cyclic-imp and Liver-Neoplasms

cyclic-imp has been researched along with Liver-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for cyclic-imp and Liver-Neoplasms

Article	Year
Comparison of the effects of 6- thio- and 6-methylthiopurine ribonucleoside cyclic monophosphates withtheir corresponding nucleosides on the growth of rat hepatoma cells. Cancer research, 1977, Volume: 37, Issue:3 The cyclic nucleotide forms of 6-mercaptopurine and 6-methylmercaptopurine have been found to be cytotoxic to rat hepatoma cells. Studies with an inhibitor of phosphodiesterase suggest that the cytotoxicity of both cyclic nucleotides results principally from conversion to the 5'-nucleotide. A comparison of the two thiopurine cyclic nucleotides with their nucleoside counterparts has suggested that (a) the thio derivatives act by a common mechanism which is different from that exerted by the methylthio derivatives, and (b) the methylthio cyclic nucleotide acts, at least in part, by a mechanism which differs from that exerted by the methylthio nucleoside. Topics: Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Cyclic IMP; Dose-Response Relationship, Drug; Inosine; Inosine Nucleotides; Liver Neoplasms; Methylthioinosine; Neoplasms, Experimental; Phosphodiesterase Inhibitors; Purine Nucleosides; Thioinosine	1977

Article

Year

Comparison of the effects of 6- thio- and 6-methylthiopurine ribonucleoside cyclic monophosphates withtheir corresponding nucleosides on the growth of rat hepatoma cells.

Cancer research, 1977, Volume: 37, Issue:3

The cyclic nucleotide forms of 6-mercaptopurine and 6-methylmercaptopurine have been found to be cytotoxic to rat hepatoma cells. Studies with an inhibitor of phosphodiesterase suggest that the cytotoxicity of both cyclic nucleotides results principally from conversion to the 5'-nucleotide. A comparison of the two thiopurine cyclic nucleotides with their nucleoside counterparts has suggested that (a) the thio derivatives act by a common mechanism which is different from that exerted by the methylthio derivatives, and (b) the methylthio cyclic nucleotide acts, at least in part, by a mechanism which differs from that exerted by the methylthio nucleoside.

Topics: Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Cyclic IMP; Dose-Response Relationship, Drug; Inosine; Inosine Nucleotides; Liver Neoplasms; Methylthioinosine; Neoplasms, Experimental; Phosphodiesterase Inhibitors; Purine Nucleosides; Thioinosine

1977