cycloguanil and Plasmodium falciparum Malaria
cycloguanil has been researched along with Plasmodium falciparum Malaria in 38 studies
Research
Studies (38)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 15 (39.47) | 18.2507 |
2000's | 17 (44.74) | 29.6817 |
2010's | 6 (15.79) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Bertaux, L; Bogreau, H; Bouchiba, H; Garnotel, E; Kraemer, P; Parzy, D; Pradines, B; Rogier, C; Savini, H; Simon, F | 1 |
Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B | 1 |
Corral, MG; Leroux, J; Mylne, JS; Stubbs, KA | 1 |
Dinter, D; Domijan, AM; Gajski, G; Garaj-Vrhovac, V | 1 |
Diakite, I; Hartl, DL; Ogbunugafor, CB; Weinreich, DM; Wylie, CS | 1 |
Barata, L; Boutbibe, K; Clain, J; Franetich, JF; Houzé, P; Mazier, D; Zanghi, G | 1 |
Brown, KM; Costanzo, MS; Hartl, DL | 1 |
Delfino, RT; Figueroa-Villar, JD; Santos-Filho, OA | 1 |
Bouchaud, O; Durand, R; Godineau, N; Jezic, Z; Keundjian, A; Le Bras, J; Pradines, B; Ralaimazava, P | 1 |
Alifrangis, M; Jelinek, T; Salanti, A; Schwöbel, B | 1 |
Durand, R; Le Bras, J | 1 |
Ariey, F; Duchemin, JB; Harisoa, JL; Mauclere, P; Pietra, V; Rabarijaona, LP; Raharimalala, LA; Rakotomanana, F; Ranaivo, L; Randrianarivelojosia, M; Robert, V | 1 |
Ashley, E; Cho, D; Cho, T; Edstein, MD; Ginsberg, A; Looareesuwan, S; McGready, R; Nosten, F; Seaton, E; Stepniewska, K; White, NJ | 1 |
Rakotoson, JD; Randremanana, RV; Randriamanantena, A; Randrianarivelojosia, M; Randrianasolo, L; Ratsimbasoa, A | 1 |
Bienzle, U; Ehrhardt, S; Jelinek, T; Mockenhaupt, FP; Muehlen, M; Otchwemah, R; Schreiber, J | 1 |
Björkman, A; Gil, JP; Thapar, MM | 1 |
Peters, W; Robinson, BL; Stewart, LB | 1 |
Kioy, D; Konsil, J; Manyando, C; Miller, GB; Mulenga, M; Na-Bangchang, K; Ruengweerayut, R | 1 |
Aarons, L; Bojang, K; Edwards, G; Hughes, D; Manyando, C; Simpson, JA; Ward, S; Watkins, WA; Winstanley, P | 1 |
Chishimba, S; Mharakurwa, S; Mkulama, MA; Rouse, P; Sikalima, J; Thuma, PE | 1 |
Basco, LK; Eldin de Pécoulas, P; Le Bras, J; Mazabraud, A; Wilson, CM | 1 |
Ager, AL; Canfield, CJ; Jacobus, DP; Lewis, NJ; Milhous, WK; Rossan, RN; Sweeney, TR | 1 |
Basco, LK; Doury, JC; Le Bras, J; Ramiliarisoa, O; Ringwald, P | 1 |
Cowman, AF; Genton, B; Lorry, K; Reeder, JC; Rieckmann, KH; Wines, B | 1 |
Nguyen, DS; Nguyen, PD; Sköld, O; Swedberg, G; Zindrou, S | 1 |
Edstein, MD; Rieckmann, KH; Shanks, GD; Yeo, AE | 1 |
Basco, LK; Le Bras, J | 1 |
Doerig, C; Doury, JC; Fusai, T; Parzy, D; Pradines, B; Rico, A | 1 |
Mberu, EK; Nzila-Mounda, A; Plowe, CV; Sibley, CH; Watkins, WM; Winstanley, PA | 1 |
di Piazza, JP; Durand, R; Le Bras, J; Longuet, C; Parzy, D; Pradines, B | 1 |
Bergqvist, Y; Björkman, A; Ishizaki, T; Kalkoa, M; Kaneko, A; Kaneko, O; Kobayakawa, T; Takechi, M | 1 |
Bouchaud, O; di Piazza, JP; Durand, R; Godineau, N; Le Bras, J; Longuet, C; Marchou, B; Martet, G; Parzy, D; Pradines, B; Roué, R | 1 |
Fusai, T; Keundjian, A; Kombila, M; Lebeau, C; Mabika Mamfoumbi, M; Owono Medang, M; Parzy, D; Pradines, B; Rogier, C | 1 |
Howard, V; Mookherjee, S; Nzila-Mouanda, A; Sibley, CH; Watkins, W | 1 |
Clain, J; di Piazza, JP; Durand, R; le Bras, J; Longuet, C; Sécardin, Y | 1 |
Auparakkitanon, S; Chavalitshewinkoon-Petmitr, P; Pongvilairat, G; Wilairat, P | 1 |
Fusai, T; Mosnier, J; Parzy, D; Pradines, B; Rogier, C; Spiegel, A; Tall, A; Trape, JF | 1 |
Basco, LK; Ringwald, P | 1 |
Reviews
1 review(s) available for cycloguanil and Plasmodium falciparum Malaria
Article | Year |
---|---|
The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Antimetabolites; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 2003 |
Trials
2 trial(s) available for cycloguanil and Plasmodium falciparum Malaria
Article | Year |
---|---|
Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil.
