cyclosporine has been researched along with Aging in 81 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 30 (37.04) | 18.2507 |
2000's | 33 (40.74) | 29.6817 |
2010's | 17 (20.99) | 24.3611 |
2020's | 1 (1.23) | 2.80 |
Authors | Studies |
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Deng, Z; Jin, M; Li, G; Li, J; Liu, B; Liu, Z; Qian, M; Shi, W; Tang, X; Wang, M; Wang, Z; Xie, H; Zhang, S | 1 |
Bundalo, M; Cvetković, M; Gojković, I; Kostić, M; Spasojević-Dimitrijeva, B; Stanković, A; Zivković, M | 1 |
Arndt, S; Bosserhoff, AK; Fischer, MJM; Gebhardt, L; Karrer, S; Schneider, C; Zimmermann, JL | 1 |
Abbasi, MM; Argani, H; Dastmalchi, S; Ghasemi, B; Ghazizadeh, T; Ghorbanihaghjo, A; Karimi, P; Raeisi, S; Seifi, M | 1 |
Ausk, BJ; Bain, SD; Gardiner, EM; Gross, TS; Kwon, RY; Srinivasan, S; Threet, D; Worton, LE | 1 |
Grubeck-Loebenstein, B; Kern, G; Koppelstaetter, C; Mayer, G; Säemann, MD; Sturm, G; Weinberger, B; Welzl, K | 1 |
Akiyama, S; Ando, M; Ito, Y; Kato, S; Katsuno, T; Kosugi, T; Maruyama, S; Matsuo, S; Mizuno, M; Sato, W; Tsuboi, N; Yamaguchi, M; Yamamoto, R; Yasuda, Y | 1 |
Chakfe, N; Chamaraux-Tran, TN; Charles, AL; Diemunsch, P; Geny, B; Kemmel, V; Kindo, M; Lejay, A; Pottecher, J; Vogel, T; Zoll, J | 1 |
Hesselink, DA; Nauta, J; van Gelder, T; van Schaik, RH | 1 |
Coelho, MC; Mello, ES; Santos, NA; Tannuri, AC; Tannuri, U | 1 |
Johnson, TN; Thomson, M | 1 |
Korkach, IuP; Kotsiuruba, AV; Rudyk, OV; Sahach, VF; Vavilova, HL | 1 |
Chaudhry, RM; Masaoud, E; Muneer, MA; Munir, K; Tiwari, A | 1 |
Colucci, M; D'Ambrosio, A; Giordani, L; Quintieri, F; Vanacore, N | 1 |
Gaudel, C; Giordano, C; Grimaldi, PA; Jehl-Piétri, C; Lopez, P; Murdaca, J; Rousseau, AS; Sibille, B; Wagner, N | 1 |
Belosludtsev, KN; Belosludtseva, NV; Lukyanova, LD; Mironova, GD; Saris, NE; Trudovishnikov, AS | 1 |
Choi, BS; Ghee, JY; Han, DH; Hwang, HS; Kim, J; Piao, SG; Song, JH; Yang, CW | 1 |
Ghee, JY; Han, DH; Kim, S; Kobori, H; Kuro-o, M; Ohashi, N; Piao, S; Song, JH; Yang, CW; Yoon, HE | 1 |
Ausk, BJ; Bain, SD; Gross, TS; Prasad, J; Richardson, TS; Srinivasan, S; Threet, D | 1 |
Benet, LZ; Christians, U; Cummins, CL; Gottschalk, S; Leibfritz, D; Serkova, NJ | 1 |
Dai, J; Gomes, AP; Hafner, AV; Palmeira, CM; Rosenzweig, A; Sinclair, DA; Xiao, CY | 1 |
Gao, G; Gui, Y; Li, D; Li, JJ; Li, Y; Tang, XD; Walsh, MP; Wang, L; Wang, Y; Zheng, XL | 1 |
Brink, PR; Glass, PS; Liu, L; Rebecchi, MJ; Zhu, J | 1 |
Fiscella, RG | 1 |
Kim, J; Lim, SW; Piao, SG; Song, JH; Yang, CW; Yoon, HE | 1 |
Brancho, D; Calvert, JW; Chow, CW; Frank, PG; Ghigo, A; Hirsch, E; Jin, J; Kim, JY; Lefer, DJ; Lisanti, MP; Molkentin, JD; Olabisi, O; Scherer, PE; Suk, HY; Yang, TT; Yang, X; Yu, RY; Zhou, C; Zhu, H | 1 |
Fayen, JD; Jacobberger, JW; Kadereit, S; Laughlin, MJ; Miller, RE; Mohammad, SF; Shurin, SB; Sramkoski, RM; Stein, K; Templeton, D; Woods, KD | 1 |
Galán, AI; González-Gallego, J; Jiménez, R; Muñoz, ME; Palomero, J; Tuñón, MJ | 2 |
Ali-El Dein, B; El-Assmy, A; El-Bahnasawy, MS; El-Hammady, S; El-Sawy, E; Refaie, A; Shehab El-Dein, AB | 1 |
Almeida, OP; Holzhausen, M; Nassar, CA; Nassar, PO; Spolidorio, DM; Spolidorio, LC | 1 |
Bernardini, R; Campa, L; Caputo, R; de Libero, C; Lombardi, E; Massai, C; Novembre, E; Pucci, N; Vierucci, A | 1 |
Tadano, K; Yuhki, Y | 1 |
Blalock, EM; Chen, KC; Kadish, I; Kraner, SD; Landfield, PW; Norris, CM; Porter, NM; Thibault, V | 1 |
Dupuis, LL; Saunders, EF; Taylor, T | 1 |
