Page last updated: 2024-10-25

cyclopentolate and Retrolental Fibroplasia

cyclopentolate has been researched along with Retrolental Fibroplasia in 19 studies

Cyclopentolate: A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
cyclopentolate : A carboxylic ester resulting from the formal condensation of (1-hydroxycyclopentyl)(phenyl)acetic acid with N,N-dimethylethanolamine. A tertiary amine antimuscarinic with actions similar to atropine, it is used as its hydrochloride salt to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action.

Research Excerpts

ExcerptRelevanceReference
"Preterm infants undergoing Retinopathy of Prematurity Eye Exams (ROPEE) may experience adverse events, possibly from systemic absorption of cyclopentolate."9.22Systemic Absorption of Cyclopentolate and Adverse Events After Retinopathy of Prematurity Exams. ( Erickson, SW; Hall, RW; Hendrickson, H; Lowery, S; Mitchell, A; Yates, C, 2016)
"We report for the first time, to our knowledge, the acquisition of noncontact ultra-wide-field oral fluorescein angiograms in premature infants with retinopathy of prematurity."7.80Noncontact high-resolution ultra-wide-field oral fluorescein angiography in premature infants with retinopathy of prematurity. ( Fung, TH; Mordant, DJ; Muqit, MM; Patel, CK; Smith, LM, 2014)
"Cyclopentolate is standardly used in ophthalmologic examinations of neonates to facilitate screening for retinopathy of prematurity."7.80Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice. ( El-Remessy, AB; Goei, S; Manasco, KB; Matragoon, S; Rozette, NA; Sethi, S, 2014)
"Preterm infants undergoing Retinopathy of Prematurity Eye Exams (ROPEE) may experience adverse events, possibly from systemic absorption of cyclopentolate."5.22Systemic Absorption of Cyclopentolate and Adverse Events After Retinopathy of Prematurity Exams. ( Erickson, SW; Hall, RW; Hendrickson, H; Lowery, S; Mitchell, A; Yates, C, 2016)
" Caffeine is frequently used for apnea of prematurity."3.83Atrial arrhythmia after newborn eye exam, to caffeine or not to caffeine? ( Ahmad, A; Klein, B; Mondal, T, 2016)
"We report for the first time, to our knowledge, the acquisition of noncontact ultra-wide-field oral fluorescein angiograms in premature infants with retinopathy of prematurity."3.80Noncontact high-resolution ultra-wide-field oral fluorescein angiography in premature infants with retinopathy of prematurity. ( Fung, TH; Mordant, DJ; Muqit, MM; Patel, CK; Smith, LM, 2014)
"Cyclopentolate is standardly used in ophthalmologic examinations of neonates to facilitate screening for retinopathy of prematurity."3.80Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice. ( El-Remessy, AB; Goei, S; Manasco, KB; Matragoon, S; Rozette, NA; Sethi, S, 2014)
"A 2-month-old girl who had been born at 27-weeks' gestation was admitted for her screening examination for retinopathy of prematurity and given two drops each of cyclopentolate 0."3.71Acute gastric dilatation complicating the use of mydriatics in a preterm newborn. ( Sarici, SU; Unal, S; Yurdakök, M, 2001)
" These agents are rarely absorbed to systemic circulation and in some cases result with serious side effects like skin rash, tachycardia, feeding intolerance, discomfort, apnea, gastric dilatation and ileus, despite different treatment models and dosage reducing strategies."1.40Fatal necrotising enterocolitis due to mydriatic eye drops. ( Demet, T; Mehmet, Y; Murat, S; Nilgun, K; Ozge, KA; Ozgun, U; Zafer, D, 2014)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.53)18.7374
1990's2 (10.53)18.2507
2000's2 (10.53)29.6817
2010's10 (52.63)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Kremer, LJ2
Medlicott, N2
Sime, MJ3
Broadbent, R3
Edmonds, L2
Berry, MJ1
Austin, NC1
Alsweiler, JM1
Reith, DM2
McCaffrey, F1
Kremer, L1
Reith, D1
Medlicott, NJ1
Moshfeghi, DM1
Silva, RA1
Berrocal, AM1
Fung, TH1
Muqit, MM1
Mordant, DJ1
Smith, LM1
Patel, CK1
Lee, JM1
Kodsi, SR1
Gaffar, MA1
Rubin, SE1
Rozette, NA1
Matragoon, S1
Sethi, S1
Goei, S1
Manasco, KB1
El-Remessy, AB1
Ozgun, U1
Demet, T1
Ozge, KA1
Zafer, D1
Murat, S1
Mehmet, Y1
Nilgun, K1
Fledelius, HC1
Bangsgaard, R1
Slidsborg, C1
laCour, M1
Mitchell, A1
Hall, RW1
Erickson, SW1
Yates, C1
Lowery, S1
Hendrickson, H1
Ahmad, A1
Mondal, T1
Klein, B1
Punyawattanaporn, A1
Tengtrisorn, S1
Sangsupawanich, P1
Derinoz, O1
Emeksiz, HC1
Vicente, GV1
Bahri, M1
Palafoutas, JJ1
Wang, H1
Mehta, N1
Isenberg, S1
Everett, S1
Parelhoff, E1
Wheatcroft, S1
Sharma, A1
McAllister, J1
Laws, DE1
Morton, C1
Weindling, M1
Clark, D1
Sarici, SU1
Yurdakök, M1
Unal, S1
LaRoche, GR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy[NCT03448640]60 participants (Actual)Observational2016-01-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for cyclopentolate and Retrolental Fibroplasia

