cyclosporine and Aging

cyclosporine has been researched along with Aging in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	30 (37.04)	18.2507
2000's	33 (40.74)	29.6817
2010's	17 (20.99)	24.3611
2020's	1 (1.23)	2.80

Authors

Authors	Studies
Deng, Z; Jin, M; Li, G; Li, J; Liu, B; Liu, Z; Qian, M; Shi, W; Tang, X; Wang, M; Wang, Z; Xie, H; Zhang, S	1
Bundalo, M; Cvetković, M; Gojković, I; Kostić, M; Spasojević-Dimitrijeva, B; Stanković, A; Zivković, M	1
Arndt, S; Bosserhoff, AK; Fischer, MJM; Gebhardt, L; Karrer, S; Schneider, C; Zimmermann, JL	1
Abbasi, MM; Argani, H; Dastmalchi, S; Ghasemi, B; Ghazizadeh, T; Ghorbanihaghjo, A; Karimi, P; Raeisi, S; Seifi, M	1
Ausk, BJ; Bain, SD; Gardiner, EM; Gross, TS; Kwon, RY; Srinivasan, S; Threet, D; Worton, LE	1
Grubeck-Loebenstein, B; Kern, G; Koppelstaetter, C; Mayer, G; Säemann, MD; Sturm, G; Weinberger, B; Welzl, K	1
Akiyama, S; Ando, M; Ito, Y; Kato, S; Katsuno, T; Kosugi, T; Maruyama, S; Matsuo, S; Mizuno, M; Sato, W; Tsuboi, N; Yamaguchi, M; Yamamoto, R; Yasuda, Y	1
Chakfe, N; Chamaraux-Tran, TN; Charles, AL; Diemunsch, P; Geny, B; Kemmel, V; Kindo, M; Lejay, A; Pottecher, J; Vogel, T; Zoll, J	1
Hesselink, DA; Nauta, J; van Gelder, T; van Schaik, RH	1
Coelho, MC; Mello, ES; Santos, NA; Tannuri, AC; Tannuri, U	1
Johnson, TN; Thomson, M	1
Korkach, IuP; Kotsiuruba, AV; Rudyk, OV; Sahach, VF; Vavilova, HL	1
Chaudhry, RM; Masaoud, E; Muneer, MA; Munir, K; Tiwari, A	1
Colucci, M; D'Ambrosio, A; Giordani, L; Quintieri, F; Vanacore, N	1
Gaudel, C; Giordano, C; Grimaldi, PA; Jehl-Piétri, C; Lopez, P; Murdaca, J; Rousseau, AS; Sibille, B; Wagner, N	1
Belosludtsev, KN; Belosludtseva, NV; Lukyanova, LD; Mironova, GD; Saris, NE; Trudovishnikov, AS	1
Choi, BS; Ghee, JY; Han, DH; Hwang, HS; Kim, J; Piao, SG; Song, JH; Yang, CW	1
Ghee, JY; Han, DH; Kim, S; Kobori, H; Kuro-o, M; Ohashi, N; Piao, S; Song, JH; Yang, CW; Yoon, HE	1
Ausk, BJ; Bain, SD; Gross, TS; Prasad, J; Richardson, TS; Srinivasan, S; Threet, D	1
Benet, LZ; Christians, U; Cummins, CL; Gottschalk, S; Leibfritz, D; Serkova, NJ	1
Dai, J; Gomes, AP; Hafner, AV; Palmeira, CM; Rosenzweig, A; Sinclair, DA; Xiao, CY	1
Gao, G; Gui, Y; Li, D; Li, JJ; Li, Y; Tang, XD; Walsh, MP; Wang, L; Wang, Y; Zheng, XL	1
Brink, PR; Glass, PS; Liu, L; Rebecchi, MJ; Zhu, J	1
Fiscella, RG	1
Kim, J; Lim, SW; Piao, SG; Song, JH; Yang, CW; Yoon, HE	1
Brancho, D; Calvert, JW; Chow, CW; Frank, PG; Ghigo, A; Hirsch, E; Jin, J; Kim, JY; Lefer, DJ; Lisanti, MP; Molkentin, JD; Olabisi, O; Scherer, PE; Suk, HY; Yang, TT; Yang, X; Yu, RY; Zhou, C; Zhu, H	1
Fayen, JD; Jacobberger, JW; Kadereit, S; Laughlin, MJ; Miller, RE; Mohammad, SF; Shurin, SB; Sramkoski, RM; Stein, K; Templeton, D; Woods, KD	1
Galán, AI; González-Gallego, J; Jiménez, R; Muñoz, ME; Palomero, J; Tuñón, MJ	2
Ali-El Dein, B; El-Assmy, A; El-Bahnasawy, MS; El-Hammady, S; El-Sawy, E; Refaie, A; Shehab El-Dein, AB	1
Almeida, OP; Holzhausen, M; Nassar, CA; Nassar, PO; Spolidorio, DM; Spolidorio, LC	1
Bernardini, R; Campa, L; Caputo, R; de Libero, C; Lombardi, E; Massai, C; Novembre, E; Pucci, N; Vierucci, A	1
Tadano, K; Yuhki, Y	1
Blalock, EM; Chen, KC; Kadish, I; Kraner, SD; Landfield, PW; Norris, CM; Porter, NM; Thibault, V	1
Dupuis, LL; Saunders, EF; Taylor, T	1
Bullock, MR; Gilman, CB; Hafez, N; Hamm, RJ; Kunene, NK; Mazzeo, AT	1
Klaassen, C; Kuper, CF; Tegelenbosch-Schouten, M; Van Zijverden, M; Wolterbeek, AP	1
Basile, DP; Donohoe, DL; James, L; Lund, H; Mattson, DL; Spurgeon-Pechman, KR	1
Blancho, G; Brault, Y; Burke, JT; Campistol, JM; Chapman, J; Friend, P; Grandaliano, G; Mota, A; Murgia, MG; Oberbauer, R; Russ, G; Tufveson, G	1
Chen, LZ; Chen, SY; Deng, SX; Fei, JG; Li, J; Li, SX; Meng, FH; Qiu, J; Ren, B; Wang, CX	1
Abberger, T; Aydin, S; Jennings, P; Koppelstaetter, C; Mayer, G; Pfaller, W; Wolf, AM	1
Cho, HJ; Huh, K; Jin, SM; Mook-Jung, I; Youn, HD	1
Casez, JP; del Pozo, E; Jaeger, P; Lippuner, K; MacKenzie, A; Payne, T; Ruch, W	1
Higa, S; Islam, MR; Mimura, G; Murakami, K; Wakugami, T	1
Billingham, ME; Brown, BW; Joshi, A; Masek, MA; Weiss, LM	1
Reams, GP	1
Charlton, RK; Goodrich, JP; Jones, KW; King, TB; Peters, TG; Sill, TM	1
Brezis, M; Greenfeld, Z; Peleg, I; Pisanty, S; Rosen, S	1
Sadrieh, N; Thomas, PE	1
Epstein, S; Jacobs, T; Jee, W; Joffe, I; Katz, I; Ke, HZ; Li, M; Liang, XG; Stein, B	1
Calconi, G; Caldato, C; D'Annibale, A; da Porto, A; Maresca, MC; Mastrosimone, S; Palminteri, G; Vianello, A	1
Minouchi, T; Shibata, N; Shimakawa, H; Yamaji, A	1
Daskalakis, P; Hong, JH; Miles, AM; Sommer, BG; Sumrani, N	1
Flechner, SM; Hodge, EE; Novick, AC; Sankari, BR; Streem, SB; Wyner, LM	1
Ciofani, A; Dussini, N; Golato, M; Liani, M; Salvati, F; Stanziale, R; Tresca, E	1
Cooney, GF; Habucky, K; Hoppu, K	1
Anderson, GW; Even, C; Harty, JT; Palmer, GA; Plagemann, PG; Rowland, RR	1