Bullock, MR; Gilman, CB; Hafez, N; Hamm, RJ; Kunene, NK; Mazzeo, AT | 1 |
Klaassen, C; Kuper, CF; Tegelenbosch-Schouten, M; Van Zijverden, M; Wolterbeek, AP | 1 |
Basile, DP; Donohoe, DL; James, L; Lund, H; Mattson, DL; Spurgeon-Pechman, KR | 1 |
Blancho, G; Brault, Y; Burke, JT; Campistol, JM; Chapman, J; Friend, P; Grandaliano, G; Mota, A; Murgia, MG; Oberbauer, R; Russ, G; Tufveson, G | 1 |
Chen, LZ; Chen, SY; Deng, SX; Fei, JG; Li, J; Li, SX; Meng, FH; Qiu, J; Ren, B; Wang, CX | 1 |
Abberger, T; Aydin, S; Jennings, P; Koppelstaetter, C; Mayer, G; Pfaller, W; Wolf, AM | 1 |
Cho, HJ; Huh, K; Jin, SM; Mook-Jung, I; Youn, HD | 1 |
Casez, JP; del Pozo, E; Jaeger, P; Lippuner, K; MacKenzie, A; Payne, T; Ruch, W | 1 |
Higa, S; Islam, MR; Mimura, G; Murakami, K; Wakugami, T | 1 |
Billingham, ME; Brown, BW; Joshi, A; Masek, MA; Weiss, LM | 1 |
Reams, GP | 1 |
Charlton, RK; Goodrich, JP; Jones, KW; King, TB; Peters, TG; Sill, TM | 1 |
Brezis, M; Greenfeld, Z; Peleg, I; Pisanty, S; Rosen, S | 1 |
Sadrieh, N; Thomas, PE | 1 |
Epstein, S; Jacobs, T; Jee, W; Joffe, I; Katz, I; Ke, HZ; Li, M; Liang, XG; Stein, B | 1 |
Calconi, G; Caldato, C; D'Annibale, A; da Porto, A; Maresca, MC; Mastrosimone, S; Palminteri, G; Vianello, A | 1 |
Minouchi, T; Shibata, N; Shimakawa, H; Yamaji, A | 1 |
Daskalakis, P; Hong, JH; Miles, AM; Sommer, BG; Sumrani, N | 1 |
Flechner, SM; Hodge, EE; Novick, AC; Sankari, BR; Streem, SB; Wyner, LM | 1 |
Ciofani, A; Dussini, N; Golato, M; Liani, M; Salvati, F; Stanziale, R; Tresca, E | 1 |
Cooney, GF; Habucky, K; Hoppu, K | 1 |
Anderson, GW; Even, C; Harty, JT; Palmer, GA; Plagemann, PG; Rowland, RR | 1 |
Berquist, WE; Cacciarelli, TV; Concepcion, W; Cox, KL; Esquivel, CO; Hammer, GB; Moore, DH; So, SK | 1 |
Dahlback, M; Eirefelt, S; Karlsson, BW; Lundin, PD; Pierzynowski, SG; Podlesny, J; Siwinska-Golebiowska, H; Taljanski, W; Westrom, BR | 1 |
Busson, M; Cogny Van Weydevelt, F; Hauet, T; Hurault de Ligny, B; Lebranchu, Y; N'Doye, P; Peyronnet, P; Touchard, G; Toupance, O | 1 |
Aggarwal, S; Gupta, S; Tsuruo, T | 1 |
Erben, RG; Gärtner, R; Stangassinger, M | 1 |
Mizuno, N; Takagi, C; Takahashi, K; Yamamoto, N | 1 |
Heinemann, U; Müller, W; Schuchmann, S | 1 |
Chang, CT; Choc, MG; Cooney, GF; Dunn, SP; Lindsay, C; McDiarmid, S; Smith, HT; Sommerauer, J; Wong, RL | 1 |
Jones, RC; Khehra, RS | 1 |
Kirk, CJ; Miller, RA | 1 |
Fleck, C | 1 |
Itoh, K; Jinbo, T; Kawada, E; Kubota, K; Kurabayashi, H; Matsushima, T; Murakami, H; Shirakura, T; Tamura, J | 1 |
Aberturas, MR; Berges, L; Chacón, M; Guzmán, M; Molpeceres, J | 1 |
Marsh, JC | 1 |
Mather, M; Rottenberg, H | 1 |
Balshaw, RF; Corr, T; Currie, CJ; Keown, PA; Nevill, TJ; Schultz, KR; Strong, DK; Toze, CL | 1 |
Appelbaum, FR; Bensinger, WI; Blume, KG; Bryant, E; Chauncey, TR; Flowers, ME; Georges, GE; Gooley, TA; Grumet, FC; Hegenbart, U; Kiem, HP; Maloney, DG; McSweeney, PA; Minor, S; Molina, AJ; Nash, RA; Niederwieser, D; Radich, J; Sandmaier, BM; Shizuru, JA; Storb, RF; Torok-Storb, B; Wagner, JL; Yu, C | 1 |
Hsu, CF; Hsu, TG; Kong, CW; Liu, TY; Lu, FJ; Tsai, K | 1 |
Benamenyo, JP; Droz, D; Niaudet, P | 1 |
Mather, MW; Rottenberg, H | 1 |
Blalock, EM; Chen, KC; Landfield, PW; Norris, CM; Porter, NM | 1 |
Augustine, JM; Bryson, S; Caspi, J; Diaz, RJ; Ito, S; Martell, MF; Radde, IC; Tsao, PW; Wong, PY; Young, DS | 1 |
Hunt, CM; Stave, GM; Westerkam, WR | 1 |
