cyclobenzaprine has been researched along with Leishmaniasis, Visceral in 2 studies
cyclobenzaprine: RN given refers to parent cpd; Lisseril is synonymous for HCl; structure
cyclobenzaprine : 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.
Leishmaniasis, Visceral: A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyclobenzaprine (CBP) is a tricyclic structurally related to the antidepressant amitriptyline, differing only by the presence of a double bond in the central ring." | 1.46 | Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice. ( Abengózar, MA; Almeida-Amaral, EE; Andrade-Neto, VV; Barbas, C; Cunha-Júnior, EF; da Costa-Silva, TA; Galisteo Junior, AJ; Lima, ML; Rivas, L; Tempone, AG; Torres-Santos, EC, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lima, ML | 2 |
| Abengózar, MA | 2 |
| Torres-Santos, EC | 2 |
| Borborema, SET | 1 |
| Godzien, J | 1 |
| López-Gonzálvez, Á | 1 |
| Barbas, C | 2 |
| Rivas, L | 2 |
| Tempone, AG | 2 |
| Cunha-Júnior, EF | 1 |
| Andrade-Neto, VV | 1 |
| da Costa-Silva, TA | 1 |
| Galisteo Junior, AJ | 1 |
| Almeida-Amaral, EE | 1 |
2 other studies available for cyclobenzaprine and Leishmaniasis, Visceral
| Article | Year |
|---|---|
Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis.
Topics: Adenosine Triphosphate; Amitriptyline; Animals; Antiprotozoal Agents; Energy Metabolism; Humans; Lei | 2022 |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.
Topics: Amitriptyline; Animals; Antiprotozoal Agents; Humans; Interferon-gamma; Interleukin-10; Interleukin- | 2017 |