cyclopentane has been researched along with Orthomyxoviridae Infections in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.27) | 18.2507 |
| 2000's | 16 (36.36) | 29.6817 |
| 2010's | 27 (61.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Govorkova, EA; Marathe, BM; Mostafa, HH; Pascua, PNQ; Russell, CJ; Vogel, P; Webby, RJ | 1 |
| Fujii, Y; Hatayama, K; Liu, K; Matsukawa, A; Morishima, T; Nishibori, M; Nosaka, N; Tsukahara, H; Yamada, M; Yashiro, M | 1 |
| Itoh, Y; Kanazu, T; Kitano, M; Kobayashi, M; Kodama, M; Sato, A; Yoshida, R | 1 |
| Homma, T; Imamura, Y; Iwanaga, N; Izumikawa, K; Kajihara, T; Kakeya, H; Kitano, M; Kohno, S; Kurihara, S; Miyazaki, T; Nakamura, S; Seki, M; Tanaka, A; Yanagihara, K | 1 |
| Arikata, M; Ishida, H; Ishigaki, H; Itoh, Y; Kawaoka, Y; Kitagawa, N; Kitano, M; Kobayashi, M; Le, QM; Nakayama, M; Ogasawara, K; Pham, VL; Sato, A; Shichinohe, S; Tsuchiya, H; Yoshida, R | 1 |
| Arikata, M; Higuchi, M; Hiono, T; Igarashi, M; Ishida, H; Ishigaki, H; Ishijima, M; Ito, M; Itoh, Y; Kawaoka, Y; Kida, H; Kitagawa, N; Kitano, M; Mitsuishi, Y; Miyamoto, H; Nakayama, M; Ogasawara, K; Okamatsu, M; Pham, VL; Quynh Mai, L; Sakoda, Y; Shichinohe, S; Suzuki, Y; Takada, A; Tsuchiya, H; Yoshida, R | 1 |
| Bae, JY; Baek, LJ; Cheong, HJ; Heo, J; Hwang, MW; Jang, SI; Kim, D; Kim, H; Kim, JI; Lee, I; Lee, S; Park, MS; Park, S; Song, JW; Song, KJ | 1 |
| Bahl, J; Baranovich, T; Culhane, M; Darnell, D; Govorkova, EA; Kaplan, BS; Lowe, JF; Marathe, BM; Stigger-Rosser, E; Webby, RJ | 1 |
| Homma, T; Kitano, M; Kobayashi, M; Naito, A; Onishi, M; Sato, A; Taniguchi, K; Yoshinaga, T | 1 |
| Doi, M; Igarashi, M; Ishida, H; Ishigaki, H; Ishii, A; Itoh, Y; Kida, H; Kitagawa, N; Nakamura, S; Nakayama, M; Ogasawara, K; Okamatsu, M; Sakoda, Y; Sasamura, T; Shichinohe, S; Shiohara, M; Tsuchiya, H | 1 |
| Cai, Y; Chen, W; Fang, X; Farooqui, A; Huang, L; Kelvin, AA; Kelvin, DJ; Khan, A; Lin, P; Liu, Y; Paquette, SG; Su, M; Wu, S; Zeng, T; Zhang, L | 1 |
| Bayer, W; Drexler, I; Katschinski, B; Krawczyk, A; Landsberg, CD; Le-Trilling, VT; Megger, DA; Rückborn, MU; Sitek, B; Tao, S; Tenbusch, M; Trilling, M | 1 |
| Chen, R; Chen, T; Du, Q; Hao, Y; Li, J; Li, R; Li, Y; Li, Z; Xie, H; Yang, Z; Zhong, N | 1 |
| Abed, Y; Barbeau, X; Boivin, G; Carbonneau, J; Fage, C; Lagüe, P; Tu, V | 1 |
| Isoda, N; Kanazu, T; Kida, H; Kobayashi, M; Kodama, M; Nomura, N; Noshi, T; Okamatsu, M; Sakoda, Y; Sato, A; Soda, K; Yamano, Y; Yoshida, R | 1 |
| Abed, Y; Boivin, G; Simon, P | 1 |
| Babu, YS; Hurst, BL; Klumpp, K; Morrey, JD; Smee, DF; Tarbet, EB; Wong, MH | 1 |
| DeLiberto, T; DuBois, RM; Govorkova, EA; Gramer, MR; Krauss, S; Negovetich, NJ; Senne, DA; Stallknecht, DE; Stoner, TD; Swafford, S; Webster, RG | 1 |
| Babu, YS; Bantia, S; Kellogg, D; Parker, CD | 1 |
