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cycloleucine and Neuroblastoma

cycloleucine has been researched along with Neuroblastoma in 5 studies

Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" The cotransporter activity in human neuroblastoma SH-SY5Y cells was assessed by bumetanide-sensitive K+ influx, and protein expression was evaluated by Western blot analysis."3.70Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate. ( Murali, SG; Sun, D, 1998)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, RK1
Wurtman, RJ1
Cox, AJ1
Nitsch, RM1
Sorrentino, G2
Singh, IN2
Massarelli, R1
Kanfer, JN2
Sun, D1
Murali, SG1
Lakshmanan, M1
Goncalves, E1
Lessly, G1
Foti, D1
Robbins, J1

Other Studies

5 other studies available for cycloleucine and Neuroblastoma

ArticleYear
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Aug-15, Volume: 92, Issue:17

    Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents

1995
Stimulation of phospholipase C activity by norepinephrine, t-ACPD and bombesin in LA-N-2 cells.
    European journal of pharmacology, 1996, Jul-11, Volume: 308, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine; Bombesin; Cycloleucine; Excitatory A

1996
Amyloid beta protein (25-35) stimulation of phospholipase C in LA-N-2 cells.
    Journal of neurochemistry, 1997, Volume: 69, Issue:1

    Topics: Adrenergic Agonists; Adrenergic alpha-Agonists; Amyloid beta-Peptides; Bombesin; Calcium; Chelating

1997
Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bumetanide; Carrier Proteins; Cycloleucine

1998
The transport of thyroxine into mouse neuroblastoma cells, NB41A3: the effect of L-system amino acids.
    Endocrinology, 1990, Volume: 126, Issue:6

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Antimycin A; Binding, Competitive; Biological Transport

1990
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