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cycloleucine and Epilepsy

cycloleucine has been researched along with Epilepsy in 13 studies

Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"The anticonvulsant activity of (S)-4-carboxy-3-hydroxyphenylglycine ((S)-4C3HPG) (an antagonist of Group I and an agonist of Group II metabotropic glutamate (mGlu) receptors), of (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3S)-ACPD) (an agonist of Group II mGlu receptors), and of L-serine-O-phosphate (an agonist of Group III mGlu receptors) was studied against sound-induced seizures in genetically epilepsy-prone (GEP) rats following bilateral microinjection into the inferior colliculus."3.69Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats. ( Chapman, AG; Jane, DE; Meldrum, BS; Tang, E; Yip, PK, 1997)
"The spread of experimentally kindled seizures in rats results in sustained increases in plasma vasopressin (VP) and VP mRNA in the supraoptic nucleus (SON)."1.30Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus. ( Al-Ghoul, WM; Greenwood, RS; Meeker, RB, 1998)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burke, JP1
Hablitz, JJ1
Kadowaki, D1
Kinno, I1
Kadoya, K1
Mori, A1
Hiramatsu, M1
Attwell, PJ1
Kaura, S1
Sigala, G1
Bradford, HF1
Croucher, MJ1
Jane, DE2
Watkins, JC1
Holmes, KH1
Keele, NB2
Shinnick-Gallagher, P2
Tang, E1
Yip, PK1
Chapman, AG1
Meldrum, BS1
Merlin, LR1
Wong, RK1
Kim, D1
Jun, KS1
Lee, SB1
Kang, NG1
Min, DS1
Kim, YH1
Ryu, SH1
Suh, PG1
Shin, HS1
Rutecki, PA1
Yang, Y1
Libri, V1
Constanti, A1
Postlethwaite, M1
Bowery, NG1
Al-Ghoul, WM1
Meeker, RB1
Greenwood, RS1
Neugebauer, V1
Sheardown, MJ1
Taschenberger, H1
Roy, BL1
Lowe, DA1

Other Studies

13 other studies available for cycloleucine and Epilepsy

ArticleYear
Metabotropic glutamate receptor activation decreases epileptiform activity in rat neocortex.
    Neuroscience letters, 1994, Jun-06, Volume: 174, Issue:1

    Topics: Aminobutyrates; Animals; Bicuculline; Cerebral Cortex; Cycloleucine; Epilepsy; Evoked Potentials; Fe

1994
(+-)-1-Amino-1,3-cyclopentane-trans-dicarboxylic acid (trans-ACPD) induced inositol triphosphoric acid formation in the brain of iron-induced epileptic rats and epileptic El mice.
    Research communications in chemical pathology and pharmacology, 1994, Volume: 84, Issue:2

    Topics: Animals; Brain; Chlorides; Cycloleucine; Disease Models, Animal; Epilepsy; Ferric Compounds; Inosito

1994
Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist.
    Brain research, 1995, Nov-06, Volume: 698, Issue:1-2

    Topics: Animals; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniqu

1995
Loss of mGluR-mediated hyperpolarizations and increase in mGluR depolarizations in basolateral amygdala neurons in kindling-induced epilepsy.
    Journal of neurophysiology, 1996, Volume: 76, Issue:4

    Topics: Amygdala; Animals; Cycloleucine; Electric Conductivity; Epilepsy; Evoked Potentials; In Vitro Techni

1996
Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats.
    European journal of pharmacology, 1997, May-30, Volume: 327, Issue:2-3

    Topics: Animals; Behavior, Animal; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Female; Glycine

1997
Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro.
    Journal of neurophysiology, 1997, Volume: 78, Issue:1

    Topics: Animals; Cycloleucine; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Picrotoxin; Receptor

1997
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.
    Nature, 1997, Sep-18, Volume: 389, Issue:6648

    Topics: Animals; Ataxia; Binding Sites; Brain; Carbachol; Cerebellum; Cycloleucine; Epilepsy; Hippocampus; I

1997
Metabotropic glutamate receptor activation modulates epileptiform activity in the hippocampus.
    Neuroscience, 1997, Volume: 81, Issue:4

    Topics: 4-Aminopyridine; Adrenergic Antagonists; Animals; Bicuculline; Cholinergic Antagonists; Cycloleucine

1997
Blockade of GABA(B) receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 358, Issue:2

    Topics: Animals; Benzylamines; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Electric Sti

1998
Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus.
    Journal of neuroscience research, 1998, Nov-01, Volume: 54, Issue:3

    Topics: Amygdala; Animals; Calcium; Cerebral Cortex; Cycloleucine; Disease Models, Animal; Epilepsy; Immunoh

1998
Differential effects of metabotropic glutamate receptor antagonists on bursting activity in the amygdala.
    Journal of neurophysiology, 1999, Volume: 81, Issue:5

    Topics: Amygdala; Animals; Benzoates; Cycloleucine; Electrophysiology; Epilepsy; Excitatory Amino Acid Antag

1999
Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex.
    Neuroreport, 1992, Volume: 3, Issue:10

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists

1992
Effects of a metabotropic glutamate agonist, trans-ACPD, on cortical epileptiform activity.
    Neuroreport, 1992, Volume: 3, Issue:7

    Topics: Animals; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Epilepsy; Glutamates; In V

1992