| Babu, YS; Bantia, S; Ilyushina, NA; Kellogg, D; Parker, C; Upshaw, R | 1 |
| Baba, K; Ishida, H; Ishigaki, H; Itoh, Y; Kanazu, T; Kitano, M; Kodama, M; Nakayama, M; Nihashi, Y; Noda, T; Ogasawara, K; Sato, A; Sato, K; Torii, R; Yoshida, R | 1 |
| Campbell, G; Chumakova, O; Linde, J; Linde, S; Paessler, S; Peng, BH; Smith, J; Yun, N; Zacks, M | 1 |
| Abed, Y; Beaulieu, E; Boivin, G; Bouhy, X; Mallett, C; Pizzorno, A; Russell, R | 1 |
| Bannai, H; Hobo, S; Kondo, T; Matsumura, T; Minamijima, YH; Muranaka, M; Nemoto, M; Tsujimura, K; Yamada, M; Yamanaka, T | 1 |
| Daly, JM | 1 |
| Abed, Y; Boivin, G; Pizzorno, A | 1 |
| Feng, E; Hilgenfeld, R; Jiang, H; Li, J; Liu, H; Wang, J; Ye, D; Zhang, D; Zhao, F; Zheng, M | 1 |
| Bailey, KW; Baldwin, TJ; Morrey, JD; Sidwell, RW; Smee, DF; Wong, MH | 1 |
| Ali, S; Babu, YS; Bantia, S; Brouillette, W; Chand, P; Dehghani, A; El-Kattan, Y; Hutchison, TL; Kotian, PL; Lin, TH; Rowland, S | 1 |
| Babu, YS; Bantia, S; Chand, P; El-Kattan, Y; Kotian, PL; Lin, TH | 1 |
| Arnold, CS; Bantia, S; Chand, P; Parker, CD; Upshaw, R | 1 |
| Gubareva, LV; Hayden, FG; Mishin, VP; Signorelli, KL | 1 |
| Reece, PA | 1 |
| Arnold, CS; Barr, IG; Dziuba, N; Holbrook, MR; Hurt, AC; Kilpatrick, JM; Linde, NS; Paessler, S; Smith, JN; Yun, NE; Zacks, MA; Zhang, L | 1 |
| Ananth, SL; Babu, YS; Bantia, S; Chand, P; Dehghani, A; El-Kattan, Y; Elliott, AJ; Horn, LL; Hutchison, TL; Kotian, P; Laver, GW; Lin, TH; Montgomery, JA; Parker, CD | 1 |
| Babu, YS; Bailey, KW; Barnard, DL; Huffman, JH; Morrey, JD; Sidwell, RW; Smee, DF | 1 |
| Ananth, SL; Andries, K; Babu, YS; Bantia, S; Chand, P; Dehghani, A; El-Kattan, Y; Horn, LL; Hutchison, TL; Kellog, DL; Kotian, PL; Lin, T; Montgomery, JA; Parker, CD | 1 |
| Bailey, KW; Burger, RA; Sidwell, RW; Smee, DF | 1 |
| Bailey, K; Bush, K; Drusano, GL; Preston, SL; Sidwell, RW; Smee, D | 1 |
| Babu, YS; Bailey, KW; Barnard, DL; Bush, K; Feng, WC; Huffman, JH; Morrey, JD; Sidwell, RW; Smee, DF | 1 |
| Bush, K; Goloubeva, OG; Govorkova, EA; Leneva, IA; Webster, RG | 1 |
| Babu, YS; Bush, K; Chand, P; Desai-Krieger, D; Jakeman, KJ; McKown, LA; Streeter, AJ; Sweet, C; Wagaman, PC | 1 |
| Bailey, KW; Morrison, AC; Sidwell, RW; Smee, DF | 1 |
| Bennink, JR; Cox, JH; Eisenlohr, LC; Johnson, PR; Yewdell, JW | 1 |
2 review(s) available for cyclopentane and Orthomyxoviridae Infections
| Article | Year |
|---|---|
Recent advances in neuraminidase inhibitor development as anti-influenza drugs.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Benzoic Acid; Cyclopentanes; Drug Design; Enzyme Inhibitors; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Influenza, Human; Models, Molecular; Neuraminidase; Orthomyxoviridae; Orthomyxoviridae Infections; Oseltamivir; Zanamivir | 2012 |
Neuraminidase inhibitor resistance in influenza viruses.
