cyclobenzaprine has been researched along with Serotonin Syndrome in 9 studies
cyclobenzaprine: RN given refers to parent cpd; Lisseril is synonymous for HCl; structure
cyclobenzaprine : 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate." | 7.77 | Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome. ( Mestres, J; Oprea, TI; Seifert, SA, 2011) |
| "Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications." | 5.33 | Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs. ( Brown, DR; Keegan, MT; Rabinstein, AA, 2006) |
| " We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone." | 3.79 | Neuropsychiatric side effects of cyclobenzaprine. ( Sederholm, B; Shprecher, D; Sloan, CT, 2013) |
| "The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate." | 3.77 | Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome. ( Mestres, J; Oprea, TI; Seifert, SA, 2011) |
| "The serotonin syndrome is a rare toxicological emergency increasingly seen in emergency practice, secondary to increased use of proserotinergic drugs." | 1.35 | Serotonin syndrome in a patient taking Lexapro and Flexeril: a case report. ( Day, LT; Jeanmonod, RK, 2008) |
| "Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications." | 1.33 | Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs. ( Brown, DR; Keegan, MT; Rabinstein, AA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Bansal, V | 1 |
| Aranke, M | 1 |
| Vu, P | 1 |
| Javed, S | 1 |
| Shprecher, D | 1 |
| Sloan, CT | 1 |
| Sederholm, B | 1 |
| Kawai, Y | 1 |
| DeMonbrun, AG | 1 |
| Chambers, RS | 1 |
| Nolan, DA | 1 |
| Dolcourt, BA | 1 |
| Malas, NM | 1 |
| Quasney, MW | 1 |
| Day, LT | 1 |
| Jeanmonod, RK | 1 |
| Gillman, PK | 1 |
| Mestres, J | 1 |
| Seifert, SA | 1 |
| Oprea, TI | 1 |
| Abernethy, DR | 1 |
| Bai, JP | 1 |
| Burkhart, K | 1 |
| Xie, HG | 1 |
| Zhichkin, P | 1 |
| Lamberg, JJ | 1 |
| Gordin, VN | 1 |
| Keegan, MT | 1 |
| Brown, DR | 1 |
| Rabinstein, AA | 1 |
9 other studies available for cyclobenzaprine and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin syndrome from combination hydrocodone and cyclobenzaprine in a patient with cerebral palsy.
Topics: Cerebral Palsy; Female; Humans; Hydrocodone; Middle Aged; Pain; Serotonin Syndrome | 2023 |
Neuropsychiatric side effects of cyclobenzaprine.
Topics: Amitriptyline; Antidepressive Agents; Delirium; Humans; Male; Middle Aged; Movement Disorders; Muscl | 2013 |
A Previously Healthy Adolescent With Acute Encephalopathy and Decorticate Posturing.
Topics: Acute Febrile Encephalopathy; Adolescent; Amitriptyline; Brain; Bupropion; Decerebrate State; Diagno | 2017 |
Serotonin syndrome in a patient taking Lexapro and Flexeril: a case report.
Topics: Adult; Amitriptyline; Citalopram; Female; Humans; Selective Serotonin Reuptake Inhibitors; Serotonin | 2008 |
Is there sufficient evidence to suggest cyclobenzaprine might be implicated in causing serotonin toxicity?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Humans; Selective Serotonin Reuptake | 2009 |
Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Norepinephrine Plasma Membrane Transport Pr | 2011 |
Integration of diverse data sources for prediction of adverse drug events.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Serotonin Syndrome | 2011 |
Serotonin syndrome in a patient with chronic pain polypharmacy.
Topics: Adult; Amitriptyline; Anti-Allergic Agents; Antidepressive Agents; Carisoprodol; Cetirizine; Chronic | 2014 |
Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs.
Topics: Aged; Amitriptyline; Drug Interactions; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; | 2006 |