Page last updated: 2024-08-21

cyclopropanecarboxylic acid and Propionic Acidemia

cyclopropanecarboxylic acid has been researched along with Propionic Acidemia in 1 studies

*Propionic Acidemia: Autosomal recessive metabolic disorder caused by mutations in PROPIONYL-COA CARBOXYLASE genes that result in dysfunction of branch chain amino acids and of the metabolism of certain fatty acids. Neonatal clinical onset is characterized by severe metabolic acidemia accompanied by hyperammonemia, HYPERGLYCEMIA, lethargy, vomiting, HYPOTONIA; and HEPATOMEGALY. Survivors of the neonatal onset propionic acidemia often show developmental retardation, and intolerance to dietary proteins. Late-onset form of the disease shows mild mental and/or developmental retardation, sometimes without metabolic acidemia. [MeSH]

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Armstrong, AJ; Collado, MS; Dillberger, JE; Figler, RA; Henke, BR; Hoang, SA; Johns, BA; Olson, MW; Pourtaheri, TD; Reardon, JE; Roper, TD; Taylor, JM; Wamhoff, BR1

Other Studies

1 other study(ies) available for cyclopropanecarboxylic acid and Propionic Acidemia

ArticleYear
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.
    Journal of medicinal chemistry, 2021, 04-22, Volume: 64, Issue:8

    Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Animals; Area Under Curve; Butyrates; Cells, Cultured; Dogs; Drug Evaluation, Preclinical; Half-Life; Hepatocytes; Humans; Mice; Models, Biological; Propionic Acidemia; Rats; ROC Curve; Structure-Activity Relationship

2021