Berquist, WE; Cacciarelli, TV; Concepcion, W; Cox, KL; Esquivel, CO; Hammer, GB; Moore, DH; So, SK	1
Dahlback, M; Eirefelt, S; Karlsson, BW; Lundin, PD; Pierzynowski, SG; Podlesny, J; Siwinska-Golebiowska, H; Taljanski, W; Westrom, BR	1
Busson, M; Cogny Van Weydevelt, F; Hauet, T; Hurault de Ligny, B; Lebranchu, Y; N'Doye, P; Peyronnet, P; Touchard, G; Toupance, O	1
Aggarwal, S; Gupta, S; Tsuruo, T	1
Erben, RG; Gärtner, R; Stangassinger, M	1
Mizuno, N; Takagi, C; Takahashi, K; Yamamoto, N	1
Heinemann, U; Müller, W; Schuchmann, S	1
Chang, CT; Choc, MG; Cooney, GF; Dunn, SP; Lindsay, C; McDiarmid, S; Smith, HT; Sommerauer, J; Wong, RL	1
Jones, RC; Khehra, RS	1
Kirk, CJ; Miller, RA	1
Fleck, C	1
Itoh, K; Jinbo, T; Kawada, E; Kubota, K; Kurabayashi, H; Matsushima, T; Murakami, H; Shirakura, T; Tamura, J	1
Aberturas, MR; Berges, L; Chacón, M; Guzmán, M; Molpeceres, J	1
Marsh, JC	1
Mather, M; Rottenberg, H	1
Balshaw, RF; Corr, T; Currie, CJ; Keown, PA; Nevill, TJ; Schultz, KR; Strong, DK; Toze, CL	1
Appelbaum, FR; Bensinger, WI; Blume, KG; Bryant, E; Chauncey, TR; Flowers, ME; Georges, GE; Gooley, TA; Grumet, FC; Hegenbart, U; Kiem, HP; Maloney, DG; McSweeney, PA; Minor, S; Molina, AJ; Nash, RA; Niederwieser, D; Radich, J; Sandmaier, BM; Shizuru, JA; Storb, RF; Torok-Storb, B; Wagner, JL; Yu, C	1
Hsu, CF; Hsu, TG; Kong, CW; Liu, TY; Lu, FJ; Tsai, K	1
Benamenyo, JP; Droz, D; Niaudet, P	1
Mather, MW; Rottenberg, H	1
Blalock, EM; Chen, KC; Landfield, PW; Norris, CM; Porter, NM	1
Augustine, JM; Bryson, S; Caspi, J; Diaz, RJ; Ito, S; Martell, MF; Radde, IC; Tsao, PW; Wong, PY; Young, DS	1
Hunt, CM; Stave, GM; Westerkam, WR	1
Azzarone, A; Carrieri, G; Funakoshi, Y; Murase, N; Nalesnik, M; Starzl, TE; Thomson, AW; Todo, S; Woo, J	1

Reviews

6 review(s) available for cyclosporine and Aging

Article	Year
Intestinal metabolism and transport of drugs in children: the effects of age and disease. Journal of pediatric gastroenterology and nutrition, 2008, Volume: 47, Issue:1 Topics: Aging; Biological Availability; Child; Cyclosporine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Humans; Intestinal Absorption; Intestine, Small; Liver; Midazolam; Tissue Distribution	2008
Understanding dry eye disease: a managed care perspective. The American journal of managed care, 2011, Volume: 17 Suppl 16 Topics: Adrenal Cortex Hormones; Aging; Clinical Trials as Topic; Cyclosporine; Dietary Supplements; Eye; Fatty Acids, Essential; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Managed Care Programs; Ophthalmic Solutions; Practice Guidelines as Topic; Quality of Life	2011
[Cyclosporine]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 12 Topics: Aging; Biomarkers; Chromatography, High Pressure Liquid; Cyclosporine; Dosage Forms; Drug Interactions; Drug Monitoring; Food-Drug Interactions; Humans; Immunoassay; Immunosuppressive Agents; Kidney Diseases; Liver Diseases; Specimen Handling	2004
Do calcium channel blockers have renal protective effects? Drugs & aging, 1994, Volume: 5, Issue:4 Topics: Aging; Animals; Calcium Channel Blockers; Clinical Trials as Topic; Cyclosporine; Diabetic Nephropathies; Dihydropyridines; Diltiazem; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension, Renal; Kidney; Kidney Transplantation; Rats; Rats, Inbred SHR; Verapamil	1994
Cyclosporin pharmacokinetics in paediatric transplant recipients. Clinical pharmacokinetics, 1997, Volume: 32, Issue:6 Topics: Adolescent; Adult; Aging; Area Under Curve; Biological Availability; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Drug Monitoring; Heart Transplantation; Humans; Immunosuppressive Agents; Infant; Kidney Transplantation; Liver Transplantation; Middle Aged; Organ Transplantation; Tissue Distribution	1997
Results of immunosuppression in aplastic anaemia. Acta haematologica, 2000, Volume: 103, Issue:1 Topics: Aged; Aging; Anemia, Aplastic; Antilymphocyte Serum; Child; Cyclosporine; Granulocyte Colony-Stimulating Factor; Humans; Immunosuppression Therapy; Immunosuppressive Agents	2000

Trials

7 trial(s) available for cyclosporine and Aging

Article	Year
Patient age and the prognosis of idiopathic membranous nephropathy. PloS one, 2014, Volume: 9, Issue:10 Topics: Age Factors; Aged; Aging; Anti-Inflammatory Agents; Cyclosporine; Follow-Up Studies; Glomerulonephritis, Membranous; Hospitalization; Humans; Immunosuppressive Agents; Japan; Male; Middle Aged; Prednisolone; Prognosis; Proteinuria; Urinary Tract Infections	2014
Effects of salinomycin on cell-mediated immunity of broiler chickens against hydropericardium syndrome and Newcastle disease viruses. Poultry science, 2009, Volume: 88, Issue:1 Topics: Adjuvants, Immunologic; Aging; Animals; Chickens; Cyclophosphamide; Cyclosporine; Immunity, Cellular; Immunosuppressive Agents; Ionophores; Levamisole; Newcastle Disease; Pericardial Effusion; Pyrans; Time Factors	2009
