cyclic-gmp and Rhinitis--Allergic--Seasonal

It has been shown that injections of low doses of common environmental antigens or irritants cause a reduced sensitivity during a subsequent exposure to the same antigen and irritant. On the basis of these findings, the following study was performed: 20 allergic patients who manifested allergic symptoms were observed during skin end-point titration testing, which is described in the manuscript. During the testing procedure, 60% of the patients reported a complete relief of symptoms. It is postulated that a cytoprotective dose was given during the testing procedure that caused the symptoms to be relieved. The second part of the study was a double-blind placebo control study in which 40 patients received the end-point dose and 10 patients received placebo. All patients entered the study with allergic symptoms. None of the placebo patients reported any relief of symptoms when given their injection. Of patients who received the active ingredient, 67.5% reported relief of symptoms within 5 to 10 minutes after the subcutaneous administration of the active ingredient. With these findings, it is postulated that this low dose of active ingredient caused the production of prostaglandin E intracellularly, which causes an increase in cyclic AMP and a decrease in cyclic GMP, which results in the resolution of symptoms.

Topics: Cyclic AMP; Cyclic GMP; Desensitization, Immunologic; Dose-Response Relationship, Immunologic; Double-Blind Method; Humans; Prostaglandins E; Rhinitis, Allergic, Seasonal; Skin Tests

Sinesterases that intervene in cAMP and oGMP equilibrium in the cytoplasm of mast cells are activated by the adrenergic system through beta-receptors. A study was made on 96 atopic patients with mono sensitization to Dermatophagoides pteronissinus, in 3 groups. Radioligands were used to quantitate the number of beta receptors. In the control group mean no/cell was 541, bronchial symptomatic patients had 327 and nasal symptomatics 348. Asymptomatic patients were similar to controls. The results were similar with pollen-sensitive patients. Beta receptor decrease is a consequence of clinical allergy in atopic patients and is secondary to the immunological events that follow antigen-antibody reactions and cell membrane changes.

Topics: Adenylyl Cyclases; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Cyclic AMP; Cyclic GMP; Enzyme Activation; Humans; Hypersensitivity, Immediate; Mast Cells; Mites; Phosphoric Diester Hydrolases; Receptors, Adrenergic, beta; Rhinitis, Allergic, Seasonal; Signal Transduction

From clinical practice, the authors concluded that the principal pathogenic factor in allergic rhinitis is deficient resistance of the body surface, and the patient is exposed to invasion of wind-evil. 495 cases of the allergic rhinitis have been treated with the method of invigorating vital energy and strengthening the body surface resistance (Bu Qi Gu Biao); the total effective rate was 84%, and the recurrence rate was 13.2% in a follow-up of 2 years. The changes in plasma cyclic nucleotides of the patients, and the ultrastructure of nasal mucosa of patients and animal models were also observed before and after treatment. The results showed that the TCM therapy tended to normalize the plasma cyclic nucleotide level, to improve the morphology and function of cells and organelles, to restore the function of mucosal cilia, to reduce the infiltration of eosinophils and their degranulation, to reduce tissue edema, and to eliminate the deposit of immune complexes.

Topics: Adolescent; Adult; Aged; Animals; Child; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Nasal Mucosa; Rabbits; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal

The authors summarized 500 cases of allergic rhinitis treated by "Bu Qi Gu Biao" therapy since 1980. After treatment, long term curative effect was 87%. Moreover, the authors had observed serum IgE, IgA and IgG, plasma cyclic nucleotides, blood flow in nasal mucosa, and ultrastructure of nasal mucosa before and after the treatment in 200 cases. The results indicated that "Bu Qi Gu Biao" therapy could adjust immune function and cyclic nucleotides metabolism in organism, improve blood flow in nasal mucosa tissue, restore or improve cell's shape and function and eliminate partial deposition of immune compound in vascular basement membrane. Therefore, it could control or eliminate the symptoms of allergic rhinitis.

Topics: Adolescent; Adult; Aged; Child; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Humans; Immunoglobulins; Male; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal

Cyclic nucleotides (CND) levels of nasal secretions were studied in allergic rhinitis patients and control subjects. In methacholine-induced nasal secretion, allergic rhinitis patients had lower cAMP levels, higher cGMP levels and a lower cAMP/cGMP ratio than the control subjects. A close relationship was found between CND levels and the severity of daily symptoms in both methacholine-induced and antigen-induced nasal secretions.

Topics: Cyclic AMP; Cyclic GMP; Humans; Nasal Mucosa; Nasal Provocation Tests; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Secretory Rate

The effect of isoproterenol on the cyclic nucleotide level in peripheral lymphocytes and granulocytes with allergic rhinitis patients and normal subjects has been studied. Responsiveness to 10(-5) M isoproterenol of lymphocytes decreased in the case of allergic rhinitis patients. When asthma was complicated to perennial rhinitis, a more significant depression was noted. In granulocytes the same tendency as with lymphocytes was noted although the difference was not significant. Basal level and responsiveness to 5 X 10(-3) M theophylline of both lymphocytes and granulocytes were similar in allergic rhinitis patients to normal subjects. The ratio of plasma cAMP to cGMP concentration was lower in the allergic rhinitis patients although the difference was not significant.

Topics: Adolescent; Adult; Asthma; Child; Cyclic AMP; Cyclic GMP; Granulocytes; Humans; Isoproterenol; Lymphocytes; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Theophylline