cyclin-d1 and Granuloma--Plasma-Cell

cyclin-d1 has been researched along with Granuloma--Plasma-Cell* in 1 studies

Other Studies

1 other study(ies) available for cyclin-d1 and Granuloma--Plasma-Cell

Article	Year
Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor). Laboratory investigation; a journal of technical methods and pathology, 2000, Volume: 80, Issue:7 Inflammatory myofibroblastic tumor (IMT) is composed of myofibroblasts, plasma cells, and lymphocytes. Cytokines are possibly involved in its pathogenesis. Human herpesvirus-8 (HHV-8) encodes cell cycle regulatory and signaling proteins. A combination of nested PCR with several negative controls and Southern blot methods showed the presence of HHV-8 DNA in seven cases of IMT. Additionally, strong expression was demonstrated by in situ hybridization in many tumoral nuclei. Most of the myofibroblasts in all of the cases were immunoreactive for human IL-6 and cyclin D1. These cytokines probably have a paracrine action and may sustain myofibroblastic growth. HHV-8 could play an essential role in triggering IMT development by a local reactivation of viral lytic replication. The relationship between HHV-8 and immunosuppression status as the only associated cause for tumorigenesis should be revised. Topics: Adult; Aged; Cyclin D1; DNA, Viral; Female; Granuloma, Plasma Cell; Herpesvirus 8, Human; Humans; Interleukin-6; Leg; Lung Neoplasms; Lymph Nodes; Lymphatic Diseases; Male; Middle Aged; Soft Tissue Neoplasms	2000

Article

Year

Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor).

Laboratory investigation; a journal of technical methods and pathology, 2000, Volume: 80, Issue:7

Inflammatory myofibroblastic tumor (IMT) is composed of myofibroblasts, plasma cells, and lymphocytes. Cytokines are possibly involved in its pathogenesis. Human herpesvirus-8 (HHV-8) encodes cell cycle regulatory and signaling proteins. A combination of nested PCR with several negative controls and Southern blot methods showed the presence of HHV-8 DNA in seven cases of IMT. Additionally, strong expression was demonstrated by in situ hybridization in many tumoral nuclei. Most of the myofibroblasts in all of the cases were immunoreactive for human IL-6 and cyclin D1. These cytokines probably have a paracrine action and may sustain myofibroblastic growth. HHV-8 could play an essential role in triggering IMT development by a local reactivation of viral lytic replication. The relationship between HHV-8 and immunosuppression status as the only associated cause for tumorigenesis should be revised.

Topics: Adult; Aged; Cyclin D1; DNA, Viral; Female; Granuloma, Plasma Cell; Herpesvirus 8, Human; Humans; Interleukin-6; Leg; Lung Neoplasms; Lymph Nodes; Lymphatic Diseases; Male; Middle Aged; Soft Tissue Neoplasms

2000