Severe human traumatic brain injury, but not cyclosporin a treatment, depresses activated T lymphocytes early after injury. Journal of neurotrauma, 2006, Volume: 23, Issue:6 Topics: Adult; Aging; Brain; Brain Injuries; CD3 Complex; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cyclosporine; Female; Glasgow Coma Scale; Humans; Immunity, Cellular; Immunosuppressive Agents; Lymphocyte Count; Male; Pilot Projects; Prospective Studies; T-Lymphocytes	2006
Incidence of anemia in sirolimus-treated renal transplant recipients: the importance of preserving renal function. Transplant international : official journal of the European Society for Organ Transplantation, 2007, Volume: 20, Issue:9 Topics: Adolescent; Adult; Aged; Aging; Anemia; Child; Child, Preschool; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Erythropoietin; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Immunosuppressive Agents; Incidence; Kidney; Kidney Transplantation; Linear Models; Longitudinal Studies; Male; Middle Aged; Sirolimus	2007
Maintenance cyclosporin monotherapy after renal transplantation--clinical predictors of long-term outcome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:9 Topics: Adult; Aging; Cyclosporine; Forecasting; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Middle Aged; Postoperative Care; Time Factors; Treatment Failure; Treatment Outcome	1997
Improved cyclosporine bioavailability in black pediatric liver transplant recipients after administration of the microemulsion formulation. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1999, Volume: 5, Issue:2 Topics: Adolescent; Aging; Biological Availability; Black People; Child; Child, Preschool; Cross-Over Studies; Cyclosporine; Emulsions; Female; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Retrospective Studies	1999
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood, 2001, Jun-01, Volume: 97, Issue:11 Topics: Adult; Aged; Aging; Cause of Death; Cyclosporine; Female; Graft Rejection; Graft vs Tumor Effect; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Multiple Myeloma; Mycophenolic Acid; Neutrophils; Platelet Count; Remission Induction; Survival Rate; T-Lymphocytes; Transplantation Conditioning; Whole-Body Irradiation	2001

Other Studies

68 other study(ies) available for cyclosporine and Aging

Article	Year
SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice. The EMBO journal, 2020, 09-15, Volume: 39, Issue:18 Topics: Aging; Animals; Cellular Senescence; Cyclosporine; Hair Follicle; Mice; Mice, Knockout; NFATC Transcription Factors; Sirtuins; Stem Cells	2020
Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia. Therapeutic drug monitoring, 2017, Volume: 39, Issue:6 Topics: Adolescent; Aging; Alleles; Child; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation; Genetic Variation; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Serbia; Transplant Recipients	2017
Cold atmospheric plasma causes a calcium influx in melanoma cells triggering CAP-induced senescence. Scientific reports, 2018, 07-03, Volume: 8, Issue:1 Topics: Aging; Calcium; Calcium Channels; Cell Line, Tumor; Chelating Agents; Cold Temperature; Cryotherapy; Cyclosporine; Endoplasmic Reticulum; Humans; Melanoma; Mitochondria; Plasma Gases; Ryanodine	2018
Oxidative stress-induced renal telomere shortening as a mechanism of cyclosporine-induced nephrotoxicity. Journal of biochemical and molecular toxicology, 2018, Volume: 32, Issue:8 Topics: Aging; Animals; Biomarkers; Body Weight; Creatinine; Cyclosporine; Immunosuppressive Agents; Kidney; Male; Oxidative Stress; Rats, Wistar; Telomerase; Telomere Shortening; Urea	2018
Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton. PloS one, 2014, Volume: 9, Issue:1 Topics: Age Factors; Aging; Animals; Bone and Bones; Cyclosporine; Dose-Response Relationship, Drug; Female; Mice; Osteogenesis	2014
Effect of different immunosuppressive drugs on immune cells from young and old healthy persons. Gerontology, 2014, Volume: 60, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aging; Calcineurin Inhibitors; Cell Proliferation; Cyclosporine; Female; Humans; Hydrogen Peroxide; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Leukocytes, Mononuclear; Male; Phytohemagglutinins; Sirolimus; Tacrolimus; Telomere Shortening; TOR Serine-Threonine Kinases; Young Adult	2014
Skeletal muscle ischemia-reperfusion injury and cyclosporine A in the aging rat. Fundamental & clinical pharmacology, 2016, Volume: 30, Issue:3 Topics: Aging; Animals; Cyclosporine; Enzyme Inhibitors; Male; Muscle, Skeletal; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury	2016
A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. Pharmacogenomics, 2008, Volume: 9, Issue:6 Topics: Adult; Aging; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Cyclosporine; Humans; Immunosuppressive Agents; Inactivation, Metabolic; Kidney Transplantation; Multidrug Resistance-Associated Protein 2; Pharmacogenetics; Polymorphism, Single Nucleotide	2008
