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cycloleucine and Aging

cycloleucine has been researched along with Aging in 27 studies

Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"To investigate the postnatal development of the carrier-mediated transport process by which certain amino acids are absorbed from the air space of the lung into the blood-stream, a solution of the 14C-labeled nonmetabolized amino acid cycloleucine was administered into the lungs of anesthetized rats of various ages and the rate of absorption of the compound measured."1.27Postnatal development of carrier-mediated absorption of a foreign amino acid from the rat lung. ( Hemberger, JA; Schanker, LS, 1984)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19905 (18.52)18.7374
1990's17 (62.96)18.2507
2000's5 (18.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Oppelt, D1
Rodnight, R1
Horn, J1
Fitarelli, D1
Kommers, T1
Oliveira, D1
Wofchuk, S1
Segovia, G1
Mora, F1
Schanker, LS1
Hemberger, JA1
Parent, A1
Rowe, W1
Meaney, MJ1
Quirion, R1
Schoepp, DD3
Goldsworthy, J1
Johnson, BG2
Salhoff, CR2
Baker, SR1
Holler, T1
Cappel, E1
Klein, J1
Löffelholz, K1
Bevilacqua, JA1
Downes, CP1
Lowenstein, PR1
McGahon, B2
Lynch, MA3
Wright, RA1
Burnett, JP1
Mayne, NG1
Belagaje, R1
Wu, S1
Monn, JA1
Takagi, H1
De Barry, J2
Kudo, Y1
Yoshioka, T1
Blue, ME1
Martin, LJ1
Brennan, EM1
Johnston, MV1
Jouvenceau, A1
Dutar, P1
Billard, JM1
Golshani, P1
Warren, RA1
Jones, EG1
Fitzjohn, SM1
Bortolotto, ZA1
Palmer, MJ1
Doherty, AJ1
Ornstein, PL1
Kingston, AE1
Lodge, D1
Collingridge, GL1
Maguire, C1
Kelly, A1
McGahon, BM1
Martin, DS1
Horrobin, DF1
Brumberg, JC1
Nowak, LG1
McCormick, DA1
Saransaari, P1
Oja, SS1
Attucci, S1
Albani-Torregrossa, S1
Moroni, F1
Pellegrini-Giampietro, DE1
Kern, HL1
Ramsey, RB1
Fischer, VW1
Reynolds, RA1
Segal, S1
Vecil, GG1
Li, PP1
Warsh, JJ1
Casabona, G1
Genazzani, AA1
Di Stefano, M1
Sortino, MA1
Nicoletti, F1
Gombos, G1
Levy, O1
Foulkes, EC1
Mort, TL1
Buncher, CR1
Cotman, C1
Monaghan, D1

Reviews

2 reviews available for cycloleucine and Aging

ArticleYear
Transport of organic solutes in the lens.
    Current topics in eye research, 1979, Volume: 1

    Topics: Aging; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Calcium; Carbohydrate Meta

1979
Multiple excitatory amino acid receptor regulation of intracellular Ca2+. Implications for aging and Alzheimer's disease.
    Annals of the New York Academy of Sciences, 1989, Volume: 568

    Topics: Aging; Alzheimer Disease; Brain Chemistry; Calcium; Cycloleucine; Humans; Phosphatidylinositols; Rec

1989

Other Studies

25 other studies available for cycloleucine and Aging

ArticleYear
Role of intracellular calcium stores on the effect of metabotropic glutamate receptors on phosphorylation of glial fibrillary acidic protein in hippocampal slices from immature rats.
    Neurochemical research, 2004, Volume: 29, Issue:8

    Topics: Aging; Animals; Calcium; Cycloleucine; Glial Fibrillary Acidic Protein; Hippocampus; In Vitro Techni

2004
Effects of the metabotropic glutamate receptor agonist, ACPD, on the extracellular concentrations of GABA and acetylcholine in the prefrontal cortex of the rat during the normal process of aging.
    Brain research bulletin, 2005, Feb-15, Volume: 65, Issue:1

    Topics: Acetylcholine; Age Factors; Aging; Analysis of Variance; Animals; Cycloleucine; Dose-Response Relati

2005
Postnatal development of carrier-mediated absorption of a foreign amino acid from the rat lung.
    Pharmacology, 1984, Volume: 28, Issue:1

    Topics: Absorption; Aging; Amino Acids; Animals; Animals, Newborn; Carbon Radioisotopes; Cycloleucine; Femal