Topics: Acids, Carbocyclic; Adult; Animals; Antiviral Agents; Catalytic Domain; Child; Clinical Trials as Topic; Cyclopentanes; Drug Administration Schedule; Enzyme Inhibitors; Guanidines; Humans; Immunocompromised Host; Influenza A Virus, H5N1 Subtype; Influenza, Human; Neuraminidase; Orthomyxoviridae; Orthomyxoviridae Infections; Oseltamivir; Seasons; Sentinel Surveillance; Viral Proteins; Virulence; Zanamivir | 2007 |
1 trial(s) available for cyclopentane and Orthomyxoviridae Infections
| Article | Year |
|---|---|
Efficacy of a single intravenous dose of the neuraminidase inhibitor peramivir in the treatment of equine influenza.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Chromatography, Liquid; Cyclopentanes; Guanidines; Horse Diseases; Horses; Influenza A Virus, H3N8 Subtype; Injections, Intravenous; Neuraminidase; Orthomyxoviridae Infections; Tandem Mass Spectrometry | 2012 |
41 other study(ies) available for cyclopentane and Orthomyxoviridae Infections
| Article | Year |
|---|---|
Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Bronchoalveolar Lavage Fluid; Cyclopentanes; Cytokines; Disease Models, Animal; Female; Guanidines; Immunocompromised Host; Inflammation Mediators; Influenza B virus; Mice; Mice, Inbred NOD; Mice, SCID; Morbidity; Mortality; Orthomyxoviridae Infections; Viral Load; Virus Replication | 2017 |
Combined effect of anti-high-mobility group box-1 monoclonal antibody and peramivir against influenza A virus-induced pneumonia in mice.
Topics: Acids, Carbocyclic; Animals; Antibodies, Monoclonal; Antiviral Agents; Cyclopentanes; Cytokines; Drug Therapy, Combination; Guanidines; HMGB1 Protein; Inflammation; Injections, Intramuscular; Lung; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Orthomyxoviridae Infections; Pneumonia, Viral | 2019 |
Efficacy of repeated intravenous injection of peramivir against influenza A (H1N1) 2009 virus infection in immunosuppressed mice.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Body Weight; Cyclopentanes; Cyclophosphamide; Drug Administration Schedule; Female; Guanidines; Immunosuppressive Agents; Influenza A Virus, H1N1 Subtype; Injections, Intravenous; Lung; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Oseltamivir; Phosphorous Acids; Survival Analysis; Treatment Outcome | 2013 |
The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice.
Topics: Acids, Carbocyclic; Administration, Intravenous; Administration, Oral; Animals; Antiviral Agents; Chemokine CXCL2; Chemokines; Coinfection; Cyclopentanes; Guanidines; Influenza A Virus, H1N1 Subtype; Interferon-gamma; Interleukin-6; Lung; Male; Mice; Mice, Inbred CBA; Orthomyxoviridae Infections; Oseltamivir; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Survival Analysis; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Efficacy of repeated intravenous administration of peramivir against highly pathogenic avian influenza A (H5N1) virus in cynomolgus macaques.
Topics: Acids, Carbocyclic; Administration, Intravenous; Animals; Antiviral Agents; Body Temperature; Body Weight; Chemokine CCL2; Cyclopentanes; Drug Administration Schedule; Female; Guanidines; Influenza A Virus, H5N1 Subtype; Interferon-gamma; Interleukin-12 Subunit p40; Interleukin-6; Macaca fascicularis; Orthomyxoviridae Infections; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Virulence; Virus Replication | 2014 |
Protective efficacy of passive immunization with monoclonal antibodies in animal models of H5N1 highly pathogenic avian influenza virus infection.
Topics: Acids, Carbocyclic; Animals; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; Cell Line; Cyclopentanes; Dogs; Drug Therapy, Combination; Female; Guanidines; Immunization, Passive; Immunocompromised Host; Influenza A Virus, H5N1 Subtype; Interleukin-6; Lung; Macaca fascicularis; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Models, Animal; Neuraminidase; Orthomyxoviridae Infections; Viral Load | 2014 |
Combination effects of peramivir and favipiravir against oseltamivir-resistant 2009 pandemic influenza A(H1N1) infection in mice.