Effects of immunosuppressants on hepatocyte cell mitosis during liver regeneration in growing animal models of partial hepatectomy. Transplantation proceedings, 2008, Volume: 40, Issue:5 Topics: Aging; Animals; Animals, Newborn; Animals, Suckling; Cyclosporine; Hepatectomy; Hepatocytes; Immunosuppression Therapy; Immunosuppressive Agents; Kinetics; Liver Regeneration; Methylprednisolone; Mitosis; Mitotic Index; Models, Animal; Rats; Tacrolimus; Weaning	2008
[Mitochondrial permeability transition pore opening inhibition by ecdysterone in heart mitochondria of aging rats]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2008, Volume: 54, Issue:4 Topics: Aging; Animals; Arsenicals; Calcium; Cyclosporine; Ecdysterone; Free Radical Scavengers; Ion Channel Gating; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Superoxides	2008
Modulation of human peripheral blood mononuclear cell proliferative response by diltiazem : in vitro comparison in younger versus older subjects. Drugs & aging, 2009, Volume: 26, Issue:1 Topics: Adult; Age Factors; Aged; Aging; Antibodies, Monoclonal; Antihypertensive Agents; CD3 Complex; Cell Proliferation; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Interleukin-2; Leukocytes, Mononuclear; Male; Middle Aged; Pokeweed Mitogens; Tuberculin; Young Adult	2009
Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice. Pflugers Archiv : European journal of physiology, 2009, Volume: 458, Issue:5 Topics: Aging; Animals; Calcineurin; Calcineurin Inhibitors; Cell Division; Cell Fusion; Cell Nucleus; Citrate (si)-Synthase; Cyclosporine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Muscle Fibers, Fast-Twitch; Muscle Fibers, Skeletal; Muscle, Skeletal; NFATC Transcription Factors; PPAR-beta; Proliferating Cell Nuclear Antigen; Satellite Cells, Skeletal Muscle; Succinate Dehydrogenase; Thiazoles	2009
Physiological aspects of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-induced pore: tissue specificity, age profile and dependence on the animal's adaptation to hypoxia. Journal of bioenergetics and biomembranes, 2009, Volume: 41, Issue:4 Topics: Adaptation, Physiological; Aging; Animals; Calcium; Cells, Cultured; Cyclosporine; Hypoxia; Immunity, Innate; Ion Channel Gating; Mitochondria, Liver; Organ Specificity; Palmitic Acid; Porosity; Rats	2009
Effect of sirolimus on calcineurin inhibitor-induced nephrotoxicity using renal expression of KLOTHO, an antiaging gene. Transplantation, 2010, Jul-27, Volume: 90, Issue:2 Topics: Aging; Animals; Calcineurin Inhibitors; Colforsin; Cyclosporine; DNA Primers; Fibroblast Growth Factor-23; Gene Expression Regulation; Glucuronidase; Immunosuppressive Agents; Kidney; Klotho Proteins; Mice; Nephritis, Interstitial; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sirolimus; Tacrolimus	2010
Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:3 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Angiotensin II; Animals; Blotting, Western; Chronic Disease; Cyclosporine; Deoxyguanosine; Disease Models, Animal; Glucuronidase; Immunoenzyme Techniques; Immunosuppressive Agents; Kidney Diseases; Klotho Proteins; Male; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Vasoconstrictor Agents	2011
Rescuing loading induced bone formation at senescence. PLoS computational biology, 2010, Sep-09, Volume: 6, Issue:9 Topics: Aging; Analysis of Variance; Animals; Biomechanical Phenomena; Bone and Bones; Calcium; Cellular Senescence; Computational Biology; Cyclosporine; Female; Mice; Mice, Inbred C57BL; Models, Biological; NFATC Transcription Factors; Osteocytes; Osteogenesis; Osteoporosis; Reproducibility of Results; Tibia; Weight-Bearing	2010
Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology, 2011, Volume: 32, Issue:1 Topics: Age Factors; Aging; Animals; Blood-Brain Barrier; Brain; Cyclosporine; Energy Metabolism; Everolimus; Female; Immunosuppressive Agents; Male; Rats; Rats, Wistar; Sex Characteristics; Sirolimus	2011
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging, 2010, Volume: 2, Issue:12 Topics: Acetylation; Age Factors; Aging; Amino Acid Sequence; Animals; Cardiomegaly; Cyclophilins; Cyclosporine; Disease Models, Animal; Humans; Lysine; Mice; Mice, 129 Strain; Mice, Knockout; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Myocytes, Cardiac; Peptidyl-Prolyl Isomerase F; Protein Conformation; Sirtuin 3; Structure-Activity Relationship; Time Factors	2010
Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:5 Topics: Aging; Animals; Aorta; Calcineurin Inhibitors; Cyclosporine; Hydrogen Peroxide; Immunosuppressive Agents; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Models, Animal; Oxidants; Oxidative Stress; Signal Transduction; Sirolimus; Tacrolimus; TOR Serine-Threonine Kinases; Vasoconstriction	2011
Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A. Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:5 Topics: Aging; Animals; Cardiotonic Agents; Cell Separation; Cyclosporine; Hemodynamics; Image Processing, Computer-Assisted; Immunosuppressive Agents; In Vitro Techniques; Male; Microscopy, Confocal; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; NAD; Permeability; Rats; Rats, Inbred F344; Reactive Oxygen Species	2011
Statin upregulates the expression of klotho, an anti-aging gene, in experimental cyclosporine nephropathy. Nephron. Experimental nephrology, 2012, Volume: 120, Issue:4 Topics: Aging; Animals; Cyclosporine; Glucuronidase; Immunosuppressive Agents; Kidney; Kidney Diseases; Klotho Proteins; Male; Mice; Pravastatin; Up-Regulation	2012
Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. The Journal of biological chemistry, 2013, Feb-01, Volume: 288, Issue:5 Topics: Aging; Amino Acid Sequence; Animals; Calcineurin; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclosporine; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Hyperlipidemias; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phosphodiesterase Inhibitors; Receptors, Adrenergic, beta; Signal Transduction; Triglycerides	2013
Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes. Experimental hematology, 2002, Volume: 30, Issue:7 Topics: Abatacept; Adult; Aging; Antigens, CD; Antigens, Differentiation; Cell Division; CTLA-4 Antigen; Cyclosporine; DNA-Binding Proteins; Fetal Blood; Flow Cytometry; Gene Expression Regulation; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immune Tolerance; Immunoconjugates; Immunosuppressive Agents; Infant, Newborn; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Transcription Factors; Transcription, Genetic	2002
Effects of aging and cyclosporin treatment on the hepatobiliary efflux of glutathione. Life sciences, 2003, Nov-14, Volume: 73, Issue:26 Topics: Aging; Animals; Biliary Tract; Cyclosporine; Glutathione; Glutathione Disulfide; Immunosuppressive Agents; Injections, Intraperitoneal; Liver; Male; Rats; Rats, Wistar	2003
Critical evaluation of the factors influencing erectile function after renal transplantation. International journal of impotence research, 2004, Volume: 16, Issue:6 Topics: Adolescent; Adult; Aging; Cyclosporine; Diabetes Complications; Erectile Dysfunction; Hemoglobins; Humans; Immunosuppressive Agents; Kidney Transplantation; Logistic Models; Male; Middle Aged; Penile Erection; Prognosis; Surveys and Questionnaires	2004
Influence of age on combined effects of cyclosporin and nifedipine on rat alveolar bone. Journal of periodontology, 2004, Volume: 75, Issue:2 Topics: Administration, Oral; Aging; Alkaline Phosphatase; Alveolar Process; Animals; Bone Density; Bone Marrow; Calcium; Calcium Channel Blockers; Cyclosporine; Image Processing, Computer-Assisted; Immunosuppressive Agents; Injections, Subcutaneous; Male; Nifedipine; Rats; Rats, Wistar; Time Factors	2004
Long eyelashes in a case series of 93 children with vernal keratoconjunctivitis. Pediatrics, 2005, Volume: 115, Issue:1 Topics: Adolescent; Aging; Case-Control Studies; Child; Child, Preschool; Conjunctivitis, Allergic; Cyclosporine; Eyelashes; Female; Humans; Immunosuppressive Agents; Male; Multivariate Analysis; Reference Values	2005
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, May-04, Volume: 25, Issue:18 Topics: Adenoviridae; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Calcineurin; Cells, Cultured; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Fluorescent Antibody Technique; Genetic Vectors; Glial Fibrillary Acidic Protein; Immunohistochemistry; Inflammation; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microarray Analysis; Presenilin-1; Rats; Rats, Inbred F344; Up-Regulation	2005
Disposition of two oral formulations of cyclosporine in pediatric patients receiving hematopoietic stem cell transplants. Pharmacotherapy, 2006, Volume: 26, Issue:1 Topics: Adolescent; Aging; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Child; Child, Preschool; Cyclosporine; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Liver Function Tests; Male; Pharmaceutical Solutions; Sex Characteristics	2006
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age. Toxicologic pathology, 2007, Volume: 35, Issue:2 Topics: Administration, Oral; Aging; Animals; Cell Count; Cyclophosphamide; Cyclosporine; Female; Germinal Center; Immunosuppressive Agents; Injections, Intravenous; Male; Peyer's Patches; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar	2007
Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:1 Topics: Acute Kidney Injury; Aging; Animals; Blood Pressure; Capillaries; Catecholamines; Creatinine; Cyclosporine; Diet; Disease Progression; Hypertension, Renal; Immunohistochemistry; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Glomerulus; Kidney Tubules; Male; Organ Size; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Sodium; Sodium, Dietary	2007
