cyclooctatin and Breast-Neoplasms

cyclooctatin has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for cyclooctatin and Breast-Neoplasms

Article	Year
16,17-dihydroxycyclooctatin, a new diterpene from Streptomyces sp. LZ35. Drug discoveries & therapeutics, 2013, Volume: 7, Issue:5 Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number of secondary metabolite pathways, including a complete gene cluster for the biosynthesis of cyclooctatin. This cluster contains four genes, cotB1-4, located in a 5-kb region. Optimization of fermentation medium for LZ35Δheng (SR107) led to the identification of cyclooctatin (1) and 16,17-dihydroxycyclooctatin (2), a new diterpene. The structures of these substances were elucidated on the basis of 1D-, 2D-NMR, and HRESIMS data. Cytotoxicity against MDA-MB-231 and A549 cell lines was also evaluated. Results demonstrated that gene cluster and pathway analysis are key to guided isolation of new natural products. Topics: Breast Neoplasms; Cell Line, Tumor; Diterpenes; Female; Fermentation; Genome, Bacterial; Humans; Magnetic Resonance Spectroscopy; Multigene Family; Streptomyces	2013

Article

Year

16,17-dihydroxycyclooctatin, a new diterpene from Streptomyces sp. LZ35.

Drug discoveries & therapeutics, 2013, Volume: 7, Issue:5

Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number of secondary metabolite pathways, including a complete gene cluster for the biosynthesis of cyclooctatin. This cluster contains four genes, cotB1-4, located in a 5-kb region. Optimization of fermentation medium for LZ35Δheng (SR107) led to the identification of cyclooctatin (1) and 16,17-dihydroxycyclooctatin (2), a new diterpene. The structures of these substances were elucidated on the basis of 1D-, 2D-NMR, and HRESIMS data. Cytotoxicity against MDA-MB-231 and A549 cell lines was also evaluated. Results demonstrated that gene cluster and pathway analysis are key to guided isolation of new natural products.

Topics: Breast Neoplasms; Cell Line, Tumor; Diterpenes; Female; Fermentation; Genome, Bacterial; Humans; Magnetic Resonance Spectroscopy; Multigene Family; Streptomyces

2013