cyclic-guanosine-monophosphate-adenosine-monophosphate and Liver-Diseases

Liver diseases represent a major global health burden accounting for approximately 2 million deaths per year worldwide. The liver functions as a primary immune organ that is largely enriched with various innate immune cells, including macrophages, dendritic cells, neutrophils, NK cells, and NKT cells. Activation of these cells orchestrates the innate immune response and initiates liver inflammation in response to the danger signal from pathogens or injured cells and tissues. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a crucial signaling cascade of the innate immune system activated by cytosol DNA. Recognizing DNA as an immune-stimulatory molecule is an evolutionarily preserved mechanism in initiating rapid innate immune responses against microbial pathogens. The cGAS is a cytosolic DNA sensor eliciting robust immunity

Topics: Animals; Cell Transformation, Neoplastic; Disease Susceptibility; Humans; Immunity, Innate; Liver Diseases; Membrane Proteins; Nucleotides, Cyclic; Nucleotidyltransferases; Protein Binding; Protein Transport; Risk Factors; Signal Transduction