cyclocreatine has been researched along with Mental Retardation, X-Linked in 4 studies
cyclocreatine: structure given in first source
Mental Retardation, X-Linked: A class of genetic disorders resulting in INTELLECTUAL DISABILITY that is associated either with mutations of GENES located on the X CHROMOSOME or aberrations in the structure of the X chromosome (SEX CHROMOSOME ABERRATIONS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy." | 3.96 | Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency. ( Alessandrì, MG; Baroncelli, L; Battini, R; Butt, M; Cacciante, F; Cerri, E; Cioni, G; Do, MT; Gennaro, M; Lupori, L; Mazziotti, R; McKew, JC; Pizzorusso, T; Putignano, E; Sagona, G, 2020) |
| " Exposure at the no observed adverse effect level in creatine transporter-deficient (554 μg*hr/ml) mice exceeded exposure at the maximum tolerated dose in wild-type (248 μg*hr/ml) mice." | 1.62 | Use of an animal model of disease for toxicology enables identification of a juvenile no observed adverse effect level for cyclocreatine in creatine transporter deficiency. ( Butt, M; Cavagnaro, J; Do, MT; McKew, JC; Terse, PS, 2021) |
| "Cyclocreatine-treated Slc6a8-/y mice also exhibited a profound improvement in cognitive abilities, as seen with novel object recognition as well as spatial learning and memory tests." | 1.38 | Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. ( Benoit, SC; Blanco, VM; Chambers, JB; Clark, JF; Daikoku, T; Degrauw, TJ; Kurosawa, Y; Lindquist, DM; Pyne-Geithman, GJ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gorshkov, K | 1 |
| Wang, AQ | 1 |
| Sun, W | 1 |
| Fisher, E | 1 |
| Frigeni, M | 1 |
| Singleton, M | 1 |
| Thorne, N | 1 |
| Class, B | 1 |
| Huang, W | 1 |
| Longo, N | 1 |
| Do, MT | 3 |
| Ottinger, EA | 1 |
| Xu, X | 1 |
| Zheng, W | 1 |
| Cacciante, F | 1 |
| Gennaro, M | 1 |
| Sagona, G | 1 |
| Mazziotti, R | 1 |
| Lupori, L | 1 |
| Cerri, E | 1 |
| Putignano, E | 1 |
| Butt, M | 2 |
| McKew, JC | 2 |
| Alessandrì, MG | 1 |
| Battini, R | 1 |
| Cioni, G | 1 |
| Pizzorusso, T | 1 |
| Baroncelli, L | 1 |
| Cavagnaro, J | 1 |
| Terse, PS | 1 |
| Kurosawa, Y | 1 |
| Degrauw, TJ | 1 |
| Lindquist, DM | 1 |
| Blanco, VM | 1 |
| Pyne-Geithman, GJ | 1 |
| Daikoku, T | 1 |
| Chambers, JB | 1 |
| Benoit, SC | 1 |
| Clark, JF | 1 |
4 other studies available for cyclocreatine and Mental Retardation, X-Linked
| Article | Year |
|---|---|
Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts.
Topics: Brain Diseases, Metabolic, Inborn; Cells, Cultured; Chromatography, High Pressure Liquid; Creatine; | 2019 |
Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency.
Topics: Animals; Autistic Disorder; Blood-Brain Barrier; Brain Diseases, Metabolic, Inborn; Cerebrovascular | 2020 |
Use of an animal model of disease for toxicology enables identification of a juvenile no observed adverse effect level for cyclocreatine in creatine transporter deficiency.
Topics: Animals; Antineoplastic Agents; Brain; Brain Diseases, Metabolic, Inborn; Creatine; Creatinine; Dise | 2021 |
Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency.
Topics: Animals; Base Sequence; Brain; Cognition; Cognition Disorders; Creatinine; Disease Models, Animal; D | 2012 |