Azzarone, A; Carrieri, G; Funakoshi, Y; Murase, N; Nalesnik, M; Starzl, TE; Thomson, AW; Todo, S; Woo, J | 1 |
6 review(s) available for cyclosporine and Aging
Article | Year |
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Intestinal metabolism and transport of drugs in children: the effects of age and disease.
Topics: Aging; Biological Availability; Child; Cyclosporine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Humans; Intestinal Absorption; Intestine, Small; Liver; Midazolam; Tissue Distribution | 2008 |
Understanding dry eye disease: a managed care perspective.
Topics: Adrenal Cortex Hormones; Aging; Clinical Trials as Topic; Cyclosporine; Dietary Supplements; Eye; Fatty Acids, Essential; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Managed Care Programs; Ophthalmic Solutions; Practice Guidelines as Topic; Quality of Life | 2011 |
[Cyclosporine].
Topics: Aging; Biomarkers; Chromatography, High Pressure Liquid; Cyclosporine; Dosage Forms; Drug Interactions; Drug Monitoring; Food-Drug Interactions; Humans; Immunoassay; Immunosuppressive Agents; Kidney Diseases; Liver Diseases; Specimen Handling | 2004 |
Do calcium channel blockers have renal protective effects?
Topics: Aging; Animals; Calcium Channel Blockers; Clinical Trials as Topic; Cyclosporine; Diabetic Nephropathies; Dihydropyridines; Diltiazem; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension, Renal; Kidney; Kidney Transplantation; Rats; Rats, Inbred SHR; Verapamil | 1994 |
Cyclosporin pharmacokinetics in paediatric transplant recipients.
Topics: Adolescent; Adult; Aging; Area Under Curve; Biological Availability; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Drug Monitoring; Heart Transplantation; Humans; Immunosuppressive Agents; Infant; Kidney Transplantation; Liver Transplantation; Middle Aged; Organ Transplantation; Tissue Distribution | 1997 |
Results of immunosuppression in aplastic anaemia.
Topics: Aged; Aging; Anemia, Aplastic; Antilymphocyte Serum; Child; Cyclosporine; Granulocyte Colony-Stimulating Factor; Humans; Immunosuppression Therapy; Immunosuppressive Agents | 2000 |
7 trial(s) available for cyclosporine and Aging
Article | Year |
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Patient age and the prognosis of idiopathic membranous nephropathy.
Topics: Age Factors; Aged; Aging; Anti-Inflammatory Agents; Cyclosporine; Follow-Up Studies; Glomerulonephritis, Membranous; Hospitalization; Humans; Immunosuppressive Agents; Japan; Male; Middle Aged; Prednisolone; Prognosis; Proteinuria; Urinary Tract Infections | 2014 |
Effects of salinomycin on cell-mediated immunity of broiler chickens against hydropericardium syndrome and Newcastle disease viruses.
Topics: Adjuvants, Immunologic; Aging; Animals; Chickens; Cyclophosphamide; Cyclosporine; Immunity, Cellular; Immunosuppressive Agents; Ionophores; Levamisole; Newcastle Disease; Pericardial Effusion; Pyrans; Time Factors | 2009 |
Severe human traumatic brain injury, but not cyclosporin a treatment, depresses activated T lymphocytes early after injury.
Topics: Adult; Aging; Brain; Brain Injuries; CD3 Complex; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cyclosporine; Female; Glasgow Coma Scale; Humans; Immunity, Cellular; Immunosuppressive Agents; Lymphocyte Count; Male; Pilot Projects; Prospective Studies; T-Lymphocytes | 2006 |
Incidence of anemia in sirolimus-treated renal transplant recipients: the importance of preserving renal function.