Population pharmacokinetics of mycophenolic acid in senile Chinese kidney transplant recipients. Transplantation proceedings, 2007, Volume: 39, Issue:5 Topics: Adult; Aged; Aging; Area Under Curve; China; Cyclosporine; Humans; Immunosuppressive Agents; Liver Function Tests; Middle Aged; Mycophenolic Acid	2007
Cyclosporine A induces senescence in renal tubular epithelial cells. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:3 Topics: Aging; Apoptosis; Cell Line; Cyclosporine; DNA; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Kidney Tubules; Necrosis; RNA, Messenger; Time Factors	2007
Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling. Aging cell, 2008, Volume: 7, Issue:2 Topics: Active Transport, Cell Nucleus; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Calcineurin; Calcineurin Inhibitors; Calcium; Calcium Signaling; Cells, Cultured; Chelating Agents; Cyclosporine; Disease Models, Animal; DNA-Binding Proteins; Egtazic Acid; Enzyme Activation; Humans; Ionophores; Mice; Neuroblastoma; NFATC Transcription Factors; Promoter Regions, Genetic; Up-Regulation	2008
Different effects of cyclosporin A on bone remodeling in young and adult rats. Bone, 1995, Volume: 16, Issue:4 Suppl Topics: Absorptiometry, Photon; Administration, Oral; Aging; Amino Acids; Analysis of Variance; Animals; Bone Density; Bone Remodeling; Creatinine; Cyclosporine; Female; Osteocalcin; Rats; Rats, Wistar; Tibia	1995
Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin. The Tohoku journal of experimental medicine, 1993, Volume: 169, Issue:1 Topics: Aging; Animals; Cyclosporine; Diabetes Mellitus, Type 1; Female; Fluorescent Antibody Technique; Lymphocyte Subsets; Male; Pancreas; Rats; Rats, Inbred BB; Tacrolimus	1993
"Quilty" revisited: a 10-year perspective. Human pathology, 1995, Volume: 26, Issue:5 Topics: Adolescent; Adult; Aging; Biopsy; Cardiomyopathies; Coronary Disease; Cyclosporine; Endocardium; Female; Graft Rejection; Heart Transplantation; Humans; Immunohistochemistry; Lymphoid Tissue; Lymphoproliferative Disorders; Male; Myocardium; Postoperative Care; Postoperative Period; Sex Characteristics; Virus Diseases	1995
Kidney transplantation in the older patient. The Journal of the Florida Medical Association, 1994, Volume: 81, Issue:8 Topics: Aged; Aging; Azathioprine; Cause of Death; Cyclosporine; Female; Florida; Follow-Up Studies; Graft Rejection; Graft Survival; Humans; Kidney Transplantation; Male; Middle Aged; Muromonab-CD3; Prednisone; Survival Rate; Treatment Outcome	1994
Potential interaction between prolonged cyclosporin administration and aging in the rat kidney. Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717 Topics: Aging; Animals; Collagen; Cyclosporine; Kidney; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger	1994
Characterization of rat cytochrome P450 isozymes involved in the covalent binding of cyclosporin A to microsomal proteins. Toxicology and applied pharmacology, 1994, Volume: 127, Issue:2 Topics: Aging; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Catalysis; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Female; Glutathione; Isoenzymes; Kidney; Male; Mannitol; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Testosterone; Tritium; Troleandomycin	1994
Influence of age on cyclosporin A-induced alterations in bone mineral metabolism in the rat in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1994, Volume: 9, Issue:1 Topics: Administration, Oral; Aging; Animals; Blood Urea Nitrogen; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Calcitriol; Calcium; Creatinine; Cyclosporine; Disease Models, Animal; Male; Osteocalcin; Osteoporosis; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Tibia	1994
Influence of donor age on cadaver kidney graft function and survival: univariate and multivariate analyses. Nephron, 1993, Volume: 65, Issue:4 Topics: Adolescent; Adult; Age Factors; Aged; Aging; Cadaver; Child; Cyclosporine; Female; Graft Survival; Humans; Immunosuppression Therapy; Kidney; Kidney Transplantation; Male; Middle Aged; Multivariate Analysis; Tissue Donors	1993
Pharmacokinetics of cyclosporin A after intravenous administration to rats in various disease states. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:11 Topics: Acute Kidney Injury; Aging; Anemia; Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Liver Failure, Acute; Male; Metabolic Clearance Rate; Organ Transplantation; Rats; Rats, Sprague-Dawley	1993
The influence of donor age on function of renal allografts from live related donors. Clinical nephrology, 1993, Volume: 39, Issue:5 Topics: Adult; Age Factors; Aging; Cyclosporine; Female; Graft Rejection; Graft Survival; Histocompatibility Testing; Humans; Kidney Transplantation; Male; Retrospective Studies; Time Factors; Tissue Donors	1993
