cycloleucine has been researched along with Nerve Degeneration in 9 studies
Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, neither QA up to 5 mM nor trans-ACPD had a significant toxic effect in either KCl group." | 1.30 | NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization. ( Chen, Q; Reiner, A; Surmeier, DJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lancaster, B | 1 |
| Wheal, HV | 1 |
| Copani, A | 2 |
| Bruno, V | 2 |
| Battaglia, G | 1 |
| Leanza, G | 1 |
| Pellitteri, R | 1 |
| Russo, A | 1 |
| Stanzani, S | 1 |
| Nicoletti, F | 2 |
| Paterlini, M | 1 |
| Valerio, A | 2 |
| Baruzzi, F | 1 |
| Memo, M | 1 |
| Spano, PF | 2 |
| Chen, Q | 1 |
| Surmeier, DJ | 1 |
| Reiner, A | 1 |
| Pizzi, M | 1 |
| Benarese, M | 1 |
| Boroni, F | 1 |
| Goffi, F | 1 |
| Nixon, RA | 1 |
| Aleppo, G | 1 |
| Pisani, A | 1 |
| Aronica, E | 1 |
| D'Agata, V | 1 |
| Canonico, PL | 1 |
| Koh, JY | 1 |
| Palmer, E | 1 |
| Lin, A | 1 |
| Cotman, CW | 1 |
| Schoepp, DD | 1 |
| Johnson, BG | 1 |
| Salhoff, CR | 1 |
| McDonald, JW | 1 |
| Johnston, MV | 1 |
9 other studies available for cycloleucine and Nerve Degeneration
| Article | Year |
|---|---|
A comparative histological and electrophysiological study of some neurotoxins in the rat hippocampus.
Topics: Afferent Pathways; Animals; Cycloleucine; Dose-Response Relationship, Drug; Evoked Potentials; Hippo | 1982 |
Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide.
Topics: Aminobutyrates; Amyloid beta-Peptides; Animals; Apoptosis; Benzoates; Calcium Channels; Cells, Cultu | 1995 |
Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons.
Topics: Cell Death; Cell Line; Cycloleucine; Excitatory Amino Acid Agonists; Gene Expression; Humans; N-Meth | 1998 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 1999 |
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Cell Survival; Choline O-Acetyltransferase | 2000 |
Neurotoxicity of a non-metabolizable amino acid, 1-aminocyclopentane-1-carboxylic acid: regional protein levels and lipid composition of nervous tissue.
Topics: Animals; Axons; Brain; Cerebellum; Cycloleucine; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; N | 1976 |
Metabotropic glutamate receptors and neuronal toxicity.
Topics: Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; N-Me | 1992 |
A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; | 1991 |
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Choline O-Acetyltransferase; Corpus Striatum; Cyc | 1991 |