Topics: Acids, Carbocyclic; Amides; Animals; Antiviral Agents; Body Weight; Cyclopentanes; Dogs; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Female; Guanidines; Influenza A Virus, H1N1 Subtype; Lung; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred DBA; Orthomyxoviridae Infections; Oseltamivir; Pyrazines; Survival Rate | 2014 |
Influenza A viruses of swine circulating in the United States during 2009-2014 are susceptible to neuraminidase inhibitors but show lineage-dependent resistance to adamantanes.
Topics: Acids, Carbocyclic; Adamantane; Amino Acid Substitution; Animals; Antiviral Agents; Base Sequence; Cyclopentanes; Dogs; Drug Resistance, Viral; Enzyme Inhibitors; Genotype; Guanidines; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H1N2 Subtype; Influenza A Virus, H3N2 Subtype; Madin Darby Canine Kidney Cells; Mutation, Missense; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Phenotype; Phylogeny; Swine; Swine Diseases; Time Factors; United States; Viral Proteins; Zanamivir | 2015 |
Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae.
Topics: Acids, Carbocyclic; Administration, Intravenous; Animals; Antiviral Agents; Bacterial Load; Coinfection; Cyclopentanes; Cytokines; Disease Models, Animal; Dogs; Guanidines; Influenza A Virus, H1N1 Subtype; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Oseltamivir; Pneumococcal Infections; Streptococcus pneumoniae; Viral Load; Virus Replication | 2015 |
Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Drug Resistance, Viral; Enzyme Inhibitors; Female; Guanidines; Humans; Influenza A Virus, H5N1 Subtype; Influenza A Virus, H7N9 Subtype; Influenza Vaccines; Influenza, Human; Macaca; Mice; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Primates; Vaccination; Viral Proteins; Virus Replication | 2015 |
Assessment of Antiviral Properties of Peramivir against H7N9 Avian Influenza Virus in an Experimental Mouse Model.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Dogs; Drug Administration Schedule; Enzyme Inhibitors; Female; Guanidines; Humans; Influenza A Virus, H7N9 Subtype; Injections, Intramuscular; Lung; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred C57BL; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Survival Analysis; Treatment Outcome; Viral Load; Viral Proteins; Virus Replication | 2015 |
Broad and potent antiviral activity of the NAE inhibitor MLN4924.
Topics: Animals; Antiviral Agents; Cyclopentanes; DNA Virus Infections; DNA Viruses; Humans; Mice; NEDD8 Protein; NIH 3T3 Cells; Orthomyxoviridae; Orthomyxoviridae Infections; Pyrimidines; Ubiquitins | 2016 |
Efficacy of delayed treatment of China-made Peramivir with repeated intravenous injections in a mouse influenza model: from clinical experience to basal experiment.
Topics: Acids, Carbocyclic; Administration, Intravenous; Animals; Antiviral Agents; China; Cyclopentanes; Disease Models, Animal; Drug Administration Schedule; Female; Guanidines; Influenza A Virus, H1N1 Subtype; Injections, Intravenous; Lung; Male; Mice; Orthomyxoviridae Infections; Viral Load; Virus Shedding | 2016 |
The I427T neuraminidase (NA) substitution, located outside the NA active site of an influenza A(H1N1)pdm09 variant with reduced susceptibility to NA inhibitors, alters NA properties and impairs viral fitness.
