inositol; Male; Rats; Rats, Inbred Strains | 1992 |
Immunosuppressive effect in combination therapy of cyclosporine A, FK 506, and 15-deoxyspergualin on pancreatic islet xenotransplantation.
Topics: Animals; Cricetinae; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Graft Rejection; Graft Survival; Guanidines; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Male; Mesocricetus; Rats; Rats, Inbred Strains; T-Lymphocytes; Tacrolimus; Thymus Gland; Transplantation, Heterologous | 1992 |
Scale production of porcine isletlike cell clusters and xenotransplantation.
Topics: Animals; Cells, Cultured; Culture Techniques; Cyclosporine; Diabetes Mellitus, Experimental; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Rats; Rats, Wistar; Swine; Transplantation, Heterologous | 1992 |
Transplantation of discordant pig islet xenografts in diabetic rats.
Topics: Agglutination; Animals; Antibody Formation; Antilymphocyte Serum; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Hemagglutination; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Male; Rats; Rats, Inbred ACI; Swine; Time Factors; Transplantation, Heterologous | 1992 |
Cyclosporine therapy concomitant with renal allotransplantation induces tolerance to subsequent donor MHC-identical islet grafts.
Topics: Animals; Animals, Newborn; Cyclosporine; Diabetes Mellitus, Experimental; Immune Tolerance; Islets of Langerhans Transplantation; Kidney Transplantation; Major Histocompatibility Complex; Male; Rats; Rats, Inbred F344; Rats, Inbred WF; Transplantation, Homologous | 1992 |
Histologic classification of pancreatic allograft rejection in the rat.
Topics: Animals; Arteries; Cyclosporine; Diabetes Mellitus, Experimental; Endothelium, Vascular; Graft Rejection; Graft vs Host Disease; Immunosuppression Therapy; Inflammation; Pancreas Transplantation; Rats; Rats, Inbred BN; Rats, Inbred Lew; Time Factors | 1992 |
Intraportal FK 506 improves intrahepatic islet allograft survival.
Topics: Animals; Body Weight; Budesonide; Cyclosporine; Diabetes Mellitus, Experimental; Glucocorticoids; Graft Survival; Injections, Intravenous; Islets of Langerhans Transplantation; Portal Vein; Pregnenediones; Rats; Rats, Inbred Lew; Rats, Inbred WF; Tacrolimus; Transplantation, Homologous | 1991 |
Morphological characteristics of the endocrine pancreas in alloxan diabetes after cyclosporin A administration.
Topics: Animals; Antigen-Presenting Cells; Cyclosporine; Diabetes Mellitus, Experimental; Immunohistochemistry; Islets of Langerhans; Lymphocytes; Male; Rats; Rats, Inbred Strains | 1991 |
Vitamin and micronutrient concentrations in cyclosporine-induced renal tumor from diabetic rats.
Topics: Adenocarcinoma; Animals; Biopterins; Blood Glucose; Carnitine; Cyclosporine; Diabetes Mellitus, Experimental; Inositol; Kidney; Kidney Neoplasms; Male; Rats; Rats, Inbred Strains; Vitamins | 1991 |
Interleukin 2 receptor targeted immunotherapy in the prevention of autoimmune beta-cell destruction as observed in diabetic BB/OK rats grafted with BB/OK rat islets.
Topics: Animals; Antibodies, Monoclonal; Autoimmune Diseases; Combined Modality Therapy; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Immunity, Cellular; Immunotherapy; Islets of Langerhans; Islets of Langerhans Transplantation; Rats; Rats, Inbred BB; Receptors, Interleukin-2 | 1989 |
High dose nicotinamide fails to prevent diabetes in BB rats.
Topics: Age Factors; Animals; Autoimmune Diseases; Blood Glucose; Cyclosporine; Deferoxamine; Diabetes Mellitus, Experimental; DNA Damage; Drug Evaluation, Preclinical; Hyperplasia; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred BB | 1989 |