Topics: Adolescent; Adult; Aged; Aging; Anemia; Child; Child, Preschool; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Erythropoietin; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Immunosuppressive Agents; Incidence; Kidney; Kidney Transplantation; Linear Models; Longitudinal Studies; Male; Middle Aged; Sirolimus | 2007 |
Maintenance cyclosporin monotherapy after renal transplantation--clinical predictors of long-term outcome.
Topics: Adult; Aging; Cyclosporine; Forecasting; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Middle Aged; Postoperative Care; Time Factors; Treatment Failure; Treatment Outcome | 1997 |
Improved cyclosporine bioavailability in black pediatric liver transplant recipients after administration of the microemulsion formulation.
Topics: Adolescent; Aging; Biological Availability; Black People; Child; Child, Preschool; Cross-Over Studies; Cyclosporine; Emulsions; Female; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Retrospective Studies | 1999 |
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects.
Topics: Adult; Aged; Aging; Cause of Death; Cyclosporine; Female; Graft Rejection; Graft vs Tumor Effect; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Multiple Myeloma; Mycophenolic Acid; Neutrophils; Platelet Count; Remission Induction; Survival Rate; T-Lymphocytes; Transplantation Conditioning; Whole-Body Irradiation | 2001 |
68 other study(ies) available for cyclosporine and Aging
Article | Year |
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SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice.
Topics: Aging; Animals; Cellular Senescence; Cyclosporine; Hair Follicle; Mice; Mice, Knockout; NFATC Transcription Factors; Sirtuins; Stem Cells | 2020 |
Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia.
Topics: Adolescent; Aging; Alleles; Child; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation; Genetic Variation; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Serbia; Transplant Recipients | 2017 |
Cold atmospheric plasma causes a calcium influx in melanoma cells triggering CAP-induced senescence.
Topics: Aging; Calcium; Calcium Channels; Cell Line, Tumor; Chelating Agents; Cold Temperature; Cryotherapy; Cyclosporine; Endoplasmic Reticulum; Humans; Melanoma; Mitochondria; Plasma Gases; Ryanodine | 2018 |
Oxidative stress-induced renal telomere shortening as a mechanism of cyclosporine-induced nephrotoxicity.
Topics: Aging; Animals; Biomarkers; Body Weight; Creatinine; Cyclosporine; Immunosuppressive Agents; Kidney; Male; Oxidative Stress; Rats, Wistar; Telomerase; Telomere Shortening; Urea | 2018 |
Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton.
Topics: Age Factors; Aging; Animals; Bone and Bones; Cyclosporine; Dose-Response Relationship, Drug; Female; Mice; Osteogenesis | 2014 |
Effect of different immunosuppressive drugs on immune cells from young and old healthy persons.
Topics: Adult; Aged; Aged, 80 and over; Aging; Calcineurin Inhibitors; Cell Proliferation; Cyclosporine; Female; Humans; Hydrogen Peroxide; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Leukocytes, Mononuclear; Male; Phytohemagglutinins; Sirolimus; Tacrolimus; Telomere Shortening; TOR Serine-Threonine Kinases; Young Adult | 2014 |
Skeletal muscle ischemia-reperfusion injury and cyclosporine A in the aging rat.
Topics: Aging; Animals; Cyclosporine; Enzyme Inhibitors; Male; Muscle, Skeletal; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury | 2016 |
A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine.
Topics: Adult; Aging; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Cyclosporine; Humans; Immunosuppressive Agents; Inactivation, Metabolic; Kidney Transplantation; Multidrug Resistance-Associated Protein 2; Pharmacogenetics; Polymorphism, Single Nucleotide | 2008 |
Effects of immunosuppressants on hepatocyte cell mitosis during liver regeneration in growing animal models of partial hepatectomy.
Topics: Aging; Animals; Animals, Newborn; Animals, Suckling; Cyclosporine; Hepatectomy; Hepatocytes; Immunosuppression Therapy; Immunosuppressive Agents; Kinetics; Liver Regeneration; Methylprednisolone; Mitosis; Mitotic Index; Models, Animal; Rats; Tacrolimus; Weaning | 2008 |
[Mitochondrial permeability transition pore opening inhibition by ecdysterone in heart mitochondria of aging rats].
Topics: Aging; Animals; Arsenicals; Calcium; Cyclosporine; Ecdysterone; Free Radical Scavengers; Ion Channel Gating; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Superoxides | 2008 |
Modulation of human peripheral blood mononuclear cell proliferative response by diltiazem : in vitro comparison in younger versus older subjects.
Topics: Adult; Age Factors; Aged; Aging; Antibodies, Monoclonal; Antihypertensive Agents; CD3 Complex; Cell Proliferation; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Interleukin-2; Leukocytes, Mononuclear; Male; Middle Aged; Pokeweed Mitogens; Tuberculin; Young Adult | 2009 |
Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice.