Topics: Acids, Carbocyclic; Amino Acid Substitution; Animals; Antiviral Agents; Catalytic Domain; Computer Simulation; Cyclopentanes; Drug Resistance, Viral; Enzyme Inhibitors; Genetic Fitness; Guanidines; Influenza A Virus, H1N1 Subtype; Inhibitory Concentration 50; Mice; Molecular Dynamics Simulation; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Reverse Genetics | 2017 |
Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Cytokines; Disease Models, Animal; Guanidines; Humans; Influenza A Virus, H5N1 Subtype; Influenza A Virus, H7N1 Subtype; Influenza A Virus, H7N7 Subtype; Influenza, Human; Lung; Mice; Mutation; Neuraminidase; Orthomyxoviridae Infections; Viral Load; Virus Replication | 2017 |
Prophylactic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H274Y neuraminidase mutation.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cell Line; Cyclopentanes; Dogs; Guanidines; Influenza A Virus, H1N1 Subtype; Injections, Intramuscular; Male; Mice; Mice, Inbred BALB C; Mutation; Neuraminidase; Orthomyxoviridae Infections; Viral Proteins | 2010 |
Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cell Line; Cyclopentanes; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Mice; Mice, Inbred BALB C; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir | 2010 |
Antiviral susceptibility of avian and swine influenza virus of the N1 neuraminidase subtype.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Birds; Catalytic Domain; Cyclopentanes; Drug Resistance, Viral; Enzyme Inhibitors; Guanidines; Humans; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza in Birds; Influenza, Human; Models, Molecular; Mutation; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Protein Conformation; Species Specificity; Swine; Swine Diseases; Viral Proteins; Zanamivir | 2010 |
Combination of peramivir and rimantadine demonstrate synergistic antiviral effects in sub-lethal influenza A (H3N2) virus mouse model.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Synergism; Female; Guanidines; Influenza A Virus, H3N2 Subtype; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Rimantadine; Survival Rate; Weight Loss | 2010 |
A single intramuscular injection of neuraminidase inhibitor peramivir demonstrates antiviral activity against novel pandemic A/California/04/2009 (H1N1) influenza virus infection in mice.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Body Weight; Cyclopentanes; Disease Models, Animal; Female; Guanidines; Influenza A Virus, H1N1 Subtype; Injections, Intramuscular; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Rodent Diseases; Survival Analysis | 2011 |
Efficacy of single intravenous injection of peramivir against influenza B virus infection in ferrets and cynomolgus macaques.
Topics: Acids, Carbocyclic; Animals; Cyclopentanes; Ferrets; Guanidines; Influenza B virus; Injections, Intravenous; Macaca; Orthomyxoviridae Infections | 2011 |
Neuropathology of H5N1 virus infection in ferrets.
Topics: Acids, Carbocyclic; Animals; Antigens, Viral; Antiviral Agents; Astrocytes; Brain Diseases; Central Nervous System; Cyclopentanes; Cytokines; Ferrets; Guanidines; Influenza A Virus, H5N1 Subtype; Meningoencephalitis; Neuraminidase; Orthomyxoviridae Infections; Virus Replication | 2012 |
Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus.
Topics: Acids, Carbocyclic; Amino Acid Substitution; Animals; Antiviral Agents; Cell Line; Cyclopentanes; Dogs; Drug Resistance, Viral; Ferrets; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Inhibitory Concentration 50; Male; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Pandemics; Reverse Genetics; Viral Proteins; Virus Replication; Zanamivir | 2012 |
Neuraminidase inhibitors for treatment of equine influenza - when all else fails?
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Guanidines; Horse Diseases; Influenza A Virus, H3N8 Subtype; Orthomyxoviridae Infections | 2012 |
Therapeutic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H275Y neuraminidase mutation.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Drug Resistance, Viral; Female; Guanidines; Influenza A Virus, H1N1 Subtype; Injections, Intramuscular; Mice; Mice, Inbred BALB C; Mutation; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Treatment Outcome; Viral Proteins | 2012 |
Inhibition of influenza virus infections in immunosuppressed mice with orally administered peramivir (BCX-1812).
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Cyclophosphamide; Female; Guanidines; Immunocompromised Host; Immunosuppressive Agents; Influenza A virus; Lung; Mice; Mice, SCID; Neuraminidase; Orthomyxoviridae Infections; Oxygen; Survival Rate | 2003 |
Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.
Topics: Administration, Intranasal; Amides; Animals; Antiviral Agents; Crystallography, X-Ray; Cyclopentanes; Influenza A virus; Mice; Models, Molecular; Neuraminidase; Orthomyxoviridae Infections; Stereoisomerism; Structure-Activity Relationship | 2004 |
Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.
Topics: Acetamides; Acids, Carbocyclic; Administration, Intranasal; Administration, Oral; Animals; Antiviral Agents; Cyclopentanes; Dose-Response Relationship, Drug; Guanidines; Mice; Orthomyxoviridae; Orthomyxoviridae Infections; Oseltamivir; Pyrans; Sialic Acids; Structure-Activity Relationship; Survival Rate; Treatment Outcome; Zanamivir | 2005 |
Anti-influenza virus activity of peramivir in mice with single intramuscular injection.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Guanidines; Influenza A Virus, H1N1 Subtype; Injections, Intramuscular; Mice; Neuraminidase; Orthomyxoviridae Infections | 2006 |
Evaluation of methyl inosine monophosphate (MIMP) and peramivir activities in a murine model of lethal influenza A virus infection.