Long-term follow-up of kidneys transplanted from elderly cadaveric donors. World journal of urology, 1996, Volume: 14, Issue:4 Topics: Adolescent; Adult; Aged; Aging; Cadaver; Child; Cyclosporine; Female; Follow-Up Studies; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Longitudinal Studies; Male; Middle Aged; Tissue Donors; Treatment Outcome	1996
Abnormalities of GPIb and GPIIb/IIIa platelet surface glycoproteins in adult and paediatric renal transplant patients. Nephron, 1997, Volume: 75, Issue:3 Topics: Adult; Aging; Blood Platelets; Child; Cyclosporine; Fibrinogen; Humans; Immunosuppressive Agents; Kidney Transplantation; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex	1997
C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age. Journal of neurovirology, 1995, Volume: 1, Issue:3-4 Topics: Aging; Animals; Antibodies, Viral; Arterivirus Infections; Blotting, Northern; Cyclosporine; Female; Immune System; Immunosuppressive Agents; Lactate dehydrogenase-elevating virus; Leukemia Virus, Murine; Male; Mice; Mice, Inbred AKR; Mice, Transgenic; Motor Neuron Disease; Poliomyelitis; RNA, Viral; Spinal Cord	1995
Factors affecting survival after orthotopic liver transplantation in infants. Transplantation, 1997, Jul-27, Volume: 64, Issue:2 Topics: Aging; Antilymphocyte Serum; Cause of Death; Cyclosporine; Graft Rejection; Graft Survival; Humans; Infant; Liver Transplantation; Lymphoproliferative Disorders; Portal Vein; Retrospective Studies; Survival Rate; Thrombosis	1997
Pulmonary delivery of intratracheally instilled and aerosolized cyclosporine A to young and adult rats. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:8 Topics: Aerosols; Aging; Animals; Biological Availability; Cyclosporine; Female; Glycerol; Half-Life; Lung; Male; Rats; Rats, Sprague-Dawley; Trachea	1997
Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans. Journal of clinical immunology, 1997, Volume: 17, Issue:6 Topics: Adult; Aged; Aging; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Gene Expression; Genes, MDR; Humans; Immunosuppressive Agents; T-Lymphocyte Subsets	1997
Skeletal effects of low-dose cyclosporin A in aged male rats: lack of relationship to serum testosterone levels. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998, Volume: 13, Issue:1 Topics: Aging; Animals; Body Weight; Bone and Bones; Calcification, Physiologic; Cell Count; Cyclosporine; Eating; Injections, Subcutaneous; Linear Models; Male; Osteoclasts; Osteogenesis; Rats; Rats, Wistar; Testosterone	1998
Effect of cyclosporine A on the gastrointestinal absorption of acyclovir in neonatal and adult rats. Biology of the neonate, 1998, Volume: 74, Issue:3 Topics: Acyclovir; Aging; Animals; Animals, Newborn; Antiviral Agents; Biological Availability; Cyclosporine; Digestive System; Drug Interactions; Female; Immunosuppressive Agents; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Kidney; Kinetics; Male; Rats; Rats, Wistar; Weight Gain	1998
Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Sep-15, Volume: 18, Issue:18 Topics: Aging; Alzheimer Disease; Animals; Calcium; Carcinogens; Cell Death; Cyclosporine; Diploidy; Disease Models, Animal; Down Syndrome; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Karyotyping; Male; Membrane Potentials; Mice; Mice, Neurologic Mutants; Mitochondria; NADP; Neurons; Potassium; Quinoxalines; Signal Transduction; Trisomy; Vitamin E	1998
Investigation into avian pneumovirus persistence in poults and chicks using cyclosporin A immunosuppression. Research in veterinary science, 1999, Volume: 66, Issue:2 Topics: Aging; Animals; Chickens; Cloaca; Cyclosporine; Harderian Gland; Immunosuppressive Agents; Kidney; Lung; Pneumovirus; Pneumovirus Infections; Poultry Diseases; Time Factors; Trachea; Turbinates	1999
Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells. Cellular immunology, 1999, Nov-01, Volume: 197, Issue:2 Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Ceramides; Colforsin; Cyclosporine; Dimethyl Sulfoxide; Enzyme Activation; Humans; Hydrogen Peroxide; Immunologic Memory; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; MAP Kinase Kinase 4; MAP Kinase Kinase 7; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Sorbitol; Ultraviolet Rays	1999
Determination of the glomerular filtration rate (GFR): methodological problems, age-dependence, consequences of various surgical interventions, and the influence of different drugs and toxic substances. Physiological research, 1999, Volume: 48, Issue:4 Topics: Aging; Animals; Cyclosporine; Female; Fluorescein-5-isothiocyanate; Glomerular Filtration Rate; Humans; Inulin; Kidney; Kidney Diseases; Kinetics; Metals; Nephrectomy; Rats; Rats, Wistar; Species Specificity; Uremia	1999