1984
Increased production of inositol phosphates and diacylglycerol in aged cognitively impaired rats after stimulation of muscarinic, metabotropic-glutamate and endothelin receptors.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Carbachol; Cognition Disorders; Cycloleucine; Diglycerides; Inosit

1995
3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus.
    Journal of neurochemistry, 1994, Volume: 63, Issue:2

    Topics: Aging; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Do

1994
Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats.
    Journal of neurochemistry, 1993, Volume: 61, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cycloleucine; Enzyme Activation; Glutamates; Glutamic Acid; Hippoc

1993
Transiently selective activation of phosphoinositide turnover in layer V pyramidal neurons after specific mGluRs stimulation in rat somatosensory cortex during early postnatal development.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Carbachol; Cycloleucine; Female; Lithium; Male; P

1995
The synergism between ACPD and arachidonic acid on glutamate release in hippocampus is age-dependent.
    European journal of pharmacology, 1996, Aug-15, Volume: 309, Issue:3

    Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Glut

1996
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
    Neuropharmacology, 1996, Volume: 35, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Dr

1996
The t-ACPD-induced current response in rat cerebellum.
    Annals of the New York Academy of Sciences, 1993, Dec-20, Volume: 707

    Topics: Aging; Animals; Cerebellum; Cycloleucine; Evoked Potentials; Gene Expression Regulation, Development

1993
Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. Metabotropic receptors.
    The Journal of comparative neurology, 1997, Sep-15, Volume: 386, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cycloleucine; Gene Expression Regulation, Develop

1997
Is activation of the metabotropic glutamate receptors impaired in the hippocampal CA1 area of the aged rat?
    Hippocampus, 1997, Volume: 7, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Agonists

1997
Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse.
    Journal of neurophysiology, 1998, Volume: 80, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn;

1998
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
    Neuropharmacology, 1998, Volume: 37, Issue:12

    Topics: Aging; Amino Acids; Animals; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Criceti

1998
Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes.
    Neuroscience, 1999, Volume: 90, Issue:4

    Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Drug Synergism; Electric Stimulation;

1999
Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids.
    Neuroscience, 1999, Volume: 94, Issue:1

    Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Docosahexaenoic Acids; Eating; Excita

1999
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jul-01, Volume: 20, Issue:13

    Topics: Action Potentials; Aging; Animals; Calcium; Chelating Agents; Cycloleucine; Egtazic Acid; Female; Fe

2000
Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus.
    Neurochemical research, 2000, Volume: 25, Issue:8

    Topics: Aging; Animals; Brain Ischemia; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitat

2000
Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus.
    Neurochemical research, 2001, Volume: 26, Issue:10

    Topics: Aging; Animals; Animals, Newborn; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; Kinetics; Metho

2001
Effect of 1-aminocyclopentane-1-carboxylic acid (cycloleucine) on developing rat central nervous system phospholipids.
    Journal of neurochemistry, 1978, Volume: 30, Issue:2

    Topics: Aging; Amino Acids; Animals; Central Nervous System; Cycloleucine; Female; Male; Myelin Sheath; Phos

1978
Regulatory characteristics of amino acid transport in newborn rat renal cortex cells.
    Biochimica et biophysica acta, 1976, Mar-19, Volume: 426, Issue:3

    Topics: Aging; Amino Acids; Aminoisobutyric Acids; Anaerobiosis; Animals; Animals, Newborn; Biological Trans

1976
Evidence for metabotropic excitatory amino acid receptor heterogeneity: developmental and brain regional studies.
    Journal of neurochemistry, 1992, Volume: 59, Issue:1

    Topics: Aging; Alanine; Animals; Animals, Newborn; Brain; Cycloleucine; Drug Interactions; Male; Phosphatidy

1992
Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices.
    Journal of neurochemistry, 1992, Volume: 59, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Brain; Colforsin; Cyclic AMP; Cycloleucine; Dose-Response Relation

1992
Developmental changes of EAA metabotropic receptor activity in rat cerebellum.
    Neuroreport, 1992, Volume: 3, Issue:10

    Topics: Aging; Animals; Cerebellum; Cycloleucine; Hydrolysis; Inositol; Inositol Phosphates; Rats; Rats, Wis

1992
Intestinal cadmium permeability in mature and immature rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1991, Volume: 197, Issue:4

    Topics: Aging; Animals; Cadmium; Cycloleucine; Ethanol; Jejunum; Male; Mucus; Permeability; Rats; Rats, Inbr

1991