cycloprodigiosin and Disease-Models--Animal

Cycloprodigiosin hydrochloride (cPrG*HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG*HCl was also observed in vivo. These results indicate that cPrG*HCl is a potent antimalarial drug.

Topics: Animals; Antimalarials; Disease Models, Animal; Drug Evaluation, Preclinical; Gram-Negative Aerobic Bacteria; Humans; In Vitro Techniques; Indoles; Malaria; Male; Mice; Mice, Inbred ICR; Plasmodium falciparum; Pyrroles