[The role of protein kinases and phosphatases in erythroid colony formation of elderly]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1999, Volume: 36, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Aging; Cyclosporine; Erythroid Precursor Cells; Hematopoiesis; Humans; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Protein Kinases; Tacrolimus	1999
Dependency of cyclosporine tissue distribution and metabolism on the age and gender of rats after a single intravenous dose. International journal of pharmaceutics, 2000, Mar-20, Volume: 197, Issue:1-2 Topics: Aging; Algorithms; Animals; Antibodies, Monoclonal; Area Under Curve; Cyclosporine; Feces; Female; Fluorescence Polarization Immunoassay; Immunosuppressive Agents; Injections, Intravenous; Male; Rats; Rats, Wistar; Sex Characteristics; Tissue Distribution	2000
Aging enhances the activation of the permeability transition pore in mitochondria. Biochemical and biophysical research communications, 2000, Jul-05, Volume: 273, Issue:2 Topics: Aging; Animals; Apoptosis; Brain; Calcium; Cyclosporine; In Vitro Techniques; Lymphocytes; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitochondria; Mitochondria, Liver; Permeability	2000
Effect of gastrointestinal inflammation and age on the pharmacokinetics of oral microemulsion cyclosporin A in the first month after bone marrow transplantation. Bone marrow transplantation, 2000, Volume: 26, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aging; Area Under Curve; Bone Marrow Transplantation; Child; Child, Preschool; Cohort Studies; Cyclosporine; Drug Compounding; Emulsions; Gastroenteritis; Humans; Immunosuppressive Agents; Infant; Infusions, Intravenous; Middle Aged; Time Factors	2000
Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes. Free radical biology & medicine, 2001, Apr-15, Volume: 30, Issue:8 Topics: Aging; Animals; Antioxidants; Bile Acids and Salts; Bilirubin; Catalase; Cyclosporine; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Liver; Male; Oxidation-Reduction; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Transaminases	2001
Age-related changes in the mitochondrial depolarization induced by oxidative injury in human peripheral blood leukocytes. Free radical research, 2001, Volume: 35, Issue:4 Topics: Adult; Aged; Aging; Cell Line; Cyclosporine; Female; Flow Cytometry; Humans; Immunosuppressive Agents; Leukocytes; Male; Membrane Potentials; Middle Aged; Mitochondria; Oxidation-Reduction; Oxidative Stress; tert-Butylhydroperoxide	2001
One-year routine renal transplant biopsies in children. Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:12 Topics: Acute Disease; Adolescent; Adult; Aging; Biopsy; Child; Child, Preschool; Cryopreservation; Cyclosporine; Female; Graft Rejection; Humans; Immunosuppressive Agents; Incidence; Kidney; Kidney Diseases; Kidney Transplantation; Male; Postoperative Period; Renal Circulation; Time Factors; Vascular Diseases	2001
The inhibition of calcium signaling in T lymphocytes from old mice results from enhanced activation of the mitochondrial permeability transition pore. Mechanisms of ageing and development, 2002, Mar-31, Volume: 123, Issue:6 Topics: Aging; Animals; Calcium; Calcium Signaling; Cells, Cultured; Cyclosporine; Female; Flavin-Adenine Dinucleotide; Fluorescent Dyes; Immunologic Memory; Intracellular Membranes; Ion Channels; Ionomycin; Ionophores; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidation-Reduction; Rhodamine 123; Spleen; Superoxides; T-Lymphocytes	2002
Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture. Neuroscience, 2002, Volume: 110, Issue:2 Topics: Aging; Animals; Apoptosis Regulatory Proteins; Calcineurin; Calcineurin Inhibitors; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Carrier Proteins; Cell Differentiation; Cells, Cultured; Chelating Agents; Cyclosporine; Female; Fetus; Hippocampus; Immunosuppressive Agents; Membrane Potentials; Neurons; Phosphoprotein Phosphatases; Pregnancy; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tacrolimus; Tacrolimus Binding Protein 1A	2002
Pharmacodynamics and pharmacokinetics of cyclosporin A in the newborn pig. Developmental pharmacology and therapeutics, 1992, Volume: 18, Issue:1-2 Topics: Aging; Animals; Animals, Newborn; Cell Division; Cells, Cultured; Cyclosporine; Infusions, Intravenous; Lymphocytes; Swine	1992
Effect of age and gender on the activity of human hepatic CYP3A. Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking	1992
Effect of FK 506 in the prophylaxis of autoimmune glomerulonephritis in NZB/WF1 mice. Transplantation proceedings, 1991, Volume: 23, Issue:6 Topics: Aging; Animals; Autoantibodies; Concanavalin A; Cyclosporine; DNA; Female; Glomerulonephritis, IGA; Lymphocyte Activation; Mice; Mice, Inbred Strains; Spleen; Tacrolimus	1991