cyclobenzaprine has been researched along with Low Back Ache in 11 studies
cyclobenzaprine: RN given refers to parent cpd; Lisseril is synonymous for HCl; structure
cyclobenzaprine : 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al." | 9.22 | Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain. ( Gottlieb, M; Njie, A, 2016) |
| "To evaluate efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15- and 30-mg capsules in patients with muscle spasm associated with acute, painful musculoskeletal conditions." | 9.14 | Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design. ( Altman, CA; Borenstein, DG; Malanga, GA; Ruoff, GE; Weil, AJ; Xie, F, 2009) |
| "Cyclobenzaprine hydrochloride has the most recent and largest clinical trials demonstrating its benefit, but carisoprodol and metaxalone also appear to be effective." | 6.42 | Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. ( Toth, PP; Urtis, J, 2004) |
| "Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al." | 5.22 | Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain. ( Gottlieb, M; Njie, A, 2016) |
| "To evaluate efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15- and 30-mg capsules in patients with muscle spasm associated with acute, painful musculoskeletal conditions." | 5.14 | Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design. ( Altman, CA; Borenstein, DG; Malanga, GA; Ruoff, GE; Weil, AJ; Xie, F, 2009) |
| "Adding cyclobenzaprine or oxycodone/acetaminophen to naproxen for the treatment of acute low back pain does nothing more than increase adverse effects." | 3.83 | PURLs: More isn't better with acute low back pain treatment. ( Frazer, K; Stevermer, JJ, 2016) |
| "Cyclobenzaprine hydrochloride has the most recent and largest clinical trials demonstrating its benefit, but carisoprodol and metaxalone also appear to be effective." | 2.42 | Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. ( Toth, PP; Urtis, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| O'Neal, M | 1 |
| Alwan, R | 1 |
| Friedman, BW | 1 |
| Dym, AA | 1 |
| Davitt, M | 1 |
| Holden, L | 1 |
| Solorzano, C | 1 |
| Esses, D | 1 |
| Bijur, PE | 1 |
| Gallagher, EJ | 1 |
| Chaffee, DM | 1 |
| Frazer, K | 1 |
| Stevermer, JJ | 1 |
| Schneider, BJ | 1 |
| Kennedy, DJ | 1 |
| Kumbhare, D | 1 |
| Gottlieb, M | 1 |
| Njie, A | 1 |
| Malanga, GA | 1 |
| Ruoff, GE | 1 |
| Weil, AJ | 1 |
| Altman, CA | 1 |
| Xie, F | 1 |
| Borenstein, DG | 1 |
| Toth, PP | 1 |
| Urtis, J | 1 |
| Meyer, MA | 1 |
| Vas, J | 1 |
| Perea-Milla, E | 1 |
| Mendez, C | 1 |
| Silva, LC | 1 |
| Herrera Galante, A | 1 |
| Aranda Regules, JM | 1 |
| Martinez Barquin, DM | 1 |
| Aguilar, I | 1 |
| Faus, V | 1 |
| Harwood, MI | 1 |
| Chang, SI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Ketoprofen Gel to Placebo in Patients Presented With Mechanical Low Back Pain to the Emergency Department: A Randomized Placebo Controlled Trial[NCT02619695] | Phase 4 | 160 participants (Anticipated) | Interventional | 2015-06-30 | Recruiting | ||
| "Interest of the Return to Primary Care of the Low Back Booklet of Health Insurance in the Recovery of Common Acute Low Back Pain"[NCT03953625] | 33 participants (Actual) | Interventional | 2018-11-29 | Completed | |||
| A Randomized Three-armed Comparative Effectiveness Study of Various Medications for Musculoskeletal Low Back Pain: Defining the Added Benefit of Muscle Relaxants and Opioids.[NCT01587274] | Phase 4 | 323 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Achieving Peri-Operative Pain Control Without Opioids[NCT04813991] | Phase 3 | 0 participants (Actual) | Interventional | 2022-03-15 | Withdrawn (stopped due to Enrollment was never initiated and the PI is leaving the institution so the study is closing.) | ||
| Aromatherapy for Management of Back Pain in the Emergency Department[NCT03377088] | 60 participants (Anticipated) | Interventional | 2017-12-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Roland Morris Disability Questionnaire (RMDQ) is a 24 item instrument that evaluates the impact of low back pain on one's daily life. It is most sensitive for patients with mild to moderate disability due to acute, sub-acute or chronic low back pain. Each question can be answered as either a yes or no. The score ranges from 0 to 24 where a higher score reflects greater impairment and, therefore, worsening in the quality of life. The change in RMDQ is obtained by subtracting the RMDQ score at one week after discharge from the baseline score." (NCT01587274)
Timeframe: Baseline and one week after discharge from emergency department
| Intervention | units on a scale (Median) |
|---|---|
| Opioid | 5 |
| Skeletal Muscle Relaxant | 4 |
| Naproxen Alone | 7 |
3 reviews available for cyclobenzaprine and Low Back Ache
| Article | Year |
|---|---|
Cyclobenzaprine in the Treatment of Low Back Pain.
Topics: Amitriptyline; Humans; Low Back Pain; Muscle Relaxants, Central | 2016 |
Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.
Topics: Amitriptyline; Carisoprodol; Humans; Low Back Pain; Muscle Relaxants, Central; Oxazolidinones; Rando | 2004 |
Clinical inquiries. What is the most effective treatment for acute low back pain?
Topics: Acetaminophen; Adrenal Cortex Hormones; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Bed | 2002 |
3 trials available for cyclobenzaprine and Low Back Ache
| Article | Year |
|---|---|
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agen | 2015 |
Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adult; Amitriptyline; Dose-Response Relationship | 2016 |
Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design.
Topics: Adolescent; Adult; Aged; Algorithms; Amitriptyline; Delayed-Action Preparations; Double-Blind Method | 2009 |
5 other studies available for cyclobenzaprine and Low Back Ache
| Article | Year |
|---|---|
Does Flexeril Work? Utility of Muscle Relaxants in Lower Back Pain.
Topics: Amitriptyline; Humans; Low Back Pain; Muscles; Vasodilator Agents | 2022 |
PURLs: More isn't better with acute low back pain treatment.
Topics: Acetaminophen; Amitriptyline; Drug Combinations; Female; Humans; Low Back Pain; Male; Muscle Relaxan | 2016 |
Second-Order Peer Reviews of Clinically Relevant Articles for the Physiatrist: Naproxen with Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo to Treating Acute Low Back Pain: A Randomized Clinical Trial.
Topics: Acetaminophen; Amitriptyline; Humans; Low Back Pain; Naproxen; Oxycodone; Peer Review; Physiatrists | 2017 |
Persistent low back pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Humans; Low Back Pain; Muscle Relaxants, C | 2005 |
Efficacy and safety of acupuncture for the treatment of non-specific acute low back pain: a randomised controlled multicentre trial protocol [ISRCTN65814467].
Topics: Acetaminophen; Acupuncture; Acute Disease; Adult; Amitriptyline; Analgesics; Bayes Theorem; Clinical | 2006 |