ArticleYear
Low dose or very low dose phenylephrine and cyclopentolate microdrops for retinopathy of prematurity eye examinations (The Little Eye Drop Study): a randomised controlled non-inferiority trial.
    Archives of disease in childhood. Fetal and neonatal edition, 2023, Volume: 108, Issue:4

    Topics: Birth Weight; Cyclopentolate; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Very Low B

2023
Randomised controlled pilot trial comparing low dose and very low- dose microdrop administration of phenylephrine and cyclopentolate for retinopathy of prematurity eye examinations in neonates.
    Archives of disease in childhood, 2021, Volume: 106, Issue:6

    Topics: Administration, Ophthalmic; Cyclopentolate; Dose-Response Relationship, Drug; Female; Humans; Infant

2021
Systemic Absorption of Cyclopentolate and Adverse Events After Retinopathy of Prematurity Exams.
    Current eye research, 2016, Volume: 41, Issue:12

    Topics: Absorption, Physiological; Chromatography, Liquid; Cyclopentolate; Female; Follow-Up Studies; Gestat

2016
A randomized controlled trial to determine the lowest effective dose for adequate mydriasis in premature infants.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2012, Volume: 16, Issue:4

    Topics: Cyclopentolate; Drug Combinations; Female; Gestational Age; Humans; Infant, Newborn; Infant, Prematu

2012
Reduction in mydriatic drop size in premature infants.
    The British journal of ophthalmology, 1993, Volume: 77, Issue:6

    Topics: Cyclopentolate; Drug Administration Schedule; Drug Combinations; Female; Humans; Infant; Infant, New

1993

Other Studies

14 other studies available for cyclopentolate and Retrolental Fibroplasia

ArticleYear
A Survey of Neonatal Nurses on Mydriatic Regimens Used in Neonatal Retinopathy of Prematurity Eye Examinations.
    American journal of perinatology, 2022, Volume: 39, Issue:16

    Topics: Australia; Cross-Sectional Studies; Cyclopentolate; Drug-Related Side Effects and Adverse Reactions;

2022
Exudative retinal detachment following photocoagulation in older premature infants for retinopathy of prematurity: description and management.
    Retina (Philadelphia, Pa.), 2014, Volume: 34, Issue:1

    Topics: Administration, Topical; Cyclopentolate; Exudates and Transudates; Gestational Age; History, Ancient

2014
Noncontact high-resolution ultra-wide-field oral fluorescein angiography in premature infants with retinopathy of prematurity.
    JAMA ophthalmology, 2014, Volume: 132, Issue:1

    Topics: Administration, Oral; Cyclopentolate; Female; Fluorescein; Fluorescein Angiography; Fluorescent Dyes

2014
Cardiopulmonary arrest following administration of Cyclomydril eyedrops for outpatient retinopathy of prematurity screening.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2014, Volume: 18, Issue:2

    Topics: Cardiopulmonary Resuscitation; Cyclopentolate; Drug Combinations; Female; Gestational Age; Heart Arr

2014
Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice.
    Neonatology, 2014, Volume: 106, Issue:1

    Topics: Administration, Ophthalmic; Animals; Animals, Newborn; Body Weight; Cyclopentolate; Eating; Mice, In

2014
Fatal necrotising enterocolitis due to mydriatic eye drops.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2014, Volume: 24 Suppl 2

    Topics: Blood Pressure; Cyclopentolate; Enterocolitis, Necrotizing; Fatal Outcome; Gestational Age; Humans;

2014
The usefulness of the Retinomax autorefractor for childhood screening validated against a Danish preterm cohort examined at the age of 4 years.
    Eye (London, England), 2015, Volume: 29, Issue:6

    Topics: Amblyopia; Anisometropia; Child, Preschool; Cyclopentolate; Denmark; Female; Gestational Age; Humans

2015
Atrial arrhythmia after newborn eye exam, to caffeine or not to caffeine?
    Journal of neonatal-perinatal medicine, 2016, Volume: 9, Issue:4

    Topics: Apnea; Atrial Premature Complexes; Bradycardia; Caffeine; Central Nervous System Stimulants; Cyclope

2016
Pupil dilatation after single and triple doses of mydriatic agent in preterm infants.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2009, Volume: 92, Issue:11

    Topics: Cyclopentolate; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Male; Mydriatic

2009
Use of physostigmine for cyclopentolate overdose in an infant.
    Pediatrics, 2012, Volume: 130, Issue:3

    Topics: Antidotes; Cholinergic Antagonists; Cyclopentolate; Drug Overdose; Female; Humans; Infant; Infant, N

2012
A comparison of mydriatic eyedrops in low-weight infants.
    Ophthalmology, 1984, Volume: 91, Issue:3

    Topics: Blood Pressure; Cyclopentolate; Drug Combinations; Humans; Infant, Low Birth Weight; Infant, Newborn

1984
Systemic effects of screening for retinopathy of prematurity.
    The British journal of ophthalmology, 1996, Volume: 80, Issue:5

    Topics: Anesthetics, Local; Blood Gas Analysis; Blood Pressure; Cyclopentolate; Female; Humans; Infant; Infa

1996
Acute gastric dilatation complicating the use of mydriatics in a preterm newborn.
    Pediatric radiology, 2001, Volume: 31, Issue:8

    Topics: Acute Disease; Cyclopentolate; Female; Gastric Dilatation; Humans; Infant; Infant, Newborn; Infant,

2001
Safety of ocular drugs in pediatrics.
    Ophthalmology, 1987, Volume: 94, Issue:2

    Topics: Cyclopentolate; Humans; Infant; Infant, Newborn; Mydriatics; Phenylephrine; Pupil; Retinopathy of Pr

1987