cyclic-guanosine-monophosphate-adenosine-monophosphate has been researched along with Pseudomonas-Infections* in 1 studies
1 other study(ies) available for cyclic-guanosine-monophosphate-adenosine-monophosphate and Pseudomonas-Infections
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The cyclic dinucleotide 2'3'-cGAMP induces a broad antibacterial and antiviral response in the sea anemone
In mammals, cyclic dinucleotides (CDNs) bind and activate STING to initiate an antiviral type I interferon response. CDNs and STING originated in bacteria and are present in most animals. By contrast, interferons are believed to have emerged in vertebrates; thus, the function of CDN signaling in invertebrates is unclear. Here, we use a CDN, 2'3' cyclic guanosine monophosphate-adenosine monophosphate (2'3'-cGAMP), to activate immune responses in a model cnidarian invertebrate, the starlet sea anemone Topics: Animals; Anti-Bacterial Agents; Antiviral Agents; Immunity, Innate; NF-kappa B; Nucleotides, Cyclic; Pseudomonas aeruginosa; Pseudomonas Infections; Sea Anemones; Signal Transduction; Transcriptional Activation | 2021 |