cycloleucine has been researched along with Epilepsy in 13 studies
Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anticonvulsant activity of (S)-4-carboxy-3-hydroxyphenylglycine ((S)-4C3HPG) (an antagonist of Group I and an agonist of Group II metabotropic glutamate (mGlu) receptors), of (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3S)-ACPD) (an agonist of Group II mGlu receptors), and of L-serine-O-phosphate (an agonist of Group III mGlu receptors) was studied against sound-induced seizures in genetically epilepsy-prone (GEP) rats following bilateral microinjection into the inferior colliculus." | 3.69 | Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats. ( Chapman, AG; Jane, DE; Meldrum, BS; Tang, E; Yip, PK, 1997) |
| "The spread of experimentally kindled seizures in rats results in sustained increases in plasma vasopressin (VP) and VP mRNA in the supraoptic nucleus (SON)." | 1.30 | Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus. ( Al-Ghoul, WM; Greenwood, RS; Meeker, RB, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burke, JP | 1 |
| Hablitz, JJ | 1 |
| Kadowaki, D | 1 |
| Kinno, I | 1 |
| Kadoya, K | 1 |
| Mori, A | 1 |
| Hiramatsu, M | 1 |
| Attwell, PJ | 1 |
| Kaura, S | 1 |
| Sigala, G | 1 |
| Bradford, HF | 1 |
| Croucher, MJ | 1 |
| Jane, DE | 2 |
| Watkins, JC | 1 |
| Holmes, KH | 1 |
| Keele, NB | 2 |
| Shinnick-Gallagher, P | 2 |
| Tang, E | 1 |
| Yip, PK | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Merlin, LR | 1 |
| Wong, RK | 1 |
| Kim, D | 1 |
| Jun, KS | 1 |
| Lee, SB | 1 |
| Kang, NG | 1 |
| Min, DS | 1 |
| Kim, YH | 1 |
| Ryu, SH | 1 |
| Suh, PG | 1 |
| Shin, HS | 1 |
| Rutecki, PA | 1 |
| Yang, Y | 1 |
| Libri, V | 1 |
| Constanti, A | 1 |
| Postlethwaite, M | 1 |
| Bowery, NG | 1 |
| Al-Ghoul, WM | 1 |
| Meeker, RB | 1 |
| Greenwood, RS | 1 |
| Neugebauer, V | 1 |
| Sheardown, MJ | 1 |
| Taschenberger, H | 1 |
| Roy, BL | 1 |
| Lowe, DA | 1 |
13 other studies available for cycloleucine and Epilepsy
| Article | Year |
|---|---|
Metabotropic glutamate receptor activation decreases epileptiform activity in rat neocortex.
Topics: Aminobutyrates; Animals; Bicuculline; Cerebral Cortex; Cycloleucine; Epilepsy; Evoked Potentials; Fe | 1994 |
(+-)-1-Amino-1,3-cyclopentane-trans-dicarboxylic acid (trans-ACPD) induced inositol triphosphoric acid formation in the brain of iron-induced epileptic rats and epileptic El mice.
Topics: Animals; Brain; Chlorides; Cycloleucine; Disease Models, Animal; Epilepsy; Ferric Compounds; Inosito | 1994 |
Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist.
Topics: Animals; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniqu | 1995 |
Loss of mGluR-mediated hyperpolarizations and increase in mGluR depolarizations in basolateral amygdala neurons in kindling-induced epilepsy.
Topics: Amygdala; Animals; Cycloleucine; Electric Conductivity; Epilepsy; Evoked Potentials; In Vitro Techni | 1996 |
Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats.
Topics: Animals; Behavior, Animal; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Female; Glycine | 1997 |
Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro.
Topics: Animals; Cycloleucine; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Picrotoxin; Receptor | 1997 |
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.
Topics: Animals; Ataxia; Binding Sites; Brain; Carbachol; Cerebellum; Cycloleucine; Epilepsy; Hippocampus; I | 1997 |
Metabotropic glutamate receptor activation modulates epileptiform activity in the hippocampus.
Topics: 4-Aminopyridine; Adrenergic Antagonists; Animals; Bicuculline; Cholinergic Antagonists; Cycloleucine | 1997 |
Blockade of GABA(B) receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro.
Topics: Animals; Benzylamines; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Electric Sti | 1998 |
Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus.
Topics: Amygdala; Animals; Calcium; Cerebral Cortex; Cycloleucine; Disease Models, Animal; Epilepsy; Immunoh | 1998 |
Differential effects of metabotropic glutamate receptor antagonists on bursting activity in the amygdala.
Topics: Amygdala; Animals; Benzoates; Cycloleucine; Electrophysiology; Epilepsy; Excitatory Amino Acid Antag | 1999 |
Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists | 1992 |
Effects of a metabotropic glutamate agonist, trans-ACPD, on cortical epileptiform activity.
Topics: Animals; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Glutamates; In V | 1992 |