cycloleucine has been researched along with Pancreatic Neoplasms in 2 studies
Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with pancreatic cancer, CAI/RT had no significant effect on local recurrence (log-rank P = 0." | 2.73 | Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. ( Hermans, JJ; Hop, WC; Incrocci, L; Jeekel, J; Kazemier, G; Morak, MJ; van Dekken, H; van der Gaast, A; van Eijck, CH, 2008) |
| "Methionine addiction is a fundamental and general hallmark of cancer caused by enhanced methyl flux." | 1.62 | Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model. ( Bouvet, M; Hamada, K; Han, Q; Hoffman, RM; Inubushi, S; Kawaguchi, K; Nishino, H; Sugisawa, N; Tan, Y; Tashiro, Y; Unno, M; Yamamoto, J, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sugisawa, N | 1 |
| Yamamoto, J | 1 |
| Han, Q | 1 |
| Tan, Y | 1 |
| Tashiro, Y | 1 |
| Nishino, H | 1 |
| Inubushi, S | 1 |
| Hamada, K | 1 |
| Kawaguchi, K | 1 |
| Unno, M | 1 |
| Bouvet, M | 1 |
| Hoffman, RM | 1 |
| Morak, MJ | 1 |
| van der Gaast, A | 1 |
| Incrocci, L | 1 |
| van Dekken, H | 1 |
| Hermans, JJ | 1 |
| Jeekel, J | 1 |
| Hop, WC | 1 |
| Kazemier, G | 1 |
| van Eijck, CH | 1 |
1 trial available for cycloleucine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial.
Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemo | 2008 |
1 other study available for cycloleucine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carbon-Sulfur Lyases; Cell Pro | 2021 |