cycloheximide and Cancer of Pancreas

Topics: 5' Untranslated Regions; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Cell Line, Tumor; Cycloheximide; Eukaryotic Initiation Factor-4A; G-Quadruplexes; Genes, ras; Humans; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Oxidation-Reduction; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Polyribosomes; Protein Biosynthesis; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; ral GTP-Binding Proteins; Ribosomes; RNA Helicases; RNA, Messenger; Sequence Analysis, RNA; Transcription Factors; Transcriptome; Triterpenes; YAP-Signaling Proteins

Topics: Adenosine Triphosphate; Animals; Butadienes; CD24 Antigen; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cycloheximide; Electron Transport Complex I; Energy Metabolism; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; HMGB1 Protein; Humans; Inflammation; MAP Kinase Kinase 2; Mice; Mitochondria; NF-kappa B; Nitriles; Pancreatic Neoplasms; Phosphorylation; Protein Binding; Protein Synthesis Inhibitors; Receptor for Advanced Glycation End Products; RNA Interference; RNA, Small Interfering; Rotenone; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Microenvironment; Uncoupling Agents

Topics: Biglycan; Cell Division; Chondroitin ABC Lyase; Cycloheximide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Extracellular Matrix Proteins; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genetic Vectors; Humans; Immunoblotting; Mutation; Pancreatic Neoplasms; Phosphorylation; Protein Synthesis Inhibitors; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Smad3 Protein; Smad4 Protein; Smad7 Protein; Trans-Activators; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured; Up-Regulation

Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Cycloheximide; Drug Resistance, Neoplasm; Gene Expression; Humans; Membrane Glycoproteins; Pancreatic Neoplasms; Protein Synthesis Inhibitors; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Calcium; Caspase Inhibitors; Caspases; Caspases, Initiator; Cycloheximide; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Molecular Chaperones; Oxidative Stress; Pancreas; Pancreatic Neoplasms; Phosphorylation; Protein Biosynthesis; Protein Processing, Post-Translational; Pyrazines; RNA, Small Interfering; Thapsigargin; Transcription Factor CHOP; Ubiquitin

Topics: Apoptosis; Cell Division; Cell Line, Tumor; Cell Survival; Cholera Toxin; Chromones; Cycloheximide; Cycloparaffins; Enzyme Inhibitors; Genes, Reporter; Glucagon-Like Peptide-1 Receptor; Humans; Indomethacin; Kinetics; Mitogen-Activated Protein Kinase 3; Morpholines; Pancreatic Neoplasms; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

Topics: Cell Line, Tumor; Cell Proliferation; Cycloheximide; Cytokines; Dactinomycin; Humans; Immunoglobulin G; Inflammation; Intercellular Signaling Peptides and Proteins; Interleukin-8; Leukemia Inhibitory Factor; Pancreatic Neoplasms; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha

Topics: Animals; Antihypertensive Agents; Bacterial Toxins; Cholera Toxin; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Cycloheximide; Diterpenes; Growth Hormone; Humans; In Vitro Techniques; Kinetics; Male; Pancreatic Neoplasms; Pertussis Toxin; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin; Virulence Factors, Bordetella

Topics: Amino Acid Oxidoreductases; Animals; Apoptosis; Cell Survival; Cricetinae; Cycloheximide; Dactinomycin; DNA; Electrophoresis, Agar Gel; Gene Expression; Humans; Insulinoma; Interleukin-1; Islets of Langerhans; Kinetics; Microscopy, Electron, Scanning; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nucleosomes; Pancreatic Neoplasms; Penicillamine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Time Factors; Tumor Cells, Cultured

Topics: Animals; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Drug Stability; Drug Synergism; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 1; Hexokinase; Insulin; Insulin Secretion; Insulinoma; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured

Topics: Adenocarcinoma; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dactinomycin; Epithelium; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; Membrane Proteins; Pancreatic Neoplasms; Protein Biosynthesis; Protein Kinase C; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured

Topics: Animals; Aromatase Inhibitors; Binding Sites; Cycloheximide; Dactinomycin; Drug Screening Assays, Antitumor; Estrogens; Female; Gonadotropin-Releasing Hormone; Humans; Leuprolide; Medroxyprogesterone Acetate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Pancreatic Neoplasms; Receptors, Estrogen; Tissue Plasminogen Activator; Toremifene; Tumor Cells, Cultured

Topics: Acute Disease; Animals; Antigens, Neoplasm; Base Sequence; Biomarkers, Tumor; Blood Physiological Phenomena; Cell Line; Culture Media; Cycloheximide; Gene Expression; Kinetics; Lectins, C-Type; Male; Molecular Sequence Data; Pancreatic Neoplasms; Pancreatitis; Pancreatitis-Associated Proteins; Proteins; Rats; Rats, Sprague-Dawley; Reference Values; RNA Probes; RNA, Messenger; Tumor Cells, Cultured

