cycloleucine has been researched along with Seizures in 14 studies
Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The group I mGluR antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) dose-dependently antagonised PTZ-induced seizures with a mean ED50 value of 465 nmol." | 3.70 | Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice. ( Dalby, NO; Thomsen, C, 1998) |
| "The spread of experimentally kindled seizures in rats results in sustained increases in plasma vasopressin (VP) and VP mRNA in the supraoptic nucleus (SON)." | 1.30 | Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus. ( Al-Ghoul, WM; Greenwood, RS; Meeker, RB, 1998) |
| " Dose-response curves for stimulation of phosphoinositide (PI) hydrolysis by the selective metabotropic glutamate receptor (mGluR) agonist, (1S,3R)-1-aminocyclopentane dicarboxylic acid [(1S,3R)-ACPD] were performed with cortical slices from mice treated with lorazepam or vehicle for 7 days and subject to 0, 1, 2, 3, 4 and 7 days of withdrawal." | 1.29 | The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function. ( Mortensen, M; Suzdak, PD; Thomsen, C, 1995) |
| "Pharmacologically, limbic seizures were attenuated by the mGluR partial agonist/antagonist L-2-amino-3-phosphonopropionate (L-AP3) and dantrolene, an inhibitor of intracellular calcium mobilization, but not by D-AP3 or ionotropic glutamate receptor antagonists (MK-801 or GYKI-52466)." | 1.29 | Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists. ( Fix, AS; Griffey, KI; Helton, DR; Johnson, JA; Schoepp, DD; Tizzano, JP, 1993) |
| "1S,3R-ACPD-induced seizures were antagonized by systemic administration of dantrolene, an inhibitor of intracellular calcium mobilization, but not by the ionotropic glutamate antagonists MK-801 or GYKI-52466." | 1.29 | Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. ( Fix, AS; McDonald, JW; Schoepp, DD; Tizzano, JP, 1993) |
| "This resulted in delayed-onset seizures and selective hippocampal neuronal damage that was indirectly mediated by NMDA receptors." | 1.28 | Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage. ( Sacaan, AI; Schoepp, DD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 12 (85.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lancaster, B | 1 |
| Wheal, HV | 1 |
| Zand, R | 1 |
| Izquierdo, I | 1 |
| Tizzano, JP | 3 |
| Griffey, KI | 2 |
| Schoepp, DD | 5 |
| Laudrup, P | 2 |
| Klitgaard, H | 2 |
| Mortensen, M | 1 |
| Suzdak, PD | 1 |
| Thomsen, C | 2 |
| Johnson, JA | 1 |
| Fix, AS | 2 |
| Helton, DR | 1 |
| McDonald, JW | 2 |
| Camón, L | 1 |
| Vives, P | 1 |
| de Vera, N | 1 |
| Martínez, E | 1 |
| Al-Ghoul, WM | 1 |
| Meeker, RB | 1 |
| Greenwood, RS | 1 |
| Dalby, NO | 1 |
| Akiyama, K | 1 |
| Daigen, A | 1 |
| Yamada, N | 1 |
| Itoh, T | 1 |
| Kohira, I | 1 |
| Ujike, H | 1 |
| Otsuki, S | 1 |
| Sacaan, AI | 1 |
| Johnson, BG | 1 |
| Salhoff, CR | 1 |
| Johnston, MV | 1 |
14 other studies available for cycloleucine and Seizures
| Article | Year |
|---|---|
A comparative histological and electrophysiological study of some neurotoxins in the rat hippocampus.
Topics: Afferent Pathways; Animals; Cycloleucine; Dose-Response Relationship, Drug; Evoked Potentials; Hippo | 1982 |
Anticonvulsant activity of cyclopentano amino acids.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Anticonvulsants; Cycloleucine; Dose-Response Relationsh | 1980 |
Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Cycloleucine; Dose-Response Relationship, Drug; | 1995 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; D | 1993 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; D | 1993 |
The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Cycloleucine; Drug Tolerance; Hydrolysis; In Vitro Techniques; | 1995 |
Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists.
Topics: Animals; Anticonvulsants; Cycloleucine; Dose-Response Relationship, Drug; Hippocampus; Injections; L | 1993 |
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain Injuries; Cell Nucleus; Corpu | 1993 |
Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Cycloleucine; Excitatory Amino Acid Agonists; Gl | 1998 |
Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus.
Topics: Amygdala; Animals; Calcium; Cerebral Cortex; Cycloleucine; Disease Models, Animal; Epilepsy; Immunoh | 1998 |
Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice.
Topics: Animals; Cerebral Ventricles; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Indans; Infu | 1998 |
Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats.
Topics: Amygdala; Animals; Cerebral Cortex; Cycloleucine; Electric Stimulation; Hydrolysis; Ibotenic Acid; I | 1992 |
Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage.
Topics: Animals; Behavior, Animal; Biotransformation; Cell Death; Cycloleucine; GTP-Binding Proteins; Hippoc | 1992 |
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Choline O-Acetyltransferase; Corpus Striatum; Cyc | 1991 |