Topics: Aging; Animals; Calcineurin; Calcineurin Inhibitors; Cell Division; Cell Fusion; Cell Nucleus; Citrate (si)-Synthase; Cyclosporine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Muscle Fibers, Fast-Twitch; Muscle Fibers, Skeletal; Muscle, Skeletal; NFATC Transcription Factors; PPAR-beta; Proliferating Cell Nuclear Antigen; Satellite Cells, Skeletal Muscle; Succinate Dehydrogenase; Thiazoles | 2009 |
Physiological aspects of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-induced pore: tissue specificity, age profile and dependence on the animal's adaptation to hypoxia.
Topics: Adaptation, Physiological; Aging; Animals; Calcium; Cells, Cultured; Cyclosporine; Hypoxia; Immunity, Innate; Ion Channel Gating; Mitochondria, Liver; Organ Specificity; Palmitic Acid; Porosity; Rats | 2009 |
Effect of sirolimus on calcineurin inhibitor-induced nephrotoxicity using renal expression of KLOTHO, an antiaging gene.
Topics: Aging; Animals; Calcineurin Inhibitors; Colforsin; Cyclosporine; DNA Primers; Fibroblast Growth Factor-23; Gene Expression Regulation; Glucuronidase; Immunosuppressive Agents; Kidney; Klotho Proteins; Mice; Nephritis, Interstitial; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sirolimus; Tacrolimus | 2010 |
Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Angiotensin II; Animals; Blotting, Western; Chronic Disease; Cyclosporine; Deoxyguanosine; Disease Models, Animal; Glucuronidase; Immunoenzyme Techniques; Immunosuppressive Agents; Kidney Diseases; Klotho Proteins; Male; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Vasoconstrictor Agents | 2011 |
Rescuing loading induced bone formation at senescence.
Topics: Aging; Analysis of Variance; Animals; Biomechanical Phenomena; Bone and Bones; Calcium; Cellular Senescence; Computational Biology; Cyclosporine; Female; Mice; Mice, Inbred C57BL; Models, Biological; NFATC Transcription Factors; Osteocytes; Osteogenesis; Osteoporosis; Reproducibility of Results; Tibia; Weight-Bearing | 2010 |
Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.
Topics: Age Factors; Aging; Animals; Blood-Brain Barrier; Brain; Cyclosporine; Energy Metabolism; Everolimus; Female; Immunosuppressive Agents; Male; Rats; Rats, Wistar; Sex Characteristics; Sirolimus | 2011 |
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Topics: Acetylation; Age Factors; Aging; Amino Acid Sequence; Animals; Cardiomegaly; Cyclophilins; Cyclosporine; Disease Models, Animal; Humans; Lysine; Mice; Mice, 129 Strain; Mice, Knockout; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Myocytes, Cardiac; Peptidyl-Prolyl Isomerase F; Protein Conformation; Sirtuin 3; Structure-Activity Relationship; Time Factors | 2010 |
Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility.
Topics: Aging; Animals; Aorta; Calcineurin Inhibitors; Cyclosporine; Hydrogen Peroxide; Immunosuppressive Agents; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Models, Animal; Oxidants; Oxidative Stress; Signal Transduction; Sirolimus; Tacrolimus; TOR Serine-Threonine Kinases; Vasoconstriction | 2011 |
Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A.
Topics: Aging; Animals; Cardiotonic Agents; Cell Separation; Cyclosporine; Hemodynamics; Image Processing, Computer-Assisted; Immunosuppressive Agents; In Vitro Techniques; Male; Microscopy, Confocal; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; NAD; Permeability; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2011 |
Statin upregulates the expression of klotho, an anti-aging gene, in experimental cyclosporine nephropathy.
Topics: Aging; Animals; Cyclosporine; Glucuronidase; Immunosuppressive Agents; Kidney; Kidney Diseases; Klotho Proteins; Male; Mice; Pravastatin; Up-Regulation | 2012 |
Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
Topics: Aging; Amino Acid Sequence; Animals; Calcineurin; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclosporine; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Hyperlipidemias; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phosphodiesterase Inhibitors; Receptors, Adrenergic, beta; Signal Transduction; Triglycerides | 2013 |
Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.
Topics: Abatacept; Adult; Aging; Antigens, CD; Antigens, Differentiation; Cell Division; CTLA-4 Antigen; Cyclosporine; DNA-Binding Proteins; Fetal Blood; Flow Cytometry; Gene Expression Regulation; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immune Tolerance; Immunoconjugates; Immunosuppressive Agents; Infant, Newborn; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Transcription Factors; Transcription, Genetic | 2002 |
Effects of aging and cyclosporin treatment on the hepatobiliary efflux of glutathione.
Topics: Aging; Animals; Biliary Tract; Cyclosporine; Glutathione; Glutathione Disulfide; Immunosuppressive Agents; Injections, Intraperitoneal; Liver; Male; Rats; Rats, Wistar | 2003 |
Critical evaluation of the factors influencing erectile function after renal transplantation.
