cyclic-gmp has been researched along with Temporomandibular-Joint-Disorders* in 1 studies
1 other study(ies) available for cyclic-gmp and Temporomandibular-Joint-Disorders
| Article | Year |
|---|---|
Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K
To investigate the role of heme oxygenase-1 (HO-1), carbon monoxide (CO), and biliverdin (BVD) in the zymosan-induced TMJ arthritis in rats.. Mechanical threshold was assessed before and 4 h after TMJ arthritis induction in rats. Cell influx, myeloperoxidase activity, and histological changes were measured in the TMJ lavages and tissues. Trigeminal ganglion and periarticular tissues were used for HO-1, TNF-α, and IL-1β mRNA time course expression and immunohistochemical analyses. Hemin (0.1, 0.3, or 1 mg kg. Hemin (1 mg kg. HO-1/BVD/CO pathway activation provides anti-nociceptive and anti-inflammatory effects on the zymosan-induced TMJ hypernociception in rats. Topics: Animals; Arthritis; Biliverdine; Carbon Monoxide; Cyclic GMP; Cytokines; Down-Regulation; Heme Oxygenase-1; KATP Channels; Male; Nociception; Pain Threshold; Peroxidase; Potassium Channel Blockers; Rats; Rats, Wistar; Signal Transduction; Temporomandibular Joint Disorders; Trigeminal Ganglion; Zymosan | 2018 |