Topics: Base Sequence; Cell Division; Cyclic AMP; Cycloheximide; DNA Primers; Epidermal Growth Factor; Gastrins; Molecular Sequence Data; Octreotide; Pancreatic Neoplasms; Protein Kinase C; Receptors, Somatostatin; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation

Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured

Topics: 3T3 Cells; Animals; Carcinoma; Carcinoma, Acinar Cell; Coated Pits, Cell-Membrane; Cycloheximide; Endocytosis; Gastrins; Gastrointestinal Neoplasms; Humans; Lysosomes; Mice; Microscopy, Confocal; Microscopy, Immunoelectron; Neoplasm Proteins; Pancreatic Neoplasms; Protein Synthesis Inhibitors; Rats; Receptors, Cholecystokinin; Recombinant Proteins; Transfection; Transferrin; Tumor Cells, Cultured

Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Pancreatic Neoplasms; Peptide Fragments; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: Animals; Biological Factors; Cell Line; Colonic Neoplasms; Culture Media, Conditioned; Cycloheximide; Cytochalasin B; Deoxyglucose; Dose-Response Relationship, Drug; Endopeptidase K; Glucose; Glucose Transporter Type 4; Humans; Insulin; Lactic Acid; Molecular Weight; Monokines; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Pancreatic Neoplasms; Rats; Somatomedins; Tumor Cells, Cultured

Topics: Animals; Antineoplastic Agents, Hormonal; Cycloheximide; Dactinomycin; Gene Expression Regulation, Neoplastic; Mice; Mice, SCID; Neoplasm Proteins; Nucleic Acid Synthesis Inhibitors; Octreotide; Pancreatic Neoplasms; Protein Synthesis Inhibitors; Rats; Receptors, Somatostatin; Somatostatin; Tumor Cells, Cultured; Up-Regulation

Topics: Apoptosis; Cycloheximide; DNA-Binding Proteins; Drug Interactions; Humans; I-kappa B Proteins; Interleukin-1; NF-kappa B; NF-KappaB Inhibitor alpha; Pancreatic Neoplasms; Protein Biosynthesis; Protein Synthesis Inhibitors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: 3T3 Cells; Adenocarcinoma; Alleles; Amino Acids; Animals; Blotting, Western; Cell Line; Codon; Codon, Nonsense; Cycloheximide; DNA-Binding Proteins; Genes, Dominant; Humans; Loss of Heterozygosity; Mesoderm; Mice; Models, Molecular; Mutation; Nerve Growth Factors; Pancreatic Neoplasms; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Ribonucleases; RNA, Messenger; Signal Transduction; Smad Proteins; Smad2 Protein; Smad4 Protein; Time Factors; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Ubiquitin; Xenopus; Xenopus Proteins

Topics: Adenocarcinoma; Adenoma; Animals; Autophagy; Azaserine; Carcinoma in Situ; Cycloheximide; Male; Pancreatic Neoplasms; Rats; Rats, Wistar; Time Factors; Vinblastine

Topics: Animals; Apoptosis; Carbon Monoxide; Cell Survival; Cycloheximide; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Activation; Etoposide; Graft Survival; Guanylate Cyclase; Insulinoma; Islets of Langerhans; Islets of Langerhans Transplantation; Kinetics; Male; Mice; Mice, Inbred C57BL; Oligopeptides; Pancreatic Neoplasms; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: Carcinoma; Cells, Cultured; Cycloheximide; Dactinomycin; Hot Temperature; Humans; Hydrogen-Ion Concentration; Isoelectric Point; Molecular Weight; Pancreatic Neoplasms; Plasminogen Activators

Topics: Animals; Cell Division; Cycloheximide; Fibroblast Growth Factor 2; Kinetics; Ornithine Decarboxylase; Pancreatic Neoplasms; Protein Biosynthesis; Rats; RNA; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured

Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Cell Line; Cycloheximide; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Pancreatic Neoplasms; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; RNA, Messenger; Signal Transduction; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha

Topics: Adenoma, Islet Cell; Animals; Calcium; Clone Cells; Colchicine; Cricetinae; Cycloheximide; Cytoplasmic Granules; Glucagon; Insulinoma; Monensin; Pancreatic Neoplasms; Tumor Cells, Cultured

Topics: Animals; Autoradiography; Binding Sites; Cell Line; Cell Membrane; Cycloheximide; Dexamethasone; Electrophoresis; Pancreatic Neoplasms; Rats; Receptors, Gastrointestinal Hormone; Receptors, Vasoactive Intestinal Peptide; Temperature; Tunicamycin; Vasoactive Intestinal Peptide