Topics: Adolescent; Adult; Aging; Cyclosporine; Diabetes Complications; Erectile Dysfunction; Hemoglobins; Humans; Immunosuppressive Agents; Kidney Transplantation; Logistic Models; Male; Middle Aged; Penile Erection; Prognosis; Surveys and Questionnaires | 2004 |
Influence of age on combined effects of cyclosporin and nifedipine on rat alveolar bone.
Topics: Administration, Oral; Aging; Alkaline Phosphatase; Alveolar Process; Animals; Bone Density; Bone Marrow; Calcium; Calcium Channel Blockers; Cyclosporine; Image Processing, Computer-Assisted; Immunosuppressive Agents; Injections, Subcutaneous; Male; Nifedipine; Rats; Rats, Wistar; Time Factors | 2004 |
Long eyelashes in a case series of 93 children with vernal keratoconjunctivitis.
Topics: Adolescent; Aging; Case-Control Studies; Child; Child, Preschool; Conjunctivitis, Allergic; Cyclosporine; Eyelashes; Female; Humans; Immunosuppressive Agents; Male; Multivariate Analysis; Reference Values | 2005 |
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.
Topics: Adenoviridae; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Calcineurin; Cells, Cultured; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Fluorescent Antibody Technique; Genetic Vectors; Glial Fibrillary Acidic Protein; Immunohistochemistry; Inflammation; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microarray Analysis; Presenilin-1; Rats; Rats, Inbred F344; Up-Regulation | 2005 |
Disposition of two oral formulations of cyclosporine in pediatric patients receiving hematopoietic stem cell transplants.
Topics: Adolescent; Aging; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Child; Child, Preschool; Cyclosporine; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Liver Function Tests; Male; Pharmaceutical Solutions; Sex Characteristics | 2006 |
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age.
Topics: Administration, Oral; Aging; Animals; Cell Count; Cyclophosphamide; Cyclosporine; Female; Germinal Center; Immunosuppressive Agents; Injections, Intravenous; Male; Peyer's Patches; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2007 |
Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium.
Topics: Acute Kidney Injury; Aging; Animals; Blood Pressure; Capillaries; Catecholamines; Creatinine; Cyclosporine; Diet; Disease Progression; Hypertension, Renal; Immunohistochemistry; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Glomerulus; Kidney Tubules; Male; Organ Size; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Sodium; Sodium, Dietary | 2007 |
Population pharmacokinetics of mycophenolic acid in senile Chinese kidney transplant recipients.
Topics: Adult; Aged; Aging; Area Under Curve; China; Cyclosporine; Humans; Immunosuppressive Agents; Liver Function Tests; Middle Aged; Mycophenolic Acid | 2007 |
Cyclosporine A induces senescence in renal tubular epithelial cells.
Topics: Aging; Apoptosis; Cell Line; Cyclosporine; DNA; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Kidney Tubules; Necrosis; RNA, Messenger; Time Factors | 2007 |
Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling.
Topics: Active Transport, Cell Nucleus; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Calcineurin; Calcineurin Inhibitors; Calcium; Calcium Signaling; Cells, Cultured; Chelating Agents; Cyclosporine; Disease Models, Animal; DNA-Binding Proteins; Egtazic Acid; Enzyme Activation; Humans; Ionophores; Mice; Neuroblastoma; NFATC Transcription Factors; Promoter Regions, Genetic; Up-Regulation | 2008 |
Different effects of cyclosporin A on bone remodeling in young and adult rats.
Topics: Absorptiometry, Photon; Administration, Oral; Aging; Amino Acids; Analysis of Variance; Animals; Bone Density; Bone Remodeling; Creatinine; Cyclosporine; Female; Osteocalcin; Rats; Rats, Wistar; Tibia | 1995 |
Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin.
Topics: Aging; Animals; Cyclosporine; Diabetes Mellitus, Type 1; Female; Fluorescent Antibody Technique; Lymphocyte Subsets; Male; Pancreas; Rats; Rats, Inbred BB; Tacrolimus | 1993 |
"Quilty" revisited: a 10-year perspective.
Topics: Adolescent; Adult; Aging; Biopsy; Cardiomyopathies; Coronary Disease; Cyclosporine; Endocardium; Female; Graft Rejection; Heart Transplantation; Humans; Immunohistochemistry; Lymphoid Tissue; Lymphoproliferative Disorders; Male; Myocardium; Postoperative Care; Postoperative Period; Sex Characteristics; Virus Diseases | 1995 |
Kidney transplantation in the older patient.
Topics: Aged; Aging; Azathioprine; Cause of Death; Cyclosporine; Female; Florida; Follow-Up Studies; Graft Rejection; Graft Survival; Humans; Kidney Transplantation; Male; Middle Aged; Muromonab-CD3; Prednisone; Survival Rate; Treatment Outcome | 1994 |
Potential interaction between prolonged cyclosporin administration and aging in the rat kidney.
Topics: Aging; Animals; Collagen; Cyclosporine; Kidney; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Characterization of rat cytochrome P450 isozymes involved in the covalent binding of cyclosporin A to microsomal proteins.
