cycloleucine has been researched along with Glial Cell Tumors in 3 studies
Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found in cultured glioma (C6BU-1) cells that excitatory amino acids (EAAs) such as glutamate, N-methyl-D-aspartate (NMDA), aspartate, and metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylate caused an increase in the inositol 1,4,5-trisphosphate formation and the intracellular Ca2+ concentration ([Ca2+]i) in the absence of extracellular Mg2+ and Ca2+." | 3.69 | Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction. ( Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S, 1994) |
| " Guanylyl imidodiphosphate (Gpp(NH)p) causes an affinity shift on the L-glutamate dose-response curve, increasing the IC50 value." | 1.30 | Characterization of metabotropic glutamate receptors in rat C6 glioma cells. ( Albasanz, JL; Martín, M; Ros, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shinno, H | 1 |
| Mikuni, M | 1 |
| Saitoh, K | 1 |
| Tomita, U | 1 |
| Yamawaki, S | 1 |
| Takahashi, K | 1 |
| Lee, RK | 1 |
| Wurtman, RJ | 1 |
| Cox, AJ | 1 |
| Nitsch, RM | 1 |
| Albasanz, JL | 1 |
| Ros, M | 1 |
| Martín, M | 1 |
3 other studies available for cycloleucine and Glial Cell Tumors
| Article | Year |
|---|---|
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine M | 1994 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents | 1995 |
Characterization of metabotropic glutamate receptors in rat C6 glioma cells.
Topics: Animals; Brain Neoplasms; Cell Membrane; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Am | 1997 |