cyclin-d1 and Multiple-Sclerosis

To analyse whether the expression of apoptotic transcripts is associated with the conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS). Eleven candidate transcripts belonging to the death receptor pathway, BCL-2, the inflammasome complex and NF-ΚB family were studied in the nonconverting and converting CIS patients during the four-year follow-up period. Conversion to MS was associated with marked variability in the expression of proapoptotic genes that were linked to TGF-B1 gene levels. The predominant expression of proapoptotic genes in patients with CIS suggests an increased potential to undergo apoptosis with the goal of terminating immune responses and regulating immune system homeostasis.

Topics: Adult; Apoptosis; CARD Signaling Adaptor Proteins; Caspase 1; Cohort Studies; Cyclin D1; Cytokines; Cytoskeletal Proteins; Demyelinating Diseases; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; NF-kappa B; Receptors, Death Domain; Signal Transduction; Transforming Growth Factor beta1