cyclic-gmp and Schistosomiasis

Supernatants obtained from non-stimulated lymphocytes, lymphocytes stimulated with phytohaemagglutinin and lymphocytes from patients with schistosomiasis that were stimulated with Schistosomiasis haematobium ova were shown to enhance a number of eosinophil functions. Eosinophil chemotaxis, phagocytosis, microbicidal activity, Nitro blue tetrazolium reduction, hexose monophosphate shunt activity and glycolysis were increased. Eosinophil iodination was not affected. Only those supernatants obtained from phytohaemagglutinin stimulated lymphocytes and lymphocytes from patients with schistosomiasis that were stimulated with S. haematobium ova showed eosinophil chemotactic activity. The active factor was found to be heat stable, and had no effect on cAMP and cGMP metabolism. The most likely mechanism of enhanced eosinophil function is through the increased activity of the hexose monophosphate shunt activity and glycolysis.

Topics: Blood Bactericidal Activity; Chemotaxis, Leukocyte; Cyclic AMP; Cyclic GMP; Eosinophils; Glycolysis; Hexosephosphates; Humans; Lymphocyte Activation; Lymphocytes; Lymphokines; Nitroblue Tetrazolium; Phagocytosis; Schistosomiasis