Topics: Acids, Carbocyclic; Age Factors; Animals; Antiviral Agents; Body Weight; Cyclopentanes; Disease Models, Animal; Female; Guanidines; Influenza A Virus, H1N1 Subtype; Inosine Monophosphate; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections | 2006 |
Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Ferrets; Guanidines; Influenza A Virus, H5N1 Subtype; Injections, Intramuscular; Lung; Mice; Orthomyxoviridae Infections; Oseltamivir; Survival Analysis; Treatment Outcome | 2008 |
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
Topics: Acids, Carbocyclic; Administration, Oral; Animals; Antiviral Agents; Catalytic Domain; Crystallography, X-Ray; Cyclopentanes; Drug Design; Enzyme Inhibitors; Guanidines; Influenza A virus; Influenza B virus; Mice; Models, Molecular; Neuraminidase; Orthomyxoviridae Infections; Protein Binding; Stereoisomerism; Structure-Activity Relationship | 2000 |
In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201.
Topics: Acetamides; Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Disease Models, Animal; Female; Guanidines; Influenza A virus; Influenza B virus; Lung; Mice; Mice, Inbred C57BL; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Respiratory Function Tests; Ribavirin; Virus Replication | 2001 |
Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir.
Topics: Acetamides; Acids, Carbocyclic; Administration, Intranasal; Administration, Oral; Animals; Antiviral Agents; Cyclopentanes; Enzyme Inhibitors; Female; Guanidines; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Neuraminidase; Orthomyxoviridae; Orthomyxoviridae Infections; Oseltamivir; Pyrans; Sialic Acids; Species Specificity; Survival Analysis; Time Factors; Zanamivir | 2001 |
Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice.
Topics: Acids, Carbocyclic; Animals; Antibody Formation; Antiviral Agents; Cyclopentanes; Enzyme Inhibitors; Female; Guanidines; Influenza A virus; Lung; Lymphocytes; Mice; Mice, Inbred BALB C; Neuraminidase; Orthomyxoviridae Infections; Oxygen; Phenotype; Spleen | 2001 |
Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing.
Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Disease Models, Animal; Female; Guanidines; Mice; Mice, Inbred BALB C; Neuraminidase; Orthomyxoviridae Infections; Treatment Outcome | 2001 |
Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201.
Topics: Acids, Carbocyclic; Administration, Oral; Animals; Antiviral Agents; Cyclopentanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanidines; Influenza A virus; Influenza B virus; Mice; Mice, Inbred BALB C; Neuraminidase; Orthomyxoviridae Infections | 2001 |
Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses.
Topics: Acetamides; Acids, Carbocyclic; Animals; Antiviral Agents; Body Weight; Brain; Cyclopentanes; Disease Models, Animal; Dogs; Female; Guanidines; Influenza A virus; Influenza A Virus, H5N1 Subtype; Influenza A Virus, H9N2 Subtype; Lung; Mice; Mice, Inbred BALB C; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Pyrans; Sialic Acids; Treatment Outcome; Virus Replication; Zanamivir | 2001 |
Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection.
Topics: Acetamides; Acids, Carbocyclic; Animals; Antiviral Agents; Area Under Curve; Body Temperature; Cell Count; Cyclopentanes; Enzyme Inhibitors; Ferrets; Guanidines; Half-Life; Hemagglutination Inhibition Tests; Influenza A virus; Lung; Male; Nasal Cavity; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir | 2002 |
Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin.
Topics: Acids, Carbocyclic; Alphainfluenzavirus; Animals; Antiviral Agents; Cell Culture Techniques; Cyclopentanes; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Ribavirin | 2002 |
Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum.
Topics: Adenovirus Early Proteins; Animals; Antigen-Presenting Cells; Antigens; Antigens, Viral; Antiviral Agents; Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Glycoproteins; H-2 Antigens; Histocompatibility Antigens Class I; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Oncogene Proteins, Viral; Orthomyxoviridae Infections; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Vaccinia virus | 1990 |