Topics: Antimalarials; Biotransformation; Case-Control Studies; Cohort Studies; Contraceptives, Oral, Hormonal; Female; Humans; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Trimester, Third; Proguanil; Thailand; Triazines | 2003 |
The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.
Topics: Adolescent; Adult; Antimalarials; Atovaquone; Drug Combinations; Female; Humans; Malaria, Falciparum; Naphthoquinones; Pregnancy; Proguanil; Thailand; Triazines; Zambia | 2005 |
Other Studies
35 other study(ies) available for cycloguanil and Plasmodium falciparum Malaria
Article | Year |
---|---|
First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros.
Topics: Animals; Antimalarials; Atovaquone; Comoros; Drug Resistance; France; Genotype; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Travel; Treatment Failure | 2008 |
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Models, Molecular; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase | 2010 |
Herbicidal properties of antimalarial drugs.
Topics: Antimalarials; Arabidopsis; Herbicides; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadiazine; Sulfadoxine; Triazines | 2017 |
Cytogenetic and oxidative status of human lymphocytes after exposure to clinically relevant concentrations of antimalarial drugs atovaquone and proguanil hydrochloride in vitro.
Topics: Adult; Antimalarials; Atovaquone; Cell Survival; Cytogenetics; DNA Damage; Dose-Response Relationship, Drug; Drug Combinations; Glutathione; Humans; Lymphocytes; Malaria, Falciparum; Male; Malondialdehyde; Oxidative Stress; Plasmodium falciparum; Proguanil; Triazines | 2015 |
Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.
Topics: Antimalarials; Computational Biology; Drug Resistance; Evolution, Molecular; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Models, Biological; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 2016 |
In Vitro Analysis of the Interaction between Atovaquone and Proguanil against Liver Stage Malaria Parasites.
Topics: Antimalarials; Atovaquone; Drug Combinations; Hepatocytes; Humans; Inhibitory Concentration 50; Liver; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Triazines | 2016 |
Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum.
Topics: Drug Resistance; Evolution, Molecular; Folic Acid Antagonists; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 2011 |
Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR.
Topics: Animals; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Liver; Malaria, Falciparum; Models, Chemical; Models, Genetic; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Triazines | 2002 |
Profile and evolution of the chemosusceptibility of falciparum malaria imported into France in 2000.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; France; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Proguanil; Quinine; Triazines | 2002 |
Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Atovaquone; Codon; Drug Resistance; Electron Transport Complex III; Genetic Markers; Humans; Malaria, Falciparum; Mutation; Naphthoquinones; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proguanil; Triazines | 2003 |
In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; Madagascar; Malaria, Falciparum; Mefloquine; Parasitemia; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Triazines | 2002 |
Susceptibility of Plasmodium falciparum to the drugs used to treat severe malaria (quinine) and to prevent malaria (mefloquine, cycloguanil) in Comoros Union and Madagascar.
Topics: Animals; Antimalarials; Comoros; Drug Resistance; Humans; In Vitro Techniques; Madagascar; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Proguanil; Quinine; Triazines | 2004 |
Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.
Topics: Animals; Antimalarials; Atovaquone; Child, Preschool; Cytochromes b; Drug Combinations; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid Antagonists; Ghana; Humans; Infant; Malaria, Falciparum; Male; Mutation; Naphthoquinones; Plasmodium falciparum; Polymorphism, Restriction Fragment Length; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Triazines | 2004 |
In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil.
Topics: Animals; Antimalarials; Atovaquone; Culture Media; Cytochrome b Group; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Naphthoquinones; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Recurrence; Triazines | 2005 |
The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Therapy, Combination; Folic Acid Antagonists; Malaria, Falciparum; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Sesquiterpenes; Triazines | 2004 |
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Humans; Infant; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Proguanil; Prospective Studies; Triazines | 2006 |
Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia.
Topics: Animals; Antimalarials; Child; Child, Preschool; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Mutation, Missense; Peptide Synthases; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proguanil; Protozoan Proteins; Pyrimethamine; Rural Population; Tetrahydrofolate Dehydrogenase; Triazines; Zambia | 2008 |
Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Base Sequence; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Triazines | 1995 |
PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.