Topics: Aging; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Catalysis; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Female; Glutathione; Isoenzymes; Kidney; Male; Mannitol; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Testosterone; Tritium; Troleandomycin | 1994 |
Influence of age on cyclosporin A-induced alterations in bone mineral metabolism in the rat in vivo.
Topics: Administration, Oral; Aging; Animals; Blood Urea Nitrogen; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Calcitriol; Calcium; Creatinine; Cyclosporine; Disease Models, Animal; Male; Osteocalcin; Osteoporosis; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Tibia | 1994 |
Influence of donor age on cadaver kidney graft function and survival: univariate and multivariate analyses.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Cadaver; Child; Cyclosporine; Female; Graft Survival; Humans; Immunosuppression Therapy; Kidney; Kidney Transplantation; Male; Middle Aged; Multivariate Analysis; Tissue Donors | 1993 |
Pharmacokinetics of cyclosporin A after intravenous administration to rats in various disease states.
Topics: Acute Kidney Injury; Aging; Anemia; Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Liver Failure, Acute; Male; Metabolic Clearance Rate; Organ Transplantation; Rats; Rats, Sprague-Dawley | 1993 |
The influence of donor age on function of renal allografts from live related donors.
Topics: Adult; Age Factors; Aging; Cyclosporine; Female; Graft Rejection; Graft Survival; Histocompatibility Testing; Humans; Kidney Transplantation; Male; Retrospective Studies; Time Factors; Tissue Donors | 1993 |
Long-term follow-up of kidneys transplanted from elderly cadaveric donors.
Topics: Adolescent; Adult; Aged; Aging; Cadaver; Child; Cyclosporine; Female; Follow-Up Studies; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Longitudinal Studies; Male; Middle Aged; Tissue Donors; Treatment Outcome | 1996 |
Abnormalities of GPIb and GPIIb/IIIa platelet surface glycoproteins in adult and paediatric renal transplant patients.
Topics: Adult; Aging; Blood Platelets; Child; Cyclosporine; Fibrinogen; Humans; Immunosuppressive Agents; Kidney Transplantation; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex | 1997 |
C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age.
Topics: Aging; Animals; Antibodies, Viral; Arterivirus Infections; Blotting, Northern; Cyclosporine; Female; Immune System; Immunosuppressive Agents; Lactate dehydrogenase-elevating virus; Leukemia Virus, Murine; Male; Mice; Mice, Inbred AKR; Mice, Transgenic; Motor Neuron Disease; Poliomyelitis; RNA, Viral; Spinal Cord | 1995 |
Factors affecting survival after orthotopic liver transplantation in infants.
Topics: Aging; Antilymphocyte Serum; Cause of Death; Cyclosporine; Graft Rejection; Graft Survival; Humans; Infant; Liver Transplantation; Lymphoproliferative Disorders; Portal Vein; Retrospective Studies; Survival Rate; Thrombosis | 1997 |
Pulmonary delivery of intratracheally instilled and aerosolized cyclosporine A to young and adult rats.
Topics: Aerosols; Aging; Animals; Biological Availability; Cyclosporine; Female; Glycerol; Half-Life; Lung; Male; Rats; Rats, Sprague-Dawley; Trachea | 1997 |
Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans.
Topics: Adult; Aged; Aging; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Gene Expression; Genes, MDR; Humans; Immunosuppressive Agents; T-Lymphocyte Subsets | 1997 |
Skeletal effects of low-dose cyclosporin A in aged male rats: lack of relationship to serum testosterone levels.
Topics: Aging; Animals; Body Weight; Bone and Bones; Calcification, Physiologic; Cell Count; Cyclosporine; Eating; Injections, Subcutaneous; Linear Models; Male; Osteoclasts; Osteogenesis; Rats; Rats, Wistar; Testosterone | 1998 |
Effect of cyclosporine A on the gastrointestinal absorption of acyclovir in neonatal and adult rats.
Topics: Acyclovir; Aging; Animals; Animals, Newborn; Antiviral Agents; Biological Availability; Cyclosporine; Digestive System; Drug Interactions; Female; Immunosuppressive Agents; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Kidney; Kinetics; Male; Rats; Rats, Wistar; Weight Gain | 1998 |
Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome.
Topics: Aging; Alzheimer Disease; Animals; Calcium; Carcinogens; Cell Death; Cyclosporine; Diploidy; Disease Models, Animal; Down Syndrome; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Karyotyping; Male; Membrane Potentials; Mice; Mice, Neurologic Mutants; Mitochondria; NADP; Neurons; Potassium; Quinoxalines; Signal Transduction; Trisomy; Vitamin E | 1998 |
Investigation into avian pneumovirus persistence in poults and chicks using cyclosporin A immunosuppression.
Topics: Aging; Animals; Chickens; Cloaca; Cyclosporine; Harderian Gland; Immunosuppressive Agents; Kidney; Lung; Pneumovirus; Pneumovirus Infections; Poultry Diseases; Time Factors; Trachea; Turbinates | 1999 |
Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells.
Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Ceramides; Colforsin; Cyclosporine; Dimethyl Sulfoxide; Enzyme Activation; Humans; Hydrogen Peroxide; Immunologic Memory; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; MAP Kinase Kinase 4; MAP Kinase Kinase 7; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Sorbitol; Ultraviolet Rays | 1999 |
Determination of the glomerular filtration rate (GFR): methodological problems, age-dependence, consequences of various surgical interventions, and the influence of different drugs and toxic substances.
Topics: Aging; Animals; Cyclosporine; Female; Fluorescein-5-isothiocyanate; Glomerular Filtration Rate; Humans; Inulin; Kidney; Kidney Diseases; Kinetics; Metals; Nephrectomy; Rats; Rats, Wistar; Species Specificity; Uremia | 1999 |
[The role of protein kinases and phosphatases in erythroid colony formation of elderly].
Topics: Adult; Aged; Aged, 80 and over; Aging; Cyclosporine; Erythroid Precursor Cells; Hematopoiesis; Humans; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Protein Kinases; Tacrolimus | 1999 |
Dependency of cyclosporine tissue distribution and metabolism on the age and gender of rats after a single intravenous dose.
Topics: Aging; Algorithms; Animals; Antibodies, Monoclonal; Area Under Curve; Cyclosporine; Feces; Female; Fluorescence Polarization Immunoassay; Immunosuppressive Agents; Injections, Intravenous; Male; Rats; Rats, Wistar; Sex Characteristics; Tissue Distribution | 2000 |
Aging enhances the activation of the permeability transition pore in mitochondria.
Topics: Aging; Animals; Apoptosis; Brain; Calcium; Cyclosporine; In Vitro Techniques; Lymphocytes; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitochondria; Mitochondria, Liver; Permeability | 2000 |
Effect of gastrointestinal inflammation and age on the pharmacokinetics of oral microemulsion cyclosporin A in the first month after bone marrow transplantation.
Topics: Administration, Oral; Adolescent; Adult; Aging; Area Under Curve; Bone Marrow Transplantation; Child; Child, Preschool; Cohort Studies; Cyclosporine; Drug Compounding; Emulsions; Gastroenteritis; Humans; Immunosuppressive Agents; Infant; Infusions, Intravenous; Middle Aged; Time Factors | 2000 |
Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes.
Topics: Aging; Animals; Antioxidants; Bile Acids and Salts; Bilirubin; Catalase; Cyclosporine; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Liver; Male; Oxidation-Reduction; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Transaminases | 2001 |
Age-related changes in the mitochondrial depolarization induced by oxidative injury in human peripheral blood leukocytes.
Topics: Adult; Aged; Aging; Cell Line; Cyclosporine; Female; Flow Cytometry; Humans; Immunosuppressive Agents; Leukocytes; Male; Membrane Potentials; Middle Aged; Mitochondria; Oxidation-Reduction; Oxidative Stress; tert-Butylhydroperoxide | 2001 |
One-year routine renal transplant biopsies in children.
Topics: Acute Disease; Adolescent; Adult; Aging; Biopsy; Child; Child, Preschool; Cryopreservation; Cyclosporine; Female; Graft Rejection; Humans; Immunosuppressive Agents; Incidence; Kidney; Kidney Diseases; Kidney Transplantation; Male; Postoperative Period; Renal Circulation; Time Factors; Vascular Diseases | 2001 |
The inhibition of calcium signaling in T lymphocytes from old mice results from enhanced activation of the mitochondrial permeability transition pore.
Topics: Aging; Animals; Calcium; Calcium Signaling; Cells, Cultured; Cyclosporine; Female; Flavin-Adenine Dinucleotide; Fluorescent Dyes; Immunologic Memory; Intracellular Membranes; Ion Channels; Ionomycin; Ionophores; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidation-Reduction; Rhodamine 123; Spleen; Superoxides; T-Lymphocytes | 2002 |
Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture.
Topics: Aging; Animals; Apoptosis Regulatory Proteins; Calcineurin; Calcineurin Inhibitors; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Carrier Proteins; Cell Differentiation; Cells, Cultured; Chelating Agents; Cyclosporine; Female; Fetus; Hippocampus; Immunosuppressive Agents; Membrane Potentials; Neurons; Phosphoprotein Phosphatases; Pregnancy; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tacrolimus; Tacrolimus Binding Protein 1A | 2002 |
Pharmacodynamics and pharmacokinetics of cyclosporin A in the newborn pig.
Topics: Aging; Animals; Animals, Newborn; Cell Division; Cells, Cultured; Cyclosporine; Infusions, Intravenous; Lymphocytes; Swine | 1992 |
Effect of age and gender on the activity of human hepatic CYP3A.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking | 1992 |
Effect of FK 506 in the prophylaxis of autoimmune glomerulonephritis in NZB/WF1 mice.
Topics: Aging; Animals; Autoantibodies; Concanavalin A; Cyclosporine; DNA; Female; Glomerulonephritis, IGA; Lymphocyte Activation; Mice; Mice, Inbred Strains; Spleen; Tacrolimus | 1991 |