cyclin-d1 and Schistosomiasis-mansoni

cyclin-d1 has been researched along with Schistosomiasis-mansoni* in 2 studies

Other Studies

2 other study(ies) available for cyclin-d1 and Schistosomiasis-mansoni

Article	Year
Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice. Scientific reports, 2023, Nov-21, Volume: 13, Issue:1 Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide. The transcription factor c-Jun, which is induced in S. mansoni infection-associated liver disease, can promote hepatocyte survival but can also trigger hepatocellular carcinogenesis. We aimed to analyze the hepatic role of c-Jun following S. mansoni infection. We adopted a hepatocyte-specific c-Jun knockout mouse model (Alb-Cre/c-Jun loxP) and analyzed liver tissue and serum samples by quantitative real-time PCR array, western blotting, immunohistochemistry, hydroxyproline quantification, and functional analyses. Hepatocyte-specific c-Jun knockout (c-Jun Topics: Animals; Cell Proliferation; Cyclin D1; Hepatocytes; Humans; Liver; Mice; Schistosoma mansoni; Schistosomiasis mansoni	2023
In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens. Microbes and infection, 2007, Volume: 9, Issue:12-13 Infection with Schistosoma mansoni induces a wide range of effects on the immune responses of the host. In the present study we investigated the influence of soluble egg antigens (SEA) on the cell cycle of peripheral blood mononuclear cells (PBMC) from infected and non-infected individuals with S. mansoni resident in an endemic area and blood donors from non-endemic area. The cell cycle, the expression of activation markers and cyclin D(+)(1,2,3) CD3(+) frequency was assessed by flow cytometry. Stimulation of PBMC from infected patients with SEA resulted in a lower frequency of CD3(+) T cells in S phase when compared with the non-infected group. In addition, infected patients presented a decrease of activation marker expression (CD69(+), HLA-DR(+) and CD28(-) on CD4(+) cells and CD25(+), HLA-DR(+) on CD8(+) cells). A reduced frequency was observed of cyclin D(1,2,3) expression in SEA-stimulated T cells from infected individuals when compared with those from the non-infected group. The decreased expression of activation markers and frequency of cyclin D(1,2,3) in T cells may result in arrest of T cells in the G(0)/G(1) phase of the cell cycle, thus explaining the down-regulation observed in chronic schistosomiasis. Topics: Animals; Antigens, Helminth; CD3 Complex; Cells, Cultured; Chronic Disease; Cyclin D1; Cyclin D2; Cyclin D3; Cyclins; Down-Regulation; Feces; G1 Phase; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Parasite Egg Count; Schistosoma mansoni; Schistosomiasis mansoni; T-Lymphocytes	2007

Article

Year

Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice.

Scientific reports, 2023, Nov-21, Volume: 13, Issue:1

Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide. The transcription factor c-Jun, which is induced in S. mansoni infection-associated liver disease, can promote hepatocyte survival but can also trigger hepatocellular carcinogenesis. We aimed to analyze the hepatic role of c-Jun following S. mansoni infection. We adopted a hepatocyte-specific c-Jun knockout mouse model (Alb-Cre/c-Jun loxP) and analyzed liver tissue and serum samples by quantitative real-time PCR array, western blotting, immunohistochemistry, hydroxyproline quantification, and functional analyses. Hepatocyte-specific c-Jun knockout (c-Jun

Topics: Animals; Cell Proliferation; Cyclin D1; Hepatocytes; Humans; Liver; Mice; Schistosoma mansoni; Schistosomiasis mansoni

2023

In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens.

Microbes and infection, 2007, Volume: 9, Issue:12-13

Infection with Schistosoma mansoni induces a wide range of effects on the immune responses of the host. In the present study we investigated the influence of soluble egg antigens (SEA) on the cell cycle of peripheral blood mononuclear cells (PBMC) from infected and non-infected individuals with S. mansoni resident in an endemic area and blood donors from non-endemic area. The cell cycle, the expression of activation markers and cyclin D(+)(1,2,3) CD3(+) frequency was assessed by flow cytometry. Stimulation of PBMC from infected patients with SEA resulted in a lower frequency of CD3(+) T cells in S phase when compared with the non-infected group. In addition, infected patients presented a decrease of activation marker expression (CD69(+), HLA-DR(+) and CD28(-) on CD4(+) cells and CD25(+), HLA-DR(+) on CD8(+) cells). A reduced frequency was observed of cyclin D(1,2,3) expression in SEA-stimulated T cells from infected individuals when compared with those from the non-infected group. The decreased expression of activation markers and frequency of cyclin D(1,2,3) in T cells may result in arrest of T cells in the G(0)/G(1) phase of the cell cycle, thus explaining the down-regulation observed in chronic schistosomiasis.

Topics: Animals; Antigens, Helminth; CD3 Complex; Cells, Cultured; Chronic Disease; Cyclin D1; Cyclin D2; Cyclin D3; Cyclins; Down-Regulation; Feces; G1 Phase; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Parasite Egg Count; Schistosoma mansoni; Schistosomiasis mansoni; T-Lymphocytes

2007