Topics: Administration, Oral; Animals; Antimalarials; Aotus trivirgatus; Atovaquone; Drug Synergism; Folic Acid Antagonists; Imides; Injections, Subcutaneous; Malaria, Falciparum; Mice; Naphthoquinones; Phenyl Ethers; Plasmodium falciparum; Proguanil; Sulfamethoxazole; Triazines | 1993 |
In vitro activity of cycloguanil against African isolates of Plasmodium falciparum.
Topics: Animals; Erythrocytes; Humans; Liver; Malaria, Falciparum; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Triazines | 1993 |
Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea.
Topics: Animals; Antimalarials; Base Sequence; Dihydropteroate Synthase; DNA Primers; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Triazines | 1996 |
Plasmodium falciparum: mutation pattern in the dihydrofolate reductase-thymidylate synthase genes of Vietnamese isolates, a novel mutation, and coexistence of two clones in a Thai patient.
Topics: Animals; Antimalarials; Base Sequence; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thailand; Thymidylate Synthase; Triazines; Vietnam | 1996 |
Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant Plasmodium falciparum isolates.
Topics: Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Triazines | 1997 |
In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
Topics: Animals; Antimalarials; Confidence Intervals; Drug Resistance; Folic Acid Antagonists; Humans; Lethal Dose 50; Malaria, Falciparum; Nonlinear Dynamics; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1997 |
Proguanil resistance in Plasmodium falciparum African isolates: assessment by mutation-specific polymerase chain reaction and in vitro susceptibility testing.
Topics: Africa; Amino Acid Substitution; Animals; Asparagine; Codon; DNA, Protozoan; Drug Resistance, Microbial; Humans; Malaria, Falciparum; Microbial Sensitivity Tests; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Sequence Analysis, DNA; Serine; Tetrahydrofolate Dehydrogenase; Triazines | 1997 |
Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.
Topics: Animals; Antimalarials; Humans; Kenya; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Proguanil; Protozoan Proteins; Pyrimethamine; Sensitivity and Specificity; Tetrahydrofolate Dehydrogenase; Triazines | 1998 |
[Considering disparities in resistance of Plasmodium falciparum in Africa in chemoprevention decisions].
Topics: Africa; Animals; Antimalarials; Chloroquine; Cross-Cultural Comparison; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Folic Acid Antagonists; Humans; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Proguanil; Seasons; Travel; Triazines | 1998 |
Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil.
Topics: Adolescent; Antimalarials; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Genotype; Humans; Infant; Malaria, Falciparum; Malaria, Vivax; Mixed Function Oxygenases; Proguanil; Tetrahydrofolate Dehydrogenase; Triazines | 1999 |
[Resistance to chloroquine and cycloguanil of Plasmodium falciparum in patients arriving in France after travel in Africa without chemoprophylaxis].
Topics: Africa; Animals; Antimalarials; Chloroquine; Codon; Drug Resistance, Multiple; Folic Acid Antagonists; France; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Seasons; Tetrahydrofolate Dehydrogenase; Travel; Triazines | 1998 |
[In vitro sensitivity of Plasmodium falciparum isolates from Gabon to chloroquine and cycloguanil].
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Gabon; Humans; Infant; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Triazines | 1999 |
Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples.
Topics: Alleles; Animals; Antimalarials; DNA Primers; DNA Restriction Enzymes; DNA, Protozoan; Humans; Inhibitory Concentration 50; Kenya; Malaria, Falciparum; Plasmodium falciparum; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase; Triazines | 1999 |
Increased incidence of cycloguanil resistance in malaria cases entering France from Africa, determined as point mutations in the parasites' dihydrofolate-reductase genes.
Topics: Africa; Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; France; Genes, Protozoan; Humans; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proguanil; Tetrahydrofolate Dehydrogenase; Triazines | 1999 |
Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro.
Topics: Amsacrine; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Enzyme Inhibitors; Etoposide; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Naphthyridines; Norfloxacin; Nucleic Acid Synthesis Inhibitors; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Thailand; Topoisomerase II Inhibitors; Triazines | 2000 |
Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates.
Topics: Amodiaquine; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antimalarials; Artemether; Artemisinins; Chloroquine; Doxycycline; Drug Resistance; Erythrocytes; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Scintillation Counting; Senegal; Sesquiterpenes; Statistics, Nonparametric; Triazines | 2000 |
Molecular epidemiology of malaria in Yaounde, Cameroon. VI. Sequence variations in the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene and in vitro resistance to pyrimethamine and cycloguanil.
Topics: Animals; Antimalarials; Cameroon; DNA Primers; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Triazines | 2000 |