cycloguanil has been researched along with Malaria in 28 studies
*Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (32.14) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Genther, CS; Smith, CS | 1 |
| Chan, C; Dascombe, MJ; Douglas, KT; Hyde, JE; McKie, JH; Read, M; Roser, SA; Sirawaraporn, W; Yates, R; Yuthavong, Y | 1 |
| Ager, AL; Bliss, RA; Canfield, CJ; Jacobus, DP; Jensen, NP; Kotecka, BM; Rieckmann, KH; Terpinski, J | 1 |
| Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B | 1 |
| Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y | 1 |
| Biamonte, MA; Le Roch, KG; Wanner, J | 1 |
| Azas, N; Basmaciyan, L; Cohen, A; Crozet, MD; Dallemagne, P; Deharo, E; Dumètre, A; Hutter, S; Laget, M; Lancelot, JC; Lesnard, A; Lorthiois, A; Mazier, D; Paloque, L; Rathelot, P; Rault, S; Sibley, CH; Suzanne, P; Valentin, A; Vanelle, P; Verhaeghe, P | 1 |
| Cheenpracha, S; Jaidee, A; Kamchonwongpaisan, S; Laphookhieo, S; Promchai, T; Pyne, SG; Rattanajak, R; Ritthiwigrom, T; Trisuwan, K | 1 |
| Abraham, M; Ambachew, B; Antonova-Koch, Y; Burrows, J; Calla, J; Campo, B; Chaumeau, V; Chen, K; Cheung, AL; Conway, AJ; Eribez, K; Fidock, DA; Gagaring, K; Gamo, FJ; Ibanez, M; Jado, JC; Kyle, DE; Lincoln, C; Llinás, M; Lukens, AK; Luth, MR; Maher, SP; McNamara, CW; Meister, S; Nosten, F; Ottilie, S; Owen, E; Plouffe, D; Rouillier, M; Sakata-Kato, T; Serrano, FN; Siegel, D; Taggard, CM; Vanaerschot, M; Winzeler, EA; Wirth, DF; Zhong, Y; Zhou, Y | 1 |
| Blasco, B; Moon, RW; Sutherland, CJ; van Schalkwyk, DA | 1 |
| Andrews, KT; Arnold, MS; Chua, MJ; Engel, JA; Fisher, GM; Skinner-Adams, TS | 1 |
| Hastings, MD; Sibley, CH | 1 |
| Schapira, A | 1 |
| Rossan, RN; Schmidt, LH | 1 |
| Howells, RE; Judge, BM | 1 |
| Graham, NB; Howells, RE; Judge, BM; McNeill, ME | 1 |
| Edstein, MD; Rieckmann, KH; Shanks, GD; Yeo, AE | 1 |
| Edstein, MD; Rieckmann, KH; Shanks, GD; Teja-Isavadharm, P; Webster, HK | 1 |
| Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ | 1 |
| Doury, JC; Fusai, T; Keundjian, A; Touze, JE | 1 |
| Bahr, S; Edstein, MD; Kotecka, B; Rieckmann, KH; Shanks, GD | 1 |
| de Alencastro, RB; Figueroa-Villar, JD; Santos-Filho, OA | 1 |
| Bjorkman, A; Flacks, H; Hanson, AP; Hogh, B; Petersen, E | 1 |
| Milhous, WK; Peterson, DS; Wellems, TE | 1 |
| Flachs, H; Hanson, AP; Høgh, B; Petersen, E | 1 |
| Barutwanayo, M; Coosemans, MH; Gryseels, B; Onori, E; Otoul, C; Wéry, M | 1 |
| Koech, DK; Sixsmith, DG; Spencer, HC; Watkins, WW | 1 |
| Bent, NS; Gilles, HM; Howells, RE | 1 |
1 review(s) available for cycloguanil and Malaria
| Article | Year |
|---|---|
Recent advances in malaria drug discovery.
Topics: Animals; Antimalarials; Drug Discovery; Humans; Liver; Liver Transplantation; Malaria; Molecular Structure | 2013 |
1 trial(s) available for cycloguanil and Malaria
| Article | Year |
|---|---|
Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil.
Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1987 |
26 other study(ies) available for cycloguanil and Malaria
| Article | Year |
|---|---|
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Acid Antagonists; Malaria; Mice; Plasmodium berghei; Triazines | 1977 |
Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
Topics: Animals; Antimalarials; Drug Design; Drug Resistance; Folic Acid Antagonists; Malaria; Male; Mice; Multienzyme Complexes; Mutation; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1998 |
Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials.
Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Guanidines; Malaria; Male; Mice; Plasmodium berghei; Plasmodium falciparum; Prodrugs; Proguanil; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2001 |
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Models, Molecular; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase | 2010 |
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites | 2011 |
Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium.
Topics: Animals; Antimalarials; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Drug Discovery; Erythrocytes; Hep G2 Cells; Humans; Liver; Malaria; Male; Mice; Parasitemia; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship; Trophozoites | 2015 |
Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.
Topics: Alkaloids; Animals; Annonaceae; Antimalarials; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; KB Cells; Malaria; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plasmodium berghei; Plasmodium falciparum; Vero Cells | 2016 |
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
Topics: Antimalarials; Chemoprevention; Drug Discovery; Drug Evaluation, Preclinical; Humans; Malaria; Mitochondria; Plasmodium | 2018 |
Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents.
Topics: Antimalarials; Benzothiazoles; Colorimetry; Diamines; Dihydroorotate Dehydrogenase; Erythrocytes; Fluorescence; Humans; L-Lactate Dehydrogenase; Malaria; Organic Chemicals; Oxidoreductases Acting on CH-CH Group Donors; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium knowlesi; Proguanil; Pyrimethamine; Quinolines; Sensitivity and Specificity; Triazines | 2017 |
Adaptation of the [3H]Hypoxanthine Uptake Assay for In Vitro-Cultured Plasmodium knowlesi Malaria Parasites.
Topics: Animals; Antimalarials; Chloroquine; Clindamycin; Hypoxanthine; Inhibitory Concentration 50; Malaria; Plasmodium falciparum; Plasmodium knowlesi; Proguanil; Triazines | 2016 |
Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax.
Topics: Alleles; Amino Acid Sequence; Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Inhibitory Concentration 50; Malaria; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Plasmodium vivax; Point Mutation; Proguanil; Pyrimethamine; Recombinant Proteins; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Triazines | 2002 |
Concomitant resistance to pyrimethamine and cycloguanil of chloroquine-resistant falciparum malaria from East Africa: an in vitro study of 12 isolates.
Topics: Africa, Eastern; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1984 |
Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys.
Topics: Acedapsone; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance, Microbial; Macaca mulatta; Malaria; Particle Size; Plasmodium falciparum; Plasmodium vivax; Proguanil; Pyrimethamine; Time Factors; Triazines | 1984 |
Sustained-release implants in the chemotherapy of experimental rodent malaria I. A comparison of the effects of some antimalarials in polydimethylsiloxane matrices.
Topics: Animals; Antimalarials; Chloroquine; Dimethylpolysiloxanes; Drug Implants; Malaria; Male; Mefloquine; Mice; Mice, Inbred Strains; Naphthoquinones; Piperidines; Plasmodium berghei; Primaquine; Proguanil; Pyrimethamine; Quinolines; Silicone Elastomers; Sulfadiazine; Triazines | 1981 |
Sustained-release implants in the chemotherapy of experimental rodent malaria II. The effects of sulphadiazine, pyrimethamine and cycloguanil in biodegradable polymer matrices.
Topics: Animals; Biodegradation, Environmental; Drug Implants; Malaria; Male; Mice; Mice, Inbred Strains; Plasmodium berghei; Proguanil; Pyrimethamine; Sulfadiazine; Triazines | 1981 |
A statistical analysis of the antimalarial activity of proguanil and cycloguanil in human volunteers.
Topics: Adolescent; Adult; Animals; Antimalarials; Biological Assay; Chromatography, High Pressure Liquid; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Regression Analysis; Triazines | 1994 |
Oxidative activation of proguanil and dapsone acetylation in Thai soldiers.
Topics: Acetylation; Biotransformation; Chromatography, High Pressure Liquid; Dapsone; Humans; Malaria; Military Personnel; Oxidation-Reduction; Polymorphism, Genetic; Proguanil; Thailand; Triazines | 1994 |
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Trimester, Third; Proguanil; Triazines | 1993 |
Human pharmacokinetics of chloroquine and proguanil delivered in a single capsule for malaria chemoprophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria; Male; Middle Aged; Proguanil; Triazines | 1995 |
In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand.
Topics: Animals; Antimalarials; Drug Resistance, Microbial; Folic Acid Antagonists; Malaria; Plasmodium falciparum; Prodrugs; Proguanil; Saimiri; Thailand; Triazines | 1997 |
Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance.
Topics: Amino Acid Sequence; Animals; Antimalarials; Binding Sites; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Liver; Malaria; Models, Biological; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 2001 |
In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1990 |
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.
Topics: Amino Acid Sequence; Animals; Binding Sites; DNA; Drug Resistance; Humans; Malaria; Models, Structural; Molecular Structure; Mutation; Plasmodium falciparum; Proguanil; Protein Conformation; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 1990 |
Malaria breakthrough despite chlorproguanil chemoprophylaxis in an area without antifol resistance.
Topics: Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; Humans; Malaria; Plasmodium falciparum; Proguanil; Triazines | 1988 |
Response of Plasmodium falciparum to dihydrofolate reductase inhibitors in Malindi, Kenya.
Topics: Child; Drug Resistance, Microbial; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Kenya; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Sulfanilamides; Triazines | 1986 |
A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii.
Topics: Animals; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Malaria; Male; Mice; Plasmodium; Proguanil; Pyrimethamine; Triazines | 1985 |